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11. 发明申请

WO2006127236A3 SURGICAL INSTRUMENTS AND METHODS FOR USE IN REDUCED-ACCESS SURGICAL SITES 审中-公开
标题翻译：手术仪器和用于减少手术手术的方法
公开(公告)号：WO2006127236A3
公开(公告)日：2009-04-23
申请号：PCT/US2006017443
申请日：2006-05-04
申请人： CARDIOTHORACIC SYS INC , DAVIS JOHN W , WILLIS GEOFFREY H , WILLIS ERIC , GRESL CHARLES , CALLAS PETER , VASSILIADES THOMAS
发明人： DAVIS JOHN W , WILLIS GEOFFREY H , WILLIS ERIC , GRESL CHARLES , CALLAS PETER , VASSILIADES THOMAS
IPC分类号： A61B1/32
CPC分类号： A61B17/0218 , A61B90/50 , A61B90/57 , A61B2017/0243 , A61B2017/306
摘要： Devices and methods for stabilizing a portion of an organ or tissue in a closed or restricted space surgical site. Devices and methods for manipulating an organ or tissue in a closed or restricted space surgical site. Devices and methods for positioning and orienting stabilizers and manipulators I a closed or restricted space surgical site.
摘要翻译：用于稳定封闭或受限空间手术部位的器官或组织的一部分的装置和方法。用于操纵封闭或受限空间外科手术部位的器官或组织的装置和方法。用于定位和定向稳定器和操纵器的装置和方法I是封闭或受限的空间外科手术部位。

12. 发明申请

WO2008020975A3 DEVICES AND METHODS FOR ATRIAL APPENDAGE EXCLUSION 审中-公开
标题翻译：用于ATRIAL附录排除的装置和方法
公开(公告)号：WO2008020975A3
公开(公告)日：2008-10-30
申请号：PCT/US2007016824
申请日：2007-07-26
申请人： CARDIOTHORACIC SYS INC , CHIN ALBERT K , DAVID JOHN W , SHROFF KETAN , AGARWAL AMIT , UEMURA SHUJI , CANTU ALFREDO R , WILLIS GEOFFREY H , CALLAS PETER , GRESL CHARLES
发明人： CHIN ALBERT K , DAVID JOHN W , SHROFF KETAN , AGARWAL AMIT , UEMURA SHUJI , CANTU ALFREDO R , WILLIS GEOFFREY H , CALLAS PETER , GRESL CHARLES
IPC分类号： A61B1/00
CPC分类号： A61B17/122 , A61B17/064 , A61B17/0643 , A61B17/068 , A61B17/1227 , A61B2017/00243 , A61B2017/0647 , A61B2017/0649 , A61B2017/1225
摘要： Devices, tools and methods for occluding fluid flow between two walls of tissue in a patient. Two walls of tissue are compressed together with sufficient compressive force to prevent fluid flow between the two walls, while ensuring that the compressive force is not so great as to cause tissue necrosis. The devices, tools and methods may be carried out using minimally invasive surgical techniques, such as in reduced-access surgical sites. Devices, tools and methods are provided for occluding an atrial appendix.
摘要翻译：用于阻塞患者组织的两个壁之间的流体流动的装置，工具和方法。组织的两个墙壁以足够的压缩力被压缩在一起，以防止两个壁之间的流体流动，同时确保压缩力不会大到导致组织坏死。装置，工具和方法可以使用微创手术技术进行，例如在减少手术部位。提供了用于阻塞心房附件的装置，工具和方法。

13. 发明申请

WO2008013743A3 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A3
公开(公告)日：2008-07-03
申请号：PCT/US2007016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
发明人： MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，该方法包括将导管组件引入血管内腔的阻塞区域并用导管组件重新阻塞阻塞区域。在再通之前或再通过期间，可以通过导管组件将治疗剂递送至受阻区域下游的脉管区域。治疗剂可能具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且利用医疗装置对阻塞区域进行再通。处理剂可被输送至受阻区域下游的容器区域。治疗剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其他方法中，可将输送套管引入闭塞血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤性质的治疗剂可通过输送套管输送至未灌注区域。在递送治疗剂之后，可以通过将血管成形术装置推进到闭塞的血管中来使闭塞的血管再通。

14. 发明申请

WO2008042034A2 APPARATUS AND METHODS FOR PERFORMING MINIMALLY-INVASIVE SURGICAL PROCEDURES 审中-公开
标题翻译：用于执行最小的外科手术的装置和方法
公开(公告)号：WO2008042034A2
公开(公告)日：2008-04-10
申请号：PCT/US2007016811
申请日：2007-07-26
申请人： CARDIOTHORACIC SYS INC , KENDALE AMAR , PEREZ JUAN I , VILLAGOMEZ FRED , BARRIGAR FREDERICK , LAMBERTI JOSEPH N , AGARWAL AMIT , CALLAS PETER , STEWART MICHAEL C , LIN ARTHUR , ABBOTT RYAN , CANTU ALFREDO R
发明人： KENDALE AMAR , PEREZ JUAN I , VILLAGOMEZ FRED , BARRIGAR FREDERICK , LAMBERTI JOSEPH N , AGARWAL AMIT , CALLAS PETER , STEWART MICHAEL C , LIN ARTHUR , ABBOTT RYAN , CANTU ALFREDO R
IPC分类号： A61B18/14 , A61B5/04
CPC分类号： A61B17/32 , A61B1/00096 , A61B1/00101 , A61B1/0125 , A61B1/018 , A61B1/313 , A61B17/3421 , A61B17/3478 , A61B18/18 , A61B2017/00243 , A61B2017/320044 , A61B2017/3445 , A61B2017/3456
摘要： Devices, tools and methods for performing minimally invasive surgical procedures. Methods of performing minimally invasive ablation procedures. Methods of performing rapid exchange of tools in a device while the device remains in a reduced-access surgical space.
摘要翻译：用于执行微创外科手术的装置，工具和方法。执行微创消融手术的方法。在设备保持在缩小的手术空间中时，在设备中执行工具的快速交换的方法。

15. 发明申请

WO2008020975A2 DEVICES AND METHODS FOR ATRIAL APPENDAGE EXCLUSION 审中-公开
标题翻译：器械和方法为心房附件排除
公开(公告)号：WO2008020975A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/016824
申请日：2007-07-26
申请人： CARDIOTHORACIC SYSTEMS, INC. , CHIN, Albert, K. , DAVID, John, W. , SHROFF, Ketan , AGARWAL, Amit , UEMURA, Shuji , CANTU, Alfredo, R. , WILLIS, Geoffrey, H. , CALLAS, Peter , GRESL, Charles
发明人： CHIN, Albert, K. , DAVID, John, W. , SHROFF, Ketan , AGARWAL, Amit , UEMURA, Shuji , CANTU, Alfredo, R. , WILLIS, Geoffrey, H. , CALLAS, Peter , GRESL, Charles
IPC分类号： A61B17/08
CPC分类号： A61B17/122 , A61B17/064 , A61B17/0643 , A61B17/068 , A61B17/1227 , A61B2017/00243 , A61B2017/0647 , A61B2017/0649 , A61B2017/1225
摘要： Devices, tools and methods for occluding fluid flow between two walls of tissue in a patient. Two walls of tissue are compressed together with sufficient compressive force to prevent fluid flow between the two walls, while ensuring that the compressive force is not so great as to cause tissue necrosis. The devices, tools and methods may be carried out using minimally invasive surgical techniques, such as in reduced-access surgical sites. Devices, tools and methods are provided for occluding an atrial appendix.
摘要翻译：
设备，工具和方法用于堵塞病人组织两壁之间的流体流动。两个组织壁被压缩在一起，并具有足够的压缩力以防止两个壁之间的流体流动，同时确保压缩力不会太大以致引起组织坏死。该装置，工具和方法可以使用微创手术技术来执行，例如在手术部位减少的手术中。设备，工具和方法用于阻塞心房附件。

16. 发明申请

WO2006127241A2 ABLATION INSTRUMENTS AND METHODS FOR PERFORMING ABALATION 审中-公开
标题翻译：排除仪器和执行排放的方法
公开(公告)号：WO2006127241A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/017527
申请日：2006-05-05
申请人： CARDIOTHORACIC SYSTEMS, INC. , CHIN, Albert, K. , CALLAS, Peter , UEMURA, Shuji , WILLIS, Geoffrey, H.
发明人： CHIN, Albert, K. , CALLAS, Peter , UEMURA, Shuji , WILLIS, Geoffrey, H.
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B2018/0022 , A61B2018/00351 , A61B2018/00375
摘要： Methods, devices and instruments provided for performing ablation transmurally across the wall of an organ. Devices may directly access tissue to be ablated through direct access openings formed in the patient and, optionally, an organ where the ablation is to be performed. Instruments facilitating making openings, dissecting, and delivery of ablation instruments are also described.
摘要翻译：提供用于跨器官壁穿透消融的方法，装置和仪器。装置可以直接通过形成在患者中的直接进入开口和任选地进行消融的器官进入烧蚀组织。还描述了促进消融器械的开口，解剖和输送的仪器。

17. 发明申请

WO2006104836A3 APPARATUS FOR REGULATING TISSUE WELDER JAWS 审中-公开
公开(公告)号：WO2006104836A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/010569
申请日：2006-03-24
申请人： ORIGIN MEDSYSTEMS, INC. , LAU, Liming , LIN, Arthur , HO, Sam , ABBOTT, Ryan , DANG, Kenny , MCQUISTON, Jesse , CALLAS, Peter , ESCANO, Arnold , STEWART, Michael , JARRARD, Jerry , LAMBERTI, Joseph , WILLIAMS, Justin , YEE, Christopher
发明人： LAU, Liming , LIN, Arthur , HO, Sam , ABBOTT, Ryan , DANG, Kenny , MCQUISTON, Jesse , CALLAS, Peter , ESCANO, Arnold , STEWART, Michael , JARRARD, Jerry , LAMBERTI, Joseph , WILLIAMS, Justin , YEE, Christopher
IPC分类号： A61B18/08 , A61B17/14 , A61B17/28
摘要： A surgical apparatus and methods for severing and welding tissue, in particular blood vessels, including an elongated shaft (36) having a pair of relatively movable jaws (40,42). at a distal end thereof . A first heating element (46) on one of the jaws heats up to a first temperature and form a welded region within the tissue, while a second heating element (48) on one of the jaws heats up to a second temperature and sever the tissue within the welded region. A control handle (38) includes controls for opening and closing the jaws, and may include an actuator for sending current through the first and second heating elements. A force -limiting mechanism (164) provided either within the control handle, in the elongated shaft, or at the jaws limits the pressure applied to the tissue by the jaws to ensure that the tissue is severed and the ends effectively welded within a short amount of time.

18. 发明申请

WO2010138919A2 SYSTEM AND METHOD FOR SYNCHRONIZING ENERGY DELIVERY TO THE CARDIAC RHYTHM 审中-公开
标题翻译：用于同步向CARDIAC RHYTHM提供能量的系统和方法
公开(公告)号：WO2010138919A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036734
申请日：2010-05-28
申请人： ANGIODYNAMICS, INC. , CALLAS, Peter , LOVEWELL, James , STRIBLING, Bradley, C. , WARDEN, Dave
发明人： CALLAS, Peter , LOVEWELL, James , STRIBLING, Bradley, C. , WARDEN, Dave
IPC分类号： A61N1/365 , A61N1/368 , A61B5/04
CPC分类号： A61N1/3706 , A61N1/327 , A61N1/365 , A61N1/3702
摘要： A system for synchronizing application of treatment signals with a cardiac rhythm is provided. The system includes a memory that receives and stores a synchronization signal indicating that a predetermined phase such as R-wave of a cardiac rhythm of a patient has started. A synchronization module analyzes whether the stored synchronization signal is erroneous and if so, prevents a medical treatment device from applying a treatment energy signal such as an IRE pulse to a patient to take into account an irregular heart beat and noise in the synchronization signal in order to maximize safety of the patient.
摘要翻译：提供了一种用于同步处理信号与心律的应用的系统。该系统包括存储器，其接收并存储指示诸如患者的心律的R波之类的预定相位已经开始的同步信号。同步模块分析所存储的同步信号是否是错误的，如果是，则防止医疗设备向患者施加诸如IRE脉冲的治疗能量信号，以按顺序考虑同步信号中的不规则心跳和噪声以最大限度地提高患者的安全性。

19. 发明申请

WO2009061483A1 METHOD FOR TREATING CORONARY VESSELS 审中-公开
标题翻译：治疗冠脉血管的方法
公开(公告)号：WO2009061483A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/012597
申请日：2008-11-06
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , CALLAS, Peter, L. , WILLIS, Eric, J. , EL-NOUNOU, Fozan, O. , LUDWIG, Florian, N. , WEBLER, William, E. , CONSIGNY, Paul, M.
发明人： CALLAS, Peter, L. , WILLIS, Eric, J. , EL-NOUNOU, Fozan, O. , LUDWIG, Florian, N. , WEBLER, William, E. , CONSIGNY, Paul, M.
IPC分类号： A61B17/00 , A61B17/02 , A61B17/32 , A61B19/00 , A61B17/22 , A61M25/00
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri- adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译：提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。根据液压解剖周围空间内的组织平面的条件，处理剂通过输送装置输送。提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，并且包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。

20. 发明申请

WO2008042034A3 APPARATUS AND METHODS FOR PERFORMING MINIMALLY-INVASIVE SURGICAL PROCEDURES 审中-公开
公开(公告)号：WO2008042034A3
公开(公告)日：2008-04-10
申请号：PCT/US2007/016811
申请日：2007-07-26
申请人： CARDIOTHORACIC SYSTEMS, INC. , KENDALE, Amar , PEREZ, Juan, I. , VILLAGOMEZ, Fred , BARRIGAR, Frederick , LAMBERTI, Joseph, N. , AGARWAL, Amit , CALLAS, Peter , STEWART, Michael, C. , LIN, Arthur , ABBOTT, Ryan , CANTU, Alfredo, R.
发明人： KENDALE, Amar , PEREZ, Juan, I. , VILLAGOMEZ, Fred , BARRIGAR, Frederick , LAMBERTI, Joseph, N. , AGARWAL, Amit , CALLAS, Peter , STEWART, Michael, C. , LIN, Arthur , ABBOTT, Ryan , CANTU, Alfredo, R.
IPC分类号： A61B18/04 , A61B1/00 , A61B1/12
摘要： Devices, tools and methods for performing minimally invasive surgical procedures. Methods of performing minimally invasive ablation procedures. Methods of performing rapid exchange of tools in a device while the device remains in a reduced-access surgical space.

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