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11. 发明申请

US20100075962A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：吲哚衍生物，其制备方法和组合物，用于预防和治疗含有其作为活性成分的代谢异常
公开(公告)号：US20100075962A1
公开(公告)日：2010-03-25
申请号：US12442930
申请日：2007-09-27
申请人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/5377 , C07D209/04 , C07D401/02 , C07D413/02 , A61K31/405 , A61K31/454 , A61P3/04 , A61P3/10
CPC分类号： C07D209/18 , C07D405/12 , C07D409/14
摘要： Disclosed are indole derivatives a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了吲哚衍生物及其制备方法，以及用于预防和治疗代谢疾病的组合物，其含有活性成分。吲哚衍生物对DGAT（二酰基甘油酰基转移酶）具有抑制作用，其在脂质代谢过程中引起诸如肥胖症和糖尿病等代谢疾病。具有有效控制脂质代谢和能量代谢的能力，因此该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

12. 发明申请

US20080248024A1 THERAPEUTIC AGENT FOR CANCER, INFLAMMATION, AND AUTO-IMMUNE DISEASE CONTAINING INHIBITOR OF ZINC FINGER PROTEIN 91 审中-公开
标题翻译：含有锌指蛋白91的抑制剂的癌症，炎症和自身免疫疾病的治疗剂
公开(公告)号：US20080248024A1
公开(公告)日：2008-10-09
申请号：US12039640
申请日：2008-02-28
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , Xuejun Jin
IPC分类号： A61K39/395 , A61P35/00 , A61K31/70 , G01N33/53 , A61P9/00 , A61P29/00 , C12Q1/68 , A61K38/02
CPC分类号： C07K16/18 , A61K38/1709 , C12N15/113 , C12N2310/14 , G01N33/57415 , G01N33/57434 , G01N33/57438 , G01N33/57446 , G01N33/6872 , G01N2333/4703 , G01N2510/00 , G01N2800/00
摘要： The present invention relates to a use of ZFP91 based on the functions of ZFP91 (Zinc Finger Protein 91) and the interaction of ZFP91 with NF-κB (Nuclear factor kappa B) signal transduction pathway proteins, more precisely a method to inhibit the activation of NF-κB alternative pathway by regulating ZFP91 activation, to inhibit tumor growth by inhibiting the transcription factor HIF-1 (hypoxia inducible factor-1) activation, to inhibit cancer malignancy by inhibiting angiogenesis, or reversely a method to increase the activation of NF-κB alternative pathway or to increase angiogenesis by increasing activation of HIF-1. The method of regulating ZFP91 activation of the present invention can increase or reduce HIF-1α stability by increasing or reducing the activation of NF-κB alternative pathway, so that it can be effectively used for the development of an anticancer agent, a therapeutic agent for arthritis, a therapeutic agent for ulcerative colitis, an anti-inflammatory agent and an angiogenesis inducer.
摘要翻译：本发明涉及基于ZFP91（锌指蛋白91）的功能和ZFP91与NF-κB（核因子κB）信号转导途径蛋白的相互作用的ZFP91的应用，更准确地说是抑制活化的方法 NF-κB通过调节ZFP91激活，通过抑制转录因子HIF-1（缺氧诱导因子-1）激活抑制肿瘤生长，通过抑制血管生成来抑制癌症恶性，或反向增加NF- kappaB替代途径或通过增加HIF-1的活化来增加血管生成。调节本发明ZFP91活化的方法可以通过增加或减少NF-κB替代途径的活化来增加或降低HIF-1α的稳定性，从而可以有效地用于开发抗癌剂，治疗剂关节炎，溃疡性结肠炎的治疗剂，抗炎剂和血管发生诱导剂。

13. 发明授权

US06451846B1 Isocoumarin derivatives inhibiting angiogenesis 失效
标题翻译：抑制血管生成的异香豆素衍生物
公开(公告)号：US06451846B1
公开(公告)日：2002-09-17
申请号：US09980904
申请日：2002-02-26
申请人： Jung Joon Lee , Hang-Sub Kim , Jeong-Hyung Lee , Young-Soo Hong , Yun Joo Park
发明人： Jung Joon Lee , Hang-Sub Kim , Jeong-Hyung Lee , Young-Soo Hong , Yun Joo Park
IPC分类号： A61K3135
CPC分类号： C07D311/76
摘要： The present invention relates to novel isocoumarin derivatves inhibiting angiogenesis, a method for preparation thereof and pharmaceutical compositions comprising the said derivatives as pharmaceutically active ingredients. More particularly, the present invention relates to novel isocoumarin derivatves represented by formula (1), especially 6,8-dihydroxy-4-acetyl-isocoumarin, a method for preparing 6,8-dihydroxy-4-acetyl-isocoumarin from fungi, and pharmaceutical compositions comprising the compounds and/or 6,8-dihydroxy-4-acetyl-isocoumarin as pharmaceutically active ingredients, which would be effective for the treatment of angiogenic diseases such as cancers, rheumatoid arthritis and diabetic retinopathy.
摘要翻译：本发明涉及抑制血管生成的新型异香豆素衍生物，其制备方法和包含所述衍生物作为药物活性成分的药物组合物。更具体地说，本发明涉及由式（1）表示的新型异香豆素衍生物，特别是6,8-二羟基-4-乙酰基异香豆素，一种从真菌中制备6,8-二羟基-4-乙酰基异香豆素的方法，以及包含化合物和/或6,8-二羟基-4-乙酰基异香豆素作为药物活性成分的药物组合物，其对于治疗血管生成疾病如癌症，类风湿性关节炎和糖尿病性视网膜病变是有效的。

14. 发明授权

US07718202B2 Method for treating erectile dysfunction with acantopanax extract (ogalpi) 有权
标题翻译：用茴香精提取物治疗勃起功能障碍的方法
公开(公告)号：US07718202B2
公开(公告)日：2010-05-18
申请号：US12240503
申请日：2008-09-29
申请人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Choi
发明人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Choi
IPC分类号： A61K36/254 , A61K36/00
CPC分类号： A23L33/105 , A21D2/14 , A21D2/36 , A21D13/80 , A23G1/48 , A23G3/48 , A23G4/068 , A23G9/42 , A23L2/52 , A61K36/254
摘要： The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
摘要翻译：本发明涉及一种卵黄醇提取物，改善健康食品的勃起功能障碍及含有该成分的治疗剂，更准确地说，是具有改善勃起功能障碍，改善勃起功能障碍的健康食品和勃起功能障碍治疗的卵黄醇提取物含有相同的代理本发明的欧氏提取物具有阴茎勃起的促进作用，因此可以有效地用于改善勃起功能障碍。

15. 发明申请

US20100076039A1 COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING BENZAZOLE DERIVATIVES AS AN ACTIVE INGREDIENT 有权
标题翻译：用于预防和治疗含有苯扎唑衍生物作为活性成分的代谢性疾病的组合物
公开(公告)号：US20100076039A1
公开(公告)日：2010-03-25
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/421 , A61P3/00
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

16. 发明申请

US20070185109A1 Idene derivatives and process for the preparation thereof 有权
标题翻译： Idene衍生物及其制备方法
公开(公告)号：US20070185109A1
公开(公告)日：2007-08-09
申请号：US10599911
申请日：2005-04-13
申请人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hoe Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
发明人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hoe Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/445 , A61K31/381
CPC分类号： C07D213/30 , C07C291/02 , C07C309/66 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D213/53 , C07D233/64 , C07D277/24 , C07D295/088 , C07D295/185 , C07D307/54 , C07D317/60 , C07D317/70 , C07D333/24 , C07D333/28 , C07D417/12
摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译：式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症，糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

17. 发明申请

US20090022822A1 EXTRACT OF OGALPI, ERECTILE DYSFUNCTION FANNING HEALTHY FOOD AND ERECTILE DYSFUNCTION TREATING AGENT CONTAINING THE SAME 有权
标题翻译： OGALPI的提取物，精神分裂症功能性食物健康食品和含有其的精神分裂症治疗剂
公开(公告)号：US20090022822A1
公开(公告)日：2009-01-22
申请号：US12240503
申请日：2008-09-29
申请人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Chol
发明人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Chol
IPC分类号： A61K36/82 , A61P15/10
CPC分类号： A23L33/105 , A21D2/14 , A21D2/36 , A21D13/80 , A23G1/48 , A23G3/48 , A23G4/068 , A23G9/42 , A23L2/52 , A61K36/254
摘要： The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
摘要翻译：本发明涉及一种卵黄醇提取物，改善健康食品的勃起功能障碍及含有该成分的治疗剂，更准确地说，是具有改善勃起功能障碍，改善勃起功能障碍的健康食品和勃起功能障碍治疗的卵黄醇提取物含有相同的代理本发明的欧氏提取物具有阴茎勃起的促进作用，因此可以有效地用于改善勃起功能障碍。

18. 发明授权

US08394799B2 Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component 有权
标题翻译：抑制HIF-1活性的化合物，其制备方法和含有它们作为有效成分的药物组合物
公开(公告)号：US08394799B2
公开(公告)日：2013-03-12
申请号：US12306319
申请日：2007-07-03
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
IPC分类号： A61K31/5377 , A61K31/167 , A61K31/41 , A61K31/423 , A61P19/02 , C07C233/33 , C07D257/04 , C07D263/57 , C07D295/15
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其作为活性成分的药物组合物。 HIF-1抑制剂由于对HIF-1的抑制活性而显示出抗癌活性，HIF-1是在癌症的生长和转移中起重要作用的转录因子，而不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌的治疗剂; 胃癌和乳腺癌。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

19. 发明授权

US08304448B2 Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient 有权
标题翻译：用于治疗含有苯并唑衍生物作为活性成分的代谢紊乱的方法
公开(公告)号：US08304448B2
公开(公告)日：2012-11-06
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/40 , A61K31/405
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

20. 发明授权

US07309504B2 Extract of Acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug 失效
标题翻译：刺五加提取物用于治疗或预防肝炎或肝脏保护性药物
公开(公告)号：US07309504B2
公开(公告)日：2007-12-18
申请号：US10502140
申请日：2003-01-24
申请人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Jeong Bum Nam , Dong Hwan Shon , Hang Sub Kim
发明人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Jeong Bum Nam , Dong Hwan Shon , Hang Sub Kim
IPC分类号： A61K36/25 , A61K36/00
CPC分类号： A61K36/254
摘要： The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the extract of Acanthopanax koreanum only containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than range of 12,000˜14,000, or 4) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem of Acanthopanax koreanum. The extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.
摘要翻译：本公开涉及刺五加的提取物及其用途。更具体地说，涉及刺五加提取物，其包括1）从水中提取的刺五加提取物，2）在水提取物中，仅含有通过沉淀乙醇获得的乙醇不溶部分的刺五加的提取物，3）乙醇不溶性一部分含有分子量大于12,000〜14,000范围的多糖的刺五加提取物，或4）在乙醇不溶部分中，含有分子量大于100,000的多糖的刺五加提取物分别从刺五加的根或茎。本发明的提取物显示出对肝炎的高抑制活性并保护肝脏，因此可用于治疗或预防肝炎，或用作肝保护药物。

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