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11. 发明授权

US06478191B1 Applicator with protective barrier 有权
公开(公告)号：US06478191B1
公开(公告)日：2002-11-12
申请号：US10012441
申请日：2001-12-12
申请人： Keith R. D'Alessio , Andres Rivera , Anthony S. Voiers , Joe B. Barefoot
发明人： Keith R. D'Alessio , Andres Rivera , Anthony S. Voiers , Joe B. Barefoot
IPC分类号： B65D3700
CPC分类号： A61M35/003 , B05C17/002 , Y10S215/06 , Y10T225/30
摘要： An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.

12. 发明授权

US06425704B2 Adhesive applicators with improved applicator tips 有权
标题翻译：粘合剂涂抹器具有改进的涂抹器尖端
公开(公告)号：US06425704B2
公开(公告)日：2002-07-30
申请号：US09479060
申请日：2000-01-07
申请人： Anthony S Voiers , Keith R D'Alessio , Jeffrey G Clark , Timothy P Hickey
发明人： Anthony S Voiers , Keith R D'Alessio , Jeffrey G Clark , Timothy P Hickey
IPC分类号： B43M1106
CPC分类号： B65D81/32 , B65D83/00
摘要： An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.
摘要翻译：用于分配粘合剂材料的涂布器包括保持粘合剂材料的容器主体和构造成允许改进粘合剂的控制和经济性的施用器顶端。

13. 发明授权

US06283933B1 Applicator for dispensable liquids 有权
标题翻译：涂抹器用于可分配的液体
公开(公告)号：US06283933B1
公开(公告)日：2001-09-04
申请号：US09219851
申请日：1998-12-23
申请人： Keith R. D'Alessio , William M. Cotter
发明人： Keith R. D'Alessio , William M. Cotter
IPC分类号： A61M3500
CPC分类号： A61M35/003
摘要： A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.
摘要翻译：一次性涂抹器包括一个大致管状的施用器主体，其具有封闭的近端和敞开的远端以及内部易碎的小瓶。近端由干燥棉签覆盖，而远端由与施用器主体内部开放连通的施用器拭子覆盖。在施用器主体内是具有生物医学上可用的液体组合物的易碎小瓶，例如α-氰基丙烯酸酯粘合剂，药物或两者。施用器可用于将液体组合物施用于靶点，例如组织，特别是局部病理部位，例如口腔炎病变。

14. 发明授权

US09393344B2 Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices 有权
公开(公告)号：US09393344B2
公开(公告)日：2016-07-19
申请号：US11653433
申请日：2007-01-11
申请人： Kenneth E. Stockman , Michael A. Carnahan , Keith R. D'Alessio , Mark W. Grinstaff
发明人： Kenneth E. Stockman , Michael A. Carnahan , Keith R. D'Alessio , Mark W. Grinstaff
IPC分类号： A61K31/74 , A61L24/04 , A61K31/785 , A61K31/787 , A61L27/18 , A61B17/00
CPC分类号： A61L26/0019 , A61B2017/0065 , A61B2017/00951 , A61K31/785 , A61K31/787 , A61K51/1279 , A61L24/0031 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L26/0052 , A61L26/008 , A61L26/0085 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/56 , C08L79/02
摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

15. 发明授权

US08262608B2 Applicators for multiple component formulations and the like, and methods of use thereof 有权
标题翻译：多组分配方等的涂布器及其使用方法
公开(公告)号：US08262608B2
公开(公告)日：2012-09-11
申请号：US12019996
申请日：2008-01-25
申请人： Jeffrey G. Clark , Keith R. D'Alessio
发明人： Jeffrey G. Clark , Keith R. D'Alessio
IPC分类号： A61M37/00
CPC分类号： A61M35/006 , A61B17/00491 , A61B2017/00495 , A61B2017/320012 , A61B2090/037 , A61J1/065 , A61J1/2093
摘要： One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.
摘要翻译：本发明的一个方面涉及一种可用于单独容纳一种或多种液体和一种或多种固体（例如可聚合水凝胶的组分）的施用器系统及其使用方法。在某些实施例中，施加器系统被进一步设计成便于施用器内的固体和液体的混合。此外，在某些实施例中，施用器系统也被设计成便于将混合物施加到表面。

16. 发明申请

US20100280312A1 Self-Contained Medical Applicators for Surgical Sealants, and Methods of Use Thereof 有权
标题翻译：用于外科密封剂的自给式医用涂布器及其使用方法
公开(公告)号：US20100280312A1
公开(公告)日：2010-11-04
申请号：US12771656
申请日：2010-04-30
申请人： Keith R. D'Alessio , Matthew J. Morton , John L. Manhard , Stephen W. Cline , Jared D.G Butlin , John Conn
发明人： Keith R. D'Alessio , Matthew J. Morton , John L. Manhard , Stephen W. Cline , Jared D.G Butlin , John Conn
IPC分类号： A61B17/03 , A61B1/00
CPC分类号： A61B17/00491 , A61B17/545 , A61B2017/00398 , A61B2017/00495 , A61B2017/00734 , A61M5/19 , A61M5/20 , B05C17/00509 , B05C17/00516 , B05C17/00553 , B05C17/00569 , B05C17/01 , B05C17/0103
摘要： Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.
摘要翻译：本发明的方面涉及可以将多种成分制剂容纳在单独的材料容器中的涂布器及其使用方法，该组件然后可以在使用时容易地组合而不由使用者组装。在某些实施方案中，本发明的装置可用于但不限于将水凝胶制剂施用于硬脑膜，疝修补中的腹部组织，脊柱附近的组织，肺组织，肠组织或任何内部组织。在某些实施方案中，本发明的装置可以被配置成将液体制剂的喷雾或物流施加到表面。在某些实施方案中，本发明的装置可以被配置成通过内窥镜或腹腔镜递送制剂。

17. 发明授权

US06705790B2 Adhesive applicators with improved applicator tips 有权
标题翻译：粘合剂涂抹器具有改进的涂抹器尖端
公开(公告)号：US06705790B2
公开(公告)日：2004-03-16
申请号：US10134603
申请日：2002-04-30
申请人： Julian A. Quintero , Keith R. D'Alessio , Daniel L. Hedgpeth , Roy Thompson
发明人： Julian A. Quintero , Keith R. D'Alessio , Daniel L. Hedgpeth , Roy Thompson
IPC分类号： B43M1100
CPC分类号： B65D81/32 , B65D83/00
摘要： An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.
摘要翻译：用于分配粘合剂材料的涂布器包括保持粘合剂材料的容器主体和构造成允许改进粘合剂的控制和经济性的施用器顶端。

18. 发明授权

US06607631B1 Adhesive compositions with reduced coefficient of friction 有权
标题翻译：具有降低的摩擦系数的粘合剂组合物
公开(公告)号：US06607631B1
公开(公告)日：2003-08-19
申请号：US09657912
申请日：2000-09-08
申请人： Ibraheem T. Badejo , Wendy Y. Su , Keith R. D'Alessio , Jerry Jonn , Julian A. Quintero , Michelle Knotts , Timothy P. Hickey , Lawrence H. Mainwaring , Upvan Narang
发明人： Ibraheem T. Badejo , Wendy Y. Su , Keith R. D'Alessio , Jerry Jonn , Julian A. Quintero , Michelle Knotts , Timothy P. Hickey , Lawrence H. Mainwaring , Upvan Narang
IPC分类号： C09J18304
CPC分类号： A61L24/06 , C09J4/00 , C08L35/04 , C08F222/32
摘要： A polymerizable monomer adhesive composition includes a 1,1-disubstituted ethylene monomer and at least one slip additive, where the slip additive causes a polymer film formed from the monomer to have a lower coefficient of friction than in an absence of the slip additive. The slip additive can be selected from, inter alia, fluorinated monomers or polymers, fluorinated additives, siloxane-containing monomers or polymers, siloxane-containing additives, fluorinated siloxanes, and long chain fatty acid esters. The slip additive can also form a second phase in a resultant polymer film, where the second phase is soluble in the monomer but is insoluble or substantially insoluble in the polymer.
摘要翻译：可聚合单体粘合剂组合物包括1,1-双取代的乙烯单体和至少一种滑爽添加剂，其中滑爽添加剂使得由单体形成的聚合物膜的摩擦系数低于不存在滑爽添加剂的摩擦系数。滑爽添加剂尤其可以选自氟化单体或聚合物，氟化添加剂，含硅氧烷的单体或聚合物，含硅氧烷的添加剂，氟化硅氧烷和长链脂肪酸酯。滑爽添加剂还可以在所得聚合物膜中形成第二相，其中第二相可溶于单体，但不溶或基本上不溶于聚合物。

19. 发明授权

US06595940B1 Applicator for dispensable liquids 有权
标题翻译：涂抹器用于可分配的液体
公开(公告)号：US06595940B1
公开(公告)日：2003-07-22
申请号：US09430290
申请日：1999-10-29
申请人： Keith R. D'Alessio , William M. Cotter , Upvan Narang , Lawrence H. Mainwaring , Ibraheem T. Badejo , Daniel L. Hedgpeth , Gabriel N. Szabo , Anthony Sherbondy , Joe B. Barefoot
发明人： Keith R. D'Alessio , William M. Cotter , Upvan Narang , Lawrence H. Mainwaring , Ibraheem T. Badejo , Daniel L. Hedgpeth , Gabriel N. Szabo , Anthony Sherbondy , Joe B. Barefoot
IPC分类号： A61M3500
CPC分类号： A61M35/003
摘要： A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.
摘要翻译：一次性涂抹器包括一个大致管状的施用器主体，其具有封闭的近端和敞开的远端以及内部易碎的小瓶。近端由干燥棉签覆盖，而远端由与施用器主体内部开放连通的施用器拭子覆盖。在施用器主体内是具有生物医学上可用的液体组合物的易碎小瓶，例如α-氰基丙烯酸酯粘合剂，药物或两者。施用器可用于将液体组合物施用于靶点，例如组织，特别是局部病理部位，例如口腔炎病变。

20. 发明授权

US06494896B1 Applicator for laparoscopic or endoscopic surgery 有权
标题翻译：腹腔镜或内窥镜手术敷贴器
公开(公告)号：US06494896B1
公开(公告)日：2002-12-17
申请号：US09450686
申请日：1999-11-30
申请人： Keith R. D'Alessio , Lawrence H. Mainwaring
发明人： Keith R. D'Alessio , Lawrence H. Mainwaring
IPC分类号： A61B1704
CPC分类号： A61B17/00491 , A61B17/00234 , A61B17/30 , A61B2017/00535 , A61B2017/3488
摘要： A hand-held applicator delivers liquid or semi-liquid compositions, such as adhesives, to an internal tissue or organ in an even and controlled manner. The applicator includes a pump, a tubular extension that is thin enough to pass through an endoscopic pathway or trocar, a proximal end of the tubular extension being sealingly connected to the pump, and an applicator tip that attaches to the distal end of the tubular extension. The tip includes the liquid and the pump pumps the liquid to the internal tissue in an even and controlled manner without contact of the liquid by the pump. The pump is preferably a micropipetter that includes a hand-held portion having a hand-actuatable plunger that does not come in direct, physical contact with the liquid to be dispensed. The composition may be an adhesive such as an alpha-cyanoacrylate. The device may further include a wound closure device including at least two closure pins extending from the distal end of the tubular extension. The wound closure device retracts from the applicator device and orients and aligns a wound or incision target tissue site immediately prior to application of the medical composition. The device provides improved control, ergonomics, and convenience. The device is particularly useful in the field of surgery, especially in the field of laparoscopic or endoscopic surgery, where an even and controlled amount of a medically-acceptable adhesive is to be applied to a target site on an internal tissue or organ.
摘要翻译：手持式施药器以均匀和受控的方式将液体或半液体组合物（例如粘合剂）递送至内部组织或器官。施用器包括泵，足够薄以穿过内窥镜通路或套管针的管状延伸部，管状延伸部的近端密封地连接到泵，以及附接到管状延伸部的远端的施用器末端。尖端包括液体，并且泵以均匀且受控的方式将液体泵送到内部组织，而不会被泵与液体接触。泵优选地是微量吸嘴，其包括手持部分，其具有手动致动柱塞，其不会与待分配的液体直接地物理接触。组合物可以是诸如α-氰基丙烯酸酯的粘合剂。所述装置还可以包括伤口闭合装置，其包括从所述管状延伸部的远端延伸的至少两个闭合销。伤口闭合装置从施用器装置缩回并且在施用医疗组合物之前定向和对准伤口或切口目标组织部位。该设备提供改进的控制，人体工程学和便利性。该装置在手术领域特别有用，特别是在腹腔镜或内窥镜手术领域中，其中均匀和受控量的医学上可接受的粘合剂应用于内部组织或器官上的靶位点。

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