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11. 发明授权

US5712086A Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions 失效
$Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions$
标题翻译：用于辐射灭菌的含细胞的级分和I型和II型光动力学反应的猝灭剂的方法
公开(公告)号：US5712086A
公开(公告)日：1998-01-27
申请号：US486668
申请日：1995-06-07
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A61K41/00 , A61L2/00 , C12N7/06 , A01N1/02 , A61M37/00 , C12N13/00
CPC分类号： C12N7/00 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0066 , A61L2/0011 , C12N2760/10163 , C12N2760/20263
摘要： A process is presented for transfusing cells which have been sterilized with radiation and a quencher of type I and type II photodynamic reactions. The cells are removed from a donor and exposed to virucidally effective amount of radiation in the presence of a quencher of type I and type II reactions, or a mixture of a quencher for type I reactions and a quencher of type II reactions. Subsequently, the sterilized cell containing fraction is returned to the donor.
摘要翻译：提出了一种用于输入已经用辐射灭菌的细胞和I型和II型光动力学反应的猝灭剂的方法。在I型和II型反应的猝灭剂或I型反应的猝灭剂和II型反应的猝灭剂的混合物存在下，从供体中除去细胞并暴露于病毒有效量的辐射。随后，将灭菌的含细胞的级分返回给供体。

12. 发明授权

US5348939A Fibronectin-containing ophthalmic solution, method of preserving an ophthalmic solution, and method of treatment of ophthalmic wounds 失效
标题翻译：含有纤连蛋白的眼用溶液，眼用溶液的保存方法以及眼科伤口的治疗方法
公开(公告)号：US5348939A
公开(公告)日：1994-09-20
申请号：US60224
申请日：1993-05-11
申请人： Bernard Horowitz , Richard W. Shulman , Adrianne J. Setton , Toyohiko Nishimura , Yoichi Kawashima
发明人： Bernard Horowitz , Richard W. Shulman , Adrianne J. Setton , Toyohiko Nishimura , Yoichi Kawashima
IPC分类号： A61K9/08 , A61K9/00 , A61K38/16 , A61K38/17 , A61K38/39 , A61K47/14 , A61K47/18 , A61K47/36 , A61P27/02 , A61K37/10
CPC分类号： A61K38/39 , A61K9/0048 , Y10S514/912
摘要： A stable and soluble multi-dose ophthalmic solution is disclosed. The solution contains fibronectin, an amino acid, a sugar, and a lower alkyl p-hydroxybenzoate. A method of treatment of ophthalmic wounds employing the ophthalmic solution, a process for preparing fibronectin for ophthalmic use, a method of lyophilizing an aqueous solution of fibronectin free of albumin, a method for inhibiting bacterial growth in an ophthalmic solution while preserving the cellular adhesion and wound healing activities of fibronectin, and a method of treatment of ophthalmic wounds administering a wound-healing accelerator solution are also disclosed.
摘要翻译：公开了一种稳定且可溶的多剂量眼用溶液。该溶液含有纤连蛋白，氨基酸，糖和对羟基苯甲酸的低级烷基酯。一种使用眼用溶液治疗眼部伤口的方法，制备用于眼科用途的纤维连接蛋白的方法，冻干不含白蛋白的纤连蛋白水溶液的方法，在保留细胞粘附的同时抑制眼用溶液中的细菌生长的方法，还公开了纤连蛋白的伤口愈合活性，以及施用伤口愈合促进剂溶液的眼科伤口的治疗方法。

13. 发明授权

US5055485A Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides 失效
标题翻译：使用芳基二醇环氧化物灭活含有细胞和蛋白质的组合物中的病毒
公开(公告)号：US5055485A
公开(公告)日：1991-10-08
申请号：US279179
申请日：1988-12-02
申请人： Nicholas E. Geacintov , Jay E. Valinsky , Bolanle Williams , Bernard Horowitz
发明人： Nicholas E. Geacintov , Jay E. Valinsky , Bolanle Williams , Bernard Horowitz
IPC分类号： A61K31/335
CPC分类号： A61K31/335
摘要： A process of inactivating infectious viruses in a cell-containing or a protein-containing composition containing such viruses, comprising contacting such composition with an effective amount of at least one aryl diol epoxide of the formula ##STR1## in which X is an aromatic ring system having from 3 to 6 used rings,for a sufficient period of time substantially to inactivate said viruses without incurring substantial disruption or inactivation of cells or without incurring substantial protein denaturation.
摘要翻译：包含含有这种病毒的含细胞或含蛋白质的组合物中的感染性病毒失活的方法，包括使所述组合物与有效量的至少一种式“IMAGE”的芳基二醇环氧化物接触，其中X是芳族环系统具有3至6个使用的环，足够的时间基本上使所述病毒灭活而不引起细胞的显着破坏或灭活或不引起实质的蛋白质变性。

14. 发明授权

US06413714B1 Process for the sterilization of biological compositions and the product produced thereby 失效
标题翻译：用于生物组合物的灭菌和由此产生的产品的方法
公开(公告)号：US06413714B1
公开(公告)日：2002-07-02
申请号：US09580250
申请日：2000-05-26
申请人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
发明人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
IPC分类号： A01N102
CPC分类号： A61K41/0019 , A61K41/0066 , A61L2/0011 , A61L2/10 , C12N7/00 , C12N7/06 , C12N2760/20263
摘要： The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucidally effective amount of UVA1 irradiation substantially in the absence of UVA2 irradiation for a period of time sufficient to thereby inactivate said virus while retaining functionality of said composition. The biological composition is advantageously a product that contains red blood cells or platelets. The process is advantageously carried out in the presence of an irradiation sensitizer compound and/or a quencher. The present invention also concerns the product substantially identical to that produced by the inventive process.
摘要翻译：本发明涉及使生物组合物中的细胞外和细胞内病毒灭活而不引起实质性破坏或失活的方法，所述方法包括使所述组合物基本上在不存在UVA2照射的情况下对所述组合物进行病毒有效量的UVA1照射一段时间足以使所述病毒灭活同时保留所述组合物的功能。生物组合物有利地是含有红细胞或血小板的产品。该方法有利地在辐照敏化剂化合物和/或猝灭剂的存在下进行。本发明还涉及与本发明方法产生的产品基本相同的产品。

15. 发明授权

US06214534B1 Biological compositions containing quenchers of type I and type II photodynamic reactions 失效
标题翻译：含有I型和II型光动力学反应猝灭剂的生物组合物
公开(公告)号：US06214534B1
公开(公告)日：2001-04-10
申请号：US08653218
申请日：1996-05-24
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A01N102
CPC分类号： A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0066 , A61K41/0071 , A61L2/0011 , C12N7/00 , C12N2760/10163 , C12N2760/20263
摘要： The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
摘要翻译：本发明涉及通过在生物组合物中灭活细胞外或细胞内病原体病毒而产生的产物，而不会导致细胞的实质性破坏或灭活，并且没有不稳定的蛋白质或其中还含有的其它有价值的生物成分的显着损失，所述灭活过程包括将所述组合物在（a）猝灭I型光动力学反应的化合物和猝灭II型光动力学反应的化合物的混合物存在下的杀病毒有效量的照射或（b）能够淬灭I型和类型的双官能化合物 II反应，从而使所述病毒灭活同时保留所述组合物的功能。组合物有利地在照射敏化剂的存在下进行照射和化合物或双官能化合物的混合物。此外，该方法可以有利地与不同的杀病毒方法组合以增强病毒灭活。

16. 发明授权

US5637451A Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells 失效
标题翻译：以更高的光通量对酞菁红和红光进行光动力治疗红细胞是保护红细胞的
公开(公告)号：US5637451A
公开(公告)日：1997-06-10
申请号：US413054
申请日：1995-03-29
申请人： Ehud Ben-Hur , Bernard Horowitz
发明人： Ehud Ben-Hur , Bernard Horowitz
IPC分类号： A61K41/00 , A61L2/00 , A01N1/02 , A01N63/00 , C12N7/06
CPC分类号： A61L2/0011 , A61K41/0071
摘要： An improved process for inactivating an extracellular lipid enveloped virus or an intracellular lipid enveloped virus which may be present in an extracorporeal composition containing red blood cells by subjecting the composition to a virucidally effective amount of a phthalocyanine compound and red light of a fluence rate of at least above about 5 mW/cm.sup.2. Quite contrary to what would have been expected, it has been found that higher light fluence rates are, in fact, more protective of red blood cells than are lower light fluence rates.
摘要翻译：一种用于灭活细胞外脂质包膜病毒或细胞内脂质包膜病毒的改进方法，所述方法可以通过使组合物经受病毒有效量的酞菁化合物和通量密度为红细胞的红光来存在于含有红细胞的体外组合物中至少高于约5mW / cm 2。与预期的相反，已经发现，更高的光通量实际上比较低的光通量率更加保护红细胞。

17. 发明授权

US4540573A Undenatured virus-free biologically active protein derivatives 失效
公开(公告)号：US4540573A
公开(公告)日：1985-09-10
申请号：US514375
申请日：1983-07-14
申请人： Alexander R. Neurath , Bernard Horowitz
发明人： Alexander R. Neurath , Bernard Horowitz
IPC分类号： A61K39/395 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , A61K38/21 , A61K38/43 , A61L2/00 , A61K39/00 , A61K37/00 , C07G7/00 , C07C103/52
CPC分类号： A61L2/0023 , A61L2/0088 , Y10S530/829 , Y10S530/83 , Y10S530/831
摘要： A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.

18. 发明授权

US06548242B2 Process for the sterilization of biological compositions and the product thereby 失效
标题翻译：在生物组合物中灭活病毒的方法
公开(公告)号：US06548242B2
公开(公告)日：2003-04-15
申请号：US09758010
申请日：2001-01-10
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A01N102
CPC分类号： C12N7/00 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61L2/0011 , C12N2740/16063 , C12N2760/20263
摘要： The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
摘要翻译：本发明涉及通过在生物组合物中灭活细胞外或细胞内病原体病毒而产生的产物，而不会导致细胞的实质性破坏或灭活，并且没有不稳定的蛋白质或其中还含有的其它有价值的生物成分的显着损失，所述灭活过程包括将所述组合物在（a）猝灭I型光动力学反应的化合物和猝灭II型光动力学反应的化合物的混合物存在下的杀病毒有效量的照射或（b）能够淬灭I型和类型的双官能化合物 II反应，从而使所述病毒灭活同时保留所述组合物的功能。组合物有利地在照射敏化剂的存在下进行照射和化合物或双官能化合物的混合物。此外，该方法可以有利地与不同的杀病毒方法组合以增强病毒灭活。

19. 发明授权

US6087141A Process for the sterilization of biological compositions and the product produced thereby 有权
标题翻译：用于生物组合物的灭菌和由此产生的产品的方法
公开(公告)号：US6087141A
公开(公告)日：2000-07-11
申请号：US128749
申请日：1998-08-04
申请人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
发明人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
IPC分类号： A61K41/00 , A61L2/00 , C12N7/06 , C12N13/00 , C12N7/04 , A01N63/00
CPC分类号： A61K41/0019 , A61K41/0066 , A61L2/0011 , C12N7/00 , C12N2760/20263
摘要： The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucidally effective amount of UVA1 irradiation substantially in the absence of UVA2 irradition for a period of time sufficient to thereby inactivate said virus while retaining functionality of said composition. The biological composition is advantageously a product that contains red blood cells or platelets. The process is advantageously carried out in the presence of an irradiation sensitizer compound and/or a quencher. The present invention also concerns the product substantially identical to that produced bythe inventive process.
摘要翻译：本发明涉及使生物组合物中的细胞外和细胞内病毒灭活而不引起其实质性破坏或失活的方法，所述方法包括使所述组合物在基本上不存在UVA2辐照条件下对所述组合物进行病毒有效量的UVA1照射一段时间足以使所述病毒灭活同时保留所述组合物的功能。生物组合物有利地是含有红细胞或血小板的产品。该方法有利地在辐照敏化剂化合物和/或猝灭剂的存在下进行。本发明还涉及与本发明方法产生的产品基本相同的产品。

20. 发明授权

US5981163A Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions 失效
标题翻译：使用I型和II型光动力学反应的辐射和猝灭剂灭菌生物组合物的方法
公开(公告)号：US5981163A
公开(公告)日：1999-11-09
申请号：US364031
申请日：1994-12-23
申请人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
发明人： Bernard Horowitz , Bolanle Williams , Henrietta Margolis-Nunno , Sing N. Chin
IPC分类号： A61K41/00 , A61L2/00 , C12N7/06 , C12Q1/00 , C12N13/00
CPC分类号： A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0066 , A61K41/0071 , A61L2/0011 , C12N7/00 , C12N2760/10163 , C12N2760/20263
摘要： The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
摘要翻译：本发明涉及通过在生物组合物中灭活细胞外或细胞内病原体病毒而产生的产物，而不会导致细胞的实质性破坏或灭活，并且没有不稳定的蛋白质或其中还含有的其它有价值的生物成分的显着损失，所述灭活过程包括将所述组合物在（a）猝灭I型光动力学反应的化合物和猝灭II型光动力学反应的化合物的混合物存在下的杀病毒有效量的照射或（b）能够淬灭I型和类型的双官能化合物 II反应，从而使所述病毒灭活同时保留所述组合物的功能。组合物有利地在照射敏化剂的存在下进行照射和化合物或双官能化合物的混合物。此外，该方法可以有利地与不同的杀病毒方法组合以增强病毒灭活。

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