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11. 发明申请

US20060058685A1 System and method for imaging based on ultrasonic tagging of light 有权
标题翻译：基于超声波标记的成像系统和方法
公开(公告)号：US20060058685A1
公开(公告)日：2006-03-16
申请号：US11254266
申请日：2005-10-20
申请人： Pavel Fomitchov , Kajoli Krishnan , Stephen Lomnes , Floribertus Heukensfeldt Jansen
发明人： Pavel Fomitchov , Kajoli Krishnan , Stephen Lomnes , Floribertus Heukensfeldt Jansen
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0051 , A61B5/0091 , A61B5/4312 , A61K49/0017 , A61K49/0032 , A61K49/0034 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N21/1717 , G01N21/4795 , G01N2021/1729 , G01N2021/6439
摘要： A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.
摘要翻译：提供了一种基于荧光在介质中定位的成像技术。该技术包括用激发光照射介质以激发荧光，通过超声波束在多个位置扫描介质，在多个位置的每一个处经由超声波束在荧光上调制一部分发射的光检测介质边界处的调制光，并根据检测到的信号重建图像。

12. 发明授权

US08466420B2 Charge loss correction 有权
标题翻译：充电损失修正
公开(公告)号：US08466420B2
公开(公告)日：2013-06-18
申请号：US12794525
申请日：2010-06-04
申请人： Kristen Ann Wangerin , Wen Li , Yanfeng Du , Floribertus Heukensfeldt Jansen
发明人： Kristen Ann Wangerin , Wen Li , Yanfeng Du , Floribertus Heukensfeldt Jansen
IPC分类号： G01T1/161
CPC分类号： G01T1/2928 , A61B6/037
摘要： The present disclosure relates to the correction of charge loss in a radiation detector. In one embodiment, correction factors for charge loss may be determined based on depth of interaction and lateral position within a radiation detector of a charge creating event. The correction factors may be applied to subsequently measured signals to correct for the occurrence of charge loss in the measured signals.
摘要翻译：本公开涉及对辐射检测器中的电荷损失的校正。在一个实施例中，可以基于电荷产生事件的辐射检测器内的相互作用深度和横向位置确定电荷损失的校正因子。校正因子可以应用于随后测量的信号，以校正测量信号中电荷损失的发生。

13. 发明申请

US20130136328A1 METHODS AND SYSTEMS FOR ENHANCED TOMOGRAPHIC IMAGING 审中-公开
标题翻译：用于增强图像成像的方法和系统
公开(公告)号：US20130136328A1
公开(公告)日：2013-05-30
申请号：US13307753
申请日：2011-11-30
申请人： Floribertus Heukensfeldt Jansen , Ravindra Mohan Manjeshwar
发明人： Floribertus Heukensfeldt Jansen , Ravindra Mohan Manjeshwar
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T2211/436
摘要： Nuclear imaging systems, non-transitory computer readable media and methods for tomographic imaging are presented. Projection data is acquired by scanning one or more views of a subject for a designated scan interval less than a total scan interval. A first image of a target region of interest (ROI) is reconstructed using projection data acquired over a first fraction of the designated scan interval. A second target ROI image is reconstructed using at least a subset of projection data acquired over the first and/or a second fraction. A change in an image quality characteristic over the first and the second fractions is determined by determining one or more differences between the first and the second images. A value of an imaging parameter is estimated based on the change to acquire projection data for generating a target ROI image having at least a predetermined level of the image quality characteristic.
摘要翻译：提出了核成像系统，非瞬时计算机可读介质和断层成像的方法。通过扫描对象的指定扫描间隔小于总扫描间隔的一个或多个视图来获取投影数据。使用在指定的扫描间隔的第一部分获取的投影数据来重建目标感兴趣区域（ROI）的第一图像。使用在第一和/或第二分数上获取的投影数据的至少一个子集来重建第二目标ROI图像。通过确定第一和第二图像之间的一个或多个差异来确定第一和第二分数之间的图像质量特性的变化。基于该变化来估计成像参数的值，以获取用于生成具有图像质量特性的至少预定水平的目标ROI图像的投影数据。

14. 发明申请

US20120128264A1 METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 有权
标题翻译：光学成像技术在散射介质中的目标检测方法与系统
公开(公告)号：US20120128264A1
公开(公告)日：2012-05-24
申请号：US12952359
申请日：2010-11-23
申请人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
发明人： Siavash Yazdanfar , Floribertus Heukensfeldt Jansen , Stephen Lomnes , Xinghua Wang
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/0059 , A61B5/0064
摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.
摘要翻译：提供了一种增强荧光成像对比度的方法。该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

15. 发明授权

US07915591B2 Mask for coded aperture systems 有权
标题翻译：编码孔径系统的掩模
公开(公告)号：US07915591B2
公开(公告)日：2011-03-29
申请号：US12122471
申请日：2008-05-16
申请人： Scott Stephen Zelakiewicz , Jeffrey Seymour Gordon , Floribertus Heukensfeldt Jansen
发明人： Scott Stephen Zelakiewicz , Jeffrey Seymour Gordon , Floribertus Heukensfeldt Jansen
IPC分类号： G01T1/36
CPC分类号： G01T1/295
摘要： A detector for identification and localization of radioisotopes, comprising a position sensitive detector configured to observe the location of emitted high energy radiation, wherein the position sensitive detector comprises a surface comprised of a first radiation sensitive material; and an active mask disposed in front of the position sensitive detector positioned such that the emitted high energy radiation is detected by the position sensitive detector after passage through the mask, wherein the mask comprises a second radiation sensitive material.
摘要翻译：一种用于放射性同位素识别和定位的检测器，包括位置敏感检测器，其被配置为观察所发射的高能量辐射的位置，其中所述位置敏感检测器包括由第一辐射敏感材料组成的表面; 以及设置在所述位置敏感检测器前面的有源掩模，其被定位成使得所述发射的高能量辐射在通过所述掩模之后由所述位置敏感检测器检测，其中所述掩模包括第二辐射敏感材料。

16. 发明申请

US20070040122A1 Technique for reconstructing PET scan images 有权
标题翻译： PET扫描图像重建技术
公开(公告)号：US20070040122A1
公开(公告)日：2007-02-22
申请号：US11205067
申请日：2005-08-17
申请人： Ravindra Manjeshwar , Floribertus Heukensfeldt Jansen , Charles Stearns
发明人： Ravindra Manjeshwar , Floribertus Heukensfeldt Jansen , Charles Stearns
IPC分类号： G01T1/164
CPC分类号： G01T1/2985
摘要： The invention is directed to a technique for reconstructing PET scan images. According to one embodiment, the invention relates to a method for reconstructing PET scan images. The method comprises: detecting a plurality of coincidence events in a PET scanner; storing data associated with the plurality of coincidence events in a chronological list based on a detection time for each of the plurality of coincidence events; generating correction data based on scatter coincidence events and random coincidence events in the plurality of coincidence events; and reconstructing one or more PET scan images based at least in part on the chronological list of data and the correction data.
摘要翻译：本发明涉及一种重建PET扫描图像的技术。根据一个实施例，本发明涉及一种重建PET扫描图像的方法。该方法包括：在PET扫描器中检测多个符合事件; 基于多个重合事件中的每一个的检测时间，将与所述多个重合事件相关联的数据存储在时序列表中; 基于所述多个重合事件中的分散符合事件和随机符合事件生成校正数据; 以及至少部分地基于时间顺序的数据列表和校正数据重建一个或多个PET扫描图像。

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