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1. 发明申请

WO1994014681A1 DISPENSER FOR CONSECUTIVE DISPENSING OF TABLETS 审中-公开
标题翻译：用于片剂分配的分配器
公开(公告)号：WO1994014681A1
公开(公告)日：1994-07-07
申请号：PCT/DK1993000424
申请日：1993-12-17
申请人： NOVO NORDISK A/S , CHRISTOFFERSEN, Peter, Bender , HANSEN, Ib
发明人： NOVO NORDISK A/S
IPC分类号： B65D83/04
CPC分类号： A61J7/04 , B65D83/0454 , B65D2583/0409 , B65D2583/0436 , B65D2583/049
摘要： A dispenser for consecutive dispensing tablets in a fixed order comprises cylindric body (1) defining along its periphery a number of juxtaposed vertical chutes (5) each accommodating a number of tablets piled on edge radially oriented in the body (1), a cup shaped dispensing part (2) comprising a bottom plate (8) having an upstanding cylindric wall (10) and forming a stop at the lower end of the chutes (5). An opening (11) in the cylindric wall (10) allows a tablet on edge to pass from the outside of the cup into the inner space thereof. Above the opening a protrusion (12) extends radially outwards from the cylindric wall into the space between a tablet abreast of the opening (11) and a possible overlying tablet in the chute, and a wall (13) adjacent to the opening (11) extends into the lower ends of the chutes (5). A detent mechanism (6, 7) makes the body (1) and the dispensing part (2) stepwise unidirectionnally rotatable in relation to each other, the number of steps corresponding to the number of chutes, and the direction of rotation being so that the chutes are moved from a position abreast of the opening (11) towards the radially extending wall (13).
摘要翻译：用于连续分配片剂的分配器以固定顺序包括圆柱形主体（1），其沿着其周边限定多个并置的垂直滑槽（5），每个平行的纵向滑槽（5）容纳多个堆叠在主体（1）中径向取向的边缘上的片剂，杯形分配部分（2）包括具有直立的圆柱形壁（10）的底板（8），并且在滑槽（5）的下端形成停止点。圆柱形壁（10）中的开口（11）允许边缘上的片剂从杯的外部进入其内部空间。在开口上方，突起（12）从圆柱形壁径向向外延伸到开口（11）的片剂和滑槽中可能的上覆片剂之间的空间以及与开口（11）相邻的壁（13）延伸到斜槽（5）的下端。制动机构（6,7）使得主体（1）和分配部分（2）能够相对于彼此逐向旋转，阶梯数对应于滑槽的数量，并且旋转方向使得滑槽从开口（11）的位置向径向延伸的壁（13）移动。

2. 发明申请

WO1992021404A1 NASAL DISPENSER ACTUATED BY NOSE CONTACT 审中-公开
标题翻译：由NOSE联系人执行的NASAL分配器
公开(公告)号：WO1992021404A1
公开(公告)日：1992-12-10
申请号：PCT/DK1992000169
申请日：1992-05-27
申请人： NOVO NORDISK A/S , BECHGAARD, Erik , CHRISTOFFERSEN, Peter, Bender , HJORTKJAER, Rolf, Kuhlman , GIZURARSON, Sveinbjörn
发明人： NOVO NORDISK A/S
IPC分类号： A61M11
CPC分类号： A61M15/08 , A61M15/0025 , A61M15/009 , A61M2202/064
摘要： A dispenser for intranasal administration of one or several biologically active substances comprises a vessel (2) containing a pressurized propellant, at least one duct (10) connecting a nosepiece (9) with the vessel (2), and a valve (3) closing the passage from the vessel (2) to the nosepiece (9). The valve (3) has means (6) opening this valve (3) by nose contact when the nosepiece (9) is inserted in a nostril. The biologically active substance is placed in the duct (10) and is entrained by the propellant out through the nosepiece (9) and into the nostril when the valve (3) is activated by nose contact with the opening means (6). Preferably, two nosepieces are provided so that nosepieces may be concomitantly inserted in both nostrils, and the valve opening means (6) is placed between the two nosepieces to be activated by the septum of the nostrils when the nosepieces are inserted.
摘要翻译：用于鼻内施用一种或几种生物活性物质的分配器包括容纳加压推进剂的容器（2），将鼻梁（9）与血管（2）连接的至少一个管道（10）和闭合的阀（3）从船只（2）到鼻梁（9）的通道。阀（3）具有装置（6），当鼻梁（9）插入鼻孔时，通过鼻接触来打开该阀（3）。生物活性物质被放置在管道（10）中，并且当阀（3）通过与开启装置（6）鼻接触来启动时，被推进剂通过喷嘴（9）夹带并进入鼻孔。优选地，提供两个鼻子，使得鼻孔可以同时插入两个鼻孔中，并且当插入鼻孔时，阀打开装置（6）被放置在两个鼻子之间，以被鼻孔的隔膜激活。

3. 发明申请

WO1992008964A1 POWDER PIPETTE AND APPARATUS FOR HANDLING SUCH A PIPETTE 审中-公开
标题翻译：用于处理这种管子的粉末管和装置
公开(公告)号：WO1992008964A1
公开(公告)日：1992-05-29
申请号：PCT/DK1991000288
申请日：1991-09-25
申请人： NOVO NORDISK A/S , JENSEN, Erik, Thor , HANSEN, Ib
发明人： NOVO NORDISK A/S
IPC分类号： G01N01/04
CPC分类号： B01L3/0275 , B01L3/18 , B01L2200/0657 , G01N1/04 , G01N35/0099
摘要： A pipette for taking out an apportioned sample of a body of powdery material comprises a downward tapering lower part (2), the bottom end of which is dosed and split into preferably two sections along a plane through the axis of the pipette. The walls of the sections have through-going notches (4) with sharp edges, and means (5) are provided for opening and closing the pipette along its longitudinal splitting. The pipette is moulded from a plastic material in its open position. A tool to be operated manually or by a robot comprises a gripping device (7; 14) holding a pipette, a closing member (8; 12) engaging the dosing means (5) of the pipette, and an ejector (9; 15) to knock the pipette off the gripping device (7; 14), each of these members being operated by displacing them in an axial direction.
摘要翻译：用于取出粉末状物质的分配样品的移液管包括向下锥形的下部（2），其下端被配量并且沿着穿过移液管的轴线的平面被分成优选的两个部分。这些部分的壁具有具有锋利边缘的贯穿凹口（4），并且提供用于沿着其纵向分割打开和关闭移液管的装置（5）。移液管由处于其打开位置的塑料材料成型。手动操作或由机器人操作的工具包括夹持移液管的夹持装置（7; 14），接合移液管的计量装置（5）的关闭构件（8; 12）和喷射器（9; 15）将吸移管从夹持装置（7; 14）上敲出，这些构件中的每一个通过沿轴向移动来操作。

4. 发明申请

WO1993011056A1 DISPENSER FOR PILLS OR TABLETS 审中-公开
标题翻译： PILLS或PABLETS的分配器
公开(公告)号：WO1993011056A1
公开(公告)日：1993-06-10
申请号：PCT/DK1992000343
申请日：1992-11-19
申请人： NOVO NORDISK A/S , HANSEN, Ib
发明人： NOVO NORDISK A/S
IPC分类号： B65D83/04
CPC分类号： B65D83/0409 , B65D2583/0468 , B65D2583/0481
摘要： A dispenser for dispensing tablets one at a time from an unarranged stock of tablets in the dispenser. The dispenser comprises a first reservoir part axially displaceable in a second reservoir part against the force of a spring (4). A trough shaped part (5, 6) at the inner end of the first part forms with a partition (13) at the bottom of the second part a downward closed channel accommodating at least two tablets when the dispenser is in its neutral position. When the dispenser is operated by forcing the first part further into the second part, a bottom (7) closing the channel is passed free of the partition (13) and the lowermost tablet is dispensed. At the same time two fingers (9) are passed into the space left at the sides of the channel between the lowermost tablet and the adjacent tablet above it to ensure that only the lowermost tablet is dispensed.
摘要翻译：一种分配器，用于一次一片地从分配器中的未排列的片剂的片剂分配片剂。分配器包括抵抗弹簧（4）的力在第二储存部分中轴向移位的第一储存器部分。在第一部分的内端处的槽形部分（5,6）在第二部分的底部形成有分隔件（13），当分配器处于其中立位置时，该封闭通道容纳至少两个片剂。当分配器通过迫使第一部分进一步进入第二部分而操作时，关闭通道的底部（7）不通过分隔件（13），并且最下面的药片被分配。同时，两个手指（9）进入位于最下面的片剂和其上方的相邻片剂之间的通道侧面的空间中，以确保仅分配最低的片剂。

5. 发明申请

WO1992004926A1 ADAPTOR TOP 审中-公开
标题翻译：适配器顶部
公开(公告)号：WO1992004926A1
公开(公告)日：1992-04-02
申请号：PCT/DK1991000282
申请日：1991-09-20
申请人： NOVO NORDISK A/S , HANSEN, Ib , MIKKELSEN, Soren , BONNICHSEN, Frits, Frydendal
发明人： NOVO NORDISK A/S
IPC分类号： A61M05/24
CPC分类号： A61M5/24 , A61M5/2466 , A61M15/0025 , A61M2005/2407 , A61M2205/073 , A61M2205/276 , A61M2205/6045 , A61M2205/6081
摘要： A plastic top for adapting to a chosen syringe (14) a standard cartridge (8) of the kind having a neck (9) with a flange (10) and being closed by a rubber membrane (11) sealingly secured against the flange (10) by a metal cover (12) having its edge beaded behind the flange. This plastic top has a bore (2) for receiving the neck part (9) of the cartridge (8), which bore (2) has a diameter making it fit over the metal cover (12) and is provided with protrusions (3; 19) gripping behind the edge of the metal cover (12) when the neck part (9) is inserted in the bore. The outer contour of the plastic top is adapted to the syringe type in which the cartridge is going to be used. The plastic top is provided with a thread (5; 18) coaxial with the bore to receive a needle hub (13) in a way making its needle (15) penetrate the membrane (11) of the cartridge (8) when the hub (13) is mounted on the thread (5) of the plastic top.
摘要翻译：一种用于适应所选择的注射器（14）的塑料顶部，具有带有凸缘（10）的颈部（9）并且被密封地固定在凸缘（10）上的橡胶膜（11）封闭的标准筒（8）），其金属盖（12）具有在凸缘后面串珠的边缘。该塑料顶部具有用于容纳盒（8）的颈部（9）的孔（2），该孔（2）具有使其适配在金属盖（12）上的直径，并且设置有突起（3; 当颈部（9）插入孔中时，夹紧在金属盖（12）的边缘之后。塑料顶部的外轮廓适用于将要使用墨盒的注射器类型。塑料顶部设置有与孔同轴的螺纹（5; 18），以在轴套（13）上插入针座（13），使得当针（15）穿过套筒（8）的膜（11）时， 13）安装在塑料顶部的螺纹（5）上。

6. 发明申请

WO1992001485A1 TWO COMPARTMENT SYRINGE 审中-公开
标题翻译：两厢式水壶
公开(公告)号：WO1992001485A1
公开(公告)日：1992-02-06
申请号：PCT/DK1991000177
申请日：1991-06-28
申请人： NOVO NORDISK A/S , HANSEN, Ib
发明人： NOVO NORDISK A/S
IPC分类号： A61M05/19
CPC分类号： A61M5/2448 , A61M5/284 , A61M5/3129 , A61M2005/3123
摘要： A two-compartment syringe comprising a barrel (10) comprising a distal and a proximal section, the distal section (13) comprising at least one by-pass (15) and the proximal section comprising in the ready to sell form of the syringe a separate cylindrical insert (50) comprising a distal (52) and a proximal piston (60), the interior of the insert (50) having such a shape and dimension that the pistons (52, 60) are displaceable from the insert (50) into the distal section (13) of the barrel (10).
摘要翻译：一种双室注射器，其包括包括远侧和近端部分的镜筒（10），所述远端部分（13）包括至少一个旁路（15），所述近侧部分包括在所述注射器的准备销售形式中包括远端（52）和近端活塞（60）的分离的圆柱形插入件（50），插入件（50）的内部具有活塞（52,60）可从插入件（50）移位的形状和尺寸，进入筒体（10）的远端部分（13）。

7. 发明授权

EP0687319B1 A PROCESS FOR PROVIDING LOCALIZED VARIATION IN THE COLOUR DENSITY OF FABRICS 失效
标题翻译：方法用于织物色彩饱和度提供本地变异
公开(公告)号：EP0687319B1
公开(公告)日：1998-06-10
申请号：EP94908295.2
申请日：1994-02-25
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S
IPC分类号： D06P5/00 , C12N9/42
CPC分类号： D06P1/5257 , D06P1/525 , D06P1/647 , D06P5/158
摘要： Process for providing improved localised variation in the colour density of the surface of dyed fabrics, the process comprising treating a dyed fabric with a cellulytic enzyme in an aqueous liquor comprising a di- or trivalent cation and a chelating agent in a molar ratio of 1:0.1-50.

8. 发明公开

EP0687319A1 A PROCESS FOR PROVIDING LOCALIZED VARIATION IN THE COLOUR DENSITY OF FABRICS 失效
标题翻译：方法用于织物色彩饱和度提供本地变异
公开(公告)号：EP0687319A1
公开(公告)日：1995-12-20
申请号：EP94908295.0
申请日：1994-02-25
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S
IPC分类号： C12N9 , D06M16 , D06P1 , D06P5 , C12R1
CPC分类号： D06P1/5257 , D06P1/525 , D06P1/647 , D06P5/158
摘要： Process for providing improved localised variation in the colour density of the surface of dyed fabrics, the process comprising treating a dyed fabric with a cellulytic enzyme in an aqueous liquor comprising a di- or trivalent cation and a chelating agent in a molar ratio of 1:0.1-50.

9. 发明申请

WO1998028409A1 PHYTASE POLYPEPTIDES 审中-公开
公开(公告)号：WO1998028409A1
公开(公告)日：1998-07-02
申请号：PCT/DK1997000568
申请日：1997-12-15
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , LASSEN, Soren, Flensted , BECH, Lisbeth , OHMANN, Anders , BREINHOLT, Jens , FUGLSANG, Claus, Crone
IPC分类号： C12N09/16
CPC分类号： C12Y301/03026 , A23K20/189 , A23L5/25 , A23L29/06 , C12N9/16
摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.
摘要翻译：本发明涉及具有植酸酶活性的分离的多肽，相应的克隆的DNA序列，制备该多肽的方法及其在许多工业应用中的应用。特别地，本发明涉及源自担子菌的植酸酶，某些共有序列的植酸酶和真菌6-肌醇六磷酸酶。

10. 发明申请

WO1998020895A1 USE OF GLP-1 PEPTIDES 审中-公开
标题翻译：使用GLP-1肽
公开(公告)号：WO1998020895A1
公开(公告)日：1998-05-22
申请号：PCT/DK1997000509
申请日：1997-11-07
申请人： NOVO NORDISK A/S , KNUDSEN, Liselotte, Bjerre , THIM, Lars , JUDGE, Martin, Edward , HOLST, Jens, Juul , ASTRUP, Arne, Vernon , WULFF, Brigitte, Schjellerup
发明人： NOVO NORDISK A/S
IPC分类号： A61K38/26
CPC分类号： A61K38/26
摘要： GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
摘要翻译： GLP-1（1-45）或其片段或类似物可用于制备用于抑制食欲或诱导饱腹感的外周施用的药物。

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