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111. 发明授权

US09748986B2 RF telemetry receiver circuit for active medical implants 有权
公开(公告)号：US09748986B2
公开(公告)日：2017-08-29
申请号：US14629328
申请日：2015-02-23
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： H04B1/10 , H04B1/22 , A61N1/362 , A61N1/372
CPC分类号： H04B1/1027 , A61N1/362 , A61N1/37223 , A61N1/3727 , A61N1/37276 , H04B1/22
摘要： An RF telemetry receiver circuit for active implantable medical devices. The baseband binary signal (Db) is doubly modulated by a low frequency carrier (Fm) and by a high frequency carrier (Fc). The receiver circuit is a semi-passive non heterodyne circuit, devoid of a local oscillator and mixer. It comprises an antenna (104), a passive bandpass filter (108) centered on the high-frequency carrier (Fc), a passive envelope detector (120-126) and a digital demodulator (116). The envelope detector comprises a first diode circuit (120) of non-coherent detection, an active bandpass filter (122) centered on a frequency (2.Fm) twice the low frequency carrier and having a bandwidth (2.Db) twice the baseband bandwidth, and a second diode circuit (124) of non-coherent detection, outputting a baseband signal applied to the digital demodulation stage (116).

112. 发明授权

US09730595B2 Detection/stimulation microlead implantable in a vessel of the venous, arterial or lymphatic network 有权
公开(公告)号：US09730595B2
公开(公告)日：2017-08-15
申请号：US14554471
申请日：2014-11-26
申请人： SORIN CRM SAS
发明人： Willy Régnier , Philippe d'Hiver
IPC分类号： A61N1/05 , A61B5/04 , A61B5/00
CPC分类号： A61B5/04 , A61B5/6876 , A61N1/05 , A61N1/056 , A61N1/057
摘要： A microlead has a distal active portion formed by a microcable including an electrically conductive core coated with an insulation layer, with a plurality of exposed areas forming the stimulation electrodes. The microcable has a three-dimensional preshape inscribed in a cylindrical envelope volume so as to match the target vessel wall. The microcable includes a plurality of exposed areas regularly distributed over the circumference of the cylindrical envelope volume considered in axial projection, the exposed zones extending only over an angular sector of the microcable considered in cross section, said angular sector facing the outside of the envelope volume of the preshape.

113. 发明授权

US09724006B2 Systems and methods for the adaptive diagnosis of heart failure 有权
公开(公告)号：US09724006B2
公开(公告)日：2017-08-08
申请号：US14191093
申请日：2014-02-26
申请人： SORIN CRM SAS
发明人： Jérôme Dumont , Oliver Baumann
IPC分类号： A61B5/02 , A61B5/04 , A61N1/39 , A61N1/37 , G06F19/00 , A61B5/0205 , A61B5/00
CPC分类号： A61B5/04012 , A61B5/0205 , A61B5/7275 , A61N1/37 , A61N1/3925 , G06F19/00 , G16H50/20
摘要： A cardiac implant includes a classifier configured analyze the data for comparison to thresholds prioritized according to a Boolean decision tree. The implant can generate an indicator of alert status (i.e., alert or no alert). A supervisory device operated, for example, by a doctor can associate each indicator a marker (AE/no AE) indicating the presence or absence of an observed adverse event. In the presence of a false positive, a command for update of the thresholds of the decision tree is transmitted to the implant. A database of reference patients can be used to recreate or further update the decision tree to avoid the occurrence of false negatives.

114. 发明授权

US09717902B2 Pacing lead for a left cavity of the heart, implanted in the coronary system 有权
公开(公告)号：US09717902B2
公开(公告)日：2017-08-01
申请号：US14688121
申请日：2015-04-16
申请人： SORIN CRM SAS
发明人： Jean-François Ollivier
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/056 , A61N1/0573 , A61N2001/0585
摘要： A pacing lead for a left cavity of the heart, implanted in the coronary system. The lead includes a lead body with a hollow sheath of deformable material, having a central lumen open at both ends, and at least one telescopic microcable of conductive material. The microcable slides along the length of the lead body and extends beyond the distal end thereof. The part emerging beyond the distal end is an active free part comprising a plurality of distinct bare areas, intended to come into contact with the wall of a target vein of the coronary system, so as to form a network of stimulation electrodes electrically connected together in parallel. The microcable further comprises, proximally, a connector to a generator of active implantable medical device such as a pacemaker or a resynchronizer.

115. 发明申请

US20170157391A1 INTRACARDIAC CAPSULE IMPLANTABLE ON A THIN WALL, INCLUDING THE SEPTUM WALL 有权
公开(公告)号：US20170157391A1
公开(公告)日：2017-06-08
申请号：US15374701
申请日：2016-12-09
申请人： SORIN CRM SAS
发明人： Jean-François Ollivier
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375
CPC分类号： A61N1/0573 , A61N1/059 , A61N1/37205 , A61N1/37518 , A61N1/3756
摘要： An intracardiac capsule comprises a cylindrical body having an atraumatic rounded surface and a helical anchoring screw integral with the cylindrical body. The helical anchoring screw is able to penetrate tissue of a wall of the heart and is configured to provide temporary attachment, in rotation and in translation, of the capsule to an implantation site. The helical anchoring screw surrounds at least a portion of the length of the cylindrical body forming a contact region intended to come into contact with the wall of the cavity of the heart. Over the length of the contact region, the external diameter of the cylindrical body is less than the inner diameter of the helical anchoring screw, so as to leave a free gap there between. The helical anchoring screw is secured to the cylindrical body near the proximal end of the contact region, and extends freely to the opposite distal end.

116. 发明申请

US20160271388A1 IN SITU IMPLANTATION ACCESSORY FOR AN AUTONOMOUS INTRACARDIAC CAPSULE 审中-公开
标题翻译：用于自发性牙龈囊的原位植入附件
公开(公告)号：US20160271388A1
公开(公告)日：2016-09-22
申请号：US15071015
申请日：2016-03-15
申请人： SORIN CRM SAS
发明人： Jean-François Ollivier , Willy Régnier
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375 , A61N1/362
CPC分类号： A61N1/057 , A61B17/3468 , A61B2017/003 , A61M25/0082 , A61N1/056 , A61N1/0563 , A61N1/362 , A61N1/372 , A61N1/37205 , A61N1/375 , A61N1/37518 , A61N1/3756 , A61N2001/058
摘要： This accessory comprises a remotely steerable catheter (40) extended by a tip (50) comprising a base (52) to which the catheter (40) connects to and a cylindrical portion (54) defining a volume (56) suitable for housing the capsule (10). A sub-catheter (30) and the capsule are telescopically extendable with respect to the catheter between i) a retracted position and a deployed position wherein the capsule is removed from the connector and is carried by the distal end of the sub-catheter, and the distal end of sub-catheter and the proximal region (18) of the capsule being provided with disconnectable means of attachment (20, 36). The tip presents, between its base (52) and its cylindrical portion (54), a flexible portion (58) providing, between the base and the cylindrical portion, an elastic deformability in bending and compression.
摘要翻译：该附件包括由尖端（50）延伸的远程可导向导管（40），所述尖端包括导管（40）连接到其上的基座（52）和限定适于容纳胶囊的体积（56）的圆柱形部分（54）（10）。副导管（30）和胶囊在i）缩回位置和展开位置之间相对于导管可伸缩地延伸，其中胶囊从连接器移除并由副导管的远端承载，并且副导管的远端和胶囊的近端区域（18）设有可拆卸的连接装置（20,36）。尖端在其底部（52）和其圆柱形部分（54）之间提供柔性部分（58），其在基部和圆柱形部分之间提供弯曲和压缩时的弹性可变形性。

117. 发明授权

US09421374B2 Active implantable medical device for vagal stimulation with optimization of ventricular filling 有权
标题翻译：用于迷走神经刺激的主动植入式医疗装置，优化心室充盈
公开(公告)号：US09421374B2
公开(公告)日：2016-08-23
申请号：US14671380
申请日：2015-03-27
申请人： SORIN CRM SAS
发明人： Marcel Limousin
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36114 , A61N1/36139
摘要： An active implantable medical device for vagal stimulation with optimization of ventricular filling is disclosed. The device delivers stimulation pulses to the vagal nerve of the patient with an adjustable energy level. The device includes a hemodynamic sensor for measuring hemodynamic parameters of the patient's cardiac cycles and delivering a timing parameter representative of the ventricular filling time. The energy level of the vagal stimulation pulses is adjusted dynamically and repeatedly over several cardiac cycles. The energy level is varied during successive cardiac correlative changes in the filling time (FT1, FT2) are assessed, and the energy level is set to a level that maximizes the ventricular filling time.
摘要翻译：公开了一种用于迷走神经刺激的主动植入式医疗装置，其优化了心室填充。该装置以可调能量水平向刺激患者的迷走神经递送刺激脉冲。该装置包括用于测量患者心脏周期的血液动力学参数的血流动力学传感器，并且传递代表心室充盈时间的定时参数。迷走神经刺激脉冲的能量水平在几个心动周期内被动态和重复地调节。评估灌注时间（FT1，FT2）的连续心脏相关变化期间能量水平是不同的，能量水平设定为使心室充盈时间最大化的水平。

118. 发明申请

US20160175597A1 DEVICE FOR ASSESSMENT AND THERAPY OF TEMPORAL VENTRICULAR DESYNCHRONIZATION 有权
标题翻译：用于评估和治疗时间性静脉切除术的装置
公开(公告)号：US20160175597A1
公开(公告)日：2016-06-23
申请号：US15055111
申请日：2016-02-26
申请人： SORIN CRM SAS
发明人： Fabrizio Renesto , Christine Henry
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/0215 , A61B5/0452 , A61B5/0538 , A61B5/1107 , A61N1/3682 , A61N1/3684 , F04C2270/0421
摘要： A device includes a hemodynamic sensor measuring blood flow in the left chambers of a myocardium, at least one motion sensor measuring a displacement of the walls of the left ventricle of the myocardium, a first analysis module determining a time of closure of the aortic valve based on a signal of the hemodynamic sensor, a second analysis module determining a time of peak contraction of the left ventricle based on a signal from the motion sensors, and a third analysis module determining a time between the moment of peak contraction of the left ventricle and the moment of closure of the aortic valve. If the peak of contraction of the left ventricle is after the instant of closure of the aortic valve, the device adjusts the inter-ventricular delay and/or the atrioventricular delay to minimize or cancel the time disparity.
摘要翻译：一种装置包括测量心肌左室中的血液流量的血流动力学传感器，至少一个运动传感器，测量心肌左心室壁的位移，第一分析模块确定主动脉瓣关闭时间基于所述血流动力学传感器的信号，第二分析模块基于来自所述运动传感器的信号确定所述左心室的峰值收缩时间，以及第三分析模块，其确定所述左心室的峰值收缩时刻与主动脉瓣闭合的时刻。如果左心室的收缩峰值在主动脉瓣关闭之后，则该装置调节心室间延迟和/或房室延迟以最小化或消除时间差异。

119. 发明授权

US09364675B2 Autonomous intracorporeal capsule with piezoelectric energy harvesting 有权
标题翻译：具有压电能量收获的自主体内胶囊
公开(公告)号：US09364675B2
公开(公告)日：2016-06-14
申请号：US13797018
申请日：2013-03-12
申请人： SORIN CRM SAS
发明人： Martin Deterre , Elie Lefeuvre
IPC分类号： A61N1/378 , A61N1/362 , H01L41/113 , H01L41/083 , H02N2/18 , A61N1/36 , A61N1/375
CPC分类号： A61N1/362 , A61N1/36 , A61N1/3756 , A61N1/3785 , H01L41/0836 , H01L41/113 , H01L41/1134 , H01L41/1138 , H02N2/18
摘要： An intracorporeal capsule for placement in a heart and for energy harvesting using blood pressure variations is shown and described. The capsule includes a capsule body and a piezoelectric strip coupled to a rigid surface for receiving blood pressure force. The piezoelectric strip is normally perpendicular to the direction of the force on the rigid surface. The piezoelectric strip is disconnected from the capsule body along at least two edges of the piezoelectric strip such that the blood pressure force can move the rigid surface, and thereby deform the piezoelectric strip for energy harvesting.
摘要翻译：显示和描述了用于放置在心脏中并用于使用血压变化进行能量收集的体内胶囊。胶囊包括胶囊主体和联接到刚性表面以用于接收血压力的压电条。压电条通常垂直于刚性表面上的力的方向。压电条沿着压电条的至少两个边缘与胶囊主体分离，使得血压力可以移动刚性表面，从而使压电条变形以进行能量收集。

120. 发明申请

US20160151632A1 ACTIVE IMPLANTABLE MEDICAL DEVICE WITH CYCLE TO CYCLE CAPTURE DETECTION 有权
标题翻译：具有周期检测的活动可植入医疗装置
公开(公告)号：US20160151632A1
公开(公告)日：2016-06-02
申请号：US14951704
申请日：2015-11-25
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/37 , A61N1/375
CPC分类号： A61N1/3712 , A61N1/36578 , A61N1/37205 , A61N1/3756
摘要： The invention relates to a device incorporating an endocardial acceleration (EA) sensor. A capture test circuit of the device collects a sampled EA signal and extracts a limited series of EA measurements during a duration of a predetermined temporal window opened after delivery of a pacing pulse. An indicator value based on an average of absolute values of successive EA measurements of the series of EA measurements is calculated at an end of the temporal window. The indicator value is compared to a predetermined discrimination threshold to determine the presence or absence of a capture according to whether the indicator value lies above or below the predetermined discrimination threshold. The indicator value is very robust to noise and particularly efficient in terms of computing, which reduces, in large proportions, consumption of the digital processor and thus of the capsule.
摘要翻译：本发明涉及一种结合心内膜加速度（EA）传感器的装置。装置的捕获测试电路收集采样的EA信号，并且在递送起搏脉冲之后的预定时间窗口的持续时间内提取有限的一系列EA测量。在时间窗口的末尾计算基于EA测量系列的连续EA测量的绝对值的平均值的指示值。将指标值与预定判别阈值进行比较，以根据该指标值是否高于或低于预定判别阈值来确定是否存在捕获。指标值对于噪声是非常鲁棒的，并且在计算方面特别有效，这大大降低了数字处理器和胶囊的消耗。

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