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1. 发明授权

US09925383B2 Active implantable medical device with dynamic optimization of stimulation pulse energy 有权
公开(公告)号：US09925383B2
公开(公告)日：2018-03-27
申请号：US14992677
申请日：2016-01-11
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/37 , A61N1/05 , A61N1/372
CPC分类号： A61N1/3712 , A61N1/056 , A61N1/37205
摘要： The disclosure relates to a device including a circuit for adjusting the energy of the stimulation pulses, independently controlling the pulse width and the voltage of each stimulation pulse. An iterative search algorithm for determining the optimum energy includes changing both the pulse width and voltage at each new pulse delivered, by setting a high energy value and a low energy value, and delivering a stimulation pulse with the low energy value. A capture test is then carried out. In the presence of a capture, a current iteration is complete and a new iteration is done with the current low energy as a new high energy value. In the absence of capture, the algorithm is terminated with selection of the last energy value that produced the capture as the value of optimum energy.

2. 发明授权

US09592394B2 Active implantable medical device with cycle to cycle capture detection 有权
标题翻译：具有循环到周期捕获检测的有源植入式医疗设备
公开(公告)号：US09592394B2
公开(公告)日：2017-03-14
申请号：US14951704
申请日：2015-11-25
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/00 , A61N1/37 , A61N1/375 , A61N1/372 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/36578 , A61N1/37205 , A61N1/3756
摘要： The invention relates to a device incorporating an endocardial acceleration (EA) sensor. A capture test circuit of the device collects a sampled EA signal and extracts a limited series of EA measurements during a duration of a predetermined temporal window opened after delivery of a pacing pulse. An indicator value based on an average of absolute values of successive EA measurements of the series of EA measurements is calculated at an end of the temporal window. The indicator value is compared to a predetermined discrimination threshold to determine the presence or absence of a capture according to whether the indicator value lies above or below the predetermined discrimination threshold. The indicator value is very robust to noise and particularly efficient in terms of computing, which reduces, in large proportions, consumption of the digital processor and thus of the capsule.
摘要翻译：本发明涉及一种结合心内膜加速度（EA）传感器的装置。装置的捕获测试电路收集采样的EA信号，并且在递送起搏脉冲之后的预定时间窗口的持续时间内提取有限的一系列EA测量。在时间窗口的末尾计算基于EA测量系列的连续EA测量的绝对值的平均值的指示值。将指标值与预定判别阈值进行比较，以根据该指标值是否高于或低于预定判别阈值来确定是否存在捕获。指标值对于噪声是非常鲁棒的，并且在计算方面特别有效，这大大降低了数字处理器和胶囊的消耗。

3. 发明授权

US09748986B2 RF telemetry receiver circuit for active medical implants 有权
公开(公告)号：US09748986B2
公开(公告)日：2017-08-29
申请号：US14629328
申请日：2015-02-23
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： H04B1/10 , H04B1/22 , A61N1/362 , A61N1/372
CPC分类号： H04B1/1027 , A61N1/362 , A61N1/37223 , A61N1/3727 , A61N1/37276 , H04B1/22
摘要： An RF telemetry receiver circuit for active implantable medical devices. The baseband binary signal (Db) is doubly modulated by a low frequency carrier (Fm) and by a high frequency carrier (Fc). The receiver circuit is a semi-passive non heterodyne circuit, devoid of a local oscillator and mixer. It comprises an antenna (104), a passive bandpass filter (108) centered on the high-frequency carrier (Fc), a passive envelope detector (120-126) and a digital demodulator (116). The envelope detector comprises a first diode circuit (120) of non-coherent detection, an active bandpass filter (122) centered on a frequency (2.Fm) twice the low frequency carrier and having a bandwidth (2.Db) twice the baseband bandwidth, and a second diode circuit (124) of non-coherent detection, outputting a baseband signal applied to the digital demodulation stage (116).

4. 发明申请

US20160151632A1 ACTIVE IMPLANTABLE MEDICAL DEVICE WITH CYCLE TO CYCLE CAPTURE DETECTION 有权
标题翻译：具有周期检测的活动可植入医疗装置
公开(公告)号：US20160151632A1
公开(公告)日：2016-06-02
申请号：US14951704
申请日：2015-11-25
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/37 , A61N1/375
CPC分类号： A61N1/3712 , A61N1/36578 , A61N1/37205 , A61N1/3756
摘要： The invention relates to a device incorporating an endocardial acceleration (EA) sensor. A capture test circuit of the device collects a sampled EA signal and extracts a limited series of EA measurements during a duration of a predetermined temporal window opened after delivery of a pacing pulse. An indicator value based on an average of absolute values of successive EA measurements of the series of EA measurements is calculated at an end of the temporal window. The indicator value is compared to a predetermined discrimination threshold to determine the presence or absence of a capture according to whether the indicator value lies above or below the predetermined discrimination threshold. The indicator value is very robust to noise and particularly efficient in terms of computing, which reduces, in large proportions, consumption of the digital processor and thus of the capsule.
摘要翻译：本发明涉及一种结合心内膜加速度（EA）传感器的装置。装置的捕获测试电路收集采样的EA信号，并且在递送起搏脉冲之后的预定时间窗口的持续时间内提取有限的一系列EA测量。在时间窗口的末尾计算基于EA测量系列的连续EA测量的绝对值的平均值的指示值。将指标值与预定判别阈值进行比较，以根据该指标值是否高于或低于预定判别阈值来确定是否存在捕获。指标值对于噪声是非常鲁棒的，并且在计算方面特别有效，这大大降低了数字处理器和胶囊的消耗。

5. 发明授权

US09095716B2 Autonomous intracorporeal capsule with double energy harvesting 有权
标题翻译：具有双能量收获的自体体内胶囊
公开(公告)号：US09095716B2
公开(公告)日：2015-08-04
申请号：US13797078
申请日：2013-03-12
申请人： SORIN CRM SAS
发明人： Alaa Makdissi , Martin Deterre
IPC分类号： A61N1/378 , A61N1/365
CPC分类号： A61N1/36542 , A61N1/3756 , A61N1/3785
摘要： A intracorporeal medical capsule is shown and described. The capsule includes an elastically deformable base having an anchor at one end and coupled to a capsule body at the opposite end. An energy harvesting element is elastically coupled to a seismic mass within the capsule body. The elastically deformable base increases energy harvested at the energy harvesting element due to elastic movement of the capsule body in the presence of blood flow around the capsule body.
摘要翻译：显示和描述体内医疗胶囊。胶囊包括可弹性变形的基座，其在一端具有锚固件并且在相对端处联接到胶囊主体。能量收集元件弹性耦合到胶囊主体内的地震质量体。可弹性变形的基座由于在胶囊主体周围的血液流动的情况下由于胶囊主体的弹性运动而增加在能量收集元件处收获的能量。

6. 发明申请

US20150171905A1 RF TELEMETRY RECEIVER CIRCUIT FOR ACTIVE MEDICAL IMPLANTS 有权
标题翻译：用于活动医用植入物的射频远端接收器电路
公开(公告)号：US20150171905A1
公开(公告)日：2015-06-18
申请号：US14629328
申请日：2015-02-23
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： H04B1/10 , A61N1/362 , A61N1/372
CPC分类号： H04B1/1027 , A61N1/362 , A61N1/37223 , A61N1/3727 , A61N1/37276 , H04B1/22
摘要： An RF telemetry receiver circuit for active implantable medical devices. The baseband binary signal (Db) is doubly modulated by a low frequency carrier (Fm) and by a high frequency carrier (Fc). The receiver circuit is a semi-passive non heterodyne circuit, devoid of a local oscillator and mixer. It comprises an antenna (104), a passive bandpass filter (108) centered on the high-frequency carrier (Fc), a passive envelope detector (120-126) and a digital demodulator (116). The envelope detector comprises a first diode circuit (120) of non-coherent detection, an active bandpass filter (122) centered on a frequency (2.Fm) twice the low frequency carrier and having a bandwidth (2.Db) twice the baseband bandwidth, and a second diode circuit (124) of non-coherent detection, outputting a baseband signal applied to the digital demodulation stage (116).
摘要翻译：一种用于主动植入式医疗设备的RF遥测接收器电路。基带二进制信号（Db）被低频载波（Fm）和高频载波（Fc）双重调制。接收器电路是半无源非外差电路，没有本地振荡器和混频器。它包括天线（104），以高频载波（Fc）为中心的无源带通滤波器（108），无源包络检测器（120-126）和数字解调器（116）。包络检测器包括非相干检测的第一二极管电路（120），以低于两倍于低频载波的频率（2.Fm）为中心的有源带通滤波器（122），并具有基带的两倍的带宽（2.Db）带宽和非相干检测的第二二极管电路（124），输出施加到数字解调级（116）的基带信号。

7. 发明申请

US20150011903A1 NON-LINEAR FILTERING FOR THE RECONSTRUCTION OF A SURFACE ELECTROCARDIOGRAM FROM AN ENDOCARDIAL ELECTROGRAM 有权
标题翻译：用于从内部电极重建表面电极的非线性滤波
公开(公告)号：US20150011903A1
公开(公告)日：2015-01-08
申请号：US14493077
申请日：2014-09-22
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/04017 , A61B5/04021 , A61B5/04028 , A61B5/042 , A61B5/0422 , A61B5/0432 , A61B5/7221 , A61B5/725 , A61B5/7267 , A61N1/0563 , A61N1/08 , A61N1/3702 , A61N1/3925
摘要： An active medical device using non-linear filtering for the reconstruction of a surface electrocardiogram (ECG) from an endocardial electrogram (EGM) is disclosed. The device for the reconstruction of the surface ECG includes a plurality of inputs, receiving a corresponding plurality of EGM signals from endocardial or epicardial electrogram (x1[n], x2[n]), each collected on a respective EGM derivation of a plurality of EGM derivations, and at least one output delivering a reconstructed surface ECG electrocardiogram signal (y[n]), related to an ECG derivation, and a non-linear digital filter (12′, 12′, 14) with a transfer function that determines the reconstructed ECG signal based on said plurality of input EGM signals. The non-linear digital filter includes a Volterra filter type (12, 12′, 12″) whose transfer function includes a linear term (h1) and at least one quadratic (h2) and/or cubic (h3) term(s).
摘要翻译：公开了一种使用非线性滤波从心室电图（EGM）重建表面心电图（ECG）的有源医疗装置。用于重建表面ECG的装置包括多个输入，从心内膜或心外膜电描记图（x1 [n]，x2 [n]）接收相应的多个EGM信号，每个EGM信号分别在多个 EGM导出，以及传递与ECG导出相关的重构表面ECG心电图信号（y [n]）的至少一个输出和具有确定的传递函数的非线性数字滤波器（12'，12'，14）所述重建的ECG信号基于所述多个输入EGM信号。非线性数字滤波器包括Volterra滤波器类型（12,12'，12“），其传递函数包括线性项（h1）和至少一个二次（h2）和/或立方（h3）项。

8. 发明申请

US20180214702A1 ACTIVE IMPLANTABLE MEDICAL DEVICE WITH DYNAMIC OPTIMIZATION OF STIMULATION PULSE ENERGY 审中-公开
公开(公告)号：US20180214702A1
公开(公告)日：2018-08-02
申请号：US15936111
申请日：2018-03-26
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/37 , A61N1/05 , A61N1/372
CPC分类号： A61N1/3712 , A61N1/056 , A61N1/37205
摘要： The disclosure relates to a device including a circuit for adjusting the energy of the stimulation pulses, independently controlling the pulse width and the voltage of each stimulation pulse. An iterative search algorithm for determining the optimum energy includes changing both the pulse width and voltage at each new pulse delivered, by setting a high energy value and a low energy value, and delivering a stimulation pulse with the low energy value. A capture test is then carried out. In the presence of a capture, a current iteration is complete and a new iteration is done with the current low energy as a new high energy value. In the absence of capture, the algorithm is terminated with selection of the last energy value that produced the capture as the value of optimum energy.

9. 发明授权

US09050008B2 Non-linear filtering for the reconstruction of a surface electrocardiogram from an endocardial electrogram 有权
标题翻译：用于从心内膜电图重建表面心电图的非线性滤波
公开(公告)号：US09050008B2
公开(公告)日：2015-06-09
申请号：US14493077
申请日：2014-09-22
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61B5/02 , A61B5/04 , A61B5/0402 , A61B5/042 , A61B5/0432 , A61B5/00 , A61N1/05 , A61N1/08 , A61N1/37 , A61N1/39
CPC分类号： A61B5/04017 , A61B5/04021 , A61B5/04028 , A61B5/042 , A61B5/0422 , A61B5/0432 , A61B5/7221 , A61B5/725 , A61B5/7267 , A61N1/0563 , A61N1/08 , A61N1/3702 , A61N1/3925
摘要： An active medical device using non-linear filtering for the reconstruction of a surface electrocardiogram (ECG) from an endocardial electrogram (EGM) is disclosed. The device for the reconstruction of the surface ECG includes a plurality of inputs, receiving a corresponding plurality of EGM signals from endocardial or epicardial electrogram (x1[n], x2[n]), each collected on a respective EGM derivation of a plurality of EGM derivations, and at least one output delivering a reconstructed surface ECG electrocardiogram signal (y[n]), related to an ECG derivation, and a non-linear digital filter (12′, 12′, 14) with a transfer function that determines the reconstructed ECG signal based on said plurality of input EGM signals. The non-linear digital filter includes a Volterra filter type (12, 12′, 12″) whose transfer function includes a linear term (h1) and at least one quadratic (h2) and/or cubic (h3) term(s).
摘要翻译：公开了一种使用非线性滤波从心室电图（EGM）重建表面心电图（ECG）的有源医疗装置。用于重建表面ECG的装置包括多个输入，从心内膜或心外膜电描记图（x1 [n]，x2 [n]）接收相应的多个EGM信号，每个EGM信号分别在多个 EGM导出，以及传递与ECG导出相关的重构表面ECG心电图信号（y [n]）的至少一个输出和具有确定的传递函数的非线性数字滤波器（12'，12'，14）所述重建的ECG信号基于所述多个输入EGM信号。非线性数字滤波器包括Volterra滤波器类型（12,12'，12“），其传递函数包括线性项（h1）和至少一个二次（h2）和/或立方（h3）项。

10. 发明申请

US20160199654A1 ACTIVE IMPLANTABLE MEDICAL DEVICE WITH DYNAMIC OPTIMIZATION OF STIMULATION PULSE ENERGY 有权
标题翻译：具有刺激脉冲能量动态优化的主动植入式医疗装置
公开(公告)号：US20160199654A1
公开(公告)日：2016-07-14
申请号：US14992677
申请日：2016-01-11
申请人： SORIN CRM SAS
发明人： Alaa Makdissi
IPC分类号： A61N1/37 , A61N1/05
CPC分类号： A61N1/3712 , A61N1/056 , A61N1/37205
摘要： The disclosure relates to a device including a circuit for adjusting the energy of the stimulation pulses, independently controlling the pulse width and the voltage of each stimulation pulse. An iterative search algorithm for determining the optimum energy includes changing both the pulse width and voltage at each new pulse delivered, by setting a high energy value and a low energy value, and delivering a stimulation pulse with the low energy value. A capture test is then carried out. In the presence of a capture, a current iteration is complete and a new iteration is done with the current low energy as a new high energy value. In the absence of capture, the algorithm is terminated with selection of the last energy value that produced the capture as the value of optimum energy.
摘要翻译：本公开涉及一种包括用于调节刺激脉冲的能量的电路的装置，独立地控制每个刺激脉冲的脉冲宽度和电压。用于确定最佳能量的迭代搜索算法包括通过设置高能量值和低能量值来改变每个递送的新脉冲上的脉冲宽度和电压，以及递送具有低能量值的刺激脉冲。然后进行捕获测试。在存在捕获的情况下，当前迭代是完整的，并且以当前的低能量作为新的高能量值进行新的迭代。在没有捕获的情况下，通过选择产生捕获的最后一个能量值作为最佳能量的值来终止该算法。

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