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111. 发明申请

WO2009134924A1 IN VIVO MEASUREMENT OF TRACE ELEMENTS IN BONE BY X-RAY FLUORESCENCE 审中-公开
标题翻译：通过X射线荧光测量骨骼中的跟踪元素
公开(公告)号：WO2009134924A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042163
申请日：2009-04-29
申请人： THERMO NITON ANALYZERS LLC , GRODZINS, Lee
发明人： GRODZINS, Lee
IPC分类号： G01N23/223 , A61B6/00
CPC分类号： A61B6/583 , A61B6/482 , A61B6/485 , A61B6/505 , G01N2223/076 , G01N2223/6123
摘要： Methods for in vivo measurement of lead or other trace elements in bone by x-ray fluorescence (XRF) without independent measurement of underlying tissue thickness are disclosed. In one method, the lead concentration is calculated based on the intensity of a first characteristic fluoresced peak and a function having as an argument the intensity ratio of first and second characteristic fluoresced peaks, with at least one parameter of the function being empirically determined by measurements of calibration phantoms having differing thicknesses of tissue surrogate material. In another method, the lead concentration is measured by estimating tissue thickness based on the intensity of the Compton scattering peak, or ratio of Compton/Rayleigh intensities, and the intensity of a characteristic fluoresced x-ray peak corrected for attenuation by tissue of the estimated thickness. Also disclosed is a method for determining the calcium concentration and density of bone based on XRF spectrum data.
摘要翻译：公开了通过x射线荧光（XRF）体内测量骨中的铅或其他微量元素而不独立测量下面的组织厚度的方法。在一种方法中，基于第一特征荧光峰的强度和作为第一和第二特征荧光峰的强度比作为参数的函数来计算铅浓度，其中该函数的至少一个参数由经度由测量的校准体模具有不同厚度的组织替代材料。在另一种方法中，通过基于康普顿散射峰的强度或康普顿/瑞利强度的比例估计组织厚度，以及通过组织校正的特征荧光x射线峰值的强度来测量铅浓度。厚度。还公开了基于XRF光谱数据确定骨的钙浓度和密度的方法。

112. 发明申请

WO2009120758A1 ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 审中-公开
标题翻译：用于多种模式的VIVO TOMOGRAPHIC成像的动物持有人
公开(公告)号：WO2009120758A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038213
申请日：2009-03-25
申请人： VISEN MEDICAL, INC. , YARED, Wael, I. , WILSON, Andrew, K.
发明人： YARED, Wael, I. , WILSON, Andrew, K.
IPC分类号： A61B6/04 , A61D3/00
CPC分类号： A61B6/045 , A61B5/7285 , A61B6/0421 , A61B6/485 , A61B6/508 , A61B6/583 , A61B8/543 , A61B2503/40
摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.
摘要翻译：本发明有助于在相同或不同的物理位置的多个单一模态或多模态成像工作站上运输固定的被麻醉的小动物，而不损失对象位置信息。动物持有人与临床前动物成像站如micro-CT，micro-MR，micro-PET，micro-SPECT和FMT兼容。动物保持器被配置为通过（例如，装配在这些器械的）各个成像室中来容纳，并且由与所使用的所有成像模式兼容的材料制成。在某些实施例中，集成的一组基准标记井容纳在多个平面中同时由几种模态拾取的标记的分配。然后，基准标记在标准图像处理或图像分析软件中进行对准，具有简单的图像平移和旋转操作，而不需要更高级的缩放，失真或其他操作。动物保持器可选地还包括用于向动物提供吸入麻醉的系统，例如异氟烷，并且被设计成装配在提供加热以使动物体温过低最小化或防止动物低体温的成像工作站内部或外部的相同容器中。

113. 发明申请

WO2007106495A3 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICES, METHODS, AND SYSTEMS 审中-公开
标题翻译：最小的入侵肺容量减少装置，方法和系统
公开(公告)号：WO2007106495A3
公开(公告)日：2008-07-17
申请号：PCT/US2007006339
申请日：2007-03-13
申请人： PNEUMRX INC , THOMPSON DAVID , ARONSON NATHAN , WU PATRICK , LEHRBERG DAVID , MATHIS MARK , VASQUEZ JAIME
发明人： THOMPSON DAVID , ARONSON NATHAN , WU PATRICK , LEHRBERG DAVID , MATHIS MARK , VASQUEZ JAIME
IPC分类号： A61F2/04
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
摘要翻译：公开了一种肺容积减小系统，其包括可植入装置，其适于以递送配置递送到患者的肺气道，并且改变为展开配置以弯曲肺气道。本发明还公开了一种弯曲患者的肺气道的方法，包括将装置以输送构造插入气道并将装置弯曲成展开构型，从而弯曲气道。

114. 发明申请

WO2007106495A2 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICES, METHODS, AND SYSTEMS 审中-公开
标题翻译：最小的入侵肺容量减少装置，方法和系统
公开(公告)号：WO2007106495A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006339
申请日：2007-03-13
申请人： PNEUMRX, INC. , THOMPSON, David , ARONSON, Nathan , WU, Patrick , LEHRBERG, David , MATHIS, Mark , VASQUEZ, Jaime
发明人： THOMPSON, David , ARONSON, Nathan , WU, Patrick , LEHRBERG, David , MATHIS, Mark , VASQUEZ, Jaime
IPC分类号： A61F2/20 , A61M16/00
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
摘要翻译：公开了一种肺容积减小系统，其包括可植入装置，其适于以递送配置递送到患者的肺气道并且改变为展开的配置以弯曲肺气道。本发明还公开了一种弯曲患者的肺气道的方法，包括将装置以输送构造插入气道并将装置弯曲成展开构型，从而弯曲气道。

115. 发明申请

WO2005030284A3 POLYMERIC MARKER WITH HIGH RADIOPACITY FOR USE IN MEDICAL DEVICES 审中-公开
标题翻译：具有高放射性的聚合物标记用于医疗器械
公开(公告)号：WO2005030284A3
公开(公告)日：2005-07-07
申请号：PCT/US2004030526
申请日：2004-09-21
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： BAVARO VINCENT PETER , SIMPSON JOHN ARTHUR , D AQUANNI PETER , BALDWIN AARON
IPC分类号： A61B5/107 , A61B19/00 , A61F2/06 , A61F2/84 , A61L29/18 , A61L31/18 , A61M25/01
CPC分类号： A61L31/125 , A61B5/1076 , A61B5/6851 , A61B5/6853 , A61B6/12 , A61B6/485 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61L29/18 , A61L31/18 , A61M25/0012 , A61M25/0108 , A61M25/09 , A61M25/1027 , Y10T156/1089 , Y10T428/12493 , Y10T428/1372 , Y10T428/139
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped. Particles of a specific particle size distribution and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有均匀成型的粉末状的不透射线剂，在聚合物标记物中实现高的射线不透性。特定粒度分布的颗粒和润湿剂。产生标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定在适当的位置。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量损伤，同时球囊导管的标记允许气囊相对于病变适当定位。

116. 发明申请

WO2004078043A1 METHOD AND IMAGING SYSTEM FOR IMAGING THE SPATIAL DISTRIBUTION OF AN X-RAY FLUORESCENCE MARKER 审中-公开
标题翻译：用于成像X射线荧光标记的空间分布的方法和成像系统
公开(公告)号：WO2004078043A1
公开(公告)日：2004-09-16
申请号：PCT/IB2004/000543
申请日：2004-03-02
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , HARDING, Geoffrey , SCHLOMKA, Jens-Peter , MARTENS, Gerhard
发明人： HARDING, Geoffrey , SCHLOMKA, Jens-Peter , MARTENS, Gerhard
IPC分类号： A61B6/00
CPC分类号： A61B6/485 , A61B6/00 , A61B6/4092 , G01N23/223 , G01N2223/076
摘要： The invention describes a method of generating metabolic images of an investigation region (3) of a body (1) by irradiating an X-ray fluorescence marker in that region and detecting the resulting X-ray fluorescence with a fluorescence detector (30). A fan beam (12) is used as a source of primary X-radiation, thus allowing the scanning of a whole body slice (3) in one step. The fluorescence image may be directly measured, e.g. by mapping voxels (104) of the investigation region onto pixels (134) of the detector (130) with the help of a pinhole collimator (132), or it may be reconstructed by procedures of computed tomography. Moreover, a morphological image may be generated by simultaneously recording X-ray transmission through the body (1).
摘要翻译：本发明描述了通过在该区域中照射X射线荧光标记物并用荧光检测器（30）检测所得到的X射线荧光来产生身体（1）的调查区域（3）的代谢图像的方法。风扇光束（12）被用作初级X辐射源，从而允许在一个步骤中扫描全身切片（3）。可以直接测量荧光图像，例如，通过借助于针孔准直器（132）将调查区域的体素（104）映射到检测器（130）的像素（134）上，或者可以通过计算机断层摄影的程序来重构。此外，可以通过同时记录穿过身体（1）的X射线透射来产生形态学图像。

117. 发明申请

WO03022221A3 METHOD AND APPARATUS FOR ENDOBRONCHIAL DIAGNOSIS 审中-公开
标题翻译：方法和装置用于内分泌诊断
公开(公告)号：WO03022221A3
公开(公告)日：2003-07-03
申请号：PCT/US0228863
申请日：2002-09-10
申请人： PULMONX
发明人： KOTMEL ROBERT , SOLTESZ PETER , WONDKA ANTHONY , PERKINS RODNEY
IPC分类号： A61B5/055 , A61B5/08 , A61B5/083 , A61B5/087 , A61B8/08 , A61M16/04 , A61B5/00
CPC分类号： A61B5/6853 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/082 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/7278 , A61B5/742 , A61B6/481 , A61B6/485 , A61B8/12 , A61B2562/0247 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0486 , A61M25/0026 , A61M25/10 , A61M2016/0413 , A61M2025/1052
摘要： The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance. In addition, the diseased lung compartments may be temporarily isolated and the measurement tests performed to determine the affect of the isolation on overall lung performance. As a result, the most beneficial treatment options may be selected.
摘要翻译：本发明提供用于评估单个肺隔室中肺部疾病水平的系统，方法，装置和试剂盒。肺隔室包括例如肺的子部分，例如叶，片段或子段。通过测量单个肺隔室，可以通过确定反映个体子部分或肺室的疾病参数的值来更精确地定义肺系统的疾病水平。同样，隔室也可以单独成像以提供进一步的测量信息。一旦个体隔室被表征，可以基于反映例如疾病水平或治疗需要的多个变量来比较和排名。可以通过在视觉显示器上同时显示这样的变量或图像来辅助这种比较。此外，可以在肺部作为整体或在两个肺上进行相同的测试，并且确定患病肺隔室对整体肺功能的影响。此外，可以暂时隔离患病的肺隔室，并进行测量测试以确定隔离对整体肺功能的影响。因此，可以选择最有益的治疗方案。

118. 发明申请

WO2018055433A1 AUTONOMOUSLY CONTROLLABLE PULL WIRE INJECTION CATHETER, ROBOTIC SYSTEM COMPRISING SAID CATHETER AND METHOD FOR OPERATING THE SAME 审中-公开
标题翻译：自动控制的拉线注射导管，包括所述导管的机器人系统及其操作方法
公开(公告)号：WO2018055433A1
公开(公告)日：2018-03-29
申请号：PCT/IB2016/055617
申请日：2016-09-21
申请人： LAW, Peter
发明人： LAW, Peter
IPC分类号： A61B34/30 , A61B34/32 , A61M25/01 , A61M25/08
CPC分类号： A61M25/0147 , A61B5/055 , A61B6/485 , A61B8/12 , A61B34/30 , A61B34/32 , A61B34/71 , A61B2018/00351 , A61B2018/00642 , A61B2018/00875 , A61B2034/2051 , A61B2034/2061 , A61B2034/301 , A61B2090/064 , A61B2090/065 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61M25/0026 , A61M25/0041 , A61M25/005 , A61M25/0084 , A61M25/0133 , A61M25/0662 , A61M2025/0047 , A61M2025/0089 , A61M2025/015 , A61M2025/0166 , A61M2025/0681 , A61M2205/3306 , A61M2205/3317 , A61M2205/332 , A61M2205/50 , A61M2205/70
摘要： The invention relates to an autonomously controllable pull wire injection catheter 1 comprising an outer catheter guide 2, 33 having an outer catheter guide casing 39 and an inner operating catheter 3, 31 having an inner operating catheter casing 16, wherein the inner operating catheter 3, 31 comprises a catheter handle 30, a catheter tip 10, at least one needle 5 that is connected to at least one source of medicinal solution via at least one needle channel 4, 26, at least one contact force sensor 9a-f, 25, at least one electrode 7, 24, at least four actuator driven pull wires 12-15, 20-23 for moving the tip 10 of the inner operating catheter 3, 31, wherein the inner diameter of the outer catheter guide casing 39 is larger than the outer diameter of the inner operating catheter casing 16, characterized in that the inner operating catheter 3, 31 is adapted to be controlled by a microcontroller, wherein the at least one electrode 7, 24 and the at least one contact force sensor 9a-f, 25 are adapted for data exchange with the microcontroller, and wherein the at least four actuator driven pull wires 12-15, 20-23 are attached inside the inner operating catheter 3, 31 perpendicular to each other at a pre-defined distance from the tip 10 in the distal region 6. The invention also relates to a robotic system comprising said autonomously controllable pull wire injection catheter 1 and a method for operating the same.
摘要翻译：本发明涉及一种可自主控制的拉线注射导管1，其包括具有外导管引导壳体39的外导管引导件2,33和具有内操作导管壳体16的内操作导管3,31 ，其中内部操作导管3,31包括导管手柄30，导管尖端10，至少一个针5，其经由至少一个针通道4,26连接到至少一个药物源，至少一个接触部力传感器9a-f，25，至少一个电极7,24，至少四个致动器驱动拉线12-15,20-23，用于移动内操作导管3,31的尖端10，其中，外导管引导壳体39大于内操作导管壳体16的外径，其特征在于，内操作导管3,31适于由微控制器控制，其中至少一个电极7,24和at 至少一个接触力sen 接收器9a-f，25适于与微控制器进行数据交换，并且其中至少四个致动器驱动的牵拉线12-15,20-23以预定方式彼此垂直地附接在内部操作导管3,31内部，本发明还涉及包括所述自主可控拉丝注射导管1的机器人系统及其操作方法。

119. 发明申请

WO2016181388A1 BODY WORN ANTENNA 审中-公开
标题翻译：身体天天
公开(公告)号：WO2016181388A1
公开(公告)日：2016-11-17
申请号：PCT/IL2016/050489
申请日：2016-05-09
申请人： CHECK-CAP LTD.
发明人： PAHIMA, Yosi , KAPLAN, Maxim
IPC分类号： A61B1/00 , A61B5/00 , A61B6/00 , A61M31/00
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/062 , A61B5/066 , A61B6/4057 , A61B6/4258 , A61B6/483 , A61B6/485 , A61B6/56 , A61B2562/166 , H01Q1/273 , H01Q1/38 , H01Q9/285
摘要： A wearable antenna for communicating between an external transceiver and a capsule inside the gastrointestinal tract of a user, including a printed circuit board for forming a conducting pattern on a first face and on a second face of the printed circuit board; a first conducting pattern on the first face of the printed circuit board, including: a) an almost completely split conducting elongated bar across a center of the printed circuit board; b) an identical main conducting transmission area on each side of the almost completely split elongated bar; c) a thin conducting line respectively connecting between each side of the almost completely split elongated bar and the transmission area; a second conducting pattern on the second face of the printed circuit board including a U shaped conductor; wherein the U shaped conductor is positioned to serve as a balun for the conducting pattern on the first face.
摘要翻译：一种用于在用户的胃肠道内的外部收发器和胶囊之间进行通信的可佩戴天线，包括用于在印刷电路板的第一面和第二面上形成导电图案的印刷电路板; 在印刷电路板的第一面上的第一导电图案，包括：a）穿过印刷电路板的中心的几乎完全分开的导电细长条; b）在几乎完全分裂的细长条的每一侧上具有相同的主传导区域; c）分别连接在几乎完全分裂的细长条的每一侧与传输区之间的薄导电线; 在包括U形导体的印刷电路板的第二面上的第二导电图案; 其中U形导体被定位成用作第一面上的导电图案的平衡 - 不平衡变换器。

120. 发明申请

WO2016059631A2 NANO PARTICLE DETECTION WITH X-RAY CAPSULE 审中-公开
标题翻译：用X射线胶囊进行纳米颗粒检测
公开(公告)号：WO2016059631A2
公开(公告)日：2016-04-21
申请号：PCT/IL2015051016
申请日：2015-10-12
申请人： CHECK CAP LTD
发明人： KIMCHY YOAV , LEWKOWICZ SHLOMO
IPC分类号： A61B6/03
CPC分类号： A61B6/50 , A61B6/4057 , A61B6/4241 , A61B6/425 , A61B6/485 , A61K49/0065 , A61K49/0428 , B82Y15/00 , G01N23/223
摘要： A colon imaging system, including an imaging capsule, having: a. a radiation source providing X-Ray and gamma radiation with energies sufficient to induce X-Ray fluorescence from nanoparticles that adhere to cancerous tissue, and which were administered to a patient in a solution prior to examining the colon with the imaging capsule; b. a detector for detecting particle energy of particles emitted responsive to the provided radiation and forming count information disclosing a number of particles detected for each energy level; c. a transceiver for transferring the count information to an external computer for analysis, and also having a computer for constructing images of an inside of the colon based on the count information; wherein the images provide an indication of locations in the colon of which the nanoparticles adhere to.
摘要翻译：包括成像胶囊的结肠成像系统，具有：a。提供X射线和γ射线的辐射源，其能量足以从附着于癌组织的纳米颗粒诱导X射线荧光，并且在用成像胶囊检查结肠之前将其施用于溶液中的患者; 湾检测器，用于检测响应于所提供的辐射发射的颗粒的颗粒能量，并形成计数信息，其显示针对每个能级检测的多个颗粒; C。用于将计数信息传送到外部计算机进行分析的收发器，还具有基于计数信息构建冒号内部的图像的计算机; 其中图像提供纳米颗粒附着于其的结肠中的位置的指示。

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