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1. 发明申请

US20140018402A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：用于预防或治疗麦芽汁变性的药物组合物
公开(公告)号：US20140018402A1
公开(公告)日：2014-01-16
申请号：US14008112
申请日：2011-03-29
申请人： Kyu-Yang Yi , Sung-Eun Yoo , Nack-Jeong Kim , Jee-Hee Suh , Choun-Ki Joo , Jun-Sub Choi , Jae-Sik Yang , Geun-Hyeog Lee , Yun-Seok Cho , Jin-Ha Park , Hye-Sung Lee
发明人： Kyu-Yang Yi , Sung-Eun Yoo , Nack-Jeong Kim , Jee-Hee Suh , Choun-Ki Joo , Jun-Sub Choi , Jae-Sik Yang , Geun-Hyeog Lee , Yun-Seok Cho , Jin-Ha Park , Hye-Sung Lee
IPC分类号： A61K9/00 , A61K31/4178
CPC分类号： A61K9/0048 , A61K31/4178
摘要： The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.
摘要翻译：本发明提供了一种用于预防或治疗黄斑变性的药物组合物，其包括用包括咪唑的仲胺或其药学上可接受的盐作为活性成分取代的苯并吡喃衍生物。本发明的药物组合物可以以滴眼剂的形式使用。

2. 发明申请

US20130011417A1 COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES 有权
标题翻译：化合物衍生物或其药学上可接受的盐，制备所述衍生物的方法和包含所述衍生物的药物组合物
公开(公告)号：US20130011417A1
公开(公告)日：2013-01-10
申请号：US13579704
申请日：2011-02-18
申请人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
发明人： Duck Jong Han , Sung-eun Yoo , Jeehee Suh
IPC分类号： A61K31/27 , C07C233/32 , A61K31/165 , A61P37/06 , A61K31/17 , A61K39/00 , A61K39/395 , C07C271/30 , C07C275/26
CPC分类号： C07C271/24 , A61K31/165 , A61K45/06 , C07C233/32 , C07C235/56 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07C2603/34 , A61K2300/00
摘要： The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
摘要翻译：本发明涉及化学式1表示的秋水仙碱衍生物或其药学上可接受的盐，涉及制备所述衍生物的方法，以及包含所述衍生物的药物组合物。根据本发明的秋水仙碱衍生物与常规的免疫调节剂或秋水仙素相比表现出优异的免疫调节作用，因此可以有价值地用作调节器官移植中急性或慢性免疫应答的免疫调节剂。

3. 发明授权

US08143262B2 7-(3′,4′-Dialkoxyphenyl)[1,2,4]-triazolo[1,5-A]pyrimidine compounds, process for preparing thereof, and pharmaceutical composition for treating or preventing asthma, chronic obstructive pulmonary disease, arthritis, atopic dermatitis, tumor and degenerative brain diseases comprising the same 有权
标题翻译： 7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-A]嘧啶化合物，其制备方法和用于治疗或预防哮喘，慢性阻塞性肺病，关节炎，特应性皮炎，包括其的肿瘤和退行性脑疾病
公开(公告)号：US08143262B2
公开(公告)日：2012-03-27
申请号：US12531818
申请日：2008-03-07
申请人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
发明人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.
摘要翻译：本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法，以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

4. 发明申请

US20100305324A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS OR OBESITY COMPRISING PHENYLTETRAZOLE DERIVATIVE 有权
标题翻译：用于预防或治疗包含苯并噻唑衍生物的骨质疏松症或糖尿病的药物组合物
公开(公告)号：US20100305324A1
公开(公告)日：2010-12-02
申请号：US12765363
申请日：2010-04-22
申请人： Nak Jeong KIM , Myung-Ae Bae , Sung-Eun Yoo , Namsook Kang , Jung Nyoung Heo , Kyu Yang Yi , Jee Hee Suh , Sung Youn Chang , Eun Sook Hwang , Jeong-Ho Hong
发明人： Nak Jeong KIM , Myung-Ae Bae , Sung-Eun Yoo , Namsook Kang , Jung Nyoung Heo , Kyu Yang Yi , Jee Hee Suh , Sung Youn Chang , Eun Sook Hwang , Jeong-Ho Hong
IPC分类号： C07D471/04 , C07D403/10
CPC分类号： C07D471/04 , A61K31/437 , C07D403/10
摘要： A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(═O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.
摘要翻译：通过调节蛋白质TAZ，包含式（I）的苯基四唑衍生物或其药学上可接受的盐的药物组合物可有效预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症。其中A为乙基或正丁基; R1是甲基，-CH2OH，-COO2CH3，-CH2F，-CH（OCH3）2，-CH2OC（= O）CH3，苯乙烯基或-CH2OCH2SCH3; R 2是H，Br，-CO 2 CH 3，苯基，吡啶-2-基，吡啶-3-基或苯乙烯基; R3是H或甲基; X是CH或N; 并且P是H或-CH（CH 3）OCH 2 CH 3。

5. 发明申请

US20100105704A1 7-(3',4'-Dialkoxyphenyl)-[1,2,4]-Triazolo[1,5-A]Pyrimidine Compounds, Process for Preparing Thereof, and Pharmaceutical Composition for Treating or Preventing Asthma, Chronic Obstructive Pulmonary Disease, Arthritis, Atopic Dermatitis, Tumor and Degenerative Brain Diseases Comprising the Same 有权
标题翻译： 7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-A]嘧啶化合物，其制备方法和用于治疗或预防哮喘，慢性阻塞性肺疾病的药物组合物，关节炎，特应性皮炎，包括肿瘤和退行性脑疾病
公开(公告)号：US20100105704A1
公开(公告)日：2010-04-29
申请号：US12531818
申请日：2008-03-07
申请人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
发明人： Dong Ju Jeon , Zaesung No , Jong Hwan Song , Gehyeong Lee , Ikyon Kim , Chang Min Park , Hyae Gyeong Cheon , Young Sik Cho , Jin Sook Song , Myung Ae Bae , Sung-eun Yoo
IPC分类号： A61K31/519 , C07D487/04 , A61P25/00 , A61P11/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel {7-(3′,4′-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.
摘要翻译：本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法，以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

6. 发明申请

US20100063106A1 AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME 有权
标题翻译：氨基吡唑衍生物，其制备方法和用于预防或治疗含有其的异种疾病的组合物
公开(公告)号：US20100063106A1
公开(公告)日：2010-03-11
申请号：US12447394
申请日：2007-10-26
申请人： Yong-Sam JUNG , Eunhee Kim , Nakjeong Kim , Yun-Sun Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
发明人： Yong-Sam JUNG , Eunhee Kim , Nakjeong Kim , Yun-Sun Lee , Jeehee Suh , Haeyoung Suh , Kyu Yang Yi , Sung-eun Yoo
IPC分类号： A61K31/4439 , A61K31/422 , A61K31/415 , C07D401/02 , C07D413/02 , C07D231/00
CPC分类号： C07D231/38 , C07D231/40 , C07D401/12 , C07D413/04 , C07D413/12
摘要： Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.
摘要翻译：提供氨基吡唑衍生物，其制备方法和用于预防或治疗含有该组合物的缺血性疾病的组合物。由于本发明的氨基吡唑衍生物可显着减少缺血性细胞死亡，因此可有效地用于预防和治疗缺血性细胞死亡或器官保护的缺血性疾病。

7. 发明申请

US20100004466A1 Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
标题翻译：苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物
公开(公告)号：US20100004466A1
公开(公告)日：2010-01-07
申请号：US11794238
申请日：2005-12-27
申请人： Kyu Yang Yi , SunKyung Lee , Jee Hee Suh , Nak Jeong Kim , Hyunsuk Lee , Byung-Ho Lee , Sung-eun Yoo , Kyung-Hee Lee , Yong Oh Lee
发明人： Kyu Yang Yi , SunKyung Lee , Jee Hee Suh , Nak Jeong Kim , Hyunsuk Lee , Byung-Ho Lee , Sung-eun Yoo , Kyung-Hee Lee , Yong Oh Lee
IPC分类号： C07D333/54
CPC分类号： C07D333/70
摘要： The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.
摘要翻译：本发明涉及苯并噻吩-2-羰基胍衍生物，其制备方法和含有它们的药物组合物。该衍生物对钠/氢交换器NHE-1具有有效的抑制作用，改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复，并显着降低了体内缺血动物模型中的心肌梗死面积，从而显示良好的心脏保护作用。此外，衍生物保护神经元细胞和脑，如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。该衍生物可以有效地用于预防和治疗心肌梗塞，心律失常，心绞痛等缺血性心脏病，脑血管疾病如脑卒中，并用作心脏保护剂，用于接受再灌注治疗的患者，包括化学药剂作为溶栓剂，或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

8. 发明授权

US07371874B2 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor 失效
标题翻译： 6-烷基氨基-2-甲基-2' - （N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物作为抗炎抑制剂
公开(公告)号：US07371874B2
公开(公告)日：2008-05-13
申请号：US11491320
申请日：2006-07-21
申请人： Young-Dae Gong , Hyae-Gyeong Cheon , Moon-Kook Jeon , Cho Young Sik , Jong Yeon Hwang , Choi Hyung Sub , Jeon Hyun Suk , Soon-Hee Hwang , Song Jin Sook , Kim Chi Hyun , Sung-eun Yoo
发明人： Young-Dae Gong , Hyae-Gyeong Cheon , Moon-Kook Jeon , Cho Young Sik , Jong Yeon Hwang , Choi Hyung Sub , Jeon Hyun Suk , Soon-Hee Hwang , Song Jin Sook , Kim Chi Hyun , Sung-eun Yoo
IPC分类号： C07D311/00 , C07D405/00 , A61K31/35 , A61K31/46
CPC分类号： C07D311/58 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic techniques, and a use of the novel compound showing a high inhibitory effect to 5-lipoxygenase (5-LO) activity for preventing and treating leukotriene (LTA4, B4, C4, D4) activation-related diseases such as inflammatory diseases, rheumatoid arthritis, colitis, asthma and psoriasis.
摘要翻译：本发明涉及6-烷基氨基-2-甲基-2' - （N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物，其使用平行合成法制备高效的方法，一种的组合化学合成技术的用途，以及对预防和治疗白三烯（LTA4，B4，C4，D4）活化相关疾病如炎性疾病的5-脂氧合酶（5-LO）活性具有高抑制作用的新化合物的用途，类风湿关节炎，结肠炎，哮喘和牛皮癣。

9. 发明授权

US07351843B2 Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them 失效
标题翻译：呋喃羰基胍衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07351843B2
公开(公告)日：2008-04-01
申请号：US10581799
申请日：2004-12-24
申请人： Kyu Yang Yi , Sun Kyung Lee , Nak Jeong Kim , Jee Hee Suh , Soon Hee Hwang , Byung Ho Lee , Ho Won Seo , Sun Kyung Hwang , Sung Eun Yoo , Kyung Hee Lee
发明人： Kyu Yang Yi , Sun Kyung Lee , Nak Jeong Kim , Jee Hee Suh , Soon Hee Hwang , Byung Ho Lee , Ho Won Seo , Sun Kyung Hwang , Sung Eun Yoo , Kyung Hee Lee
IPC分类号： C07D307/02 , A61K31/34 , A01N43/08
CPC分类号： C07D307/68
摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
摘要翻译：本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等

10. 发明申请

US20060035948A1 Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20060035948A1
公开(公告)日：2006-02-16
申请号：US10510835
申请日：2003-04-10
申请人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho -Won Seo , Hwa-Sup Shin
发明人： Hong Lim , Dong-Ha Lee , Sun-Ok Kim , In-Young Choi , Sung-Eun Yoo , Kyu-Yang Yi , Sun-Kyung Lee , Jee-Hee Suh , Nak-Jeong Kim , Byung-Ho Lee , Ho -Won Seo , Hwa-Sup Shin
IPC分类号： A61K31/41 , C07D405/02
CPC分类号： C07D405/12
摘要： The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
摘要翻译：本发明涉及用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物。本发明的化合物可用于保护神经细胞和脑损伤; 抗氧化; 抑制NO产生; 保护心脏抑制血管发生; 保护肾脏，心脏和组织等保护器官，并在主要心血管手术中保护器官。

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