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121. 发明授权

US06990851B2 Microfluidic viscometer 有权
公开(公告)号：US06990851B2
公开(公告)日：2006-01-31
申请号：US10728528
申请日：2003-12-05
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
IPC分类号： G01N11/06 , G01N11/04 , G01F1/42
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.

122. 发明授权

US06827831B1 Controller/detector interfaces for microfluidic systems 有权
标题翻译：用于微流体系统的控制器/检测器接口
公开(公告)号：US06827831B1
公开(公告)日：2004-12-07
申请号：US09646241
申请日：2000-09-13
申请人： Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
发明人： Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
IPC分类号： G01N2726
CPC分类号： G01N27/453 , B01J19/0093 , B01J2219/00853 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/0415 , G01N27/44743 , G01N27/44791 , Y10T436/2575
摘要： The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems (620) for controlling the performance of the processes carried out within the device, e.g., monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要翻译：本发明总体上涉及用于将微流体装置与与这种装置结合使用的辅助系统进行接口的改进的方法，结构和系统。这些系统通常包括用于控制在设备内执行的过程的性能的控制和监视系统（620），例如监视和控制环境条件并监视所执行的过程的结果，例如检测。

123. 发明授权

US06647397B2 Distributed database for analytical instruments 有权
公开(公告)号：US06647397B2
公开(公告)日：2003-11-11
申请号：US10020630
申请日：2001-12-13
申请人： J. Wallace Parce
发明人： J. Wallace Parce
IPC分类号： G06F1730
CPC分类号： G01N35/0092 , B01L3/502715 , B01L2200/148 , B01L2300/023 , G01N2035/0093 , Y10S707/99945 , Y10S707/99948
摘要： A method is provided for displaying chromatographic data using a graphical user interface. This method is preferably implemented as a software package which takes chromatographic data generated by varying fluorescence levels in a sample.

124. 发明授权

US06506609B1 Focusing of microparticles in microfluidic systems 有权
标题翻译：将微粒聚焦在微流体系统中
公开(公告)号：US06506609B1
公开(公告)日：2003-01-14
申请号：US09569747
申请日：2000-05-11
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
IPC分类号： G01N700
CPC分类号： B01F13/0062 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/117497 , Y10T436/2575
摘要： Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译：提供了用于增加微尺度系统中测定通过量的粒子聚焦的方法和系统。本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。另外包括其中聚焦和/或分选颗粒的集成系统。

125. 发明授权

US06495369B1 High throughput microfluidic systems and methods 有权
标题翻译：高通量微流体系统和方法
公开(公告)号：US06495369B1
公开(公告)日：2002-12-17
申请号：US09545241
申请日：2000-04-07
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N3502
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译：本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。多孔板沿着输送系统行进到具有微流体装置的测试台。在测试台处，每个板从输送机中取出，多孔板的孔依次与微流体装置的输入端对准。在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络芯片。具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

126. 发明授权

US06451188B1 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
标题翻译：用于促进流体引入微流体装置的微型结构
公开(公告)号：US06451188B1
公开(公告)日：2002-09-17
申请号：US09539671
申请日：2000-03-30
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
摘要翻译：通过使用完全延伸通过微流体衬底的端口来促进流体引入。可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出，并用替代流体代替去除的流体，或者通过置换流体部分附加流体。在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物。

127. 发明授权

US06274337B1 High throughput screening assay systems in microscale fluidic devices 失效
标题翻译：微量流体装置中的高通量筛选测定系统
公开(公告)号：US06274337B1
公开(公告)日：2001-08-14
申请号：US09044557
申请日：1998-03-19
申请人： J. Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
发明人： J. Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
IPC分类号： C12Q102
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译：本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。

128. 发明授权

US6149787A External material accession systems and methods 有权
公开(公告)号：US6149787A
公开(公告)日：2000-11-21
申请号：US173469
申请日：1998-10-14
申请人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
发明人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
IPC分类号： B01L3/00 , G01N35/00 , G01N35/10 , G01N27/26
CPC分类号： B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L3/50273 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

129. 发明授权

US5965410A Electrical current for controlling fluid parameters in microchannels 失效
公开(公告)号：US5965410A
公开(公告)日：1999-10-12
申请号：US977528
申请日：1997-11-25
申请人： Calvin Y. H. Chow , Anne R. Kopf-Sill , J. Wallace Parce
发明人： Calvin Y. H. Chow , Anne R. Kopf-Sill , J. Wallace Parce
IPC分类号： B01L3/00 , B01L7/00 , G01N27/447 , C12P19/34
CPC分类号： B01L3/5027 , B01L7/52 , G01N27/44791 , B01L2200/147 , B01L2300/0816 , B01L2300/0883 , B01L2300/1822 , B01L2300/1827 , B01L2300/1833 , B01L2300/1838 , B01L2400/0415 , B01L2400/0487 , Y10S366/03
摘要： A novel method and device for transporting and/or monitoring a fluid in a multi-port device 400, 800, 1000 used in a microfluidic system is provided. The multi-port device includes a substrate having a novel channel configuration. A first channel region 413 having a first port and a second port for transporting fluid therebetween is defined in the substrate. A second channel region 421 having a first port and a second port for applying electric current for heating fluid or for monitoring a fluid parameter therebetween is also defined in the substrate. In some embodiments, the first channel intersects 407 with the second channel. The heating or monitoring aspect of the invention can be used with a variety of biological reactions such as PCR, LCR, and others.

130. 发明授权

US5958203A Electropipettor and compensation means for electrophoretic bias 失效
公开(公告)号：US5958203A
公开(公告)日：1999-09-28
申请号：US883638
申请日：1997-06-26
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： G01N31/20 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/26 , G01N27/447 , G01N37/00 , H02N11/00
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01J2219/00891 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L3/021 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

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