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11. 发明申请

WO2010042355A1 SAMPLE PREPARATION DEVICE 审中-公开
标题翻译：样品制备装置
公开(公告)号：WO2010042355A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/058922
申请日：2009-09-30
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul, C. , DOSMAN, Geoffrey, J.
发明人： HARRIS, Paul, C. , DOSMAN, Geoffrey, J.
IPC分类号： B01L3/00
CPC分类号： G01N1/38 , B01L3/502715 , B01L3/502761 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/123 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , B01L2400/0683
摘要： An apparatus for preparing a test sample includes a container for receiving a volume of a fluid sample. The container utilizes capillary channels and one or more chambers with removable separators to measure and commingle specific volumes of each constituent of the test sample, thereby providing a prepared test sample for an immunoassay.
摘要翻译：用于制备测试样品的装置包括用于接收体积的流体样品的容器。容器使用毛细通道和一个或多个具有可移除分离器的室以测量和混合测试样品的每个组分的比体积，从而提供用于免疫测定的制备的测试样品。

12. 发明申请

WO2008121239A1 MODULAR ASSAY READER SYSTEM AND APPARATUS 审中-公开
标题翻译：模块化测试读写器系统和设备
公开(公告)号：WO2008121239A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/003609
申请日：2008-03-19
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul C.
发明人： HARRIS, Paul C.
IPC分类号： G01N21/64 , A61B5/00
CPC分类号： G01N35/00584 , G01N35/00871 , G01N2035/00851
摘要： A modular reader system and method provides for testing a test sample and determining characteristics of the sample. A first test module is configured to perform a first reading on a test sample and produce data regarding the reading. A second test module is configured to perform a second reading of the test sample and produce data regarding the second reading. The first and second test modules are communicatively coupled to a control module. The control module collects the data produced by the first and second test modules and processes the data to determine characteristics of the test sample.
摘要翻译：模块化读取器系统和方法提供测试样品并确定样品的特性。第一测试模块被配置为在测试样本上执行第一读取并产生关于读数的数据。第二测试模块被配置为执行测试样本的二次读取并产生关于第二次读取的数据。第一和第二测试模块通信地耦合到控制模块。控制模块收集由第一和第二测试模块产生的数据并处理数据以确定测试样本的特性。

13. 发明申请

WO2006023725A2 FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS 审中-公开
标题翻译：荧光检测器系统及相关方法
公开(公告)号：WO2006023725A2
公开(公告)日：2006-03-02
申请号：PCT/US2005029559
申请日：2005-08-19
申请人： BLOOD CELL STORAGE INC , REED MICHAEL W , GEELHOOD STEVEN J , HARRIS PAUL C , PFALZGRAF RANDY D
发明人： REED MICHAEL W , GEELHOOD STEVEN J , HARRIS PAUL C , PFALZGRAF RANDY D
IPC分类号： G01N21/64 , A61B5/00 , G01N21/77
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/7703 , G01N21/80 , G01N2021/7786
摘要： Fluorescent pH detetcor and methods for measuring pH using the fluorescent ph detector.
摘要翻译：荧光pH检测器和使用荧光ph检测器测量pH的方法。

14. 发明申请

WO2003010292A2 METHODS AND APPARATUS FOR ENRICHMENT AND CULTURE OF MONOCYTIC DENDRITIC CELL PRECURSORS 审中-公开
标题翻译：用于富集和培养单核细胞树突状细胞前体的方法和设备
公开(公告)号：WO2003010292A2
公开(公告)日：2003-02-06
申请号：PCT/US2002/023865
申请日：2002-07-25
申请人： NORTHWEST BIOTHERAPEUTICS, INC. , BOSCH, Marnix, L. , TJOA, Benjamin, A. , HARRIS, Paul, C.
发明人： BOSCH, Marnix, L. , TJOA, Benjamin, A. , HARRIS, Paul, C.
IPC分类号： C12N
CPC分类号： C12N5/0087 , C12N5/0639 , C12N2501/22 , C12N2501/23 , G01N33/5005 , G01N33/56972
摘要： The present invention provides methods and materials for isolating, culturing and differentiating monocytic dendritic cell precursors to form immature and/or mature dendritic cells. In a related aspect, methods, materials, and a system are provided for isolating, culturing and differentiating monocytic dendritic cell precursors under aseptic conditions to obtain immature and/or mature dendritic cells.
摘要翻译：本发明提供用于分离，培养和分化单核细胞树突细胞前体以形成未成熟和/或成熟树突细胞的方法和材料。在相关方面，提供了用于在无菌条件下分离，培养和分化单核细胞树突细胞前体以获得未成熟和/或成熟树突细胞的方法，材料和系统。

15. 发明申请

WO0150129A3 COMPENSATION FOR NON-SPECIFIC SIGNALS IN QUANTITATIVE IMMUNOASSAYS 审中-公开
标题翻译：定量免疫中非特异性信号的补偿
公开(公告)号：WO0150129A3
公开(公告)日：2002-02-14
申请号：PCT/US0035557
申请日：2000-12-29
申请人： RESPONSE BIOMEDICAL CORP , BROOKS DONALD E , HARRIS PAUL C , OLAL ANDREW D , XIE ZONGCEN CHARLES , RICHARDS BRIAN G
发明人： BROOKS DONALD E , HARRIS PAUL C , OLAL ANDREW D , XIE ZONGCEN CHARLES , RICHARDS BRIAN G
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54306 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample are disclosed. The methods involve providing a membrane having an application point, a detection zone, and a contact region, where the contact region is between the application point and the detection zone, and has test particles and internal control particles imbedded within it; contacting the application point with the fluid sample; maintaining the membrane under conditions sufficient to allow fluid to transport analyte by capillary action to the contact region, where the analyte binds to the test particles; further maintaining the membrane under conditions sufficient to allow fluid to transport analyte-bound test particles and internal control particles to the detection zone, where they interact with a detection reagent; and detecting the amount of test particles and the amount of internal control particles in the detection zone. The amount of analyte in the fluid sample is related to a corrected test particle amount, which can be determined, for example, as the difference between the amount of test particles and the amount of internal control particles in the detection zone.
摘要翻译：公开了用于定量测量流体样品中目标分析物的量的方法。所述方法包括提供具有施加点，检测区和接触区域的膜，其中所述接触区域在所述施加点和所述检测区域之间，并且具有嵌入其中的测试颗粒和内部控制颗粒; 使应用点与流体样品接触; 在足以允许流体通过毛细管作用将分析物输送到接触区域的条件下保持膜，其中分析物结合到测试颗粒; 进一步保持膜在足以允许流体将分析物结合的测试颗粒和内部控制颗粒输送到检测区域的条件下，其中它们与检测试剂相互作用; 并检测检测区域中的测试颗粒的量和内部控制颗粒的量。流体样品中的分析物的量与校正的测试颗粒量相关，其可以例如作为检测区域中的测试颗粒的量与内部控制颗粒的量之间的差异来确定。

16. 发明申请

WO2009091501A1 HEATED ASSAYS FOR INFLUENZA 审中-公开
标题翻译：加热用于流感测定
公开(公告)号：WO2009091501A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/000035
申请日：2009-01-06
申请人： RESPONSE BIOMEDICAL CORPORATION , FONG, Whalley, K. , HARRIS, Paul, C.
发明人： FONG, Whalley, K. , HARRIS, Paul, C.
IPC分类号： G01N33/543 , G01N33/569 , C12Q1/68
CPC分类号： G01N33/54393 , G01N33/56983 , G01N2333/11
摘要： Methods of increasing specific binding, decreasing non-specific binding, and reducing false-positive interaction in solid phase assays for influenza are disclosed. In the methods, the solid phase apparatus (lateral flow solid phase apparatus or capillary flow solid phase apparatus) is subjected to elevated heat subsequent to application of a test sample to the solid phase apparatus.
摘要翻译：公开了在流感的固相测定中增加特异性结合，降低非特异性结合以及降低假阳性相互作用的方法。在该方法中，在将测试样品施加到固相装置之后，将固相装置（侧流固相装置或毛细管固相装置）进行升高的热量。

17. 发明申请

WO2008140581A2 SYSTEMS AND METHODS FOR PREPARING AND ANALYZING SAMPLES 审中-公开
标题翻译：用于制备和分析样品的系统和方法
公开(公告)号：WO2008140581A2
公开(公告)日：2008-11-20
申请号：PCT/US2007085242
申请日：2007-11-20
申请人： 3M INNOVATIVE PROPERTIES CO , RESPONSE BIOMEDICAL CORP , MACH PATRICK A , CLONEY LYNN P , GUO CHUNMEI , HARRIS PAUL C , KATZENMAIER KEVIN R , KINNAIRD BARBARA R , REIF-WENNER MARA S , ROSAUER MICHELLE L , SMITH JEFFREY D , WEBB HEATHER M
发明人： MACH PATRICK A , CLONEY LYNN P , GUO CHUNMEI , HARRIS PAUL C , KATZENMAIER KEVIN R , KINNAIRD BARBARA R , REIF-WENNER MARA S , ROSAUER MICHELLE L , SMITH JEFFREY D , WEBB HEATHER M
IPC分类号： G01N33/569 , G01N33/02 , G01N33/542 , G01N33/577
CPC分类号： G01N33/56911 , G01N1/38 , G01N33/558 , G01N33/56938
摘要： The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are characteristic of a microbe, particularly Staphylococcus aureus.
摘要翻译：本发明涉及用于制备和分析感兴趣的微生物的样品（例如粘膜样品）的系统和方法。特别地，所述系统和方法可用于检测感兴趣的微生物（即微生物）特征的一种或多种分析物，例如微生物特别是金黄色葡萄球菌的细胞壁组分。

18. 发明申请

WO2008073393A1 MULTIPLE ANALYTE IMMUNOASSAY 审中-公开
标题翻译：多分析物免疫分析
公开(公告)号：WO2008073393A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/025268
申请日：2007-12-11
申请人： RESPONSE BIOMEDICAL CORPORATION , FONG, Whalley, K. , HARRIS, Paul, C. , RICHARDS, Brian, G.
发明人： FONG, Whalley, K. , HARRIS, Paul, C. , RICHARDS, Brian, G.
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54313
摘要： Methods for measuring the amount of two or more analytes of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve determining a ratio of a detected amount of a single analyte of interest, to the sum of a detected amount of each of the analytes of interest plus a detected amount of a control, wherein the amount of each analyte of interest is directly or inversely related to the ratio for each analyte of interest.
摘要翻译：公开了用于测量流体样品中两种或更多种感兴趣分析物的量的方法以及在这些方法中有用的试剂盒。该方法包括确定单个感兴趣分析物的检测量与每种感兴趣分析物的检测量加上检测到的对照量的总和，其中每种感兴趣分析物的量直接或与每种感兴趣分析物的比例成反比。

19. 发明申请

WO2006083258A3 METHOD AND APPARATUS OF QUANTITATIVE ASSAYS 审中-公开
标题翻译：定量测定方法与装置
公开(公告)号：WO2006083258A3
公开(公告)日：2006-11-23
申请号：PCT/US2005013703
申请日：2005-04-21
申请人： RESPONSE BIOMEDICAL CORP , HARRIS PAUL C , RICHARDS BRIAN G , TIPPETT JONATHAN G
发明人： HARRIS PAUL C , RICHARDS BRIAN G , TIPPETT JONATHAN G
IPC分类号： B32B27/04 , B01F11/00 , B01F13/08 , B01F13/10 , B01F15/02 , B01L3/00 , B32B5/02 , B32B27/12 , C12M1/26 , C12M1/34 , G01N1/38 , G01N1/40 , G01N35/00
CPC分类号： G01N1/38 , B01F11/0082 , B01F13/0818 , B01F13/1013 , B01F13/1022 , B01F15/0205 , B01F15/0209 , B01F15/0215 , B01L3/5023 , B01L3/5025 , B01L2300/0672 , B01L2400/0406 , B01L2400/0475 , B01L2400/0677 , B01L2400/0683 , G01N1/40
摘要： A sample testing apparatus (100) for use in measuring an analyte in a sample (105) is disclosed. The apparatus includes a sample well (104) for receiving the sample. A solid analyte binding agent (160) is disposed in the sample well. The apparatus further 5 includes a mixing device (156) for mixing the sample with the solid analyte binding agent and a valve (129). The valve is configurable between a closed position for impeding flow of the sample from the sample well and an open position for releasing the sample from the sample well. The apparatus additionally includes a membrane (118) for receiving the sample once released from the sample well, the membrane having a capture reagent (164) 10 adapted to interact with at least one of the analyte, the analyte binding agent, or a complex thereof, to aid in determining the amount of the analyte in the sample.
摘要翻译：公开了一种用于测量样品（105）中的分析物的样品测试装置（100）。该装置包括用于接收样品的样品阱（104）。固体分析物结合剂（160）设置在样品井中。该装置还包括用于将样品与固体分析物结合剂混合的混合装置（156）和阀（129）。阀可配置在用于阻止样品从样品池流出的关闭位置和用于从样品阱释放样品的打开位置。该装置还包括用于从样品阱释放一次而接收样品的膜（118），该膜具有适于与至少一种分析物，分析物结合剂或其复合物相互作用的捕获试剂（164）10 ，以帮助确定样品中分析物的量。

20. 发明申请

WO2006083367A2 IMMUNOASSAY EMPLOYING TWO-STEP INTERNAL CALIBRATION REACTION 审中-公开
标题翻译：免疫测试采用两步内部校准反应
公开(公告)号：WO2006083367A2
公开(公告)日：2006-08-10
申请号：PCT/US2005042668
申请日：2005-11-22
申请人： RESPONSE BIOMEDICAL CORP , HARRIS PAUL C , FONG WHALLEY K , CLONEY LYNN
发明人： HARRIS PAUL C , FONG WHALLEY K , CLONEY LYNN
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , Y10S435/805 , Y10S435/81
摘要： Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods comprise sandwich assays, and utilize an internal calibration reaction that closely mimics the reaction of test particles by the use of a two-step reaction.
摘要翻译：公开了用于定量测量流体样品中感兴趣的分析物的量的方法和用于该方法的试剂盒。所述方法包括夹心测定，并且利用通过使用两步反应紧密地模拟测试颗粒的反应的内部校准反应。

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