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11. 发明申请

WO0176685A3 EROTIC STIMULATION DEVICE 审中-公开
标题翻译： EROTIC刺激装置
公开(公告)号：WO0176685A3
公开(公告)日：2002-03-28
申请号：PCT/US0111093
申请日：2001-04-04
申请人： KLEIN ERIC A
发明人： KLEIN ERIC A
IPC分类号： A44C15/00 , A61H19/00 , A61H21/00 , A61H23/02 , A61H1/00
CPC分类号： A44C15/0035 , A61H19/30 , A61H19/34 , A61H19/50 , A61H21/00 , A61H23/0263 , A61H2201/1604 , Y10S601/16
摘要： A sexual aid device comprising a battery powered electric vibrator which attaches to the user's tongue. The main embodiment attaches to the tongue using a post (18) which is inserted through a hole previously pierced in the tongue. The assembled device is shaped roughly like a dumbbell consisting of a post with retainers mounted at either end. The post has a diameter narrow enough to fit through the tongue hole, but the retainers have a larger diameter and cannot slip through the hole. An electric vibrator motor (14) is incorporated into one of the retainers. At least one of the retainers must be removable to allow device insertion. An electric battery (13) may be mounted in the same retainer as the vibrator motor (14) or in the other retainer.
摘要翻译：一种性帮助装置，包括附接到使用者舌头的电池供电电动振动器。主要实施例使用插入通过先前在舌头中刺穿的孔的柱（18）来附接到舌头。组装的装置的形状大体上类似于哑铃，其由具有安装在任一端的保持器的柱构成。该柱具有足够窄的直径以穿过舌孔，但是保持器具有较大的直径并且不能滑过该孔。电动振动电机（14）被并入其中一个保持器。至少一个保持器必须是可拆卸的，以允许设备插入。电池（13）可以安装在与振动电动机（14）相同的保持器中，或者安装在另一保持器中。

12. 发明申请

WO2010075414A3 METHOD FOR DETECTION OF XMRV 审中-公开
标题翻译：检测XMRV的方法
公开(公告)号：WO2010075414A3
公开(公告)日：2010-10-07
申请号：PCT/US2009069244
申请日：2009-12-22
申请人： CLEVELAND CLINIC FOUNDATION , SILVERMAN ROBERT H , KLEIN ERIC A , WEIGHT CHRISTOPHER J , NGUYEN CARVELL T , GUPTA JAYDIP DAS
发明人： SILVERMAN ROBERT H , KLEIN ERIC A , WEIGHT CHRISTOPHER J , NGUYEN CARVELL T , GUPTA JAYDIP DAS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/702 , C12Q2600/16
摘要： The present invention relates to the identification of Xenotropic murine leukemia virus (XMRV) nucleic acid by polymerase chain reaction (PCR) analysis (e.g., real time PCR (RT/PCR); nested RT/PCR using Tth DNA polymerase and Hot start polymerase) and the uses thereof. In particular, the invention provides methods for the detection, and in particular early detection, of XMRV in RNA isolated from samples (e.g., urine samples; expressed prostate secretion (EPS)) of prostate cancer patients and normal individuals.
摘要翻译：本发明涉及通过聚合酶链式反应（PCR）分析（例如实时PCR（RT / PCR）;使用Tth DNA聚合酶和热启动聚合酶的巢式RT / PCR）鉴定异嗜性鼠白血病病毒（XMRV）及其用途。具体而言，本发明提供了用于检测并且特别是早期检测前列腺癌患者和正常个体的样品（例如，尿液样品;表达的前列腺分泌物（EPS））中分离的RNA中的XMRV的方法。

13. 发明申请

WO2006110589A3 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
公开(公告)号：WO2006110589A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/013167
申请日：2006-04-07
申请人： THE CLEVELAND CLINIC FOUNDATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
发明人： SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
IPC分类号： C12N7/00 , C12N15/11 , C07K14/15 , C12N15/63 , C12N5/10 , C12Q1/68 , G01N33/569 , G01N33/50 , A61K39/21 , C12N7/02
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

14. 发明申请

WO2006110589A8 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译： GAMMARETROVIRUS与癌症相关
公开(公告)号：WO2006110589A8
公开(公告)日：2007-03-01
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
IPC分类号： C12N7/00 , A61K39/21 , C07K14/15 , C12N5/10 , C12N7/02 , C12N15/11 , C12N15/63 , C12Q1/68 , G01N33/50 , G01N33/569
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒（例如在个体中）的方法; 鉴定抑制病毒的物质的方法; 诱导对病毒的免疫应答的方法; 治疗与个体中XMRV存在相关的疾病（例如癌症，例如前列腺癌）的方法; 检测无症状癌症（例如前列腺癌）的方法; 鉴定处于发展成癌症风险中的个体（例如前列腺癌）的方法; 和检测病毒的工具包。

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