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11. 发明申请

WO9903823A3 NOVEL POLYAMINE ANALOGUES AS THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：新型多胺类似物作为治疗剂和诊断剂
公开(公告)号：WO9903823A3
公开(公告)日：1999-04-08
申请号：PCT/US9814896
申请日：1998-07-15
申请人： ORIDIGM CORP , VERMEULIN NICOLAAS M J , O DAY CHRISTINE L , WEBB HEATHER K , BURNS MARK R , BERGSTROM DONALD E
发明人： VERMEULIN NICOLAAS M J , O'DAY CHRISTINE L , WEBB HEATHER K , BURNS MARK R , BERGSTROM DONALD E
IPC分类号： C07D333/34 , A61K31/16 , A61K31/17 , A61K31/18 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4433 , A61K31/496 , A61K31/506 , A61K47/48 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/50 , C07C237/10 , C07C237/20 , C07C237/22 , C07C271/20 , C07C271/22 , C07C275/28 , C07C303/00 , C07C311/07 , C07C311/10 , C07C311/18 , C07C311/29 , C07C311/41 , C07C323/60 , C07D207/16 , C07D209/20 , C07D213/82 , C07D215/36 , C07D215/52 , C07D219/04 , C07D231/14 , C07D261/18 , C07D285/14 , C07D307/68 , C07D307/91 , C07D333/40 , C07D409/04 , C07D417/04 , G01N33/53 , C07C311/05 , C07C311/06 , C07C311/19 , C07C311/42 , C07D209/26 , C07D235/28 , C07D333/24 , C07D333/38 , C07D409/12
CPC分类号： C07C233/36 , A61K47/50 , C07C233/40 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/50 , C07C237/10 , C07C237/20 , C07C237/22 , C07C271/20 , C07C271/22 , G01N33/5308
摘要： Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.
摘要翻译：公开了具有比已知化合物低两个数量级的抑制常数的新型多胺转运抑制剂。这些多胺类似物是用于治疗期望抑制多胺转运或其他多胺结合蛋白例如癌症和血管成形术后损伤的疾病的有用药剂。公开了获得多胺类似物的新型化学合成方法，包括产生组合多胺文库。这些方法产生具有理想活性的类似物，用于诊断和研究测定和治疗。本发明的测定法可用于发现与多胺系统相互作用的药物的高通量筛选目标。

12. 发明申请

WO2008070058A2 METHOD AND APPARATUS FOR DETECTION OF MOLECULES USING SENSOR ARRAY 审中-公开
标题翻译：用于使用传感器阵列检测分子的方法和装置
公开(公告)号：WO2008070058A2
公开(公告)日：2008-06-12
申请号：PCT/US2007024804
申请日：2007-12-04
申请人： PURDUE RESEARCH FOUNDATION , BASHIR RASHID , ELIBOL OGUZ , NAIR PRADEEP RAMACHANDRAN , BERGSTROM DONALD , ALAM ASHRAF , REDDY BOBBY
发明人： BASHIR RASHID , ELIBOL OGUZ , NAIR PRADEEP RAMACHANDRAN , BERGSTROM DONALD , ALAM ASHRAF , REDDY BOBBY
IPC分类号： C12M1/34
CPC分类号： G01N27/127
摘要： Apparatus and methods for detecting molecules in a fluidic environment are provided, including nanodevices (10, 17, 51, 91, 156, 182, 190, 203, 240, 260) and methods for fabricating, functionalizing, and operating such nanodevices. At least one of the methods includes selective heating of nanodevices in an array.
摘要翻译：提供了用于在流体环境中检测分子的装置和方法，包括纳米器件（10,17,51,91,156,182,190,2203,240,260）以及用于制造，功能化和操作这些纳米器件的方法。至少一种方法包括选择性加热阵列中的纳米器件。

13. 发明申请

WO2007100446A3 EMBOSSED TAPE COLLATING STRIP FOR NAILS 审中-公开
标题翻译：用于钉子的胶合带收缩条
公开(公告)号：WO2007100446A3
公开(公告)日：2007-12-13
申请号：PCT/US2007003009
申请日：2007-02-05
申请人： ILLINOIS TOOL WORKS , BERGSTROM DONALD E , LAT GERONIMO E , SHELTON LAWRENCE S , MALPASS THOMAS H , SCHNIEDERMEIER HENRY W
发明人： BERGSTROM DONALD E , LAT GERONIMO E , SHELTON LAWRENCE S , MALPASS THOMAS H , SCHNIEDERMEIER HENRY W
IPC分类号： F16B15/08
CPC分类号： F16B15/08
摘要： A fastener assembly for use in a fastener driving tool includes a row of fasteners (16) arranged substantially parallel to each other and a strip (10) having a supporting substrate and an adhesive (22) composition thereon. The supporting substrate has an elongated dimension extending generally in the direction of the row of fasteners. The substrate has embossings (24) formed therein. The adhesive composition is bonded to the fasteners and maintains them in the substantially parallel arrangement in the row. A method for making the embossed strip is also disclosed.
摘要翻译：用于紧固件驱动工具的紧固件组件包括一排基本上彼此平行地布置的紧固件（16）和具有支撑衬底和其上的粘合剂（22）组合物的条带（10）。支撑衬底具有大致沿着紧固件排的方向延伸的细长尺寸。基板上形成有压花（24）。粘合剂组合物结合到紧固件上并将它们保持在行中基本平行的布置。还公开了一种用于制造压花条的方法。

14. 发明申请

WO2007100446A2 EMBOSSED TAPE COLLATING STRIP FOR NAILS 审中-公开
标题翻译：用于钉子的胶合带收缩条
公开(公告)号：WO2007100446A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/003009
申请日：2007-02-05
申请人： ILLINOIS TOOL WORKS INC. , BERGSTROM, Donald, E. , LAT, Geronimo, E. , SHELTON, Lawrence, S. , MALPASS, Thomas, H. , SCHNIEDERMEIER, Henry, W.
发明人： BERGSTROM, Donald, E. , LAT, Geronimo, E. , SHELTON, Lawrence, S. , MALPASS, Thomas, H. , SCHNIEDERMEIER, Henry, W.
CPC分类号： F16B15/08
摘要： A fastener assembly for use in a fastener driving tool includes a row of fasteners arranged substantially parallel to each other and a strip having a supporting substrate and an adhesive composition thereon. The supporting substrate has an elongated dimension extending generally in the direction of the row of fasteners. The substrate has embossings formed therein. The adhesive composition is bonded to the fasteners and maintains them in the substantially parallel arrangement in the row. A method for making the embossed strip is also disclosed.
摘要翻译：用于紧固件驱动工具的紧固件组件包括一排基本上彼此平行布置的紧固件，以及具有支撑基底和其上的粘合剂组合物的条。支撑衬底具有大致沿着紧固件排的方向延伸的细长尺寸。基板上形成有压花。粘合剂组合物结合到紧固件上并将它们保持在行中基本平行的布置。还公开了一种用于制造压花条的方法。

15. 发明申请

WO1994006810A1 OLIGONUCLEOTIDES HAVING UNIVERSAL NUCLEOSIDE SPACERS 审中-公开
标题翻译：具有通用核苷酸间隔物的寡核苷酸
公开(公告)号：WO1994006810A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008391
申请日：1993-09-07
申请人： BERGSTROM, Donald, Eugene , ANDREWS, Philip, Charles , NICHOLS, Ruthann , ZHANG, Peiming
IPC分类号： C07H05/04
CPC分类号： C07H21/00 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Oligonucleotides are made having at least ten nucleosides, at least two of which are A, T, G or C and at least one is a universal nucleoside.
摘要翻译：制备具有至少10个核苷的寡核苷酸，其中至少2个是A，T，G或C，并且至少一个是通用核苷。

16. 发明申请

WO2012024526A3 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS 审中-公开
标题翻译：结合物，颗粒，成分及相关方法
公开(公告)号：WO2012024526A3
公开(公告)日：2012-07-05
申请号：PCT/US2011048305
申请日：2011-08-18
申请人： CERULEAN PHARMA INC , ELIASOF SCOTT , FETZER OLIVER S , HWANG JUNGYEON , LIM SOO PATRICK , NG PEI-SZE , SVENSON SONKE , BERGSTROM DONALD E
发明人： ELIASOF SCOTT , FETZER OLIVER S , HWANG JUNGYEON , LIM SOO PATRICK , NG PEI-SZE , SVENSON SONKE , BERGSTROM DONALD E
IPC分类号： C12N15/11 , A61K9/16 , A61K9/50 , A61K48/00
CPC分类号： A61K47/482 , A61K9/14 , A61K31/713 , A61K47/593 , A61K47/60 , A61K47/6921 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32 , Y10T428/2982
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
摘要翻译：用于递送核酸试剂的颗粒和共轭物。含有颗粒，共轭物或两者的组合物。使用颗粒，共轭物和组合物的方法。

17. 发明申请

WO2011041180A1 FASTENER AND METHOD OF PROLONGING USE OF A DRIVER BLADE IN A FASTENING TOOL 审中-公开
标题翻译：紧固件和方法在驱动工具中使用驱动刀片
公开(公告)号：WO2011041180A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049776
申请日：2010-09-22
申请人： ILLINOIS TOOL WORKS INC. , GABRIEL, William L. , HORST, Christopher A. , BERGSTROM, Donald E.
发明人： GABRIEL, William L. , HORST, Christopher A. , BERGSTROM, Donald E.
IPC分类号： F16B33/06 , F16B1/00 , F16B15/06
CPC分类号： F16B33/06 , F16B15/06 , F16B2001/0021
摘要： A fastener (210) and a method for reducing wear on a driver blade in a fastening tool includes applying a layer of solid-based lubricant (216) between the head of a fastener and a driver blade end. The fastener is for use in a fastening tool and includes a head (214), a shank (212), and a Iayer of lubricant (216) on the head (214) of the fastener. The lubricant is graphite, molybdenum disulfide, tungsten disulfide, boron nitride, polytetrafluoroethylene (PTFE), nano-diamonds, calcium stearate, sodium stearate, oils, greases, waxes, thermoplastic polymers, or another lubricant that exhibits similar characteristics, Aromatic polyamides (such as Kevlar TM ), ultra-high molecular weight polyethylene, powdered glass, glass fibers, thermoplastic polymers, and thermoset polymers also are contemplate to provide a barrier to contact between the driver blade and fastener head. The lubricant is sprayed, rolled, brushed, blotted or otherwise applied between the head of the fastener and the driver blade end prior to firing the fastening tool.
摘要翻译：紧固件（210）和用于减少紧固工具中的驱动器叶片上的磨损的方法包括在紧固件的头部和驱动器叶片端部之间施加一层固体基润滑剂（216）。紧固件用于紧固工具，并且在紧固件的头部（214）上包括头部（214），柄部（212）和润滑剂层（216）。润滑剂是石墨，二硫化钼，二硫化钨，氮化硼，聚四氟乙烯（PTFE），纳米金刚石，硬脂酸钙，硬脂酸钠，油，油脂，蜡，热塑性聚合物或具有相似特性的其它润滑剂。芳族聚酰胺作为KevlarTM），超高分子量聚乙烯，粉末状玻璃，玻璃纤维，热塑性聚合物和热固性聚合物也被设想为驱动刀片和紧固件头之间的接触提供屏障。在点燃紧固工具之前，润滑剂被喷涂，滚动，拉丝，印迹或以其他方式施加在紧固件的头部和驱动器刀片端部之间。

18. 发明申请

WO2009126678A3 DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING FLUORESCENCE RESONANCE ENERGY TRANSFER 审中-公开
标题翻译：使用荧光共振能量转移检测目标核酸序列
公开(公告)号：WO2009126678A3
公开(公告)日：2009-12-30
申请号：PCT/US2009039855
申请日：2009-04-08
申请人： UNIV CORNELL , PURDUE RESEARCH FOUNDATION , BARANY FRANCIS , PINGLE MANEESH , BERGSTROM DONALD
发明人： BARANY FRANCIS , PINGLE MANEESH , BERGSTROM DONALD
IPC分类号： C40B20/04 , C40B30/04
CPC分类号： C12Q1/6827 , Y10T436/143333 , C12Q2561/125 , C12Q2527/107 , C12Q2525/301
摘要： A method for identifying a plurality of target nucleic acid molecules in a sample. The method provides a plurality of oligonucleotide probe sets. Each set comprises a first and a second probe, each having a target-specific portion and a tunable portion with an acceptor or a donor group. The first probe further comprises an endcapped hairpin. A reaction comprises a denaturation and hybridization cycle. Under the hybridization, the set of probes hybridize in a base-specific manner to their respective target nucleotide sequences, and ligate to one another to form a ligation product. Under conditions that permit hybridization of the tunable portions of the ligation product to one another, an internally hybridized ligation product formed, which allows the detection of the fluorescence resonance energy transfer (FRET). A method comprising PCR amplification is also disclosed.
摘要翻译：用于鉴定样品中多个靶核酸分子的方法。该方法提供多个寡核苷酸探针组。每组包括第一和第二探针，每个具有目标特异性部分和具有受体或供体基团的可调部分。第一探针还包含封端的发夹。反应包括变性和杂交循环。在杂交下，探针组以碱基特异性方式与其各自的靶核苷酸序列杂交，并且彼此连接以形成连接产物。在允许连接产物的可调部分彼此杂交的条件下，形成内部杂交的连接产物，其允许检测荧光共振能量转移（FRET）。还公开了包括PCR扩增的方法。

19. 发明申请

WO2009126678A2 DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING FLUORESCENCE RESONANCE ENERGY TRANSFER 审中-公开
标题翻译：使用荧光共振能量转移检测目标核酸序列
公开(公告)号：WO2009126678A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/039855
申请日：2009-04-08
申请人： CORNELL UNIVERSITY , PURDUE RESEARCH FOUNDATION , BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald
发明人： BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , Y10T436/143333 , C12Q2561/125 , C12Q2527/107 , C12Q2525/301
摘要： The present invention is directed to a method for identifying one or more of a plurality of target nucleic acid molecules in a sample. This method includes providing a sample potentially containing one or more target nucleic acid molecules and a plurality of oligonucleotide probe sets. Each probe set is characterized by (a) a first oligonucleotide probe, having a target-specific portion and a tunable portion with an endcapped hairpin and (b) a second oligonucleotide probe having a target specific portion and a tunable portion. One of the first and second oligonucleotide probe has an acceptor group and the other of the first and second probe has a donor group. A ligase is provided and blended with the sample and the plurality of oligonucleotide probe sets to form a ligase detection reaction mixture. The mixture is subjected to one or more ligase detection reaction cycles with each cycle comprising a denaturation and hybridization treatment. During the denaturation treatment any hybridized oligonucleotides are separated from the target nucleic acid sequences, and, during the hybridization treatment, the set of oligonucleotide probes hybridize in a base-specific manner to their respective target nucleotide sequences, if present in the sample, and ligate to one another to form a ligation product. The ligation product contains the tunable portions, the endcapped hairpin, the target-specific portions, the acceptor group, and the donor group. The ligation products are subjected to conditions effective to permit hybridization of the tunable portions of the ligation product to one another to form an internally hybridized ligation product. The fluorescence resonance energy transfer (FRET) between the donor and acceptor groups of the internally hybridized ligation product is detected, thereby indicating the presence of a target nucleic acid molecule in the sample. An alternative embodiment of the present invention involves the use of an initial PCR amplification procedure with primers provided with universal tails. Finally, FRET detection can be carried out through the use of the above-described oligonucleotide probes without any ligation.
摘要翻译：本发明涉及用于鉴定样品中多个靶核酸分子中的一种或多种的方法。该方法包括提供潜在地含有一个或多个靶核酸分子和多个寡核苷酸探针组的样品。每个探针组的特征在于：（a）具有靶特异性部分的第一寡核苷酸探针和具有封端发夹的可调部分，和（b）具有目标特异部分和可调部分的第二寡核苷酸探针。第一和第二寡核苷酸探针之一具有受体基团，第一和第二探针中的另一个具有供体基团。提供连接酶并与样品和多个寡核苷酸探针组混合以形成连接酶检测反应混合物。将混合物进行一个或多个连接酶检测反应循环，每个循环包含变性和杂交处理。在变性处理期间，将任何杂交的寡核苷酸与靶核酸序列分离，并且在杂交处理期间，寡核苷酸探针组如果存在于样品中，则以碱基特异性方式与其各自的靶核苷酸序列杂交，并连接彼此形成连接产物。连接产物包含可调部分，封端的发夹，靶特异性部分，受体基团和供体基团。连接产物经受有效的条件，允许连接产物的可调部分彼此杂交以形成内部杂交的连接产物。检测内部杂交连接产物的供体和受体组之间的荧光共振能量转移（FRET），从而表明样品中存在靶核酸分子。本发明的替代实施方案涉及使用具有通用尾部的引物的初始PCR扩增程序。最后，可以通过使用上述寡核苷酸探针而不进行任何连接来进行FRET检测。

20. 发明申请

WO2015057847A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS 审中-公开
标题翻译：结合物，颗粒，成分及相关方法
公开(公告)号：WO2015057847A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/060708
申请日：2014-10-15
申请人： CERULEAN PHARMA INC. , BERGSTROM, Donald , NG, Pei-Sze , SVENSON, Sonke
发明人： BERGSTROM, Donald , NG, Pei-Sze , SVENSON, Sonke , ELIASOF, Scott , FETZER, Oliver, S. , HWANG, Jungyeon , SOO, Patrick, Lim
IPC分类号： A61K9/14 , A61K31/713 , A61K48/00 , C12N15/113
CPC分类号： A61K9/146 , A61K9/5153 , A61K47/543 , A61K47/59 , A61K47/593 , A61K47/645 , A61K47/6935 , A61K47/6937 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
摘要翻译：用于递送核酸试剂的颗粒和共轭物。含有颗粒，共轭物或两者的组合物。使用颗粒，共轭物和组合物的方法。

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