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11. 发明专利

JP2011069800A Method of immunologically discriminating and detecting human influenza virus h1 subtype 审中-公开
标题翻译：免疫分析和检测人类流感病毒H1亚型的方法
公开(公告)号：JP2011069800A
公开(公告)日：2011-04-07
申请号：JP2009223530
申请日：2009-09-28
申请人： Bl:Kk , 株式会社ビーエル
发明人： NONAKA URAO
IPC分类号： G01N33/543 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and measuring tool, capable of speedily and easily discriminating and detecting seasonal human influenza virus H1N1 subtypes and new human influenza virus H1N1 subtypes. SOLUTION: By a first antibody reacting with substantially all human influenza A virus subtypes, and a second antibody which reacts with both of the seasonal human influenza virus H1 subtypes and new influenza virus H1 subtypes but has a weaker reactivity to the new influenza virus H1 subtypes than to the seasonal human influenza virus H1 subtypes, the new influenza virus H1 subtypes are detected based on the fact that the reactivity to the second antibody is weaker than that to the first antibody although reaction with the first antibody and that with the second antibody are both positive. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种方法和测量工具，能够快速，轻松地区分和检测季节性人流感病毒H1N1亚型和新型人类流感病毒H1N1亚型。解决方案：通过与基本上所有人类甲型流感病毒亚型反应的第一抗体和与季节性人流感病毒H1亚型和新型流感病毒H1亚型反应但对新流感具有较弱反应性的第二抗体病毒H1亚型比季节性人类流感病毒H1亚型，新的流感病毒H1亚型是基于以下事实来检测的：与第一抗体的反应性比第一抗体的反应性弱，而与第一抗体的反应第二抗体均为阳性。版权所有（C）2011，JPO＆INPIT

12. 发明专利

JP4554472B2 Parvovirus antigen detection kit 有权
公开(公告)号：JP4554472B2
公开(公告)日：2010-09-29
申请号：JP2005246369
申请日：2005-08-26
申请人：国立大学法人鳥取大学 , 株式会社ビーエル
发明人：剛實方 , 靖治難波
IPC分类号： G01N33/569 , G01N33/543 , G01N33/577

13. 发明专利

JP4478658B2 Mycobacterium tuberculosis detection kit 有权
公开(公告)号：JP4478658B2
公开(公告)日：2010-06-09
申请号：JP2006097204
申请日：2006-03-31
申请人：株式会社ビーエル
发明人：眞理子小松 , 剛望月 , 靖治難波
IPC分类号： G01N33/543 , G01N33/545 , G01N33/553 , G01N33/569 , G01N33/577

14. 发明专利

JP2008196967A Influenza virus h5 subtype immunoassay 有权
标题翻译： INFLUENZA VIRUS H5 SUBTYPE IMMUNOASSAY
公开(公告)号：JP2008196967A
公开(公告)日：2008-08-28
申请号：JP2007032346
申请日：2007-02-13
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU
IPC分类号： G01N33/569 , C07K16/10 , C12P21/08 , G01N33/543 , G01N33/553 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and a measuring instrument capable of detecting specifically, quickly and easily an influenza virus H5 subtype. SOLUTION: The present invention discloses an antibody, in particular, a monoclonal antibody reacting specifically with a specified epitope of hemaglutinin protein of the influenza virus H5 subtype. The epitope contains the amino acid in the 88th, 145th, 157th, 159th, or 205th of an amino acid sequence of the hemaglutinin protein indicated in the sequence number 1, and contains preferably the amino acid in 157th or 205th to detect a weak virulent strain and a strong virulent strain over a wide range. The present invention discloses an immunoassay using the antibody, in particular, a sandwich type immunoassay using the first antibody and the second antibody to the hemaglutinin protein, in particular, an immunochromatography, and an immunochromatographic test strip. At least one of the first antibody and the second antibody is preferably the monoclonal antibody. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够快速且容易地检测流感病毒H5亚型的方法和测量仪器。解决方案：本发明公开了抗体，特别是与流感病毒H5亚型的血凝素蛋白的特定表位特异性反应的单克隆抗体。表位含有序列号1所示的血凝蛋白蛋白质的氨基酸序列的第88位，第145位，第159位，第159位，第159位或第205位的氨基酸，优选在第157位或第205位含有氨基酸以检测弱毒性菌株和强烈的毒性应变在广泛的范围。本发明公开了使用该抗体的免疫测定法，特别是使用第一抗体和第二抗体对血凝素蛋白质，特别是免疫色谱法和免疫色谱测试条的夹心型免疫测定法。第一抗体和第二抗体中的至少一种优选为单克隆抗体。版权所有（C）2008，JPO＆INPIT

15. 发明专利

JP3886000B2 Metal colloid particles 有权
公开(公告)号：JP3886000B2
公开(公告)日：2007-02-28
申请号：JP2002063024
申请日：2002-03-08
申请人：株式会社ビーエル
发明人：一郎大倉 , 康司石塚 , 文彦蓮実 , 浦雄野中 , 靖治難波
IPC分类号： G01N33/553 , G01N33/543

16. 发明专利

JP2006138748A Container and kit for extracting specimen 有权
标题翻译：用于提取样品的容器和工具箱
公开(公告)号：JP2006138748A
公开(公告)日：2006-06-01
申请号：JP2004328700
申请日：2004-11-12
申请人： Bl:Kk , 株式会社ビーエル
发明人： NANBA YASUHARU
IPC分类号： G01N33/48 , G01N1/10 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a container for extracting specimen capable of extracting a specimen sampled using a swab into an extracting solvent by simple operation and capable of being safely discarded after use, and a kit.
SOLUTION: The container for extracting specimen is composed of a tubular body (1) having an opening end (11) and the closing end (12) opposed to it, the first lid (2) attached to the opening end (11) of the body (1) in a detachable manner, the nozzle (3) replaced with the first lid (2) to be attached to the opening end (11) of the body (1) in a freely detachable manner and the second lid (4) attached to the nozzle (3) in a freely detachable manner and the body (1) has an internal dimension sufficient to house the swab (5). The side wall (13) adjacent to the closing end (12) of the body (1) is preferably made thin by making the side wall (13) thinner than the side wall (14) adjacent to the opening end (11) of the body (1).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容器，用于提取能够通过简单操作将使用棉签取样的样本提取到提取溶剂中并且能够在使用后能够被安全地丢弃的样本。解决方案：用于提取试样的容器由具有开口端（11）和封闭端（12）相对的管状体（1）组成，第一盖（2）附接到开口端（11））以可拆卸的方式安装在主体（1）的开口端（11）上，喷嘴（3）以第一盖（2）代替，以可自由拆卸的方式安装在主体（1）的开口端（11）上，（4）以可自由拆卸的方式附接到喷嘴（3），并且主体（1）具有足以容纳棉签（5）的内部尺寸。优选地，通过使侧壁（13）比靠近所述主体（1）的开口端（11）的侧壁（14）更薄，邻近主体（1）的闭合端（12）的侧壁（13）身体（1）。版权所有（C）2006，JPO＆NCIPI

17. 发明专利

JP2006067979A Immunity detecting method for influenza a type virus 审中-公开
标题翻译：流感病毒类型的免疫检测方法
公开(公告)号：JP2006067979A
公开(公告)日：2006-03-16
申请号：JP2004258880
申请日：2004-09-06
申请人： Bl:Kk , 株式会社ビーエル
发明人： KIDA HIROSHI , SAKOTA YOSHIHIRO , NANBA YASUHARU , MOCHIZUKI TAKESHI
IPC分类号： C12N15/09 , C07K14/11 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/543 , G01N33/553 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method for quickly and easily detecting a wide range of influenza A type viruses, and to provide an apparatus for the same. SOLUTION: A recombinant NS1 protein and a monoclonal antibody to the same are obtained by cloning a fraction of a gene encoding NS1 protein which is a non structural protein common in various kinds of influenza A type viruses. This invention provides an immunoassay method using an antibody against the NS1 protein of the influenza A type viruses, especially a sandwich type immunoassay method using a first antibody and a second antibody against the NS1 protein, in particular, the invention provides an immunochromatography method and a testing split for immunochromatography. At least one of the first antibody and the second antibody is preferably the monoclonal-antibody. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种快速且容易地检测大范围的甲型流感病毒的方法，并提供用于其的装置。解决方案：通过克隆编码作为各种甲型流感病毒类型中常见的非结构蛋白质的NS1蛋白的基因的一部分获得重组NS1蛋白及其单克隆抗体。本发明提供了使用针对A型流感病毒的NS1蛋白的抗体的免疫测定方法，特别是使用第一抗体和针对NS1蛋白的第二抗体的夹心型免疫测定方法，特别是本发明提供免疫色谱法和用于免疫层析的检测。第一抗体和第二抗体中的至少一种优选为单克隆抗体。版权所有（C）2006，JPO＆NCIPI

18. 发明专利

JP2004161685A Yolk-related protein and application thereof 审中-公开
公开(公告)号：JP2004161685A
公开(公告)日：2004-06-10
申请号：JP2002330226
申请日：2002-11-14
申请人： Bl:Kk , Frontier Science Co Ltd , 株式会社ビーエル , 株式会社フロンティア・サイエンス
发明人： HARA AKIHIKO , NANBA YASUHARU , ITO KEIZO
IPC分类号： G01N33/53 , C07K14/46 , C07K16/18 , G01N33/543 , G01N33/545 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a substitution method of a conventional measuring system of an environmental hormone disruptor by detecting vitellogenin by providing a new female-specific yolk-related protein (YRP) derived from Oryzias latipes and an antibody against the protein. SOLUTION: The female-specific yolk-related protein derived from the Oryzias latipes has substantially 460 kDa molecular weight measured by gel filtration, and substantially 130 kDa molecular weight measured by dodecyl sodium sulfate-polyacrylamide gel electrophoresis. The antibody against the protein, and various kinds of immunological measuring methods of the yolk-related protein by using the antibody are also provided. COPYRIGHT: (C)2004,JPO

19. 发明专利

JP5849065B2 A型インフルエンザウイルスH5亜型の検出法有权
标题翻译：检测方法的A型流感病毒H5亚型
公开(公告)号：JP5849065B2
公开(公告)日：2016-01-27
申请号：JP2013093233
申请日：2013-04-26
申请人：株式会社ビーエル
发明人：難波靖治
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56983 , G01N2333/11

20. 发明专利

JP5827701B2 インフルエンザウイルスH5亜型の免疫検出法有权
标题翻译：检测流感病毒H5亚型的免疫方法
公开(公告)号：JP5827701B2
公开(公告)日：2015-12-02
申请号：JP2014004593
申请日：2014-01-14
申请人：株式会社ビーエル
发明人：喜田宏 , 迫田義博 , 難波靖治
IPC分类号： G01N33/543 , G01N33/548 , C07K16/10 , G01N33/569
CPC分类号： C07K16/1018 , G01N33/56994 , G01N2333/11

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