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101. 发明申请

US20140057849A1 WILD-TYPE APOLIPOPROTEIN L-I FOR USE IN THE PREVENTION OF KIDNEY DISEASES 有权
标题翻译：野生型APOLIPOPROTEIN L-I用于预防儿童疾病
公开(公告)号：US20140057849A1
公开(公告)日：2014-02-27
申请号：US14000079
申请日：2012-02-17
申请人： Etienne Pays
发明人： Etienne Pays
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/17 , Y02A50/415
摘要： A wild-type human Apolipoprotein L-I is used in a method for the prevention and/or the treatment of renal disease.
摘要翻译：野生型人载脂蛋白L-1用于预防和/或治疗肾脏疾病的方法。

102. 发明申请

US20140052067A1 DEVICES FOR PUNCTURING FOR A HUMAN OR ANIMAL BODY'S MEMBRANE 审中-公开
标题翻译：用于人体或动物体膜的刺激的装置
公开(公告)号：US20140052067A1
公开(公告)日：2014-02-20
申请号：US14006068
申请日：2012-03-14
申请人： Marion Sausse , Michel Deleers , Denis Vandormael , Cyrille Lenders
发明人： Marion Sausse , Michel Deleers , Denis Vandormael , Cyrille Lenders
IPC分类号： A61M5/158 , B29C45/00
CPC分类号： A61M5/158 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B29C45/0053
摘要： Device for puncturing a membrane of a human or animal body so as to introduce a liquid formulation thereinto, provided with a patch (10) made of a polymeric material, includes a base surface (12) having a distal side and a proximal side, and a plurality of projections (11), each projection projecting from the distal side of the base surface to end in a tip (13) arranged for puncturing the membrane. Each projection (11) has a cavity (14) and a shell (111) enveloping the cavity at the distal side. The cavity is open towards the proximal side of the base surface. The shells (111) have substantially constant thicknesses. The projections (11) include fluid channels (150) emanating from the cavities (14), running through the shells to end at orifices (15) provided in the shells, offset from the tips (13), the fluid channels being oriented obliquely relative to the proximal-distal axis (16, 160). A method provides for manufacturing the patch.
摘要翻译：用于穿刺人体或动物体的膜以将液体制剂引入其中的装置，其具有由聚合物材料制成的贴剂（10），包括具有远侧和近侧的基底表面（12）和多个突起（11），每个突出部从所述基底表面的远侧突出到末端，所述尖端设置成用于刺穿所述膜。每个突起（11）具有空腔（14）和壳体（111），其在远端侧包围空腔。空腔朝向基面的近侧敞开。壳体（111）具有基本恒定的厚度。突出物（11）包括从空腔（14）发出的流体通道（150），其穿过壳体延伸以在设置在壳体中的孔口（15）处终止，从尖端（13）偏移，流体通道倾斜相对到近端远侧轴线（16,160）。一种制造贴片的方法。

103. 发明授权

US08633025B2 Generation of neuronal cells from embryonic stem cells 有权
标题翻译：从胚胎干细胞产生神经元细胞
公开(公告)号：US08633025B2
公开(公告)日：2014-01-21
申请号：US12674050
申请日：2008-08-01
申请人： Pierre Vanderhaeghen , Nicolas Gaspard , Gilles Naeije , Jelle Van Den Ameele , Fabienne Devreker , Yvon Englert
发明人： Pierre Vanderhaeghen , Nicolas Gaspard , Gilles Naeije , Jelle Van Den Ameele , Fabienne Devreker , Yvon Englert
IPC分类号： C12N5/00
CPC分类号： C12N5/0619 , C12N5/0623 , C12N2500/25 , C12N2500/90 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.
摘要翻译：本发明涉及用于将哺乳动物多能干细胞分化为显示神经元表型的细胞的体外方法，更具体地涉及包括特别是锥体神经元和皮质抑制性中间神经元的皮层型神经元。本发明还包括如此获得的神经元细胞和细胞群，包含此类物质的组合物，以及所述神经细胞和细胞群体的进一步用途。

104. 发明申请

US20140005220A9 BETA CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS 有权
标题翻译：用于治疗增生性疾病的β-碳醇衍生物
公开(公告)号：US20140005220A9
公开(公告)日：2014-01-02
申请号：US13704109
申请日：2011-06-24
申请人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss
发明人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： A61K31/437 , C07D471/04
摘要： The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
摘要翻译：本发明提供了可用于治疗包括癌症在内的增殖性疾病，其制备中使用的中间体，其制备方法及其应用的式（Ia）和（Ib）的新型β-咔啉衍生物。

105. 发明申请

US20130338937A1 METHOD FOR DETERMINING SUSPENDED MATTER LOADS CONCENTRATIONS IN A LIQUID 审中-公开
标题翻译：用于确定液体中悬浮物负载浓度的方法
公开(公告)号：US20130338937A1
公开(公告)日：2013-12-19
申请号：US14002236
申请日：2012-03-09
申请人： Michel Verbanck , Dragana Petrovic , Jean-Pierre Vanderborght
发明人： Michel Verbanck , Dragana Petrovic , Jean-Pierre Vanderborght
IPC分类号： G01N7/00
CPC分类号： G01N7/00 , G01N9/26
摘要： The present invention relates to a method for monitoring suspended matter loads concentration in a liquid, wherein said method comprises the steps of: a) collecting environmental variables comprising: the pressure p at a depth L in said liquid, the liquid depth L at which said pressure p is collected; providing the value of the pressure p0 which is the aerial pressure; b) inserting said environmental variables in an equation; c) calculating the suspended matter loads volumetric concentration in the liquid from the absolute pressure p measured at the depth L in the liquid.
摘要翻译：本发明涉及一种用于监测液体中悬浮物负载浓度的方法，其中所述方法包括以下步骤：a）收集环境变量，包括：所述液体中的深度L处的压力p，所述液体深度L，收集压力p; 提供作为空气压力的压力p0的值; b）将所述环境变量插入到等式中; c）从在液体中的深度L测量的绝对压力p计算液体中悬浮物的载量体积浓度。

106. 发明授权

US08580496B2 Method and kit for the detection of genes associated with PIK3CA mutation and involved in PI3K/AKT pathway activation in the ER-postitive and HER2-positive subtypes with clinical implications 失效
标题翻译：用于检测与PIK3CA突变相关的基因并参与具有临床意义的ER- postitive和HER2阳性亚型中的PI3K / AKT通路激活的方法和试剂盒
公开(公告)号：US08580496B2
公开(公告)日：2013-11-12
申请号：US12860638
申请日：2010-08-20
申请人： Christos Sotiriou , Sherene Loi , Grant McArthur , Benjamin Haibe-Kains
发明人： Christos Sotiriou , Sherene Loi , Grant McArthur , Benjamin Haibe-Kains
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： A method to determine the clinical outcome of breast tumor affecting a patient if treated with an antitumoral agent against breast tumor. The method includes the step of assaying a sample of a breast tumor from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumor with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.
摘要翻译：如果用抗肿瘤剂对乳腺肿瘤治疗，则确定影响患者的乳腺肿瘤的临床结果的方法。该方法包括通过使来自该乳腺肿瘤的细胞的mRNA序列与与人突变的PIK3CA相关的多于3个核苷酸序列的一组接触，从患者中检测乳腺肿瘤的样品以获得所选择的基因的表达水平。

107. 发明申请

US20120301445A1 TOOLS FOR ISOLATING AND FOLLOWING CARDIOVASCULAR PROGENITOR CELLS 审中-公开
标题翻译：用于分离和遵循心脏血管生成细胞的工具
公开(公告)号：US20120301445A1
公开(公告)日：2012-11-29
申请号：US13574218
申请日：2010-12-31
申请人： Cedric Blanpain , Antoine Bondue
发明人： Cedric Blanpain , Antoine Bondue
IPC分类号： A61K35/34 , C12N5/077 , C12N5/0775 , A61P9/06 , C12N5/074 , G01N21/64 , A61P9/00 , A61P9/10 , C12N5/071 , C12N5/0735
CPC分类号： C12N5/0657 , C12N2501/115 , C12N2501/119 , C12N2501/135 , C12N2501/155 , C12N2501/165 , C12N2501/415 , C12N2506/02 , C12N2510/00
摘要： The present invention provides new methods and tools for isolating pluripotent cardiovascular progenitors (MCPs), by transiently detecting the cell-surface expression of genes upregulated by Mesp1. Cells obtained by the method and there uses in research and clinical settings are also part of the invention. Using genome wide transcriptional analysis, the inventors found upstream and downstream members of the Mesp1 signaling pathway, which form potential new targets for both therapy and for the identification of MCPs and differentiation of MCPs into cardiovascular cells. This invention provides novel and important insights into the molecular mechanisms of cardiovascular specification and provides potential novel methods for dramatically increasing the number of cardiovascular cells for cellular therapy in humans.
摘要翻译：本发明通过瞬时检测由Mesp1上调的基因的细胞表面表达，提供了用于分离多能心血管祖细胞（MCP）的新方法和工具。通过该方法获得并且在研究和临床环境中使用的细胞也是本发明的一部分。使用基因组广泛的转录分析，本发明人发现了Mesp1信号通路的上游和下游成员，其形成用于治疗和鉴定MCP并且将MCP分化成心血管细胞的潜在新靶标。本发明提供了对心血管规范的分子机制的新颖和重要的见解，并提供了潜在的新方法，用于显着增加人类细胞治疗的心血管细胞数量。

108. 发明申请

US20120196735A1 PHASE-SEPARATED SODA-LIME-SILICA GLASS 有权
标题翻译：相分离的SODA-LIME-SILICA GLASS
公开(公告)号：US20120196735A1
公开(公告)日：2012-08-02
申请号：US13500021
申请日：2010-10-26
申请人： Michel Bogaerts , Stephane Godet
发明人： Michel Bogaerts , Stephane Godet
IPC分类号： C03C14/00 , B82Y30/00
CPC分类号： C03C10/0009 , C03B32/02 , C03C4/005 , Y02P40/57
摘要： The invention relates to a glass having SiO2, Na2O and CaO as main components, which comprises two amorphous phases having different compositions, one of the two phases being in the form of inclusions dispersed in the volume of the other phase and comprising crystalline particles. Such a glass has good mechanical strength, in particular good resistance to scratch propagation and allows improved tempering. This glass furthermore has a pleasant aesthetic appearance.
摘要翻译：本发明涉及一种具有SiO 2，Na 2 O和CaO作为主要成分的玻璃，其包含两种具有不同组成的非晶相，两相中的一个以夹杂物的形式分散在另一相的体积中并且包含结晶颗粒。这种玻璃具有良好的机械强度，特别是良好的抗划痕传播性，并且能够改善回火。这种玻璃还具有愉悦的审美外观。

109. 发明申请

US20120071346A1 GENE-BASED ALGORITHMIC CANCER PROGNOSIS 审中-公开
标题翻译：基于基因的算法癌症预防
公开(公告)号：US20120071346A1
公开(公告)日：2012-03-22
申请号：US13306590
申请日：2011-11-29
申请人： Christos SOTIRIOU , Mauro Delorenzi , Martine Piccart , Virginie Durbecq
发明人： Christos SOTIRIOU , Mauro Delorenzi , Martine Piccart , Virginie Durbecq
IPC分类号： C40B30/04 , C40B60/12 , C12M1/40 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/574
摘要： The present invention is related to the methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score.
摘要翻译：本发明涉及通过测量肿瘤样品中的基因表达和应用基因表达等级指数（GGI）或复发评分（RS）以产生数量c风险评分的肿瘤样品中预后测定的方法和系统。

110. 发明授权

US08067172B2 Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed 失效
标题翻译：用药剂脉冲生物样品的装置，试剂盒和方法，并将样品稳定化，使其脉动
公开(公告)号：US08067172B2
公开(公告)日：2011-11-29
申请号：US12701101
申请日：2010-02-05
申请人： Patrick Stordeur , Michel Goldman
发明人： Patrick Stordeur , Michel Goldman
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12M1/34 , C12M3/08 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： A61B5/411 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150755 , A61B5/413 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.
摘要翻译：本发明涉及用脉冲发生脉冲生物样品并随后稳定生物样品如此脉冲的装置，试剂盒和方法。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。

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