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11. 发明申请

US20070011244A1 Arrangement for mobile communications and wireless publishing 审中-公开
标题翻译：移动通信和无线发布安排
公开(公告)号：US20070011244A1
公开(公告)日：2007-01-11
申请号：US10561659
申请日：2004-06-18
申请人： Shawn O'Neal , John Maier
发明人： Shawn O'Neal , John Maier
IPC分类号： G06F15/16
CPC分类号： H04L69/329 , H04L51/063 , H04L51/066 , H04L51/38 , H04L67/02 , H04L67/306 , H04W4/12 , H04W88/184 , H04W92/02
摘要： A wireless communication system for transmission of digital messages to users of wireless communication devices (600, 610, 620, 630, 640, 650) on various wireless networks (500, 510, 520, 530, 540, 550) is provided. Messages to users are encoded with formatting corresponding to the network and/or subscriber device to which a message is to be delivered. A digital content server (100) can operate to create, encode and transmit messages to users of a plurality of different wireless networks (500, 510, 520, 530, 540, 550).
摘要翻译：提供了一种用于向各种无线网络（500,510,520,530,540,550）上的无线通信设备（600,610,630,640,650）的用户传送数字消息的无线通信系统。向用户发送的消息使用对应于要传送消息的网络和/或订户设备的格式进行编码。数字内容服务器（100）可以操作以创建，编码和向多个不同的无线网络（500,510,520,530,540,550）的用户发送消息。

12. 发明申请

US20060281068A1 Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging 审中-公开
标题翻译：通过拉曼光谱成像检测恶性肿瘤的疾病状况的细胞学方法
公开(公告)号：US20060281068A1
公开(公告)日：2006-12-14
申请号：US11269596
申请日：2005-11-09
申请人： John Maier , Shona Stewart , Patrick Treado
发明人： John Maier , Shona Stewart , Patrick Treado
IPC分类号： C12Q1/00 , C12Q1/70 , C12Q1/68 , G06F19/00 , G01J3/44
CPC分类号： G01N21/65 , G01N2021/656
摘要： Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.
摘要翻译：拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。例如，本公开包括使用RMI来区分正常和患病细胞或组织，例如癌细胞，以及确定所述癌细胞的等级。在一个优选实施方案中，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾，乳腺和结肠以及非上皮组织，例如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

13. 发明申请

US20060155195A1 Method of chemical imaging to determine tissue margins during surgery 有权
公开(公告)号：US20060155195A1
公开(公告)日：2006-07-13
申请号：US11361256
申请日：2006-02-24
申请人： John Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： John Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00 , G01J3/44 , A61B18/18 , G01J3/40 , A61B5/00 , A61B5/05
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

14. 发明申请

US20050277816A1 Cytological analysis by raman spectroscopic imaging 有权
标题翻译：通过拉曼光谱成像进行细胞学分析
公开(公告)号：US20050277816A1
公开(公告)日：2005-12-15
申请号：US11000591
申请日：2004-11-30
申请人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
发明人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/4519 , G01N21/65
摘要： Raman molecular imaging is used to differentiate between normal and diseased cells or tissue. For instance benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view.
摘要翻译：拉曼分子成像用于区分正常和病变细胞或组织。例如，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾脏，乳腺和结肠，以及非上皮组织，如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。

15. 发明授权

US1333432A Vise 失效
公开(公告)号：US1333432A
公开(公告)日：1920-03-09
申请号：US32294619
申请日：1919-09-10
申请人： JOHN MAIER
发明人： JOHN MAIER
IPC分类号： B23Q1/54 , B25B1/22
CPC分类号： B23Q1/545 , B25B1/22 , Y10T403/32311

16. 发明申请

US20120078524A1 System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
标题翻译：使用荧光和拉曼技术诊断组织样本的系统和方法
公开(公告)号：US20120078524A1
公开(公告)日：2012-03-29
申请号：US13136366
申请日：2011-07-29
申请人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
发明人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
IPC分类号： G01N33/48 , G01N21/64 , G01J3/44
CPC分类号： A61B5/0059 , A61B5/417 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/10 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/6458 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/16 , G02B21/365 , G06F19/325 , G16H50/70
摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.
摘要翻译：用于确定测试生物样品的诊断的系统和方法。一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。可以评估该拉曼数据集以确定样品的诊断。诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

17. 发明授权

US07956996B2 Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging 有权
标题翻译：使用拉曼分子成像区分浸润性导管癌和浸润性小叶癌
公开(公告)号：US07956996B2
公开(公告)日：2011-06-07
申请号：US12206500
申请日：2008-09-08
申请人： John Maier , Jeffrey Cohen , Shona Stewart
发明人： John Maier , Jeffrey Cohen , Shona Stewart
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/417 , G01J3/0291 , G01J3/0294 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N33/57415 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , Y02A90/26
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

18. 发明授权

US07570356B2 System and method for classifying cells and the pharmaceutical treatment of such cells using Raman spectroscopy 有权
标题翻译：使用拉曼光谱分析细胞的系统和方法以及这种细胞的药物处理
公开(公告)号：US07570356B2
公开(公告)日：2009-08-04
申请号：US11650378
申请日：2007-01-05
申请人： Janice L. Panza , John Maier , Jason Neiss
发明人： Janice L. Panza , John Maier , Jason Neiss
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01J3/44 , G01J3/28 , G01J3/36 , G01N15/1475 , G01N21/65 , G01N2015/1006 , G01N2015/1488 , G01N2021/656
摘要： A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.
摘要翻译：将正常细胞与凋亡细胞区分开的系统和方法。选择预定矢量空间，其中矢量空间在数学上描述用于正常细胞的第一多个参考拉曼数据集和用于凋亡细胞的第二多个参考拉曼数据集。用基本上单色的光照射样品，产生基于散射光子的目标拉曼数据集。目标拉曼数据集被转换成由预定向量空间定义的向量空间。在预定向量空间中分析变换数据的分布。基于分析，样品被分类为含有正常细胞，凋亡细胞，以及正常细胞和凋亡细胞的组合。样品包括在照射样品之前用药剂处理样品的步骤。根据分类，评估药剂的治疗效果。

19. 发明授权

US07557915B2 Automated acquisition of spectral data and image data 有权
标题翻译：自动采集光谱数据和图像数据
公开(公告)号：US07557915B2
公开(公告)日：2009-07-07
申请号：US11585535
申请日：2006-10-24
申请人： John Maier , Patrick Treado , Matthew Nelson , Lindy McClelland , Shona Stewart
发明人： John Maier , Patrick Treado , Matthew Nelson , Lindy McClelland , Shona Stewart
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/274 , G01N2021/656
摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.
摘要翻译：自动获取样品光谱的系统和方法。该方法涉及包括光漂白相和光谱采集阶段的两相过程。在漂白漂白阶段，收集样品的一系列光谱数据集。在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

20. 发明申请

US20090033930A1 Spectral Imaging of Biofilms 有权
标题翻译：生物膜的光谱成像
公开(公告)号：US20090033930A1
公开(公告)日：2009-02-05
申请号：US12248344
申请日：2008-10-09
申请人： John Maier , Jeffrey Cohen
发明人： John Maier , Jeffrey Cohen
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N2021/656 , G01N2201/129
摘要： A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.
摘要翻译：鉴定微生物生物膜的光谱方法和系统。用基本上单色的辐射照射含有样品微生物的样品。基于从照射样品散射的辐射获得拉曼数据集。根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

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