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1. 发明专利

AU2003243673A1 TANGENTIAL FLOW FILTRATION DEVICES AND METHODS FOR LEUKOCYTE ENRICHMENT 未知
公开(公告)号：AU2003243673A1
公开(公告)日：2004-01-06
申请号：AU2003243673
申请日：2003-06-19
申请人： LODGE PATRICIA A , NORTHWEST BIOTHERAPEUTICS INC , BOSCH MARNIX L , HARRIS PAUL C , MONAHAN STEVEN J , TURNER ALLEN , BOYNTON ALTON L
发明人： LODGE PATRICIA A , BOSCH MARNIX L , HARRIS PAUL C , MONAHAN STEVEN J , TURNER ALLEN , BOYNTON ALTON L
IPC分类号： C12M1/26 , A61M1/34 , A61M1/36 , A61M1/38 , B01D61/00 , B01D61/14 , B01D61/16 , B01D61/18 , B01D61/22 , C12M3/00 , C12N5/06
摘要： The present invention provides tangential flow filtration devices and methods for enriching a heterogeneous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. One embodiment includes a remover unit (1) having a crossflow chamber (3) separated by a microporous filter (5) from a filtrate chamber (4), the remover unit (1) also having a tangential flow inlet (6), a fluid outlet (7) for a fluid enriched in leukocytes and a filtrate outlet (8).

2. 发明申请

WO2008140581A3 SYSTEMS AND METHODS FOR PREPARING AND ANALYZING SAMPLES 审中-公开
公开(公告)号：WO2008140581A3
公开(公告)日：2008-11-20
申请号：PCT/US2007/085242
申请日：2007-11-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY , RESPONSE BIOMEDICAL CORPORATION , MACH, Patrick A. , CLONEY, Lynn P. , GUO, Chunmei , HARRIS, Paul C. , KATZENMAIER, Kevin R. , KINNAIRD, Barbara R. , REIF-WENNER, Mara S. , ROSAUER, Michelle L. , SMITH, Jeffrey D. , WEBB, Heather M.
发明人： MACH, Patrick A. , CLONEY, Lynn P. , GUO, Chunmei , HARRIS, Paul C. , KATZENMAIER, Kevin R. , KINNAIRD, Barbara R. , REIF-WENNER, Mara S. , ROSAUER, Michelle L. , SMITH, Jeffrey D. , WEBB, Heather M.
IPC分类号： G01N33/569 , G01N33/577 , G01N33/543 , G01N33/02
摘要： The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are characteristic of a microbe, particularly Staphylococcus aureus.

3. 发明申请

WO2008106021A1 COMPARATIVE MULTIPLE ANALYTE ASSAY 审中-公开
标题翻译：比较多分析测定
公开(公告)号：WO2008106021A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002046
申请日：2008-02-15
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul, C.
发明人： HARRIS, Paul, C.
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/54313 , G01N33/54366 , G01N33/558 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81
摘要： Methods for measuring the relative amount of two or more analytes of interest in a fluid sample, as well as kits useful in the methods, are disclosed. The methods involve assays that utilize a solid phase apparatus with a membrane having an application point and at least two sample capture zones having sample capture reagents; analyte binding particles or analyte coated particles; and assessment of a ratio of such particles arrested in capture zones, wherein the ratio is equal to, or inversely equal to, the relative amounts of the analytes of interest in the fluid sample.
摘要翻译：公开了用于测量流体样品中感兴趣的两种或更多分析物的相对量的方法，以及在该方法中有用的试剂盒。该方法包括利用具有应用点的膜的固相装置和具有样品捕获试剂的至少两个样品捕获区域的测定法; 分析物结合颗粒或分析物包被的颗粒; 以及评估在捕获区域中捕获的这种颗粒的比率，其中该比例等于或相当于流体样品中感兴趣的分析物的相对量。

4. 发明申请

WO2008073393A8 MULTIPLE ANALYTE IMMUNOASSAY 审中-公开
标题翻译：多分析免疫
公开(公告)号：WO2008073393A8
公开(公告)日：2008-08-21
申请号：PCT/US2007025268
申请日：2007-12-11
申请人： RESPONSE BIOMEDICAL CORP , FONG WHALLEY K , HARRIS PAUL C , RICHARDS BRIAN G
发明人： FONG WHALLEY K , HARRIS PAUL C , RICHARDS BRIAN G
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54313
摘要： Methods for measuring the amount of two or more analytes of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve determining a ratio of a detected amount of a single analyte of interest, to the sum of a detected amount of each of the analytes of interest plus a detected amount of a control, wherein the amount of each analyte of interest is directly or inversely related to the ratio for each analyte of interest.
摘要翻译：公开了用于测量流体样品中感兴趣的两种或更多种分析物的量的方法和用于该方法的试剂盒。所述方法包括确定感兴趣的单一分析物的检测量的比率，与感兴趣的每种分析物的检测量的总和加上检测到的对照量的总和，其中每个感兴趣的分析物的量是直接的或与感兴趣的每个分析物的比例成反比。

5. 发明申请

WO2007024633A3 MULTI-DIRECTIONAL IMMUNOCHROMATOGRAPHIC ASSAYS 审中-公开
标题翻译：多方向免疫印迹测定
公开(公告)号：WO2007024633A3
公开(公告)日：2007-06-07
申请号：PCT/US2006032200
申请日：2006-08-17
申请人： RESPONSE BIOMEDICAL CORP , HARRIS PAUL C , RICHARDS BRIAN G
发明人： HARRIS PAUL C , RICHARDS BRIAN G
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Methods for quantitatively measuring the amount of one or more analyte(s) of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve providing a solid phase apparatus comprising a membrane having an application point, a sample capture zone, and a control capture zone, where the sample capture zone and the control capture zone are approximately equidistant from the application point; and providing a sample collection apparatus comprising one or more population(s) of analyte binding particles. In the assays, a fluid sample is introduced into the sample collection apparatus, and the resultant mixture is applied to the application point of the membrane. The fluid allows transport components of the assay by capillary action to and through the sample capture zone(s) and the control capture zone. The amount of each analyte of interest in the fluid sample is related (e.g., either directly or inversely) to a corrected particle amount, which can be determined, for example, as a ratio of the amount of particles in the corresponding sample capture zone and the amount of particles in the control capture zone.
摘要翻译：公开了用于定量测量流体样品中感兴趣的一种或多种分析物的量的方法和用于该方法的试剂盒。该方法包括提供一种固相装置，其包括具有应用点的膜，样品捕获区和对照捕获区，其中样品捕获区和对照捕获区与施加点大致相等; 以及提供包含一个或多个分析物结合颗粒群的样品收集装置。在测定中，将流体样品引入样品收集装置中，并将所得混合物施加到膜的施加点。流体允许通过毛细管作用将测定的运输成分传送到样品捕获区域和控制捕获区域。流体样品中感兴趣的每个分析物的量与校正的颗粒量相关（例如，直接或反向），其可以例如确定为相应样品捕获区中的颗粒的量与控制捕获区域中的颗粒数量。

6. 发明申请

WO2006083367A3 IMMUNOASSAY EMPLOYING TWO-STEP INTERNAL CALIBRATION REACTION 审中-公开
公开(公告)号：WO2006083367A3
公开(公告)日：2006-08-10
申请号：PCT/US2005/042668
申请日：2005-11-22
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul, C. , FONG, Whalley, K. , CLONEY, Lynn
发明人： HARRIS, Paul, C. , FONG, Whalley, K. , CLONEY, Lynn
IPC分类号： G01N33/543
摘要： Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods comprise sandwich assays, and utilize an internal calibration reaction that closely mimics the reaction of test particles by the use of a two-step reaction.

7. 发明申请

WO2006083258A2 METHOD AND APPARATUS OF QUANTITATIVE ASSAYS 审中-公开
标题翻译：定量测定方法和设备
公开(公告)号：WO2006083258A2
公开(公告)日：2006-08-10
申请号：PCT/US2005/013703
申请日：2005-04-21
申请人： RESPONSE BIOMEDICAL CORP. , HARRIS, Paul, C. , RICHARDS, Brian, G. , TIPPETT, Jonathan, G.
发明人： HARRIS, Paul, C. , RICHARDS, Brian, G. , TIPPETT, Jonathan, G.
IPC分类号： C12M1/34
CPC分类号： G01N1/38 , B01F11/0082 , B01F13/0818 , B01F13/1013 , B01F13/1022 , B01F15/0205 , B01F15/0209 , B01F15/0215 , B01L3/5023 , B01L3/5025 , B01L2300/0672 , B01L2400/0406 , B01L2400/0475 , B01L2400/0677 , B01L2400/0683 , G01N1/40
摘要： A sample testing apparatus (100) for use in measuring an analyte in a sample (105) is disclosed. The apparatus includes a sample well (104) for receiving the sample. A solid analyte binding agent (160) is disposed in the sample well. The apparatus further 5 includes a mixing device (156) for mixing the sample with the solid analyte binding agent and a valve (129). The valve is configurable between a closed position for impeding flow of the sample from the sample well and an open position for releasing the sample from the sample well. The apparatus additionally includes a membrane (118) for receiving the sample once released from the sample well, the membrane having a capture reagent (164) 10 adapted to interact with at least one of the analyte, the analyte binding agent, or a complex thereof, to aid in determining the amount of the analyte in the sample.
摘要翻译：公开了用于测量样本（105）中的分析物的样本测试设备（100）。该设备包括用于接收样本的样本井（104）。固体分析物结合剂（160）置于样品孔中。装置5还包括用于将样品与固体分析物结合剂和阀（129）混合的混合装置（156）。该阀可配置在用于阻止样品从样品池流动的关闭位置和用于从样品池释放样品的打开位置之间。该设备还包括用于接收样品一旦从样品孔释放的膜（118），该膜具有适于与分析物，分析物结合剂或其复合物中的至少一种相互作用的捕获剂（164）10 ，以帮助确定样品中分析物的量。

8. 发明申请

WO2004000444A1 TANGENTIAL FLOW FILTRATION DEVICES AND METHODS FOR LEUKOCYTE ENRICHMENT 审中-公开
标题翻译：水龙头渗流装置及其制备方法
公开(公告)号：WO2004000444A1
公开(公告)日：2003-12-31
申请号：PCT/US2003/019428
申请日：2003-06-19
申请人： NORTHWEST BIOTHERAPEUTICS, INC. , BOSCH, Marnix, L. , HARRIS, Paul, C. , MONAHAN, Steven, J. , TURNER, Allen , BOYNTON, Alton, L. , LODGE, Patricia, A.
发明人： BOSCH, Marnix, L. , HARRIS, Paul, C. , MONAHAN, Steven, J. , TURNER, Allen , BOYNTON, Alton, L. , LODGE, Patricia, A.
IPC分类号： B01D61/14
CPC分类号： A61M1/3496 , A61M1/3633 , A61M1/38 , A61M2202/0439 , B01D61/147 , B01D61/16 , B01D61/18 , B01D61/22 , B01D2315/10 , Y10T436/255
摘要： The present invention provides tangential flow filtration devices and methods for enriching a heterogeneous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. One embodiment includes a remover unit (1) having a crossflow chamber (3) separated by a microporous filter (5) from a filtrate chamber (4), the remover unit (1) also having a tangential flow inlet (6), a fluid outlet (7) for a fluid enriched in leukocytes and a filtrate outlet (8).
摘要翻译：本发明提供切向流过滤装置和通过去除非白细胞血液成分来富集白细胞的血液成分的非均相混合物的方法。在一个具体实施方案中，该装置可以提供富含单核细胞的组合物。一个实施例包括具有从滤液室（4）与微孔过滤器（5）分离的交叉流室（3）的去除单元（1），所述去除单元（1）还具有切向流入口（6），流体出口（7），用于富含白细胞的液体和滤液出口（8）。

9. 发明申请

WO2007024633A2 MULTI-DIRECTIONAL IMMUNOCHROMATOGRAPHIC ASSAYS 审中-公开
标题翻译：多方向免疫层析法测定
公开(公告)号：WO2007024633A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032200
申请日：2006-08-17
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul, C. , RICHARDS, Brian, G.
发明人： HARRIS, Paul, C. , RICHARDS, Brian, G.
IPC分类号： G01N33/50
CPC分类号： G01N33/558
摘要： Methods for quantitatively measuring the amount of one or more analyte(s) of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve providing a solid phase apparatus comprising a membrane having an application point, a sample capture zone, and a control capture zone, where the sample capture zone and the control capture zone are approximately equidistant from the application point; and providing a sample collection apparatus comprising one or more population(s) of analyte binding particles. In the assays, a fluid sample is introduced into the sample collection apparatus, and the resultant mixture is applied to the application point of the membrane. The fluid allows transport components of the assay by capillary action to and through the sample capture zone(s) and the control capture zone. The amount of each analyte of interest in the fluid sample is related (e.g., either directly or inversely) to a corrected particle amount, which can be determined, for example, as a ratio of the amount of particles in the corresponding sample capture zone and the amount of particles in the control capture zone.
摘要翻译：公开了用于定量测量流体样品中一种或多种感兴趣分析物的量的方法以及在这些方法中有用的试剂盒。所述方法包括提供包含膜的固相装置，所述膜具有施用点，样品捕获区和对照捕获区，其中所述样品捕获区和所述对照捕获区与所述施加点大致等距离; 并提供包含一个或多个分析物结合颗粒群的样品收集装置。在测定中，将流体样品引入到样品收集装置中，并将所得混合物施加到膜的施加点。流体通过毛细管作用允许测定的转运组分通过和通过样品捕获区和对照捕获区。流体样本中的每种感兴趣分析物的量与校正的粒子量相关（例如，直接或相反），其可以例如被确定为相应样本捕获区中的粒子的量与控制捕获区中的颗粒数量。

10. 发明申请

WO2002077646A1 COMPENSATION FOR VARIABILITY IN SPECIFIC BINDING IN QUANTITATIVE ASSAYS 审中-公开
标题翻译：对定量测定中特定结合的变异性的补偿
公开(公告)号：WO2002077646A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/008284
申请日：2002-03-14
申请人： RESPONSE BIOMEDICAL CORPORATION , HARRIS, Paul, C. , RICHARDS, Brian, G.
发明人： HARRIS, Paul, C. , RICHARDS, Brian, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , G01N33/54386
摘要： Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample are disclosed. The methods involve providing a membrane having an application, a contact region comprising analyte-binding particles, a sample capture zone, and a control capture zone, where the contact region is between the application point and the sample capture zone, and the sample capture region is between the contact region and the control capture zone (Figure 1).In the assays, a fluid allows transport components of the assay by capillary action through the contact region, to and through the sample capture zone and subsequently to and through the control capture zone. In a "sandwich assay" embodiment, the amount of analyte in the fluid sample is related to a corrected analyte-binding particle amount, which can be determined, for example, as a ratio of the amount of analyte-binding particles in the sample capture zone and the amount of analyte-binding particles on the control capture zone. In a "competitive assay" embodiment, the amountof analyte in the fluid sample is inversely related to a corrected analyte-coated particle amount, which can be determinedas a ratio of the amount of analyte-coated particles in the sample capture zone and the amount of analyte-coated particles in the control capture zone.
摘要翻译：公开了用于定量测量流体样品中目标分析物的量的方法。所述方法包括提供具有应用的膜，包含分析物结合颗粒的接触区域，样品捕获区域和控制捕获区域，其中接触区域在施加点和样品捕获区域之间，并且样品捕获区域在接触区域和控制捕获区之间（图1）。在测定中，流体允许通过毛细管作用通过接触区域，到并通过样品捕获区域并随后通过控制捕获区域将分析物的传输成分。在“夹心测定”实施方案中，流体样品中的分析物的量与校正的分析物结合粒子量相关，其可以例如由样品捕获中的分析物结合颗粒的量的比例确定区域和对照捕获区域上的分析物结合颗粒的量。在“竞争性测定”实施方案中，流体样品中的分析物与构建的分析物涂覆的颗粒量成反比，其可以被确定为样品捕获区域中分析物包被的颗粒的量与对照捕获区域中分析物包被的颗粒的量。

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