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    • 12. 发明申请
    • A FLUID TRANSFER DEVICE AND AN ACTIVE SUBSTANCE CARTRIDGE FOR THE FLUID TRANSFER DEVICE, AND A METHOD FOR CONTROLLING THE PRESSURE AT WHICH AN ACTIVE SUBSTANCE IS DELIVERED TO A SUBJECT FROM A FLUID TRANSFER DEVICE
    • 流体传输装置和用于流体传输装置的活性物质盒,以及用于控制活性物质被输送到流体传输装置的主体的压力的方法
    • WO2010070628A1
    • 2010-06-24
    • PCT/IE2009/000092
    • 2009-12-21
    • JANISYS LIMITEDO'DEA, JohnBAMBURY, Eoin
    • O'DEA, JohnBAMBURY, Eoin
    • A61M37/00
    • A61M37/0015A61M5/282A61M5/425A61M2005/14252A61M2037/0023A61M2037/003A61M2037/0061
    • A micro-needle device comprising an active substance layer (3) having a plurality of active substance chambers (4) formed therein, a drive substance layer (9) having a plurality of drive substance chambers (10) formed therein and a needle support layer (5) having a plurality of micro-needles (6) extending therefrom. An activation layer (12) comprising a plurality of heating elements (14) for heating an expandable drive substance (11) located in the drive substance chambers (10) for in turn urging the second membrane (16) into the active substance chamber (4) for pressurising and urging an active substance (2) therefrom through the corresponding micro-needle (6). A plurality of membrane accommodating recesses (25) extend into the needle support layer (5) for accommodating the first membrane (15) as the active substance in the corresponding active substance chamber (10) is pressurised. A puncturing member (33) with a piercing point (35) extends into each membrane accommodating recess (25). A barrier grating (41) extends across each active substance chamber (4) for preventing contact between the second membrane (16) and the corresponding puncturing member (33).
    • 一种微针装置,包括具有形成在其中的多个活性物质室(4)的活性物质层(3),形成有多个驱动物质室(10)的驱动物质层(9)和针支撑层 (5)具有从其延伸的多个微针(6)。 一种激活层(12),包括多个用于加热位于所述驱动物质室(10)中的可膨胀驱动物质(11)的加热元件(14),从而将所述第二隔膜(16)推进所述活性物质室(4) ),用于通过相应的微针(6)加压和推压活性物质(2)。 随着相应的活性物质室(10)中的活性物质被加压,多个膜容纳凹部(25)延伸到针支撑层(5)中,用于容纳第一膜(15)。 具有穿刺点(35)的穿刺构件(33)延伸到每个膜容纳凹部(25)中。 屏障光栅(41)延伸穿过每个活性物质室(4),以防止第二膜(16)和相应的穿刺构件(33)之间的接触。
    • 13. 发明申请
    • A SYSTEM AND A METHOD FOR INFLATING AN INFLATABLE ELEMENT WITH A LIQUID INFLATING MEDIUM AND A BALLOON CATHETER INFLATED BY THE SYSTEM AND METHOD
    • 一种用液体渗透介质和由系统和方法进行膨胀的气泡导管来吹送可充气元件的系统和方法
    • WO2009125380A1
    • 2009-10-15
    • PCT/IE2009/000014
    • 2009-04-09
    • FLIP TECHNOLOGIES LIMITEDO'DEA, JohnBAMBURY, Eoin
    • O'DEA, JohnBAMBURY, Eoin
    • A61B5/107A61M25/10
    • A61B5/1076A61M25/10182A61M25/10186A61M25/10187A61M2025/1022A61M2025/1077A61M2205/3337
    • A system for inflating a balloon (8) of a balloon catheter (4) with a liquid inflating medium which removes air during inflation of the balloon (8) comprises a vertically mounted syringe (36) containing the liquid inflating medium for inflating the balloon (8). Air in the system is displaced into a return lumen (30) and a return line (46). Air drawn into the syringe (36) with the liquid inflating medium is trapped between a piston (39) of the syringe and a top surface of the liquid inflating medium in the syringe, and thereby separated from the liquid inflating medium. Re-inflating and deflating of the balloon continues until the level of air in the balloon, the flow and return lumens and the flow and return lines (44,45) has been reduced to a predefined level. Then, an accurate determination of the inflation pressure can be read from first and second pressure sensors (50,51; 52,53) on the return and flow lines, respectively. The balloon catheter may be used to determine the volume and transverse cross-sectional area of a lumen or vessel within which the balloon is inflated.
    • 用于在气囊(8)充气期间用液体充气介质充气气球导管(4)的气囊(8)的系统包括垂直安装的注射器(36),其包含用于使气囊膨胀的液体膨胀介质 8)。 系统中的空气移动到返回管腔(30)和返回管线(46)中。 用液体膨胀介质吸入注射器(36)的空气被捕获在注射器的活塞(39)和注射器中液体膨胀介质的顶表面之间,从而与液体膨胀介质分离。 球囊的再充气和放气继续进行,直到球囊中的空气,流量和回流腔以及流动和返回管线(44,45)的水平已经减小到预定水平。 然后,可以分别从返回管线和流动管线上的第一和第二压力传感器(50,51; 52,53)读取充气压力的精确确定。 球囊导管可用于确定气囊膨胀的管腔或血管的体积和横截面积。
    • 14. 发明申请
    • A CATHETER AND A METHOD FOR PRODUCING A CATHETER
    • 一种导管和一种制造导管的方法
    • WO2009001327A3
    • 2008-12-31
    • PCT/IE2008/000069
    • 2008-06-27
    • FLIP TECHNOLOGIES LIMITEDO'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • O'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • A61M25/16A61M25/00A61B5/042A61B5/00
    • A method for producing a catheter (100) having a plurality of axially spaced apart electrodes (5) towards a distal end (4) of the catheter (100) comprises forming the electrodes (5) from a single sheet (110) of electrically conductive foil material by forming spaced apart slots (111) in the sheet material to define a plurality of spaced apart electrically conductive elements (114) extending transversely between spaced apart elongated connecting portion (112,113). The electrically conductive elements (114) subsequently form the electrodes (5), and are retained spaced apart by the connecting portions (112,113) until bonded to the catheter (100). Electrically conductive wires (10) electrically coupled to the electrically conductive elements (114) extend through an elongated slot (105) into and along an axial communicating bore (9) to a proximal end (3) of the catheter (100). Two pieces of double-sided adhesive tape (118) bonded to the electrically conductive elements (114) in turn bond the electrically conductive elements (114) to the catheter (100). After entering the wires (10) into the axial communicating bore (9) the electrically conductive elements (114) with the double-sided tape (118) are wrapped around the catheter (100) and are severed from the connecting portions (112,113). Free ends (115) of the electrically conductive elements (114) abut each other to form the electrodes (5) as band electrodes.
    • 一种用于制造导管(100)的方法,所述导管(100)具有朝向所述导管(100)的远端(4)的多个轴向间隔开的电极(5),所述方法包括: 通过在片材中形成间隔开的狭槽(111)以限定在间隔开的细长连接部分(112,113)之间横向延伸的多个间隔开的导电元件(114),从而导电箔材料的单片(110)。 导电元件(114)随后形成电极(5),并且通过连接部分(112,113)保持间隔开,直到结合到导管(100)。 电耦合到导电元件(114)的导电线(10)穿过细长槽(105)延伸到导管(100)的近端(3)中并沿着轴向连通孔(9)延伸。 结合到导电元件(114)的两片双面胶带(118)依次将导电元件(114)结合到导管(100)。 在将导线(10)插入轴向连通孔(9)之后,具有双面胶带(118)的导电元件(114)缠绕在导管(100)周围并且从连接部分(112,113)切断。 导电元件(114)的自由端(115)彼此邻接以形成电极(5)作为带状电极。
    • 15. 发明申请
    • A DEVICE AND A SYSTEM FOR USE IN A PROCEDURE FOR IMPROVING A SEALING FUNCTION OF A SPHINCTER AND A METHOD FOR IMPROVING THE SEALING FUNCTION OF A SPHINCTER
    • 用于改进喷雾器的密封功能的方法的装置和系统以及用于改进喷雾器的密封功能的方法
    • WO2009001325A1
    • 2008-12-31
    • PCT/IE2008/000067
    • 2008-06-27
    • FLIP TECHNOLOGIES LIMITEDO'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • O'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • A61B5/22A61B5/03A61B5/107
    • A61B5/1076A61B5/205A61B5/227A61B5/6853
    • A system (1) and a device (3) is used in a fundoplication procedure in order to avoid over-tightening of the fundus of the stomach when the fundus is being wrapped around the oesophagus (7) adjacent the lower oesophageal sphincter (5). The device (3) comprises a catheter (8) having a primary balloon (12) located at a distal end (9) thereof which is inflatable with a saline solution by a primary pump (26). A pair of spaced apart primary stimulating electrodes (32) on the catheter (8) within the primary balloon (12) receive a stimulating current signal from a constant current signal generator (40) under the control of a microprocessor (43), which reads voltage signals from spaced apart primary receiving electrodes (35) on the catheter (8) in the balloon (12). The microprocessor (43) determines the diameter of the primary balloon (12) at locations adjacent the primary receiving electrodes (35), and an image (47) of the inflated primary balloon (12) is displayed on a visual display screen (48) along with corresponding diameter values of the primary balloon (12). The primary balloon (12) is located in the sphincter (5) and inflated with the saline solution until the sphincter (5) has been dilated to a desired diameter, which is observed on the visual display screen (45). As the fundus of the stomach is being wrapped around the oesophagus (7) adjacent the sphincter (5) the diameter of the primary balloon (12) is observed so that the fundus is not over-tightened. A secondary balloon (50) on the catheter (8) is independently inflatable for simulating a bolus of food in the oesophagus (7) so that the dilating response of the sphincter (5) can be determined by observing the image (47) of the primary balloon (12) and the diameter values thereof on the visual display screen (45).
    • 在眼底围绕邻近下食管括约肌(5)的食道(7)周围缠绕眼底时,为了避免胃底部的过度收缩,使用系统(1)和装置(3) 。 装置(3)包括具有位于其远端(9)的主气囊(12)的导管(8),其可通过主泵(26)用盐溶液充气。 初级球囊(12)内的导管(8)上的一对间隔开的主要刺激电极(32)在微处理器(43)的控制下从恒定电流信号发生器(40)接收刺激电流信号,该微处理器读取 来自球囊(12)中的导管(8)上的间隔开的主接收电极(35)的电压信号。 微处理器(43)在与主接收电极(35)相邻的位置处确定主要球囊(12)的直径,并且充气的初级球囊(12)的图像(47)被显示在视觉显示屏幕(48)上, 以及主气球(12)的对应直径值。 主气囊(12)位于括约肌(5)中,并用盐水溶液充气,直到括约肌(5)已经扩张至在视觉显示屏(45)上观察到的所需直径。 由于胃的眼底被包围在邻近括约肌(5)的食管(7)周围,观察到主气球(12)的直径,使得眼底不被过紧。 导管(8)上的次级球囊(50)独立地可充气以模拟食管(7)中的大量食物,从而可以通过观察括约肌(5)的图像(47)来确定括约肌(5)的扩张反应 初级球囊(12)及其直径值在视觉显示屏幕(45)上。
    • 17. 发明申请
    • A DELIVERY DEVICE FOR ADMINISTERING AN ACTIVE SUBSTANCE TO A SUBJECT
    • 用于管理主体的主体的输送装置
    • WO2009069112A1
    • 2009-06-04
    • PCT/IE2008/000115
    • 2008-11-28
    • JANISYS LIMITEDO'DEA, JohnBAMBURY, Eoin
    • O'DEA, JohnBAMBURY, Eoin
    • A61M37/00A61M31/00A61K9/00
    • A61M5/2046A61K9/0021A61K9/0024A61K9/0097A61M37/0015A61M37/0069A61M2037/0023A61M2037/0046A61M2205/0244
    • A delivery device (1) for administering an active substance to a subject transdermal^ comprises a first plate member (7) having a plurality of first chambers (8) formed therein. Solid form structures (2) comprising the active substance and of conical shape having a pointed skin penetrating tip (5) are located in the first chambers (8). A second plate member (12) having a plurality of second chambers (16) comprising a driving substance (18) is secured to the first plate member (7) with a first membrane (20) of an expandable material sealably located between the respective first and second plate members (7,12). Expansion of the driving substance (18) in the second chambers (22) urges the first membrane (20) into the corresponding first chambers (8) for in turn urging the solid form structures (2) to penetrate through a second membrane (22) into the skin of the subject. A third plate member (24) comprises a plurality of electrically powered heating elements (28) aligned with the second chambers (22) for heating the driving substance (18) in the second chambers (16) for in turn expanding the driving substances (18) therein.
    • 用于向受试者透皮施用活性物质的递送装置(1)包括具有形成在其中的多个第一室(8)的第一板构件(7)。 包含活性物质和具有尖锐皮肤渗透尖端(5)的圆锥形状的固体形式结构(2)位于第一腔室(8)中。 具有包括驱动物质(18)的多个第二腔室(16)的第二板构件(12)通过可膨胀材料的第一膜(20)固定到第一板构件(7),所述第一膜(20)可密封地位于相应的第一 和第二板构件(7,12)。 驱动物质(18)在第二腔室(22)中的膨胀将第一膜(20)推到相应的第一腔室(8)中,从而推动固体形式结构(2)穿透第二隔膜(22) 进入主体的皮肤。 第三板构件(24)包括与第二室(22)对准的多个电动加热元件(28),用于加热第二室(16)中的驱动物质(18),从而使驱动物质(18 )。
    • 18. 发明申请
    • A SYSTEM, DEVICE AND A METHOD FOR DILATING A STRICTURE IN A LUMEN AND FOR DETERMINING THE TRANSVERSE CROSS-SECTIONAL AREA OF A LUMEN OR CAVITY
    • 一种系统,装置和一种用于在一个瓶子中稀释一个条件并确定一个或多个空气的横断面的区域的方法
    • WO2009001328A2
    • 2008-12-31
    • PCT/IE2008000070
    • 2008-06-27
    • FLIP TECHNOLOGIES LTDO'DEA JOHNMCHUGH ADRIANGRIFFIN PATRICK
    • O'DEA JOHNMCHUGH ADRIANGRIFFIN PATRICK
    • A61B5/03A61B5/107A61B5/22
    • A61M25/10181A61B5/0538A61B5/1076A61B5/4233A61B5/6853A61M25/1002A61M25/1011A61M25/10187A61M29/02A61M2025/1059
    • A system (1) for dilating an occlusion (3) in an oesophagus (4) comprises a device (5) having a catheter (8) extending from a proximal end (9) to a distal end (10). An inflatable balloon (12) defining a hollow interior region (14) is located on the catheter (8) adjacent the distal end (10) thereof for dilating the occlusion (3). The balloon (12) is inflated with a saline solution by a pump (34) through an axial communicating bore (20) and radial communicating bores (21) in the catheter (8). A pair of stimulating electrodes (25) on the catheter (8) within the balloon (12) adjacent axially opposite ends (18,19) thereof receive stimulating voltage signals from a signal generator (43). Receiving electrodes (28) on the catheter (8) between the stimulating electrodes (25) produce resulting voltage signals in response to the stimulating current signal on the stimulating electrodes (25) which are indicative of the transverse cross-sectional area of the balloon (12) adjacent the receiving electrodes (28) when the balloon (12) is inflated with the saline solution. A microprocessor (35) determines the diameter of the balloon (12) at the receiving electrodes (28) from the resulting signals thereon, and displays a three-dimensional image (46) of the balloon (12) on a visual display screen (47) as well as the corresponding diameter values in windows (48) on the visual display screen (47). A surgeon observes an image of the balloon (12) which corresponds to an image of the occlusion (3) and adjacent portion of the oesophagus (4) during dilating of the occlusion (3).
    • 用于扩张食管(4)中的闭塞(3)的系统(1)包括具有从近端(9)延伸到远端(10)的导管(8)的装置(5)。 限定中空内部区域(14)的可膨胀气囊(12)位于邻近其远端(10)的导管(8)上,用于扩张闭塞(3)。 气囊(12)通过泵(34)通过轴向连通孔(20)和导管(8)中的径向连通孔(21)用盐水溶液充气。 邻近轴向相对端(18,19)的球囊(12)内的导管(8)上的一对刺激电极(25)从信号发生器(43)接收刺激电压信号。 在刺激电极(25)之间的导管(8)上的接收电极(28)响应于刺激电极(25)上的刺激电流信号而产生所产生的电压信号,其表示球囊的横截面积( 12),当气囊(12)用盐水溶液充气时,邻近接收电极(28)。 微处理器(35)从其上产生的信号确定接收电极(28)处的球囊(12)的直径,并将气球(12)的三维图像(46)显示在视觉显示屏(47)上 )以及视觉显示屏幕(47)上的窗口(48)中的相应直径值。 外科医生在扩张闭塞(3)期间观察到对应于闭塞(3)和食道(4)的相邻部分的图像的球囊(12)的图像。
    • 19. 发明申请
    • “一种排除系统和一种装置和一种在一个或多个空气中排出物质的方法”
    • WO2009001326A1
    • 2008-12-31
    • PCT/IE2008/000068
    • 2008-06-27
    • FLIP TECHNOLOGIES LIMITEDO'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • O'DEA, JohnMcHUGH, AdrianGRIFFIN, Patrick
    • A61B18/14A61B5/107
    • A61B18/1492A61B5/1076A61B2018/0022A61B2018/00261A61B2018/00494A61B2018/1467A61B2090/061
    • An ablation system (1) comprising an ablation device (2) for ablating matter (100), such as cancerous tissue or an occlusion resulting from, for example, a cancerous tissue growth in an oesophagus (101) comprises a catheter (4) having a balloon (7) located adjacent the distal end (6) thereof. The balloon (7) when inflated is of cylindrical shape and is coaxial with the catheter (4). Ablating band electrodes (18) are located on an outer surface (23) of the balloon (7) for ablating the tissue (100). A pair of stimulating band electrodes (20) are located on the catheter (4) within a hollow interior region (8) defined by the balloon (7) adjacent opposite ends (11,12) of the balloon (7). A plurality of equi-spaced apart receiving band electrodes (21) are located on the catheter (4) between the stimulating electrodes (20). A stimulating current signal of known constant value is applied to the stimulating electrodes (21) when the balloon (7) is inflated with a saline solution, and voltage signals appearing on the receiving electrodes (21) are read for determining the diameter of the balloon (7) at locations corresponding to the receiving electrodes (21) so that a three- dimensional image representative of the balloon (7) can be displayed on a visual display screen (3). A doctor or surgeon can readily identify the longitudinal profile of the balloon (7) which when inflated within the oesophagus corresponds with the longitudinal profile of the oesophagus adjacent the balloon (7). This permits the doctor or surgeon to readily locate the balloon (7) with the ablating electrodes (18) aligned with the tissue (100) to be ablated.
    • 消融系统(1)包括用于消融物质(100)的消融装置(2),例如癌组织或由例如食道中的癌组织生长产生的闭塞(101),其包括导管(4),其具有 位于其远端(6)附近的气囊(7)。 充气时的气囊(7)为圆筒状,与导管(4)同轴。 烧蚀带状电极(18)位于气囊(7)的外表面(23)上,用于烧蚀组织(100)。 一对刺激带状电极(20)位于与球囊(7)的相对端(11,12)相邻的由球囊(7)限定的中空内部区域(8)内的导管(4)上。 多个等距间隔开的接收带电极(21)位于刺激电极(20)之间的导管(4)上。 当用盐水溶液充气球囊(7)时,将已知恒定值的刺激电流信号施加到刺激电极(21),并且读取出现在接收电极(21)上的电压信号以确定球囊的直径 (7)在对应于接收电极(21)的位置处,使得可以在视觉显示屏幕(3)上显示代表气球(7)的三维图像。 医生或外科医生可以容易地识别气囊(7)的纵向轮廓,其在食管内充气时与食道相邻的气囊的纵向轮廓对应(7)。 这允许医生或外科医生容易地定位具有与组织(100)对准的烧蚀电极(18)进行烧蚀的气囊(7)。