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101. 发明申请

US20100082087A1 IMPLANTABLE LEAD/ELECTRODE DELIVERY MEASUREMENT AND FEEDBACK SYSTEM 有权
标题翻译：可伸缩导线/电极传送测量和反馈系统
公开(公告)号：US20100082087A1
公开(公告)日：2010-04-01
申请号：US12243674
申请日：2008-10-01
申请人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
发明人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/08
摘要： A lead implantation system with an introducer, a lead configured to engage with the introducer such that the introducer can convey the lead to a desired internal target location, and at least one sensor. The sensor is adapted to generate an indicator of desired engagement of the system with the desired target tissue location prior to engagement of the lead with the target tissue. Also a method of implanting an implantable patient lead including advancing a lead implantation assembly towards a desired target location along an introduction axis and monitoring at least one indicator of lead implantation assembly position along the lead introduction axis. At least one indicator can be generated by the lead implantation assembly. Advancing of the lead introduction assembly can be halted when the monitoring indicates contact with the desired target tissue. The patient lead can then be advanced towards the target tissue and fixed to the target tissue.
摘要翻译：一种具有引导器的引线植入系统，引线被构造成与导引器接合，使得导引器可将引线传送到期望的内部目标位置，以及至少一个传感器。所述传感器适于在所述引线与所述目标组织接合之前产生具有期望的目标组织位置的所述系统期望接合的指示器。还有一种植入可植入患者导线的方法，包括沿着引入轴线将引线植入组件推向所需目标位置，并且沿导线引入轴监测铅植入组件位置的至少一个指示器。至少一个指示器可以由引线注入组件产生。当监测指示与所需目标组织接触时，引导组件的推进可以停止。然后可以将患者导线朝向目标组织推进并固定到靶组织。

102. 发明申请

US20200094057A1 METHOD AND SYSTEM UTILIZING A PERCENTAGE-BASED ATRIO-VENTRICULAR DELAY ADJUSTMENT 审中-公开
公开(公告)号：US20200094057A1
公开(公告)日：2020-03-26
申请号：US16574959
申请日：2019-09-18
申请人： Nima Badie , Jan O. Mangual-Soto , Luke C. McSpadden , Aditya Goil , Kyungmoo Ryu
发明人： Nima Badie , Jan O. Mangual-Soto , Luke C. McSpadden , Aditya Goil , Kyungmoo Ryu
IPC分类号： A61N1/368 , A61N1/365
摘要： A method and device for dynamic device based AV delay adjustment are provided. The method provides electrodes that are configured to be located proximate to an atrial (A) site and a right ventricular (RV) site. The method utilizes one or more processors, in an implantable medical device (IMD), for detecting an atrial paced (Ap) event or atrial sensed (As) event. The method determines a measured AV interval corresponding to an interval between the Ap event or the As event and a ventricular sensed event and calculates a percentage-based (PB) offset based on the measured AV interval. The method automatically dynamically adjusting an AV delay, utilized by the IMD, based on the measured AV interval and the PB offset and manages a pacing therapy, utilized by the IMD, based on the AV delay after the adjusting operation.

103. 发明申请

US20160279419A1 OPTIMAL PACING CONFIGURATION VIA VENTRICULAR CONDUCTION DELAYS 审中-公开
标题翻译：通过静态导通延迟的最佳配置
公开(公告)号：US20160279419A1
公开(公告)日：2016-09-29
申请号：US15172993
申请日：2016-06-03
申请人： Kyungmoo Ryu , Xiaoyi Min
发明人： Kyungmoo Ryu , Xiaoyi Min
IPC分类号： A61N1/368 , A61N1/365 , A61N1/37 , A61N1/05
CPC分类号： A61N1/3684 , A61N1/056 , A61N1/3627 , A61N1/36514 , A61N1/368 , A61N1/3686 , A61N1/371 , A61N1/37247
摘要： An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle; selecting a ventricular electrode from the series; delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response; acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series; based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities; based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy; and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：用于优化起搏配置的示例性方法包括提供与心室相关联的一系列三个或更多个心室电极的电极之间的距离; 从该系列中选择一个心室电极; 通过选择的心室电极向心室输送能量，足以引起诱发反应的能量; 通过该系列的非选择性心室电极获取与诱发反应相关的心脏电活动的信号; 基于通过未选择的心室电极获取的心脏电活动的信号和距离，确定传导速度; 基于传导速度，确定所选择的心室电极是否是用于递送心脏起搏疗法的最佳电极; 并且如果所选择的心室电极包括用于递送心脏起搏治疗的最佳电极，则要求使用所选择的心室电极递送心脏起搏治疗。还公开了各种其它方法，装置，系统等。

104. 发明授权

US09174054B1 Monitoring heart disease using implantable sensors 有权
标题翻译：使用植入式传感器监测心脏病
公开(公告)号：US09174054B1
公开(公告)日：2015-11-03
申请号：US11876560
申请日：2007-10-22
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08 , A61B5/0452 , A61N1/362 , A61B5/00
CPC分类号： A61B5/4842 , A61B5/00 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0538 , A61B5/1118 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4884 , A61B5/686 , A61B5/7275 , A61B5/746 , A61N1/08 , A61N1/3621 , A61N1/3627 , A61N1/3702 , A61N1/3704 , G06F19/00
摘要： Specific embodiments of the present invention determine a range of a physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the range. Other embodiments determine a minimum of a physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the minimum. Still other embodiments determine a maximum of the physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the maximum.
摘要翻译：本发明的具体实施方案根据多个时间段中的每一个确定生理特性的范围，并基于范围的变化来监测患者心脏病变化。其他实施例对于多个时间段中的每一个确定生理特性的最小值，并基于最小值的变化来监测患者心脏疾病的变化。另外其他实施方案确定多个时间段中的每一个的生理特性的最大值，并基于最大值的变化来监测患者心脏疾病的变化。

105. 发明授权

US09002455B2 Systems and methods for assessing and exploiting concurrent cathodal and anodal capture using an implantable medical device 有权
标题翻译：用于评估和利用可植入医疗设备并发阴极和阳极捕获的系统和方法
公开(公告)号：US09002455B2
公开(公告)日：2015-04-07
申请号：US13351958
申请日：2012-01-17
申请人： Heidi Hellman , Kyungmoo Ryu
发明人： Heidi Hellman , Kyungmoo Ryu
IPC分类号： A61N1/18 , A61B5/0452 , A61N1/37 , A61B5/042 , A61B5/00
CPC分类号： A61N1/3712 , A61B5/042 , A61B5/0452 , A61B5/7242
摘要： Techniques are provided for use by an implantable medical device for assessing and controlling concurrent anodal/cathodal capture. In one example, the device delivers bipolar pacing stimulus while sensing a bipolar intracardiac electrogram (IEGM) and while adjusting a magnitude of the pacing stimulus. The device analyzes the bipolar IEGM signals to detect an indication of activation representative of concurrent anodal and cathodal capture. Preferably, the pulse magnitude is set relative to the anodal/cathodal capture threshold based upon clinician programming in response to the needs of the patient. In this manner, concurrent anodal and cathodal capture can be selectively activated or deactivated based on clinician instructions received from a device programmer or other external programming device. Techniques exploiting both bipolar and unipolar IEGM signals to assess and control concurrent anodal/cathodal capture are also described. Techniques for use with quad-pole leads to achieve dual-site or quad-site capture are also set forth.
摘要翻译：提供技术用于可植入医疗装置用于评估和控制并发阳极/阴极捕获。在一个示例中，该装置提供双极起搏刺激，同时感测双极性心内电描记图（IEGM），同时调整起搏刺激的幅度。该器件分析双极性IEGM信号以检测表示并发阳极和阴极捕获的激活指示。优选地，响应于患者的需要，基于临床医师编程，相对于阳极/阴极俘获阈值设置脉搏幅度。以这种方式，可以基于从设备编程器或其它外部编程设备接收的临床医生指令来选择性地激活或去激活并发阳极和阴极捕获。还描述了利用双极和单极IEGM信号来评估和控制并行阳极/阴极俘获的技术。还阐述了与四极引线一起使用以实现双位点或四点捕获的技术。

106. 发明授权

US08923965B2 Systems and methods for optimizing AV/VV pacing delays using combined IEGM/impedance-based techniques for use with implantable medical devices 有权
标题翻译：使用组合的基于IEGM /阻抗的技术优化AV / VV起搏延迟的系统和方法，用于可植入医疗设备
公开(公告)号：US08923965B2
公开(公告)日：2014-12-30
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61B1/00 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

107. 发明授权

US08634902B2 Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
标题翻译：用于比较临床和诱导性室性心动过速事件的心脏分析系统
公开(公告)号：US08634902B2
公开(公告)日：2014-01-21
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

108. 发明申请

US20130184777A1 SYSTEMS AND METHODS FOR ASSESSING AND EXPLOITING CONCURRENT CATHODAL AND ANODAL CAPTURE USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗器械评估和开发并发阴道和阳极捕获的系统和方法
公开(公告)号：US20130184777A1
公开(公告)日：2013-07-18
申请号：US13351958
申请日：2012-01-17
申请人： Heidi Hellman , Kyungmoo Ryu
发明人： Heidi Hellman , Kyungmoo Ryu
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61B5/042 , A61B5/0452 , A61B5/7242
摘要： Techniques are provided for use by an implantable medical device for assessing and controlling concurrent anodal/cathodal capture. In one example, the device delivers bipolar pacing stimulus while sensing a bipolar intracardiac electrogram (IEGM) and while adjusting a magnitude of the pacing stimulus. The device analyzes the bipolar IEGM signals to detect an indication of activation representative of concurrent anodal and cathodal capture. Preferably, the pulse magnitude is set relative to the anodal/cathodal capture threshold based upon clinician programming in response to the needs of the patient. In this manner, concurrent anodal and cathodal capture can be selectively activated or deactivated based on clinician instructions received from a device programmer or other external programming device. Techniques exploiting both bipolar and unipolar IEGM signals to assess and control concurrent anodal/cathodal capture are also described. Techniques for use with quad-pole leads to achieve dual-site or quad-site capture are also set forth.
摘要翻译：提供技术用于可植入医疗装置用于评估和控制并发阳极/阴极捕获。在一个示例中，该装置提供双极起搏刺激，同时感测双极性心内电描记图（IEGM），同时调整起搏刺激的幅度。该器件分析双极性IEGM信号以检测表示并发阳极和阴极捕获的激活指示。优选地，响应于患者的需要，基于临床医师编程，相对于阳极/阴极俘获阈值设置脉搏幅度。以这种方式，可以基于从设备编程器或其它外部编程设备接收的临床医生指令来选择性地激活或去激活并发阳极和阴极捕获。还描述了利用双极和单极IEGM信号来评估和控制并行阳极/阴极俘获的技术。还阐述了与四极引线一起使用以实现双位点或四点捕获的技术。

109. 发明申请

US20130066221A1 METHOD AND SYSTEM FOR IDENTIFYING CARDIAC ARRHYTHMIA DRIVER SITES 有权
标题翻译：用于识别心脏病患者的方法和系统ARRHYTHMIA DRIVER SITES
公开(公告)号：US20130066221A1
公开(公告)日：2013-03-14
申请号：US13678764
申请日：2012-11-16
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
摘要翻译：识别用于心律失常的潜在驾驶员位置的方法包括从患者心脏的至少一部分上的多个位置获取多个电描记图。使用所获取的电描记图，生成至少一个电活动图。期望的电活动图包括复杂的分级电描记图标准偏差和平均图，主要频率图，峰 - 峰电压图和激活序列图。使用这些图中的一个或多个（例如，通过分析由这些图表示的一个或多个电描记图形态特征），可以检测至少一个潜在的驾驶员位置。

110. 发明申请

US20120165892A1 SYSTEMS AND METHODS FOR OPTIMIZING AV/VV PACING DELAYS USING COMBINED IEGM/IMPEDANCE-BASED TECHNIQUES FOR USE WITH IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：使用组合的IEGM /基于阻抗的技术优化AV / VV延迟的系统和方法与可植入医疗设备的使用
公开(公告)号：US20120165892A1
公开(公告)日：2012-06-28
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

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