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111. 发明申请

WO1994014940A1 ALKALINE LIPASE 审中-公开
标题翻译：碱性脂肪酸
公开(公告)号：WO1994014940A1
公开(公告)日：1994-07-07
申请号：PCT/DK1993000442
申请日：1993-12-22
申请人： NOVO NORDISK A/S , HASHIDA, Miyoko , IKEGAMI, Naoko , ABO, Masanobu , TAKAMURA, Yukiko
发明人： NOVO NORDISK A/S
IPC分类号： C11D03/386
CPC分类号： C12R1/545 , C11D3/38627 , C12N9/20
摘要： A highly alkaline, positionally non-specific lipase can be obtained from strains of Streptomyces, cluster 1. Strains of cluster 1 of Streptomyces were not previously known to produce lipase. The lipase preparation has more than 50 % of its optimum activity at pH 10 and is useful, e.g., in detergents.
摘要翻译：可以从链霉菌（Streptomyces），簇1的菌株获得高度碱性的位置非特异性脂肪酶。链霉菌簇1的菌株以前不知道产生脂肪酶。脂肪酶制剂在pH 10下具有超过其最佳活性的50％，并且可用于例如洗涤剂中。

112. 发明申请

WO1994014832A1 PURINE DERIVATIVES 审中-公开
标题翻译：嘌呤衍生物
公开(公告)号：WO1994014832A1
公开(公告)日：1994-07-07
申请号：PCT/DK1993000434
申请日：1993-12-21
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , LAU, Jesper , KNUTSEN, Lars, Jacob, Stray , SHEARDOWN, Malcolm , HANSEN, Anker, Jon
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , C07H19/16
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein X is halogen, trifluoromethyl, cyano, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylamino or C1-6-dialkylamino; R and R are H or straight or branched C1-6-alkyl or trifluoromethyl or R and R together form a cycloalkyl ring; Y is O, S, SO2, NH or N-alkyl; R is selected from optionally substituted heterocycles; R and R are hydrogen, benzoyl or C1-6-alkanoyl. The compounds have been found useful for treating central nervous system and cardiovascular ailments.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中X为卤素，三氟甲基，氰基，C 1-6 - 烷氧基，C 1-6 - 烷硫基，C 1-6 - 烷基氨基或C 1-6 - 二烷基氨基; R 1和R 4是H或直链或支链C 1-6 - 烷基或三氟甲基或R 1和R 4一起形成环烷基环; Y是O，S，SO 2，NH或N-烷基; R 5选自任选取代的杂环; R 6和R 7是氢，苯甲酰基或C 1-6 - 烷酰基。已经发现这些化合物可用于治疗中枢神经系统和心血管疾病。

113. 发明申请

WO1994014681A1 DISPENSER FOR CONSECUTIVE DISPENSING OF TABLETS 审中-公开
标题翻译：用于片剂分配的分配器
公开(公告)号：WO1994014681A1
公开(公告)日：1994-07-07
申请号：PCT/DK1993000424
申请日：1993-12-17
申请人： NOVO NORDISK A/S , CHRISTOFFERSEN, Peter, Bender , HANSEN, Ib
发明人： NOVO NORDISK A/S
IPC分类号： B65D83/04
CPC分类号： A61J7/04 , B65D83/0454 , B65D2583/0409 , B65D2583/0436 , B65D2583/049
摘要： A dispenser for consecutive dispensing tablets in a fixed order comprises cylindric body (1) defining along its periphery a number of juxtaposed vertical chutes (5) each accommodating a number of tablets piled on edge radially oriented in the body (1), a cup shaped dispensing part (2) comprising a bottom plate (8) having an upstanding cylindric wall (10) and forming a stop at the lower end of the chutes (5). An opening (11) in the cylindric wall (10) allows a tablet on edge to pass from the outside of the cup into the inner space thereof. Above the opening a protrusion (12) extends radially outwards from the cylindric wall into the space between a tablet abreast of the opening (11) and a possible overlying tablet in the chute, and a wall (13) adjacent to the opening (11) extends into the lower ends of the chutes (5). A detent mechanism (6, 7) makes the body (1) and the dispensing part (2) stepwise unidirectionnally rotatable in relation to each other, the number of steps corresponding to the number of chutes, and the direction of rotation being so that the chutes are moved from a position abreast of the opening (11) towards the radially extending wall (13).
摘要翻译：用于连续分配片剂的分配器以固定顺序包括圆柱形主体（1），其沿着其周边限定多个并置的垂直滑槽（5），每个平行的纵向滑槽（5）容纳多个堆叠在主体（1）中径向取向的边缘上的片剂，杯形分配部分（2）包括具有直立的圆柱形壁（10）的底板（8），并且在滑槽（5）的下端形成停止点。圆柱形壁（10）中的开口（11）允许边缘上的片剂从杯的外部进入其内部空间。在开口上方，突起（12）从圆柱形壁径向向外延伸到开口（11）的片剂和滑槽中可能的上覆片剂之间的空间以及与开口（11）相邻的壁（13）延伸到斜槽（5）的下端。制动机构（6,7）使得主体（1）和分配部分（2）能够相对于彼此逐向旋转，阶梯数对应于滑槽的数量，并且旋转方向使得滑槽从开口（11）的位置向径向延伸的壁（13）移动。

114. 发明申请

WO1994013743A1 METHOD FOR ISOLATION OF VEGETABLE OLEORESINS PRODUCIBLE BY HEXANE EXTRACTION 审中-公开
标题翻译：用于分离由HEXANE提取生产的蔬菜油蛋白的方法
公开(公告)号：WO1994013743A1
公开(公告)日：1994-06-23
申请号：PCT/DK1993000422
申请日：1993-12-16
申请人： NOVO NORDISK A/S , POMMER, Klaus
发明人： NOVO NORDISK A/S
IPC分类号： C09B61/00
CPC分类号： C12Y302/01 , C09B61/00 , C11B1/10 , C12Y302/01004 , C12Y302/01015 , C12Y302/01022 , C12Y302/01032 , C12Y304/21004
摘要： The vegetable oleoresins are produced by extraction of vegetable starting products comprising the oleoresins with a mixture of water and an organic acid immiscible with water. In this manner the use of hexane or other environmentally dangerous solvents is avoided, and also, the yield of oleoresins is improved.
摘要翻译：植物性油性树脂是通过将水和与水不混溶的有机酸的混合物萃取含有油树脂的植物性起始物来制造的。以这种方式避免使用己烷或其他环境危害的溶剂，并且改善了油树脂的产率。

115. 发明申请

WO1994012578A1 A PROCESS FOR THE TREATMENT OF CELLULOSIC FABRICS WITH CELLULASES 审中-公开
标题翻译：用纤维素处理细胞纤维织物的方法
公开(公告)号：WO1994012578A1
公开(公告)日：1994-06-09
申请号：PCT/US1993011629
申请日：1993-11-30
申请人： NOVO NORDISK A/S , SCREWS, Garrett, A. , PEDERSEN, Gitte
发明人： NOVO NORDISK A/S
IPC分类号： C09B67/00
CPC分类号： C12N9/2437 , C12Y302/01004 , D06M16/003
摘要： This invention relates to an improved cellulase treatment of cellulosic fabrics to improve fabric quality with respect to handle and appearance without loss of fabric wettability. Cellulosic fabrics are subjected to two treatments with cellulase. The resulting fabric has a soft and smooth feel and reduced pilling.
摘要翻译：本发明涉及纤维素织物改进的纤维素酶处理，以提高织物在手感和外观方面的质量，而不损失织物润湿性。用纤维素酶对纤维素织物进行两次处理。所得到的织物具有柔软和平滑的感觉并减少起球。

116. 发明申请

WO1994011525A1 IMPROVED RECOMBINANT PRODUCTION OF PROTEINS HAVING FACTOR VIII:C ACTIVITY 审中-公开
标题翻译：改进重组蛋白的生产具有因子VIII：C活性
公开(公告)号：WO1994011525A1
公开(公告)日：1994-05-26
申请号：PCT/DK1993000375
申请日：1993-11-17
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , RASMUSSEN, Mirella, Ezban , KONGERSLEV, Leif
IPC分类号： C12P21/02
CPC分类号： C07K14/755 , A61K38/00
摘要： A method for effecting an increased expression of recombinant proteins, especially proteins having Factor VIII:C activity in the presence of heparin is disclosed.
摘要翻译：公开了一种在肝素存在下实现重组蛋白，特别是具有因子VIII：C活性的蛋白质表达增加的方法。

117. 发明申请

WO1994007998A1 CELLULASE VARIANTS 审中-公开
标题翻译：纤维素酶变体
公开(公告)号：WO1994007998A1
公开(公告)日：1994-04-14
申请号：PCT/DK1993000327
申请日：1993-10-06
申请人： NOVO NORDISK A/S , SCHÜLEIN, Martin , FREDHOLM, Henrik , HJORT, Carsten, Mailand , RASMUSSEN, Grethe , NIELSEN, Egon , ROSHOLM, Peter
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06P5/02 , D06P5/137 , D06P5/158
摘要： A cellulase variant of a parent cellulase, e.g. a cellulase classified in family 45 such as a Humicola insolens 43 kD endoglucanase, comprising a cellulose binding domain (CBD), a catalytically active domain (CAD) and a region linking the cellulose binding domain and catalytically active domain (the linking region), wherein one more amino acid residues of the CBD, CAD or linking region is deleted or substituted by one or more amino acid residues and/or one or more amino acids are added to the linking region and/or another CBD is added at the opposite end of the catalytically active domain, has improved properties as regards e.g. alkaline activity, compatibility with detergent composition ingredients, particulate soil removal, colour clarification, defuzzing, depilling, harshness reduction, and sensitivity to anionic surfactants and peroxidase bleaching systems and is useful e.g. in detergent compositions, for textile treatment, in paper pulp processing, for animal feed and for stone washing of jeans.
摘要翻译：亲本纤维素酶的纤维素酶变体，例如例如分类在家族45中的纤维素酶，例如包含纤维素结合结构域（CBD），催化活性结构域（CAD）和连接纤维素结合结构域和催化活性结构域（连接区域）的区域的腐质霉43kD内切葡聚糖酶，其中 CBD，CAD或连接区的一个氨基酸残基被一个或多个氨基酸残基缺失或取代，和/或一个或多个氨基酸被添加到连接区和/或另一个CBD被加入到催化活性域，具有改进的性能，例如碱性活性，与洗涤剂组合物成分的相容性，颗粒污垢去除，颜色澄清，去污，去毛刺，粗糙度降低以及对阴离子表面活性剂和过氧化物酶漂白体系的敏感性。在洗涤剂组合物中，用于纺织品处理，纸浆加工，动物饲料和牛仔裤的石洗。

118. 发明申请

WO1994006788A1 A FUNGICIDAL COMPOUND 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO1994006788A1
公开(公告)日：1994-03-31
申请号：PCT/DK1993000293
申请日：1993-09-14
申请人： NOVO NORDISK A/S , BREINHOLT, Jens , NIELSEN, Ruby, Ione
发明人： NOVO NORDISK A/S
IPC分类号： C07D323/00
CPC分类号： C12P17/08 , A01N43/90 , A23K30/00 , A23L3/3499 , A23L3/3544 , B27K3/343 , B27K3/38 , C07D323/00 , C12R1/80
摘要： Compounds having general formula (I) or general formula (II). Compounds of formulae (I) or (II) have interesting antifungal activities and may, accordingly, be used as active ingredients in fungicidal compositions.
摘要翻译：具有通式（I）或通式（II）的化合物。式（I）或（II）的化合物具有有趣的抗真菌活性，因此可用作杀真菌组合物中的活性成分。

119. 发明申请

WO1994004035A1 USE OF LIPASE IN BAKING 审中-公开
标题翻译：在食品中使用脂肪
公开(公告)号：WO1994004035A1
公开(公告)日：1994-03-03
申请号：PCT/DK1993000274
申请日：1993-08-23
申请人： NOVO NORDISK A/S , OLESEN, Tine , QI SI, Joan , DONELYAN, Vahan
发明人： NOVO NORDISK A/S
IPC分类号： A21D08/04
CPC分类号： A21D8/042
摘要： A method of improving properties of a dough and/or a baked product made from dough by adding an enzyme preparation to the dough and/or to any ingredient of the dough and/or to any mixture of the dough ingredients, in which method: a) the enzyme preparation comprises a lipase of microbial origin and is added in an amount corresponding to at the most 2100 LU/kg of flour, or b) the dough is substantially free from added fat or contains only low amounts of added fat and the enzyme preparation comprises a lipase.
摘要翻译：一种通过向生面团和/或面团的任何成分和/或面团成分的任何混合物中加入酶制剂来改善由面团制成的生面团和/或焙烤产品的性质的方法，其中：）酶制剂包含微生物来源的脂肪酶，并且以相当于最多2100LU / kg面粉的量加入，或b）面团基本上不含加入的脂肪或仅含有少量添加的脂肪，并且酶制剂包含脂肪酶。

120. 发明申请

WO1994003592A1 STABILIZED AQUEOUS SOLUTIONS OF LIPASES 审中-公开
标题翻译：稳定的水溶性溶液
公开(公告)号：WO1994003592A1
公开(公告)日：1994-02-17
申请号：PCT/DK1993000257
申请日：1993-08-09
申请人： NOVO NORDISK A/S , BORCH, Kim , PATKAR, Shamkant, Anant
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C12N9/96 , C12N9/20
摘要： The invention relates to the use of a water-soluble inorganic salt as stabilizing additive in aqueous solutions of lipases derived from a member of the genus (Pseudomonas). More specifically, the invention provides a stabilized aqueous solution of lipases derived from members of the genus (Pseudomonas), and a method of stabilizing lipases derived from members of the genus (Pseudomonas) in an aqueous solution.
摘要翻译：本发明涉及水溶性无机盐作为稳定添加剂在衍生自属（假单胞菌属）成员的脂肪的水溶液中的用途。更具体地，本发明提供了稳定的衍生自（假单胞菌属）成员的脂肪酶水溶液，以及在水溶液中稳定来源于（假单胞菌属）成员的脂肪酶的方法。

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