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11. 发明申请

US20090082367A1 TRIAZOLE DERIVATIVE OR A SALT THEREOF 审中-公开
标题翻译：三唑衍生物或其盐
公开(公告)号：US20090082367A1
公开(公告)日：2009-03-26
申请号：US12293214
申请日：2007-03-14
申请人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
发明人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
IPC分类号： A61K31/4196 , C07D401/06 , A61K31/4439 , A61K31/497 , A61P3/10 , A61K31/4709 , C07D403/06
CPC分类号： C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/08 , C07D409/06 , C07D409/08 , C07D409/12 , C07D413/06 , C07D417/06
摘要： [Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance.[Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.
摘要翻译： [问题]提供可用于治疗其中涉及11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病和胰岛素抵抗。 [解决方法]发现三唑环的3-位被三取代甲基取代的三唑衍生物或其药学上可接受的盐，并且5位被低级烷基，环烷基或具有强的11beta-HSD1抑制活性。此外，由于本发明的三唑衍生物显示出优异的降血糖作用，因此可用于治疗糖尿病和胰岛素抵抗。

12. 发明申请

US20080238147A1 Work Vehicle 有权
标题翻译：工作车辆
公开(公告)号：US20080238147A1
公开(公告)日：2008-10-02
申请号：US12054747
申请日：2008-03-25
申请人： Hiroki Fukudome , Naoya Tsuda , Kenzo Ushiro
发明人： Hiroki Fukudome , Naoya Tsuda , Kenzo Ushiro
IPC分类号： B62D25/10
CPC分类号： B62D33/0625 , B62D25/06 , E02F3/964 , E02F9/08 , E02F9/163
摘要： A work vehicle includes a front loader mounted at a front portion of the work vehicle to be vertically pivotable, a driving control device, and a canopy device for covering the driving control device from above, the canopy device including a roof disposed upwardly of the driving control device and a support body for supporting the roof. The roof includes a front visor portion which projects, in a plan view thereof, to a position same as or more forwardly of a front end portion of the driving control device. To a lower face of said front visor portion, there are attached a pair of right and left front illumination lamps, and there is provided an upper concave portion at the right/left center thereof. A lower face of the upper concave portion is formed as an inclined face which is inclined upward from a rear portion to a front edge of the front visor portion so as to be located at a higher position than the attaching position of the front illumination lamps.
摘要翻译：工作车辆包括安装在作业车辆的前部以便可竖直枢转的前装载机，驱动控制装置和用于从上方覆盖驱动控制装置的顶盖装置，所述顶盖装置包括设置在驾驶控制装置和用于支撑屋顶的支撑体。屋顶包括前遮阳板部分，其在平面图中突出到与驱动控制装置的前端部分相同或更向前的位置。在所述前遮阳板部分的下表面上安装有一对右前照明灯和左前照明灯，并且在其左右中心设置有上凹部。上凹部的下表面形成为从前遮光板部的后部向前方倾斜的倾斜面，位于比前照明灯的安装位置更高的位置。

13. 发明授权

US07300241B2 Front loader attachment construction and work vehicle having the attachment construction 有权
标题翻译：前装载机附件结构和具有附接结构的工作车辆
公开(公告)号：US07300241B2
公开(公告)日：2007-11-27
申请号：US11069913
申请日：2005-03-01
申请人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
发明人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
IPC分类号： B66C23/00
CPC分类号： E02F3/627
摘要： An attachment construction for attaching a front loader having booms to a front of a tractor vehicle body is disclosed. The construction includes a pair of support tables projecting from the front portion of the tractor body to the right and left outer sides thereof, an engine constituting the vehicle body being disposed forwardly of the support tables, a front axle frame being secured to right and left sides of the engine, a pair of main frames disposed erect on the respective support tables for supporting the booms, and a pair of attaching brackets secured to right/left inner ends of the respective support tables for attaching the support tables to the vehicle body. Each attaching bracket includes a front attaching portion secured to the front axle frame and a rear attaching portion projecting rearwardly of the support table associated therewith and secured to a fore-and-aft intermediate portion of the vehicle body.
摘要翻译：公开了一种用于将具有吊臂的前部装载机附接到拖拉机车体的前部的附接结构。该结构包括从拖拉机主体的前部向其左右外侧突出的一对支撑台，构成车身的发动机设置在支撑台的前方，前轴框架左右固定发动机的侧面，一对直立设置在用于支撑吊杆的支撑台上的一对主框架，以及一对固定在相应的支撑台的左右内端的附接支架，用于将支撑台附接到车体。每个附接支架包括固定到前轴框架的前附接部分和从其相关联的支撑台的后方突出并固定到车身的前后中间部分的后连接部分。

14. 发明申请

US20060182598A1 Work vehicle 有权
标题翻译：工作车辆
公开(公告)号：US20060182598A1
公开(公告)日：2006-08-17
申请号：US11226896
申请日：2005-09-14
申请人： Hiroki Fukudome , Tadashi Nakao , Shuichi Takeshita
发明人： Hiroki Fukudome , Tadashi Nakao , Shuichi Takeshita
IPC分类号： B66C23/00
CPC分类号： E02F3/34 , E02F3/6273
摘要： A work vehicle includes a pair of, right and left booms detachably attached to a vehicle body, an implement attached to leading ends of the booms and a stand for supporting the booms with the implement being placed on a ground surface when the booms are detached from the vehicle body. The stand includes a pair of, right and left stand members provided in correspondence with the right and left booms and a stand connecting member for interconnecting the stand members. Each stand member is attached to the boom corresponding thereto in such a manner that the stand is movable between a use position in which each stand member projects downwardly from the boom for supporting the boom and a non-use position in which each stand member extends along the boom.
摘要翻译：工作车辆包括一对可拆卸地附接到车身上的左右起重臂，附接到起重臂的前端的工具和用于支撑悬臂的支架，当工具被拆卸时，工具被放置在地面上车体。该支架包括一对左右支架和一对左右支架，以及用于互连支架部件的支架连接部件。每个支架构件以这样的方式附接到与其对应的起重臂，使得支架可在使用位置之间移动，其中每个支架构件从用于支撑悬臂的起重臂向下突出的使用位置和每个支架构件沿其延伸的不使用位置繁荣。

15. 发明申请

US20060182597A1 Boom assembly 有权
标题翻译：起重机组装
公开(公告)号：US20060182597A1
公开(公告)日：2006-08-17
申请号：US11225850
申请日：2005-09-13
申请人： Yoshitaka Higashikawa , Naoki Onishi , Ryoichi Nishi , Hiroki Fukudome
发明人： Yoshitaka Higashikawa , Naoki Onishi , Ryoichi Nishi , Hiroki Fukudome
IPC分类号： B66C23/00
CPC分类号： E02F3/34 , Y10T29/49448
摘要： A boom assembly is bent at a longitudinal center portion thereof to present an upwardly convex shape. The assembly includes a front boom body and a rear boom body. The front boom body and the rear main body each includes a main body consisting essentially of a pair of right and left lateral plates and a top plate interconnecting upper edges of the respective lateral plates. The main body is formed with an upper face and a lower edge thereof being bent in a longitudinal direction thereof into an arc face having a predetermined radius of curvature. The front or rear main body further includes a bottom plate disposed downwardly of the top plate and between the right and left lateral plates. Each main body is formed by bending a plate member into a reverse U-shaped cross section and each bottom plate is comprised of a plate member provided separately from the plate member forming the main body.
摘要翻译：吊杆组件在其纵向中心部分处弯曲以呈现向上凸起的形状。组件包括前悬臂本体和后悬臂本体。前悬臂主体和后主体各自包括主体，主体由一对左右侧板和与各侧板的上边缘相互连接的顶板组成。该主体形成有一个上表面和一个下边缘沿其纵向方向弯曲成具有预定曲率半径的圆弧面。前后主体还包括设置在顶板下方以及左右侧板之间的底板。每个主体通过将板构件弯曲成相反的U形横截面而形成，并且每个底板由与构成主体的板构件分开设置的板构件构成。

16. 发明授权

US07922204B2 Vibration-isolating device for steering wheel of traveling working vehicle with wheel steering mechanism 有权
标题翻译：具有车轮转向机构的行驶车辆方向盘隔振装置
公开(公告)号：US07922204B2
公开(公告)日：2011-04-12
申请号：US12212232
申请日：2008-09-17
申请人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
发明人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
IPC分类号： B62D1/16
CPC分类号： F16D3/68 , B62D7/224 , F16D3/70 , F16F15/124
摘要： A vibration-isolating device for a steering wheel of a travelling working vehicle equipped with a wheel steering mechanism includes a first steering shaft (32) that transmits rotational displacement, the first steering shaft being operatively connected to the steering wheel (7); a second steering shaft (33) that transmits rotational displacement, the second steering shaft being operatively connected to the wheel steering mechanism (P, 23); and a vibration-isolating connecting mechanism (31) that operatively connects the first steering shaft (32) and the second steering shaft (33) to each other so that rotational displacement can be transmitted. When the angles of rotational displacement of the first steering shaft (32) and the second steering shaft (33) are within ranges of rotation angles for linearly driving the vehicle, rotational displacement cannot be transmitted between the first steering shaft (32) and the second steering shaft (33).
摘要翻译：一种配备有车轮转向机构的行驶工作车辆的方向盘的防振装置，包括：第一转向轴（32），其传递旋转位移，所述第一转向轴与所述方向盘（7）可操作地连接; 第二转向轴（33），其传递旋转位移，所述第二转向轴可操作地连接到所述车轮转向机构（P，23）; 以及将第一转向轴（32）和第二转向轴（33）可操作地连接的振动隔离连接机构（31），从而能够传递旋转位移。当第一转向轴（32）和第二转向轴（33）的旋转位移角度在用于线性驱动车辆的旋转角度的范围内时，旋转位移不能在第一转向轴（32）和第二转向轴转向轴（33）。

17. 发明申请

US20060073003A1 Front loader attachment construction and work vehicle having the attachment construction 有权
标题翻译：前装载机附件结构和具有附接结构的工作车辆
公开(公告)号：US20060073003A1
公开(公告)日：2006-04-06
申请号：US11069913
申请日：2005-03-01
申请人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
发明人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
IPC分类号： B66C23/00
CPC分类号： E02F3/627
摘要： An attachment construction for attaching a front loader having booms to a front of a tractor vehicle body is disclosed. The construction includes a pair of support tables projecting from the front portion of the tractor body to the right and left outer sides thereof, an engine constituting the vehicle body being disposed forwardly of the support tables, a front axle frame being secured to right and left sides of the engine, a pair of main frames disposed erect on the respective support tables for supporting the booms, and a pair of attaching brackets secured to right/left inner ends of the respective support tables for attaching the support tables to the vehicle body. Each attaching bracket includes a front attaching portion secured to the front axle frame and a rear attaching portion projecting rearwardly of the support table associated therewith and secured to a fore-and-aft intermediate portion of the vehicle body.
摘要翻译：公开了一种用于将具有吊臂的前部装载机附接到拖拉机车体的前部的附接结构。该结构包括从拖拉机主体的前部向其左右外侧突出的一对支撑台，构成车身的发动机设置在支撑台的前方，前轴框架左右固定发动机的侧面，一对直立设置在用于支撑吊杆的支撑台上的一对主框架，以及一对固定在相应的支撑台的左右内端的附接支架，用于将支撑台附接到车体。每个附接支架包括固定到前轴框架的前附接部分和从其相关联的支撑台的后方突出并固定到车身的前后中间部分的后连接部分。

18. 发明授权

US06879261B2 Operator presence sensing apparatus for a seat of a vehicle 有权
标题翻译：车辆座椅的操作者存在检测装置
公开(公告)号：US06879261B2
公开(公告)日：2005-04-12
申请号：US10393382
申请日：2003-03-20
申请人： Akifumi Nishino , Ryuji Kitagawa , Kenzo Ushiro , Hiroki Fukudome
发明人： Akifumi Nishino , Ryuji Kitagawa , Kenzo Ushiro , Hiroki Fukudome
IPC分类号： E02F9/16 , B60K28/04 , B60N2/00 , B60N2/20 , B60N2/54 , B60N2/90 , E02F9/24 , H01H3/14 , G08B21/00
CPC分类号： B60N2/502 , B60K28/04 , B60N2/002 , B60N2/20 , B60N2/544 , B60Y2200/415 , E02F9/24 , H01H3/141
摘要： An operator presence sensing apparatus for a seat of a vehicle includes a base member (7, 8) for supporting the seat (6), and a relay member (9) extending vertically between the base member and the seat. The seat is oscillatable about a pivot axis (X) extending in a transverse direction in the base member. The relay member is pivotably supported at one end thereof by the pivot axis and at the other end by the base member through a cushion spring (10). A seat lift-up spring (12) is disposed between an underside of the seat and the base member for receiving part of the weight of the seat. The seat unoccupied by the operator is oscillated to a floating position lifted from the relay member by the lift-up spring. The apparatus further comprises an operator presence sensing switch (13) for detecting the seat occupied by the operator and oscillated from the floating position to a lower seated position, and a restricting device (14, 15a) for restricting the relay member oscillating upward by action of the cushion spring when the seat is not occupied by the operator.
摘要翻译：用于车辆座椅的操作者存在感测装置包括用于支撑座椅（6）的基座构件（7,8）和在基座构件和座椅之间垂直延伸的中继构件（9）。座椅围绕在基部构件中沿横向方向延伸的枢转轴线（X）可摆动。继电器构件通过枢转轴线在其一端可枢转地支撑，另一端通过缓冲弹簧（10）由基座构件支撑。座椅提升弹簧（12）设置在座椅的下侧和基座构件之间，用于容纳座椅的一部分重量。操作者未占用的座椅通过提升弹簧振荡到从继电器构件提升的浮动位置。该装置还包括用于检测由操作者占据的座位并从浮动位置摆动到较低就座位置的操作者存在感测开关（13），以及用于限制继电器构件通过动作向上振动的限制装置（14,15a）当座椅未被操作者占用时，缓冲弹簧。

19. 发明授权

US08211919B2 Amide derivatives as rock inhibitors 失效
标题翻译：酰胺衍生物作为岩石抑制剂
公开(公告)号：US08211919B2
公开(公告)日：2012-07-03
申请号：US12065043
申请日：2006-08-29
申请人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
发明人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
IPC分类号： A61K31/44 , A61K31/47 , A61K31/505 , A61K31/54 , C07D239/02 , C07D413/00 , C07D499/48
CPC分类号： C07D213/40 , C07D213/61 , C07D213/75 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.
摘要翻译：本发明涉及新颖的酰胺衍生物及其盐。更具体地说，本发明涉及作为ROCK抑制剂的新型酰胺衍生物及其盐，涉及包含该酰胺衍生物及其盐的治疗和/或预防ROCK相关疾病的方法。

20. 发明申请

US20120046292A1 DIACYLETHYLENEDIAMINE COMPOUND 审中-公开
标题翻译：二乙烯基胺化合物
公开(公告)号：US20120046292A1
公开(公告)日：2012-02-23
申请号：US13263258
申请日：2010-04-19
申请人： Tomoaki Kawano , Yasuhiro Yonetoku , Takeshi Hanazawa , Takahiro Nigawara , Hiroki Fukudome , Hiroshi Moritani
发明人： Tomoaki Kawano , Yasuhiro Yonetoku , Takeshi Hanazawa , Takahiro Nigawara , Hiroki Fukudome , Hiroshi Moritani
IPC分类号： A61K31/197 , C07D307/79 , A61K31/343 , A61P3/04 , A61K31/495 , C07D239/42 , A61K31/498 , A61K31/5375 , C07C229/38 , C07D295/155
CPC分类号： C07D207/06 , C07B2200/05 , C07C233/62 , C07C235/46 , C07C235/50 , C07C235/84 , C07C237/34 , C07C255/46 , C07C271/20 , C07C275/26 , C07C275/28 , C07C307/06 , C07C311/51 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/18 , C07C2602/42 , C07C2602/44 , C07D209/08 , C07D209/42 , C07D209/44 , C07D211/16 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/60 , C07D211/62 , C07D213/64 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/02 , C07D217/06 , C07D217/26 , C07D231/14 , C07D231/22 , C07D239/28 , C07D239/42 , C07D241/04 , C07D241/42 , C07D257/04 , C07D263/32 , C07D263/34 , C07D263/48 , C07D271/06 , C07D271/10 , C07D275/02 , C07D277/20 , C07D277/56 , C07D277/68 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/20 , C07D295/205 , C07D307/79 , C07D309/06 , C07D317/46 , C07D317/72 , C07D319/18 , C07D333/38 , C07D333/54 , C07D333/68 , C07D333/70 , C07D409/12 , C07D451/02 , C07D495/04
摘要： [Problem]A compound which is useful as an anti-obesity agent is provided.[Means for Solution]The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.
摘要翻译： [问题]提供了可用作抗肥胖剂的化合物。 [解决方案]本发明人研究了具有DGAT1抑制作用的化合物，其有希望作为用于治疗肥胖，II型糖尿病，脂肪肝和与这些疾病相关的疾病的药物组合物的活性成分，以及作为结果发现本发明的二酰亚乙基二胺化合物具有优异的DGAT1抑制作用，从而完成了本发明。也就是说，本发明的二酰亚胺二胺化合物具有DGAT1抑制作用，因此可以用作预防和/或治疗肥胖，II型糖尿病，脂肪肝和与这些疾病相关的疾病的药剂。

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