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11. 发明申请

US20120069946A1 Compact Radioisotope Generator 审中-公开
标题翻译：紧凑型放射性同位素发生器
公开(公告)号：US20120069946A1
公开(公告)日：2012-03-22
申请号：US12887933
申请日：2010-09-22
申请人： James J. Hamill , Stefan B. Siegel , Charles Russell Buchanan
发明人： James J. Hamill , Stefan B. Siegel , Charles Russell Buchanan
IPC分类号： G21G1/06
CPC分类号： G21G1/06 , G21G2001/0094
摘要： Disclosed are a method and apparatus for making a radioisotope and a composition of matter including the radioisotope. The radioisotope is made by exposing a material to neutrons from a portable neutron source.
摘要翻译：公开了制备放射性同位素的方法和装置以及包括放射性同位素的物质组成。放射性同位素是通过将材料从便携式中子源暴露于中子而制成的。

12. 发明授权

US06429434B1 Transmission attenuation correction method for PET and SPECT 失效
标题翻译： PET和SPECT传输衰减校正方法
公开(公告)号：US06429434B1
公开(公告)日：2002-08-06
申请号：US09398497
申请日：1999-09-17
申请人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
发明人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
IPC分类号： G01T1166
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1648 , G21K1/02
摘要： A transmission source serves to detect activity from a radiation source for correcting attenuation in either PET mode or SPECT mode. The transmission source includes a detector dedicated to collecting attenuation data in PET mode. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The transmission source can either be a coincidence transmission source or a singles transmission source and includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. In a dual head tomograph device, one transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera. In SPECT mode, the point source is selected to have sufficiently high energy to shine through the patient and the collimators associated with the imaging detector.
摘要翻译：传输源用于检测来自辐射源的活动以校正PET模式或SPECT模式中的衰减。传输源包括专用于在PET模式下收集衰减数据的检测器。准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。传输源可以是重合传输源或单个传输源，并且包括准直仪，其中设置有辐射源。由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。相对于成像检测器定位在辐射源之后，是专用的衰减检测器。在双头断层摄影装置中，本发明的一个发射源与每一组成像检测器相对设置。源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。源和检测器相对于成像头是固定的。为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。在SPECT模式中，点源被选择为具有足够高的能量以照射通过患者和与成像检测器相关联的准直仪。

13. 发明申请

US20100063378A1 SYSTEM AND METHOD FOR CONSTRAINING A COMPUTERIZED TOMOGRAPHY PATIENT 有权
标题翻译：用于约束计算机图像患者的系统和方法
公开(公告)号：US20100063378A1
公开(公告)日：2010-03-11
申请号：US12558159
申请日：2009-09-11
申请人： James J. Hamill , Carl Eric Arnsdorff
发明人： James J. Hamill , Carl Eric Arnsdorff
IPC分类号： A61B6/04
CPC分类号： A61B6/037 , A61B5/103 , A61B6/0421 , A61B6/482
摘要： A constraint having a main body and at least one coupler. The main body can be substantially arcuate in shape and can be configured to constrain a patient. The at least one coupler can couple the main body to a bed or treatment pallet. The constraint can be sized to restrict a patient within a computerized tomography (CT) scan field of view.
摘要翻译：具有主体和至少一个耦合器的约束。主体可以是基本上弓形的形状，并且可以构造成约束患者。所述至少一个联接器可以将主体连接到床或处理托盘。该约束的大小可以限制在计算机断层摄影（CT）扫描视野内的患者。

14. 发明授权

US07676073B2 System and method for reducing circular artifacts in tomographic imaging 有权
标题翻译：用于减少断层成像中的圆形伪影的系统和方法
公开(公告)号：US07676073B2
公开(公告)日：2010-03-09
申请号：US11550445
申请日：2006-10-18
申请人： James J. Hamill , David D. Faul
发明人： James J. Hamill , David D. Faul
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G06T11/005
摘要： A method of reducing ring artifacts in tomographic images including providing an original digitized projection measurement comprising a plurality of intensities corresponding to a domain of points on an 2-dimensional grid, operating on said original projection measurement with a filter wherein features of high radial frequency and low angular frequency are attenuated, forming a weighted mixture of said filtered projection measurement and said original projection measurement wherein ring artifacts in said original tomographic image are substantially reduced, and reconstructing the projection measurement to form a tomographic image. Alternatively, a first tomographic image is reconstructed from said original projection measurement, a second tomographic image is reconstructed from said filtered projection measurement, and a weighted mixture is formed from said first tomographic image and said second tomographic image.
摘要翻译：一种降低断层图像中的环形伪影的方法，包括提供原始的数字化投影测量，该原始数字化投影测量包括对应于二维网格上的点的区域的多个强度，用滤波器对所述原始投影测量进行操作，其中高径向频率和低角频率被衰减，形成所述滤波投影测量和所述原始投影测量的加权混合，其中所述原始断层图像中的环形伪影被大大减少，并且重建投影测量以形成断层图像。或者，从所述原始投影测量重建第一断层图像，从所述滤波投影测量重建第二断层图像，并且从所述第一断层图像和所述第二断层图像形成加权混合。

15. 发明申请

US20080056549A1 System and Method for Reducing Circular Artifacts in Tomographic Imaging 有权
标题翻译：用于减少断层扫描成像中的圆形伪像的系统和方法
公开(公告)号：US20080056549A1
公开(公告)日：2008-03-06
申请号：US11550445
申请日：2006-10-18
申请人： James J. Hamill , David D. Faul
发明人： James J. Hamill , David D. Faul
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T11/005
摘要： A method of reducing ring artifacts in tomographic images including providing an original digitized projection measurement comprising a plurality of intensities corresponding to a domain of points on an 2-dimensional grid, operating on said original projection measurement with a filter wherein features of high radial frequency and low angular frequency are attenuated, forming a weighted mixture of said filtered projection measurement and said original projection measurement wherein ring artifacts in said original tomographic image are substantially reduced, and reconstructing the projection measurement to form a tomographic image. Alternatively, a first tomographic image is reconstructed from said original projection measurement, a second tomographic image is reconstructed from said filtered projection measurement, and a weighted mixture is formed from said first tomographic image and said second tomographic image.
摘要翻译：一种降低断层图像中的环形伪影的方法，包括提供原始的数字化投影测量，该原始数字化投影测量包括对应于二维网格上的点的区域的多个强度，用滤波器对所述原始投影测量进行操作，其中高径向频率和低角频率被衰减，形成所述滤波投影测量和所述原始投影测量的加权混合，其中所述原始断层图像中的环形伪影被大大减少，并且重建投影测量以形成断层图像。或者，从所述原始投影测量重建第一断层图像，从所述滤波投影测量重建第二断层图像，并且从所述第一断层图像和所述第二断层图像形成加权混合。

16. 发明授权

US06963065B2 Normalization apparatus for panel detector PET scanners 失效
标题翻译：面板检测仪PET扫描仪的归一化装置
公开(公告)号：US06963065B2
公开(公告)日：2005-11-08
申请号：US10418520
申请日：2003-04-18
申请人： Maurizio Conti , James J. Hamill , Michael E. Casey , Mu Chen
发明人： Maurizio Conti , James J. Hamill , Michael E. Casey , Mu Chen
IPC分类号： G01D18/00 , G01T1/172 , G01T1/29 , G12B13/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A normalization apparatus and method for a PET scanner with panel detectors for obtaining an estimate of a normalization array, for correction for count rate effects on the normalization array, and for measurement of the relation between the normalization array and the count rate. The method of the present invention is based on two quasi-independent radial and axial components, which are count rate dependent due to sensitivity changes across the detector blocks. A scatter source is disposed at the center of the FOV and a scatter-free source is disposed at the outer edge of the FOV. The method computes the normalization array through several steps which evaluate the geometric profile, the axial profile, and the correction factor. A count rate correction is introduced to extend the normalization array to any count rate.
摘要翻译：一种具有面板检测器的PET扫描仪的归一化装置和方法，用于获得归一化阵列的估计，用于校正对归一化阵列的计数率影响，以及用于测量归一化阵列与计数率之间的关系。本发明的方法是基于两个准独立的径向和轴向分量，其由于检测器块两端的灵敏度变化而依次计数。散射源设置在FOV的中心，并且不分散源设置在FOV的外边缘处。该方法通过评估几何轮廓，轴向轮廓和校正因子的几个步骤来计算归一化阵列。引入计数率校正以将归一化数组扩展到任何计数率。

17. 发明授权

US09579070B2 Optimal respiratory gating in medical imaging 有权
标题翻译：医学成像中的最佳呼吸门控
公开(公告)号：US09579070B2
公开(公告)日：2017-02-28
申请号：US13248089
申请日：2011-09-29
申请人： James J. Hamill , Ludovic Le Meunier
发明人： James J. Hamill , Ludovic Le Meunier
IPC分类号： A61B5/00 , A61B6/00 , A61B5/113 , A61B6/03 , G01R33/48 , G01R33/567
CPC分类号： A61B5/7292 , A61B5/1135 , A61B6/037 , A61B6/541 , G01R33/481 , G01R33/5676
摘要： Methods and computer-readable mediums are provided for obtaining an optimally gated medical image. For example, in one embodiment, a method is provided that acquires medical images in list mode. The method also acquires a respiration correlated signal S(t). Thereafter, a final upper strain threshold value and a final lower strain threshold value pair that has a narrowest interval are selected. The medical images are synchronized with the respiration correlated signal S(t). The synchronized images and signal are used to create an optimally gated medical image. In various embodiments, the disclosed optimal gating can be utilized in PET systems and in other embodiments the disclosed optimal gating can be utilized in SPECT systems. In yet other embodiments, the optimally gated images can be matched to MRI systems and in still other embodiments, the optimally gated images can be matched to CT systems.
摘要翻译：提供方法和计算机可读介质以获得最佳门控的医学图像。例如，在一个实施例中，提供了以列表模式获取医学图像的方法。该方法还获取呼吸相关信号S（t）。此后，选择具有最窄间隔的最终上应变阈值和最终下应变阈值对。医学图像与呼吸相关信号S（t）同步。同步的图像和信号用于创建最佳门控的医学图像。在各种实施例中，所公开的最佳选通可用于PET系统中，并且在其它实施例中，所公开的最佳门控可用于SPECT系统。在其他实施例中，最佳门控图像可以与MRI系统匹配，并且在其他实施例中，最佳门控图像可以与CT系统匹配。

18. 发明申请

US20130085375A1 Optimal Respiratory Gating In Medical Imaging 有权
标题翻译：医学影像中的最佳呼吸门控
公开(公告)号：US20130085375A1
公开(公告)日：2013-04-04
申请号：US13248089
申请日：2011-09-29
申请人： James J. Hamill , Ludovic Le Meunier
发明人： James J. Hamill , Ludovic Le Meunier
IPC分类号： A61B5/055 , A61B5/05
CPC分类号： A61B5/7292 , A61B5/1135 , A61B6/037 , A61B6/541 , G01R33/481 , G01R33/5676
摘要： Methods and computer-readable mediums are provided for obtaining an optimally gated medical image. For example, in one embodiment, a method is provided that acquires medical images in list mode. The method also acquires a respiration correlated signal S(t). Thereafter, a final upper strain threshold value and a final lower strain threshold value pair that has a narrowest interval are selected. The medical images are synchronized with the respiration correlated signal S(t). The synchronized images and signal are used to create an optimally gated medical image. In various embodiments, the disclosed optimal gating can be utilized in PET systems and in other embodiments the disclosed optimal gating can be utilized in SPECT systems. In yet other embodiments, the optimally gated images can be matched to MRI systems and in still other embodiments, the optimally gated images can be matched to CT systems.
摘要翻译：提供方法和计算机可读介质以获得最佳门控的医学图像。例如，在一个实施例中，提供了以列表模式获取医学图像的方法。该方法还获取呼吸相关信号S（t）。此后，选择具有最窄间隔的最终上应变阈值和最终下应变阈值对。医学图像与呼吸相关信号S（t）同步。同步的图像和信号用于创建最佳门控的医学图像。在各种实施例中，所公开的最佳选通可用于PET系统中，并且在其它实施例中，所公开的最佳门控可用于SPECT系统。在其他实施例中，最佳门控图像可以与MRI系统匹配，并且在其他实施例中，最佳门控图像可以与CT系统匹配。

19. 发明授权

US08060177B2 Registration of computed tomography (CT) and positron emission tomography (PET) image scans with automatic patient motion correction 有权
标题翻译：计算机断层扫描（CT）和正电子发射断层扫描（PET）图像扫描与自动患者运动校正的注册
公开(公告)号：US08060177B2
公开(公告)日：2011-11-15
申请号：US11714405
申请日：2007-03-06
申请人： James J. Hamill
发明人： James J. Hamill
IPC分类号： A61B5/05
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5235 , A61B6/541 , G01T1/1615
摘要： A method for combined computed tomography (CT) imaging and positron emission tomography (PET) imaging uses respiration-gated CT imaging in which the optimal criteria for CT scan gating are determined after the PET scan has been performed. After acquisition of first CT scan image data and PET scan image data with strain gauge levels being recorded, optimal gating criteria are calculated based on the strain gauge levels, and a second CT scan is then performed with triggering in accordance with the optimal gating criteria.
摘要翻译： CT扫描成像和正电子发射断层扫描（PET）成像的方法是使用呼吸门控CT成像，其中在执行PET扫描之后确定CT扫描门控的最佳标准。在记录了应变仪电平的第一CT扫描图像数据和PET扫描图像数据的采集之后，根据应变计电平计算最佳选通标准，然后根据最佳选通标准触发进行第二次CT扫描。

20. 发明申请

US20090076379A1 Ultrasonic Imager for Motion Measurement in Multi-Modality Emission Imaging 有权
标题翻译：超声波成像仪用于多模式发射成像中的运动测量
公开(公告)号：US20090076379A1
公开(公告)日：2009-03-19
申请号：US12125329
申请日：2008-05-22
申请人： James J. Hamill , Gunther Platsch , Michael E. Casey
发明人： James J. Hamill , Gunther Platsch , Michael E. Casey
IPC分类号： A61B8/14 , A61B5/05
CPC分类号： A61B8/08 , A61B5/7285 , A61B6/032 , A61B6/5247 , A61B6/541 , A61B8/4245 , A61B8/5238 , A61B8/543 , G01T1/1603
摘要： A medical imaging device has an emission tomograph, at least one ultrasonic (US) probe for providing images giving real-time information about the location of the internal organs of a subject, a tracking system for spatially locating the at least one ultrasonic probe in relation to the medical imaging device, and an image processing unit in which the location information obtained by the ultrasonic probe is used for attenuation correction of image information obtained by the emission tomograph.
摘要翻译：一种医疗成像装置具有发射断层摄影机，至少一个超声波（US）探头，用于提供给出关于被检体的内部器官的位置的实时信息的图像，用于相对于空间定位至少一个超声波探头的跟踪系统以及图像处理单元，其中由超声波探头获得的位置信息用于由发射断层摄影机获得的图像信息的衰减校正。

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