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    • 131. 发明授权
    • Optical information processor with monolithically integrated light emitting device, light receiving devices and optics
    • 具有单片集成发光器件,光接收器件和光学器件的光学信息处理器
    • US06781944B1
    • 2004-08-24
    • US09913397
    • 2001-08-14
    • Toshiaki Tanaka
    • Toshiaki Tanaka
    • G11B7135
    • G11B7/1387G11B7/123G11B7/1353G11B7/1365H01L31/02325H01L31/02327H01S5/0264H01S5/0265H01S5/0267
    • In an optical head of a DVD drive, a light-emitting device and light-receiving devices are disposed on one face of a substrate, and on the other face of the substrate, a diffraction light separating device, a &lgr;/4 plate, and a dielectric plate having a converging focus lens are sequentially, hierarchically integrated. With the configuration, a laser beam (transmission beam) emitted from the front light-outgoing end of the semiconductor laser device sequentially passes through the diffraction light separating device, &lgr;/4 wave plate, and dielectric plate having the converging focus lens to form an image on a recording face of a recording medium (optical recording medium). A reflected beam reflected by the recording face returns reversely along the optical path through which the transmission beam has traveled, the phase of the reflected beam is changed by the &lgr;/4 wave plate, and the phase-changed reflected beam is separated into two primary diffracted beams in two directions. The primary diffracted beams fall on the light-receiving faces of the respective light-receiving devices. As a result, information can be reproduced and/or recorded by near-field recording.
    • 在DVD驱动器的光头中,发光装置和光接收装置设置在基板的一个面上,在基板的另一面上,衍射光分离装置,λ/ 4板和 具有会聚聚焦透镜的电介质层被顺次地分级地集成。 利用该结构,从半导体激光装置的前端射出端发射的激光束(透射光束)依次通过衍射光分离装置,λ/ 4波片和具有会聚聚焦透镜的电介质板,形成 在记录介质(光记录介质)的记录面上的图像。 由记录面反射的反射光束沿着透射光束行进的光路反向返回,反射光束的相位被λ/ 4波片改变,相变反射光束被分离为两个主要 衍射光束在两个方向。 主衍射光束落在各个光接收装置的光接收面上。 结果,可以通过近场记录来再现和/或记录信息。
    • 133. 发明授权
    • Cyclic peptides and medicinal use thereof
    • 环状肽及其药用
    • US06511961B1
    • 2003-01-28
    • US09341435
    • 1999-07-09
    • Toshiya TakahashiNobuo SaitoHideyuki TakeshigeToshiaki TanakaMie Kainoh
    • Toshiya TakahashiNobuo SaitoHideyuki TakeshigeToshiaki TanakaMie Kainoh
    • A61K3800
    • C07K7/06A61K38/00C07K7/54C07K7/64C07K14/70542C07K14/7055
    • Novel cyclic peptides having VLA-4 adhesion inhibiting activity, and their application as therapeutic agents for inflammatory disease, for example allergic inflammatory disease, or hepatitis. Cyclic peptides represented by formula (I) where A and F may be the same or different, and are both selected from L- or D-form Cys, homo-Cys, Pen and Mpr, or both from the group comprising Asp, Glu, Aad, Dpr, Dab and Orn, B is selected from L-or D-form Ala, Ala(t-Bu), Val, Leu, Ile, aIle, Abu, Nle, Nva, Tle, Cha, Chg, Phe, Phg, Trp, Ala(3-Bzt), Ala(1-Naph), Ala(2-Naph), Ala(2-Pyr), Ala(2-Qui), His, Thi, Ala(4-Thz), 2-Abz, Pro, homo-Pro and Tic, C is selected from L-form Asp analogues, Gle analogues, Aad analogues, Asn analogues, Gln analogues, Ser, Ser(OMe), homo-Ser, Dpr, Dab, Orn, Met, Met)O), Met(O2), aIle, Nle, Nva, Chg, Phg, Tyr and Tle, D is selected from L- or D-form Tyr, Ser, homo-Ser, Leu, Ile, AIle, Nle, Nva, Chg, Cha, Val, Ala(t-Bu), Abu, Tle, Ala, Phg, homo-Phe, Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt), Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz, Trp and His, E is selected from L- or D-form Leu, Ile, aIle, Nle, Nva, Chg, Cha, Tle, Phg, homo-Phe, Ala(2-Naph), Ala(2-Pyr), Ala(3-Bzt, Ala(1-Naph), Ala(2-Qui), Thi, Ala(4-Thz), 2-Abz and His, G represents a disulphide bond or amide bond, R1 represents hydrogen or an acyl group, and R2 is hydrogen or an alkyl group, or salts thereof, and to their use in treating inflammatory diseases.
    • 具有VLA-4粘附抑制活性的新型环肽及其作为炎症性疾病例如过敏性炎性疾病或肝炎的治疗剂的应用。 由式(I)表示的环肽,其中A和F可以相同或不同,并且均选自L-或D-型Cys,homo-Cys,Pen和Mpr,或二者均为Asp,Glu, Aad,Dpr,Dab和Orn,B选自L-型或D-型Ala,Ala(t-Bu),Val,Leu,Ile,aIle,Abu,Nle,Nva,Tle,Cha,Chg,Phe,Phg ,Trp,Ala(3-Bzt),Ala(1-Naph),Ala(2-Naph),Ala(2-Pyr),Ala(2-Qui),His,Thi,Ala(4-Thz) -Abz,Pro,homo-Pro和Tic,C选自L型Asp类似物,Gle类似物,Aad类似物,Asn类似物,Gln类似物,Ser,Ser(OMe),homo-Ser,Dpr,Dab,Orn, Met,Met)O),Met(O 2),aIle,Nle,Nva,Chg,Phg,Tyr和Tle,D选自L-或D型Tyr,Ser,homo-Ser,Leu,Ile, Nle,Nva,Chg,Cha,Val,Ala(t-Bu),Abu,Tle,Ala,Phg,hom-Phe,Phe,Ala(2-Naph),Ala(2-Pyr),Ala(3-Bzt ),Ala(1-Naph),Ala(2-Qui),Thi,Ala(4-Thz),2-Abz,Trp和His,E选自L-或D-型Leu,Ile,aIle,Nle ,Nva,Chg,Cha,Tle,Phg,hom-Phe,Ala(2-Naph),Ala(2-Pyr), Ala(3-Bzt,Ala(1-Naph),Ala(2-Qui),Thi,Ala(4-Thz),2-Abz和His,G表示二硫键或酰胺键,R1表示氢或酰基 并且R 2是氢或烷基,或其盐,以及它们在治疗炎性疾病中的用途。
    • 135. 发明授权
    • Key switch and keyboard
    • 钥匙开关和键盘
    • US06501038B2
    • 2002-12-31
    • US09729982
    • 2000-12-06
    • Kazutoshi HayashiToshiaki TanakaJunichi MaruyamaGoro Watanabe
    • Kazutoshi HayashiToshiaki TanakaJunichi MaruyamaGoro Watanabe
    • H01H1370
    • H01H3/125H01H13/70
    • A key switch comprising a base, a key top arranged above the base, a pair of link members interlocked to each other and operatively engaged with the base and the key top to support the key top above the base and direct the key top in a vertical direction, and a switching mechanism for selectively opening and closing an electric circuit in connection with a vertical movement of the key top. Each of the link members includes a sliding portion slidably and shiftably engaged with either one of the base and the key top. At least one plate spring is disposed between at least one of the link members and either one of the base and the key top with which the sliding portion is engaged, to exert a biasing force, relative to a shifting amount of the sliding portion, onto at least one of the link members in a direction different from the vertical direction. The plate spring includes, in an integral manner, a first spring portion extending along a fixed-end side in a direction substantially parallel to a shifting direction of the sliding portion of each link member and a second spring portion extending along a free-end side in a direction intersecting the first spring portion.
    • 一种钥匙开关,包括基座,布置在基座上方的键顶,一对彼此互锁并与基座和键顶可操作地接合的连接构件,以将键顶支撑在基座上方并将键顶引导到垂直方向 方向以及切换机构,用于选择性地打开和关闭与键顶的垂直运动有关的电路。 每个连杆构件包括滑动部分,滑动部分可移动地与基座和键顶中的任一个接合。 至少一个板弹簧设置在至少一个连杆构件和滑动部分接合的基座和键顶中的任一个之间,以相对于滑动部分的移动量施加偏置力到 至少一个连接构件沿与垂直方向不同的方向。 板簧以一体的方式包括沿着基本上平行于每个连杆构件的滑动部分的移动方向的固定端侧延伸的第一弹簧部分和沿自由端侧延伸的第二弹簧部分 在与第一弹簧部分相交的方向上。