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1. 发明申请

WO1994001532A1 ALKALOPHILIC BACILLUS sp. AC13 AND PROTEASE, XYLANASE, CELLULASE OBTAINABLE THEREFROM 审中-公开
标题翻译：阿尔卡洛派 AC13和PROTEASE，XYLANASE，可获得的纤维素
公开(公告)号：WO1994001532A1
公开(公告)日：1994-01-20
申请号：PCT/DK1993000218
申请日：1993-07-02
申请人： NOVO NORDISK A/S , OUTTRUP, Helle , DAMBMANN, Claus , OLSEN, Arne, Agerlin , BISGÅRD-FRANTZEN, Henrik , SCHÜLEIN, Martin
发明人： NOVO NORDISK A/S
IPC分类号： C12N01/20
CPC分类号： C12Y302/01032 , C11D3/386 , C11D3/38636 , C11D3/38645 , C12N9/2437 , C12N9/248 , C12N9/54 , C12R1/07 , C12Y302/01004 , C12Y302/01008 , D21C5/005
摘要： The present invention relates to novel microorganisms, novel enzymes obtainable herefrom, and to a method of producing the novel enzymes. More specifically, the invention relates to novel enzymes obtainable from strains of the novel alkalophilic species (Bacillus sp. AC13). Moreover, the invention relates to a method for producing the enzymes of the invention, and to the use of the enzymes in detergents or in the paper pulp industry.
摘要翻译：本发明涉及新的微生物，可从其获得的新型酶以及生产新型酶的方法。更具体地，本发明涉及可从新型嗜碱性物种（Bacillus sp.AC13）的菌株获得的新型酶。此外，本发明涉及本发明的酶的制备方法，以及在洗涤剂或造纸工业中使用酶的方法。

2. 发明申请

WO1997030148A1 CONJUGATION OF POLYPEPTIDES 审中-公开
标题翻译：多糖的结合
公开(公告)号：WO1997030148A1
公开(公告)日：1997-08-21
申请号：PCT/DK1997000051
申请日：1997-02-07
申请人： NOVO NORDISK A/S , BISGÅRD-FRANTZEN, Henrik , OLSEN, Arne, Agerlin , PRENTO, Annette
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/96
CPC分类号： A61Q9/02 , A61K8/66 , A61K8/88 , A61K47/56 , A61K2800/57 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C11D3/3845 , C11D3/386 , C12N9/96 , C12N11/02 , C12N11/08 , C12N11/10
摘要： The present invention relates to polypeptide conjugates with reduced allergenicity comprising a polymeric carrier molecule having two or more polypeptide molecules coupled thereto. It is also the object of the invention to provide a process for producing said polypeptide conjugates with reduced allergenicity, compositions comprising a such polypeptide conjugate with reduced allergenicity, the use of said polypeptide conjugate for a number of industrial applications, such as the use in personal care products and in detergent compositions.
摘要翻译：本发明涉及具有降低的变应原性的多肽缀合物，其包含具有与其偶联的两个或多个多肽分子的聚合物载体分子。本发明的另一个目的是提供一种生产具有降低的变应原性的所述多肽缀合物的方法，包含具有降低的变应原性的这种多肽缀合物的组合物，所述多肽缀合物在多种工业应用中的用途，例如在个人用途护理产品和洗涤剂组合物。

3. 发明申请

WO1994004664A1 NEW XYLANASES HAVING HIGH ACTIVITY AND STABILITY AT ALKALINE CONDITIONS AND HIGH TEMPERATURES 审中-公开
标题翻译：在碱性条件和高温条件下具有高活性和稳定性的新型XYLANASES
公开(公告)号：WO1994004664A1
公开(公告)日：1994-03-03
申请号：PCT/DK1993000277
申请日：1993-08-25
申请人： NOVO NORDISK A/S , OLSEN, Arne, Agerlin , INGVORSEN, Kjeld , BISGÅRD-FRANTZEN, Henrik , PATKAR, Shamkant, Anant , HALKIER, Torben
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/24
CPC分类号： C12Y302/01032 , A21D8/042 , A23K20/189 , C12N9/248 , C12Y302/01008 , D21C5/005
摘要： The present invention relates to novel xylanolytic enzymes obtainable from strains of alkalophilic Bacillus sp. Moreover, the invention relates to a method for producing the enzymes and the use of the enzymes in the pulp and paper industry.
摘要翻译：本发明涉及从嗜碱芽孢杆菌属菌株获得的新型木聚糖酶。此外，本发明涉及在纸浆和造纸工业中生产酶的方法和酶的使用。

4. 发明申请

WO1996023873A1 AMYLASE VARIANTS 审中-公开
公开(公告)号：WO1996023873A1
公开(公告)日：1996-08-08
申请号：PCT/DK1996000056
申请日：1996-02-05
申请人： NOVO NORDISK A/S , BISGÅRD-FRANTZEN, Henrik , SVENDSEN, Allan , BORCHERT, Torben, Vedel
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C12C5/004 , C11D3/386 , C11D3/38672 , C11D3/38681 , C12N9/2417 , D06L1/14 , D21C5/005 , D21C5/022 , D21C5/027 , D21H17/005 , D21H17/28 , Y02E50/17 , Y02W30/648
摘要： A variant of a parent alpha -amylase, which parent alpha -amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80 % homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against a alpha -amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding a alpha -amylase having one of these amino acid sequences; in which variant: (a) at least one amino acid residue of the parent alpha -amylase has been deleted; and/or (b) at least one amino acid residue of the parent alpha -amylase has been replaced by a different amino acid residue; and/or (c) at least one amino acid residue has been inserted relative to the parent alpha -amylase; the variant having alpha -amylase activity and exhibiting at least one of the following properties relative to the parent alpha -amylase: increased thermostability; increased stability towards oxidation; and reduced Ca dependency; with the proviso that the amino acid sequence of the variant is not identical to any of the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 7, respectively.
摘要翻译：母体α-淀粉酶的变体，其母体α-淀粉酶（i）具有选自SEQ ID No.1，SEQ ID No.2，SEQ ID No.3和SEQ SEQ ID No.3所示的氨基酸序列的氨基酸序列编号7; 或（ii）与这些氨基酸序列中的一个或多个显示至少80％的同源性; 和/或显示与针对具有这些氨基酸序列之一的α-淀粉酶产生的抗体的免疫交叉反应性; 和/或由与编码具有这些氨基酸序列之一的α-淀粉酶的DNA序列相同的探针杂交的DNA序列编码; 在该变体中：（a）母体α-淀粉酶的至少一个氨基酸残基已被缺失; 和/或（b）母体α-淀粉酶的至少一个氨基酸残基被不同的氨基酸残基替代; 和/或（c）相对于母体α-淀粉酶插入至少一个氨基酸残基; 所述变体具有α-淀粉酶活性并且相对于母体α-淀粉酶显示出至少一种以下性质：增加的热稳定性; 提高氧化稳定性; 并减少Ca 2+依赖性; 条件是变体的氨基酸序列分别与SEQ ID No.1，SEQ ID No.2，SEQ ID No.3和SEQ ID No.7所示的任何氨基酸序列不同。

5. 发明申请

WO1994002597A1 MUTANT 'alpha'-AMYLASE, DETERGENT, DISH WASHING AGENT, AND LIQUEFACTION AGENT 审中-公开
标题翻译：突变型α-甲基化酶，洗涤剂，DISH洗涤剂和液化剂
公开(公告)号：WO1994002597A1
公开(公告)日：1994-02-03
申请号：PCT/DK1993000230
申请日：1993-07-06
申请人： NOVO NORDISK A/S , SVENDSEN, Allan , BISGÅRD-FRANTZEN, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C11D3/386 , C12N9/2414 , C12N9/2417
摘要： In the mutant alpha -amylase one or more of the methionine amino acid residues is exchanged with any amino acid residue except for Cys and Met. The thus produced mutant alpha -amylase exhibits an improved stability in the presence of oxidizing agents and an improved thermoactivity at moderate low pH values. The mutant alpha -a amylase is well suited as an additive to detergents, dish washing agents and liquefaction agents.
摘要翻译：在突变型α-淀粉酶中，一个或多个甲硫氨酸氨基酸残基与除Cys和Met之外的任何氨基酸残基交换。由此产生的突变型α-淀粉酶在中等低pH值下表现出在氧化剂存在下的改进的稳定性和改进的热活性。突变体α-α淀粉酶非常适合作为洗涤剂，洗碟剂和液化剂的添加剂。

6. 发明申请

WO1998016633A1 ALPHA-AMYLASE FUSED TO CELLULOSE BINDING DOMAIN, FOR STARCH DEGRADATION 审中-公开
标题翻译：融合蛋白质结合域的ALPHA-AMYLASE，用于淀粉降解
公开(公告)号：WO1998016633A1
公开(公告)日：1998-04-23
申请号：PCT/DK1997000448
申请日：1997-10-13
申请人： NOVO NORDISK A/S , BJORNVAD, Mads , PEDERSEN, Sven , SCHULEIN, Martin , BISGÅRD-FRANTZEN, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/26
CPC分类号： C12N9/2457 , C07K2319/00 , C12N9/2428 , C12N9/2451 , C12N9/246 , C12Y302/01001 , C12Y302/01041 , C12Y302/01068 , C13K1/06
摘要： The invention relates to a starch conversion method wherein the starch substrate is treated in aqueous medium with an CBD/enzyme hybrid. Further, the invention also relates to an isolated DNA sequence encoding a stable CBD/enzyme hybrid, a DNA construct comprising said DNA sequence of the invention, an expression vector comprising the DNA sequence of the invention, and a CBD/enzyme hybrid.
摘要翻译：本发明涉及淀粉转化方法，其中淀粉底物在水性介质中用CBD /酶杂交体处理。此外，本发明还涉及编码稳定的CBD /酶杂交物的分离的DNA序列，包含本发明的所述DNA序列的DNA构建体，包含本发明的DNA序列的表达载体和CBD /酶杂交体。

7. 发明申请

WO1997041213A1 'alpha'-AMYLASE MUTANTS 审中-公开
标题翻译： α-AMYLASE突变体
公开(公告)号：WO1997041213A1
公开(公告)日：1997-11-06
申请号：PCT/DK1997000197
申请日：1997-04-30
申请人： NOVO NORDISK A/S , SVENDSEN, Allan , BORCHERT, Torben, Vedel , BISGÅRD-FRANTZEN, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C12N9/2417 , C11D3/386 , C12P19/02 , C12P19/14
摘要： The invention relates to a variant of a parent Termamyl-like a-a mylase, which variant has a-amylase activity and exhibits an alt eration in at least one of the following properties relative to said parent a-amylase: substrate specificity, substrate bindin g, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca dependency and specific activity.
摘要翻译：本发明涉及母体类戊酰样α-淀粉酶的变体，该变体具有α-淀粉酶活性，并且相对于所述亲本α-淀粉酶具有以下特性中的至少一个特征：底物特异性，底物结合蛋白，底物裂解模式，热稳定性，pH /活性分布，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性和比活性。

8. 发明申请

WO1995010603A1 AMYLASE VARIANTS 审中-公开
公开(公告)号：WO1995010603A1
公开(公告)日：1995-04-20
申请号：PCT/DK1994000370
申请日：1994-10-05
申请人： NOVO NORDISK A/S , BISGÅRD-FRANTZEN, Henrik , BORCHERT, Torben, Vedel , SVENDSEN, Allan , THELLERSEN, Marianne , VAN DER ZEE, Pia
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C12N9/2417 , C11D3/386 , D06L1/14
摘要： A variant of a parent alpha -amylase enzyme having an improved washing and/or dishwashing performance as compared to the parent enzyme, wherein one or more amino acid residues of the parent enzyme have been replaced by a different amino acid residue and/or wherein one or more amino acid residues of the parent alpha -amylase have been deleted and/or wherein one or more amino acid residues have been added to the parent alpha -amylase enzyme, provided that the variant is different from one in which the methionine residue in position 197 of a parent B. licheniformis alpha -amylase has been replaced by alanine or threonine, as the only modification being made. The variant may be used for washing and dishwashing.
摘要翻译：与母体酶相比，具有改善的洗涤和/或餐具洗涤性能的母体α-淀粉酶的变体，其中母体酶的一个或多个氨基酸残基已被不同的氨基酸残基替代和/或其中一个或更多的母体α-淀粉酶的氨基酸残基已经缺失和/或其中一个或多个氨基酸残基已加入到母体α-淀粉酶中，条件是该变体不同于其中位置上的甲硫氨酸残基的变体作为唯一的修改，母本地衣芽孢杆菌α-淀粉酶的197已被丙氨酸或苏氨酸代替。该变体可用于洗涤和洗碗。

9. 发明申请

WO1996023874A1 A METHOD OF DESIGNING ALPHA-AMYLASE MUTANTS WITH PREDETERMINED PROPERTIES 审中-公开
标题翻译：设计具有预定特性的α-淀粉酶突变体的方法
公开(公告)号：WO1996023874A1
公开(公告)日：1996-08-08
申请号：PCT/DK1996000057
申请日：1996-02-05
申请人： NOVO NORDISK A/S , SVENDSEN, Allan , BISGÅRD-FRANTZEN, Henrik , BORCHERT, Torben, Vedel
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C12N9/2417 , C11D3/386
摘要： A method of constructing a variant of a parent Termamyl-like alpha -amylase, which variant has alpha -amylase activity and at least one altered property as compared to the parent alpha -amylase, comprises i) analysing the structure of the parent Termamyl-like alpha -amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like alpha -amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like alpha -amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like alpha -amylase variant, which as compared to the parent Termamyl-like alpha -amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and iii) testing the resulting Termamyl-like alpha -amylase variant for the property in question.
摘要翻译：构建母体类戊酰样α-淀粉酶的变体的方法，该变体与亲本α-淀粉酶相比具有α-淀粉酶活性和至少一种改变的性质，其包括：i）分析亲本类戊酰样的结构以鉴定至少一个氨基酸残基或至少一个类甲酰样α-淀粉酶结构的结构部分，该氨基酸残基或结构部分被认为与改变母体类戊酰样物质的性质相关 α-淀粉酶（基于结构或功能考虑评估），ii）构建与母体类戊酰样α-淀粉酶相比的类戊酰样α-淀粉酶变体，其在氨基酸残基或在i）中鉴定的结构部分，以便改变该性质，和iii）测试所得到的类戊酰样α-淀粉酶变体。

10. 发明申请

WO1995026397A1 ALKALINE BACILLUS AMYLASE 审中-公开
标题翻译：碱性巴豆酵母
公开(公告)号：WO1995026397A1
公开(公告)日：1995-10-05
申请号：PCT/DK1995000142
申请日：1995-03-29
申请人： NOVO NORDISK A/S , OUTTRUP, Helle , BISGÅRD-FRANTZEN, Henrik , OSTERGAARD, Peter, Rahbek , RASMUSSEN, Michael, Dolberg , VAN DER ZEE, Pia
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/28
CPC分类号： C11D3/38609 , C11D3/386 , C11D3/38618 , C12N9/2417 , D06L1/14 , D21C5/005 , D21C5/02 , D21H11/14 , D21H17/005 , D21H17/67 , Y02W30/648
摘要： An alpha -amylase characterized by having a specific activity at least 25 % higher than the specific activity of Termamyl3 at a temperature in the range of 25 DEG C to 55 DEG C and at a pH value in the range of pH 8 to pH 10.
摘要翻译：其特征在于在25℃至55℃的温度范围内和pH值在pH8至pH10范围内具有比Termamyl3的比活性高至少25％的比活性的α-淀粉酶。

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