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121. 发明申请

WO1994002597A1 MUTANT 'alpha'-AMYLASE, DETERGENT, DISH WASHING AGENT, AND LIQUEFACTION AGENT 审中-公开
标题翻译：突变型α-甲基化酶，洗涤剂，DISH洗涤剂和液化剂
公开(公告)号：WO1994002597A1
公开(公告)日：1994-02-03
申请号：PCT/DK1993000230
申请日：1993-07-06
申请人： NOVO NORDISK A/S , SVENDSEN, Allan , BISGÅRD-FRANTZEN, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C11D3/386 , C12N9/2414 , C12N9/2417
摘要： In the mutant alpha -amylase one or more of the methionine amino acid residues is exchanged with any amino acid residue except for Cys and Met. The thus produced mutant alpha -amylase exhibits an improved stability in the presence of oxidizing agents and an improved thermoactivity at moderate low pH values. The mutant alpha -a amylase is well suited as an additive to detergents, dish washing agents and liquefaction agents.
摘要翻译：在突变型α-淀粉酶中，一个或多个甲硫氨酸氨基酸残基与除Cys和Met之外的任何氨基酸残基交换。由此产生的突变型α-淀粉酶在中等低pH值下表现出在氧化剂存在下的改进的稳定性和改进的热活性。突变体α-α淀粉酶非常适合作为洗涤剂，洗碟剂和液化剂的添加剂。

122. 发明申请

WO1994001537A1 METHOD FOR PURIFICATION OF AN AQUEOUS ENZYME SOLUTION 审中-公开
标题翻译：净化水溶液的方法
公开(公告)号：WO1994001537A1
公开(公告)日：1994-01-20
申请号：PCT/DK1993000229
申请日：1993-07-06
申请人： NOVO NORDISK A/S , NIELSEN, Niels-Viktor
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/00
CPC分类号： C12N9/54 , C12N9/00 , Y10S435/814 , Y10S435/816
摘要： The method comprises simultaneous addition of acid and aluminate in controlled amounts, optionally in the presence of a water miscible solvent, followed by separation of the supernatant from the precipitate. Hereby impurities are more effectively separated from the enzyme which remains in the supernatant.
摘要翻译：该方法包括同时加入控制量的酸和铝酸盐，任选地在水混溶性溶剂的存在下，然后从沉淀物中分离上清液。因此杂质更加有效地与留在上清液中的酶分离。

123. 发明申请

WO1994001488A1 POLYMERIZATION OF LIGNIN AT ALKALINE pH 审中-公开
标题翻译：木质素在碱性条件下的聚合度
公开(公告)号：WO1994001488A1
公开(公告)日：1994-01-20
申请号：PCT/DK1993000217
申请日：1993-07-02
申请人： NOVO NORDISK A/S , YDE, Birgitte
发明人： NOVO NORDISK A/S
IPC分类号： C08H05/02
CPC分类号： C08H6/00 , C09J197/005
摘要： The present invention relates to a method of enzymatic polymerization and/or modification of lignin or lignin containing materials. The invention also relates to the use of this method in the manufacture of wood composites or wood laminates.
摘要翻译：本发明涉及一种用于木质素或木质素的材料的酶促聚合和/或改性的方法。本发明还涉及这种方法在制造木材复合材料或木材层压材料中的用途。

124. 发明申请

WO1994000443A1 FUNGICIDALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：杀真菌活性化合物
公开(公告)号：WO1994000443A1
公开(公告)日：1994-01-06
申请号：PCT/DK1993000190
申请日：1993-06-02
申请人： NOVO NORDISK A/S , BREINHOLT, Jens , LANGE, Lene
发明人： NOVO NORDISK A/S
IPC分类号： C07D307/46
CPC分类号： C07D307/34 , A01N43/08 , A01N63/04 , C12P17/04 , C12R1/645 , Y10S435/911
摘要： Compounds having formula (3), wherein R is hydrogen, straight or branched alkyl with 1-10 carbon atoms, straight or branched alkenyl with 2-10 carbon atoms, straight or branched alkynyl with 2-10 carbon atoms, benzyl or aryl, optionally mono- or plurisubstituted with straight or branched alkyl with 1-10 carbon atoms, hydroxy, alkoxy, halogen, an amino or a nitro group; and when R is H salts thereof, or R is acyl (R = -COR ) wherein R is straight or branched alkyl with 1-10 carbon atoms, alkenyl with 2-10 carbon atoms, alkynyl with 2-10 carbon atoms, or aryl, optionally mono- or plurisubstituted with alkyl with 1-10 carbon atoms, hydroxy, alkoxy, halogen, an amino or a nitro group. Compounds of formula (3) have interesting antifungal activities and may, accordingly, be used as active ingredients in fungicidal compositions.
摘要翻译：具有式（3）的化合物，其中R 1是氢，具有1-10个碳原子的直链或支链烷基，具有2-10个碳原子的直链或支链烯基，具有2-10个碳原子的直链或支链炔基，苄基或芳基，任选被具有1-10个碳原子的直链或支链烷基，羟基，烷氧基，卤素，氨基或硝基单取代或多取代; 当R 1为其H盐时，或R 1为酰基（R 1 = -COR 2），其中R 2为具有1-10个碳原子的直链或支链烷基，具有2个 -10个碳原子的炔基，或具有1-10个碳原子的烷基，羟基，烷氧基，卤素，氨基或硝基单取代或多取代的芳基。式（3）的化合物具有有趣的抗真菌活性，因此可用作杀真菌组合物中的活性成分。

125. 发明申请

WO1993024270A1 ROTARY TABLE WITH AN INTERMITTENTLY MOVABLE FOLLOWER 审中-公开
标题翻译：具有可互换移动式搅拌器的旋转台
公开(公告)号：WO1993024270A1
公开(公告)日：1993-12-09
申请号：PCT/DK1993000185
申请日：1993-05-27
申请人： NOVO NORDISK A/S , MANIQUE, Flemming , MARTINUSSEN, Tommy , HARE, Alex , SAABYE, Henrik , CHRISTENSEN, Svend
发明人： NOVO NORDISK A/S
IPC分类号： B23P23/00
CPC分类号： B23Q7/007 , B23Q5/34
摘要： A concommitting movement of a working station (1) operating on subjects circumconveyed on a rotary table (5) driven by a motor (8) mounted rigidly on a machine frame (16) is established by a controllable motor (4) being mounted rigidly to the working station (1) and having its output shaft coupled to the rotary table (5) through a slackless transmission. The motor (4) is controlled to alternately make the working station (1) follow the table and move in a direction opposite the movement of the periphery of the table.
摘要翻译：通过可控制的电动机（4）建立工作站（1）的运动，该工作站（1）在由刚性地安装在机架（16）上的电动机（8）驱动的旋转台（5）上循环运行的被摄体操作，工作站（1）并且其输出轴通过无松动变速器联接到旋转工作台（5）。电动机（4）被控制以交替地使工作站（1）沿着工作台移动，并沿着与工作台的周边运动相反的方向移动。

126. 发明申请

WO1993023477A1 PRODUCTION OF A LIGNIN SOLUTION OR GEL, OF A BINDER AND OF A WOOD COMPOSITE 审中-公开
标题翻译：一种木质素和一种木质复合材料的木质素溶液或凝胶的生产
公开(公告)号：WO1993023477A1
公开(公告)日：1993-11-25
申请号：PCT/DK1993000167
申请日：1993-05-18
申请人： NOVO NORDISK A/S , YDE, Birgitte
发明人： NOVO NORDISK A/S
IPC分类号： C08L97/00
CPC分类号： C08H6/00 , C08L97/02 , C09J197/005 , C08L2666/26
摘要： A solution or gel of lignin at high concentration free of solids is obtained by treating the lignin at high pH and then lowering pH to the desired value. Further, a binder for wood products (such as particle board) is produced by preparing a lignin solution or gel in this way and treating said solution or gel with a phenol oxidizing enzyme system (such as laccase or peroxidase).
摘要翻译：通过在高pH下处理木质素，然后将pH降低至所需值，获得高浓度无固体的木质素溶液或凝胶。此外，通过以这种方式制备木质素溶液或凝胶来制备木制品（例如刨花板）的粘合剂，并用酚氧化酶体系（如漆酶或过氧化物酶）处理所述溶液或凝胶。

127. 发明申请

WO1993022444A1 FUNGICIDALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：杀真菌活性化合物
公开(公告)号：WO1993022444A1
公开(公告)日：1993-11-11
申请号：PCT/DK1993000145
申请日：1993-04-30
申请人： NOVO NORDISK A/S , BREINHOLT, Jens , ROSENDAHL, Connie, Ninna , DEMUTH, Helle
发明人： NOVO NORDISK A/S
IPC分类号： C12P17/02
CPC分类号： C12R1/645 , A01N49/00 , A01N63/04 , C07D309/38 , C12P17/162
摘要： Compounds of formula (I), wherein R is hydrogen, straight or branched alkyl with 1 to 6 carbon atoms, such as methyl, straight or branched hydroxyalkyl with 1 to 6 carbon atoms, such as CH2OH, straight or branched alkylethers with 1 to 6 carbon atoms or optionally substituted aromatic ethers; each R independently are hydrogen, straight or branched alkyl with 1 to 6 carbon atoms, such as methyl, straight or branched hydroxyalkyl with 1 to 6 carbon atoms, such as CH2OH, straight or branched alkylethers with 1 to 6 carbon atoms, or optionally substituted aromatic ethers; and each R independently are hydrogen, hydroxy, methoxy, acetoxy, straight or branched alkylethers with 1 to 6 carbon atoms, or optionally substituted aromatic ethers; and wherein the chiral centres a, b, c, d, e, f, and g each independently may have the R or S configuration; except for the compound, wherein R is -CH2-OH, all of R are -CH3, and all of R are -OH (formula Ib); or agronomically acceptable salts or esters thereof have been found to have fungicidal activity. Furthermore processes for producing such compounds by cultivation of a species belonging to the genus Fusarium on suitable nutrient media are given. The invention also relates to fungicidal compositions comprising these compounds, either alone or in combination with known biocides or growth regulators, and the use of the compounds or compositions of the invention for controlling fungi.
摘要翻译：式（I）的化合物，其中R 1是氢，具有1至6个碳原子的直链或支链烷基，例如具有1至6个碳原子的甲基，直链或支链羟烷基，例如CH 2 OH，直链或支链烷基醚， 1至6个碳原子或任选取代的芳族醚; 每个R 2独立地是氢，具有1至6个碳原子的直链或支链烷基，例如甲基，具有1至6个碳原子的直链或支链羟烷基，例如CH 2 OH，具有1至6个碳原子的直链或支链烷基醚，或任选取代的芳族醚; 并且每个R 3独立地是氢，羟基，甲氧基，乙酰氧基，具有1至6个碳原子的直链或支链烷基醚或任选取代的芳族醚; 并且其中手性中心a，b，c，d，e，f和g各自独立地可以具有R或S构型; 除了其中R 1是-CH 2 -OH的化合物外，所有R 2都是-CH 3，并且所有的R 3都是-OH（式Ib）; 或其农艺学上可接受的盐或酯已被发现具有杀真菌活性。此外，给出了通过在合适的营养培养基上种植属于镰刀菌属的物种来生产这种化合物的方法。本发明还涉及包含这些化合物的杀真菌组合物，其单独或与已知的杀生物剂或生长调节剂组合，以及本发明化合物或组合物用于防治真菌的用途。

128. 发明申请

WO1993019171A1 THERMOSTABLE XYLANASES FROM THERMOTOGA 审中-公开
标题翻译： THERMOSTABLE XYLANASES从THERMOTOGA
公开(公告)号：WO1993019171A1
公开(公告)日：1993-09-30
申请号：PCT/DK1993000093
申请日：1993-03-15
申请人： NOVO NORDISK A/S , ANTRANIKIAN, Garabed , SKOHOLM, Carsten
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008 , D21C5/005
摘要： This invention relates to novel enzymes. More specifically, the invention provides novel xylanases obtainable from microorganisms of the genus Thermotoga. The invention also relates to a process for the preparation of these xylanases, an agent containing these xylanases, and the use of these xylanases for delignification of lignocellulosic pulp.
摘要翻译：本发明涉及新型酶。更具体地，本发明提供可从Thermotoga属的微生物获得的新型木聚糖酶。本发明还涉及制备这些木聚糖酶的方法，含有这些木聚糖酶的试剂，以及这些木聚糖酶用于木质纤维素纸浆脱木质素的用途。

129. 发明申请

WO1993018785A1 NOVEL MEDICAMENT 审中-公开
标题翻译：新药
公开(公告)号：WO1993018785A1
公开(公告)日：1993-09-30
申请号：PCT/DK1993000098
申请日：1993-03-18
申请人： NOVO NORDISK A/S , KIRK, Ole , PRIDAL, Lone
发明人： NOVO NORDISK A/S
IPC分类号： A61K37/28
CPC分类号： A61K38/26 , A61K9/0043 , A61K47/24
摘要： The present invention relates to novel medicaments containing GLP-1(7-37), GLP-1(7-36)amide or analogues or derivatives thereof and a phospholipid. The medicaments which are suited for nasal administration have a very favourable absorption profile.
摘要翻译：本发明涉及含有GLP-1（7-37），GLP-1（7-36）酰胺或其类似物或衍生物和磷脂的新型药物。适合于鼻内给药的药物具有非常有利的吸收特征。

130. 发明申请

WO1993017012A1 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF 审中-公开
标题翻译： 2,3,4,5-四氢-1H-3-苯并嗪和其药学上可接受的酸添加剂
公开(公告)号：WO1993017012A1
公开(公告)日：1993-09-02
申请号：PCT/DK1993000041
申请日：1993-02-05
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , FOGED, Christian , HOHLWEG, Rolf , NIELSEN, Erik, Bardrum
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： 2,3,4,5-Tetrahydro-1H-3-benzazepines having general formula (I) wherein R is Cl or Br; R and R are hydrogen, halogen, CF3, CN, NO2, or NH2. The compounds are useful in treatment of certain disorders in the central nervous system.
摘要翻译：具有通式（I）的2,3,4,5-四氢-1H-3-苯并氮杂其中R 1为Cl或Br; R 3和R 4是氢，卤素，CF 3，CN，NO 2或NH 2。该化合物可用于治疗中枢神经系统中的某些疾病。

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