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11. 发明申请

WO2006074012A3 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES 审中-公开
标题翻译：机构和组织的辅助细胞重建
公开(公告)号：WO2006074012A3
公开(公告)日：2007-02-01
申请号：PCT/US2005047291
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： A01K67/0271 , A01K2217/30 , A01K2267/025
摘要： One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non-human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or at least substantially all cell types of a solid organ or tissue; methods for cellularly reconstituting solid organs and tissues with replacement cells, such as human cells, with respect to selected cell types and/or at least substantially all cell types of an organ or tissue; modified non-human mammals for cellularly reconstituting solid organs and tissues with replacement cells; and the cellularly reconstituted solid organs and tissues. The production of human organs and tissues according to the invention overcomes the limitations associated with xenotransplantation of animal organs and tissues to humans.
摘要翻译：本发明的一个方面提供用于在非人哺乳动物宿主中生产至少基本上细胞的人类固体器官和固体组织的改进方法。本发明的相关方面提供：关于选择的细胞类型和/或至少基本上所有细胞类型的固体器官或组织获得器官和/或组织特异性基因表达和/或表型的基于移植的方法; 相对于选择的细胞类型和/或至少基本上所有细胞类型的器官或组织，用替代细胞例如人细胞细胞重建固体器官和组织的方法; 用修复的非人哺乳动物用替代细胞细胞重构固体器官和组织; 和细胞重构的固体器官和组织。根据本发明的人体器官和组织的生产克服了与动物器官和组织的异种移植相关的限制。

12. 发明申请

WO2006072018A2 METHODS FOR SUPPORTING AND PRODUCING HUMAN CELLS AND TISSUES IN NON-HUMAN MAMMAL HOSTS 审中-公开
标题翻译：支持和生产非人类雄性HOSTS中的人类细胞和组织的方法
公开(公告)号：WO2006072018A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/047510
申请日：2005-12-29
申请人： DIAMOND, Paul
发明人： DIAMOND, Paul
IPC分类号： C12N5/08
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2267/02
摘要： Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animalhosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha-galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.
摘要翻译：提供了在非人哺乳动物宿主中培养和产生含有人细胞的组合物如器官和血液的方法，以及用于制备用于移植给人类受试者的含有动物的人细胞的组合物。在一个方面，被遗传修饰或治疗以减少异种抗原表达（例如α-半乳糖基表位）的非人宿主用于减少异种抗原向托管人细胞的转移。在另一方面，使用遗传修饰以表达或过度表达促进对移植物（例如hDAF）的免疫耐受性的分子的非人宿主，使得分子被转移到宿主的人细胞。这些方面促进了人体细胞含有组合物移植到人类受试者时的免疫学接受。另一方面提供了调理治疗，其促进了在非人类宿主移植到人类受试者时已被支持的含有人细胞的组合物的免疫学接受。

13. 发明申请

WO2018237379A3 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 审中-公开
公开(公告)号：WO2018237379A3
公开(公告)日：2018-12-27
申请号：PCT/US2018/039263
申请日：2018-06-25
申请人： ENZO BIOCHEM, INC. , ELAZAR, Rabbani , DONEGAN, James, J. , DIAMOND, Paul
发明人： ELAZAR, Rabbani , DONEGAN, James, J. , DIAMOND, Paul
IPC分类号： A61K31/135 , A61K31/4245 , A61K45/06 , A61P35/00 , A61P35/02
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine- 1 -phosphate receptor agonists, such as ozanimod.

14. 发明申请

WO2005019428B1 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
标题翻译：多糖活性和表达的调控
公开(公告)号：WO2005019428B1
公开(公告)日：2005-09-29
申请号：PCT/US2004027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N15/113 , C12H21/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.
摘要翻译：本发明提供了用于控制表达的方法和系统，以及一般来说，预选的多核酸分子的细胞活性。本发明还提供用于遗传修饰细胞和多细胞生物体以抵抗病毒的方法和系统。本发明还提供用于遗传修饰细胞和多细胞生物体的方法和系统，使得它们诊断性地报告病毒感染。本发明的一个方面涉及将目标多核苷酸分子作为至少一个模板指导的聚核酸聚合酶的功能模板，使得通过聚合酶的多核酸分子作为模板的利用调节靶向的多核酸分子的活性。本发明的其它方面涉及将选择的多核核酸分子作为RNA沉默的靶标，无论沉默是否是聚合酶介导的。

15. 发明申请

WO2003063960A3 IMPROVEMENTS RELATING TO MEDICAL DEVICES 审中-公开
公开(公告)号：WO2003063960A3
公开(公告)日：2003-08-07
申请号：PCT/GB2003/000398
申请日：2003-01-31
申请人： AMTEC MEDICAL LIMITED , MCKEE, John, William , SLOANE, K., Michael , DIAMOND, Paul, Michael
发明人： MCKEE, John, William , SLOANE, K., Michael , DIAMOND, Paul, Michael
IPC分类号： A61N1/36
摘要： An integral unit for use in the electrical stimulation of a human or animal body, particularly for preventing circulatory conditions is described. It comprises one or more electrodes integrated with a bandage housing, the housing being adapted to locate and secure the unit on a selected portion of the human or animal body. Also described is a detachable electrode strip for use with an electrical stimulation unit. It comprises a sheet having at least one electrode pad, at least one terminal point and at least one connecting conductor which connects the at least one electrode pad to the at least one terminal point. The unit and strip are preferably disposable, which therefore provides advantages with regard to sterility, as well as ease of use. The present invention provides a clean and efficient system for DVT and similar apparatus.

16. 发明申请

WO2003063960A2 IMPROVEMENTS RELATING TO MEDICAL DEVICES 审中-公开
标题翻译：关于医疗器械的改进
公开(公告)号：WO2003063960A2
公开(公告)日：2003-08-07
申请号：PCT/GB2003/000398
申请日：2003-01-31
申请人： AMTEC MEDICAL LIMITED , MCKEE, John, William , SLOANE, K., Michael , DIAMOND, Paul, Michael
发明人： MCKEE, John, William , SLOANE, K., Michael , DIAMOND, Paul, Michael
IPC分类号： A61N1/36
CPC分类号： A61N1/321
摘要： An integral unit for use in the electrical stimulation of a human or animal body, particularly for preventing circulatory conditions is described. It comprises one or more electrodes integrated with a bandage housing, the housing being adapted to locate and secure the unit on a selected portion of the human or animal body. Also described is a detachable electrode strip for use with an electrical stimulation unit. It comprises a sheet having at least one electrode pad, at least one terminal point and at least one connecting conductor which connects the at least one electrode pad to the at least one terminal point. The unit and strip are preferably disposable, which therefore provides advantages with regard to sterility, as well as ease of use. The present invention provides a clean and efficient system for DVT and similar apparatus.
摘要翻译：描述了用于人体或动物体的电刺激，特别是用于预防循环状态的整体单元。它包括与绷带外壳集成的一个或多个电极，该外壳适于将该单元定位并固定在人体或动物体的选定部分上。还描述了一种用于电刺激单元的可拆卸电极条。它包括具有至少一个电极焊盘，至少一个端点和将至少一个电极焊盘连接到至少一个端点的至少一个连接导体的片材。单位和条带优选是一次性的，因此在无菌性以及易于使用方面提供了优点。本发明提供了一种用于DVT和类似装置的清洁和有效的系统。

17. 发明专利

GB2435598B Reduced xenoantigen transfer following human donor tissue hosting in non-human mammal 未知
公开(公告)号：GB2435598B
公开(公告)日：2010-04-14
申请号：GB0712278
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N5/078 , A61K39/00 , C12N5/10
摘要： Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animal-hosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha-galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.

18. 发明专利

IL184261D0 METHODS FOR SUPPORTING AND PRODUCING HUMAN CELLS AND TISSUES IN NON-HUMAN MAMMAL HOSTS 未知
公开(公告)号：IL184261D0
公开(公告)日：2007-10-31
申请号：IL18426107
申请日：2007-06-27
申请人： DIAMOND PAUL
IPC分类号： C12N20100101
摘要： Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animal-hosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha-galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.

19. 发明专利

GB2435598A Methods for supporting and producing human cells and tissues in non-human mammal hosts 未知
公开(公告)号：GB2435598A
公开(公告)日：2007-08-29
申请号：GB0712278
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N5/08 , A61K39/00 , C12N5/10
摘要： Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animalhosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha-galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.

20. 发明专利

CA2592574A1 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES 未知
公开(公告)号：CA2592574A1
公开(公告)日：2006-07-13
申请号：CA2592574
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： A01N63/00 , A01N1/02 , A61D99/00 , A61M1/00 , A61M1/10 , A61M1/14

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