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1. 发明授权

US10441797B2 Implantable cardiac resynchronizer with biventricular pacing and detection of loss of capture and anodal stimulation 有权
公开(公告)号：US10441797B2
公开(公告)日：2019-10-15
申请号：US15954255
申请日：2018-04-16
申请人： SORIN CRM SAS
发明人： Filippo Ziglio , Fabrizio Renesto
IPC分类号： A61N1/36 , A61N1/37 , A61N1/362 , A61N1/368 , A61N1/365
摘要： A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.

2. 发明授权

US09314636B2 Implantable cardiac resynchronizer with biventricular pacing and detection of loss of capture and anodal stimulation 有权
标题翻译：可植入的心脏再同步器与双心室起搏和检测捕获和阳极刺激的损失
公开(公告)号：US09314636B2
公开(公告)日：2016-04-19
申请号：US14277552
申请日：2014-05-14
申请人： SORIN CRM SAS
发明人： Filippo Ziglio , Fabrizio Renesto
IPC分类号： A61N1/37 , A61N1/39 , A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3714
摘要： An medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.
摘要翻译：使用双心室刺激刺激心脏的医疗装置。该装置包括用于检测心内膜加速度参数的传感器和被配置为接收心内膜加速度参数的处理电路。该装置还包括耦合到处理电路的刺激电子装置。处理电路被配置为使用EA参数来评估双心室刺激。评估包括将双参数模式中EA参数的值与仅左模式或右模模式下EA参数的值进行比较，并将EA参数的变异性作为AVD的函数进行比较和评估左或右模式以区分情况，包括：（a）正常操作，（b）RV或LV捕获的丧失，（c）可能的阳极刺激。处理电路还被配置为基于所确定的情况对设备的操作参数进行至少一次更新。

3. 发明授权

US09884193B2 Pacemaker with detection of atrial activity without collection of atrial electrical activity 有权
公开(公告)号：US09884193B2
公开(公告)日：2018-02-06
申请号：US14922622
申请日：2015-10-26
申请人： SORIN CRM SAS , UNIVERSITÉ DE BRETAGNE OCCIDENTALE , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
发明人： Amel Amblard , Jérôme Dumont , Fabrizio Renesto , Jacques Mansourati
IPC分类号： A61N1/00 , A61N1/365 , A61N1/39 , A61N1/05 , A61B5/00 , A61N1/375 , A61N1/368 , A61N1/372
CPC分类号： A61N1/365 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/057 , A61N1/36507 , A61N1/3682 , A61N1/37205 , A61N1/3756 , A61N1/3962
摘要： The invention relates to an active implantable pacemaker. The device analyzes a ventricular electrogram signal (EGM) and is able to recognize, in a search window, an EA4 component of endocardial acceleration (EA) associated with atrial activity. In the presence of atrioventricular conduction, the search window is determined based on the temporal position of the EA1 and/or EA2 components of the EA signal. In the absence of atrioventricular conduction, a delay is counted from a paced ventricular event and applied to mask the EA1 and/or EA2 components in the EA signal, and the window for research of the EA4 component follows the masking delay. In the presence of a confirmed EA4 component, an atrioventricular delay is applied, counted from the EA4 component, and in the opposite case a predetermined escape interval is applied, counted from the last stimulated ventricular event.

4. 发明申请

US20160228714A1 IMPLANTABLE CARDIAC RESYNCHRONIZER WITH BIVENTRICULAR PACING AND DETECTION OF LOSS OF CAPTURE AND ANODAL STIMULATION 有权
标题翻译：具有双侧腹膜的可注射的心脏康复者和检测丢失和阳性刺激的检测
公开(公告)号：US20160228714A1
公开(公告)日：2016-08-11
申请号：US15130653
申请日：2016-04-15
申请人： SORIN CRM SAS
发明人： Filippo Ziglio , Fabrizio Renesto
IPC分类号： A61N1/37 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3714
摘要： A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.
摘要翻译：使用双心室刺激刺激心脏的医疗装置。该装置包括用于检测心内膜加速度参数的传感器和被配置为接收心内膜加速度参数的处理电路。该装置还包括耦合到处理电路的刺激电子装置。处理电路被配置为使用EA参数来评估双心室刺激。评估包括将双参数模式中EA参数的值与仅左模式或右模模式下EA参数的值进行比较，并将EA参数的变异性作为AVD的函数进行比较和评估左或右模式以区分情况，包括：（a）正常操作，（b）RV或LV捕获的丧失，（c）可能的阳极刺激。处理电路还被配置为基于所确定的情况对设备的操作参数进行至少一次更新。

5. 发明申请

US20160114161A1 PACEMAKER WITH DETECTION OF ATRIAL ACTIVITY WITHOUT COLLECTION OF ATRIAL ELECTRICAL ACTIVITY 有权
标题翻译：检测没有收集ATRIAL电活动的ATRIAL活动的PACEMAKER
公开(公告)号：US20160114161A1
公开(公告)日：2016-04-28
申请号：US14922622
申请日：2015-10-26
申请人： SORIN CRM SAS , UNIVERSITÉ DE BRETAGNE OCCIDENTALE , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
发明人： Amel Amblard , Jérôme Dumont , Fabrizio Renesto , Jacques Mansourati
IPC分类号： A61N1/365 , A61N1/05 , A61N1/39
CPC分类号： A61N1/365 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/057 , A61N1/36507 , A61N1/3682 , A61N1/37205 , A61N1/3756 , A61N1/3962
摘要： The invention relates to an active implantable pacemaker. The device analyzes a ventricular electrogram signal (EGM) and is able to recognize, in a search window, an EA4 component of endocardial acceleration (EA) associated with atrial activity. In the presence of atrioventricular conduction, the search window is determined based on the temporal position of the EA1 and/or EA2 components of the EA signal. In the absence of atrioventricular conduction, a delay is counted from a paced ventricular event and applied to mask the EA1 and/or EA2 components in the EA signal, and the window for research of the EA4 component follows the masking delay. In the presence of a confirmed EA4 component, an atrioventricular delay is applied, counted from the EA4 component, and in the opposite case a predetermined escape interval is applied, counted from the last stimulated ventricular event.
摘要翻译：本发明涉及一种主动植入起搏器。该装置分析心室电图信号（EGM），并且能够在搜索窗口中识别与心房活动相关的心内加速度（EA）的EA4分量。在存在房室传导的情况下，基于EA信号的EA1和/或EA2分量的时间位置来确定搜索窗口。在没有房室传导的情况下，从起搏心室事件计数延迟，并应用于EA EA信号中的EA1和/或EA2分量，EA4组件的研究窗口遵循屏蔽延迟。在存在确认的EA4组分的情况下，应用从EA4组分计数的房室延迟，并且在相反的情况下应用从最后一次刺激的心室事件计数的预定逃逸间隔。

6. 发明申请

US20180296844A1 IMPLANTABLE CARDIAC RESYNCHRONIZER WITH BIVENTRICULAR PACING AND DETECTION OF LOSS OF CAPTURE AND ANODAL STIMULATION 审中-公开
公开(公告)号：US20180296844A1
公开(公告)日：2018-10-18
申请号：US15954255
申请日：2018-04-16
申请人： SORIN CRM SAS
发明人： Filippo Ziglio , Fabrizio Renesto
IPC分类号： A61N1/37 , A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3714
摘要： A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.

7. 发明申请

US20160175597A1 DEVICE FOR ASSESSMENT AND THERAPY OF TEMPORAL VENTRICULAR DESYNCHRONIZATION 有权
标题翻译：用于评估和治疗时间性静脉切除术的装置
公开(公告)号：US20160175597A1
公开(公告)日：2016-06-23
申请号：US15055111
申请日：2016-02-26
申请人： SORIN CRM SAS
发明人： Fabrizio Renesto , Christine Henry
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/0215 , A61B5/0452 , A61B5/0538 , A61B5/1107 , A61N1/3682 , A61N1/3684 , F04C2270/0421
摘要： A device includes a hemodynamic sensor measuring blood flow in the left chambers of a myocardium, at least one motion sensor measuring a displacement of the walls of the left ventricle of the myocardium, a first analysis module determining a time of closure of the aortic valve based on a signal of the hemodynamic sensor, a second analysis module determining a time of peak contraction of the left ventricle based on a signal from the motion sensors, and a third analysis module determining a time between the moment of peak contraction of the left ventricle and the moment of closure of the aortic valve. If the peak of contraction of the left ventricle is after the instant of closure of the aortic valve, the device adjusts the inter-ventricular delay and/or the atrioventricular delay to minimize or cancel the time disparity.
摘要翻译：一种装置包括测量心肌左室中的血液流量的血流动力学传感器，至少一个运动传感器，测量心肌左心室壁的位移，第一分析模块确定主动脉瓣关闭时间基于所述血流动力学传感器的信号，第二分析模块基于来自所述运动传感器的信号确定所述左心室的峰值收缩时间，以及第三分析模块，其确定所述左心室的峰值收缩时刻与主动脉瓣闭合的时刻。如果左心室的收缩峰值在主动脉瓣关闭之后，则该装置调节心室间延迟和/或房室延迟以最小化或消除时间差异。

8. 发明授权

US08862230B2 Pacing configuration for an implantable medical device 有权
标题翻译：可植入医疗器械的起搏配置
公开(公告)号：US08862230B2
公开(公告)日：2014-10-14
申请号：US14263643
申请日：2014-04-28
申请人： Sorin CRM SAS
发明人： Fabrizio Renesto , Lionel Giorgis
IPC分类号： A61N1/00 , A61N1/365
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3706
摘要： An implantable medical device includes a sensor configured to generate an endocardial acceleration (EA) signal representative of activity of a patient's heart. The device further includes one or more circuits configured to identify within the EA signal at least one EA signal component corresponding to at least one peak of endocardial acceleration, and extract from the at least one EA signal component at least two characteristic parameters. The one or more circuits are further configured to generate a composite index based on a combination of the at least two characteristic parameters, determine a plurality of values of the composite index for a plurality of pacing configurations, and select a current pacing configuration from among the plurality of pacing configurations based on the plurality of values of the composite index.
摘要翻译：可植入医疗装置包括被配置为产生代表患者心脏活动的心内加速度（EA）信号的传感器。该装置还包括一个或多个电路，其被配置为在EA信号内识别与至少一个心内膜加速度峰值对应的至少一个EA信号分量，并从至少一个EA信号分量提取至少两个特征参数。所述一个或多个电路还被配置为基于所述至少两个特征参数的组合来生成复合索引，确定多个起搏配置的复合索引的多个值，并且从所述多个起搏配置中选择当前起搏配置基于复合索引的多个值的多个起搏配置。

9. 发明授权

US09943693B2 Implantable cardiac resynchronizer with biventricular pacing and detection of loss of capture and anodal stimulation 有权
公开(公告)号：US09943693B2
公开(公告)日：2018-04-17
申请号：US15130653
申请日：2016-04-15
申请人： SORIN CRM SAS
发明人： Filippo Ziglio , Fabrizio Renesto
IPC分类号： A61N1/36 , A61N1/37 , A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3714
摘要： A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.

10. 发明申请

US20140343619A1 IMPLANTABLE CARDIAC RESYNCHRONIZER WITH BIVENTRICULAR PACING AND DETECTION OF LOSS OF CAPTURE AND ANODAL STIMULATION 有权
标题翻译：具有双侧腹膜的可注射的心脏康复者和检测丢失和阳性刺激的检测
公开(公告)号：US20140343619A1
公开(公告)日：2014-11-20
申请号：US14277552
申请日：2014-05-14
申请人： SORIN CRM SAS
发明人： Fabrizio Renesto , Filippo Ziglio
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3714
摘要： An medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.
摘要翻译：使用双心室刺激刺激心脏的医疗装置。该装置包括用于检测心内膜加速度参数的传感器和被配置为接收心内膜加速度参数的处理电路。该装置还包括耦合到处理电路的刺激电子装置。处理电路被配置为使用EA参数来评估双心室刺激。评估包括将双参数模式中EA参数的值与仅左模式或右模模式下EA参数的值进行比较，并将EA参数的变异性作为AVD的函数进行比较和评估左或右模式以区分情况，包括：（a）正常操作，（b）RV或LV捕获的丧失，（c）可能的阳极刺激。处理电路还被配置为基于所确定的情况对设备的操作参数进行至少一次更新。

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