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101. 发明授权

US08189105B2 Systems and methods of motion and edge adaptive processing including motion compensation features 有权
标题翻译：运动和边缘自适应处理的系统和方法，包括运动补偿特征
公开(公告)号：US08189105B2
公开(公告)日：2012-05-29
申请号：US11874096
申请日：2007-10-17
申请人： Jiande Jiang , Jun Zhang , Yong Wu , Dong Wang , Chun Wang
发明人： Jiande Jiang , Jun Zhang , Yong Wu , Dong Wang , Chun Wang
IPC分类号： H04N7/01
CPC分类号： H04N5/145 , H04N5/142 , H04N7/012 , H04N7/014 , H04N7/0142
摘要： Systems and methods of processing pixel information associated with video image deinterlacing are disclosed. In one exemplary implementation, the method may include performing an edge adaptive interpolation process on a present field so as to determine whether an edge passes through a pixel, wherein the edge adaptive interpolation process provides edge data including a first intensity estimate for the pixel, receiving motion data associated with motion compensation processing, including an estimated motion vector for at least one pixel proximate to the pixel in at least one reference field, determining a second intensity estimate for the pixel as a function of the edge data and the motion data, and performing an intensity-calculation procedure, wherein an interpolated intensity of the pixel is calculated as a function of the first intensity estimate and the second intensity estimate.
摘要翻译：公开了处理与视频图像去隔行扫描相关联的像素信息的系统和方法。在一个示例性实现中，该方法可以包括在当前场上执行边缘自适应内插处理，以便确定边缘是否通过像素，其中边缘自适应内插处理提供包括像素的第一强度估计的边缘数据，接收与运动补偿处理相关联的运动数据，包括至少一个在至少一个参考场中的像素附近的像素的运动矢量，确定作为边缘数据和运动数据的函数的像素的第二强度估计，以及执行强度计算过程，其中根据第一强度估计和第二强度估计来计算像素的内插强度。

102. 发明授权

US08188235B2 Antibodies to IL-6 and their uses 有权
标题翻译： IL-6抗体及其用途
公开(公告)号：US08188235B2
公开(公告)日：2012-05-29
申请号：US12480991
申请日：2009-06-09
申请人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
发明人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
IPC分类号： C07K16/00 , C07K16/24 , C07K16/46
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
摘要翻译：提供了结合人IL-6的抗体及其抗原结合部分。还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。

103. 发明授权

US08168304B2 Micronized wood preservative formulations comprising boron compounds 有权
标题翻译：包含硼化合物的微粉化木材防腐剂配方
公开(公告)号：US08168304B2
公开(公告)日：2012-05-01
申请号：US12691707
申请日：2010-01-21
申请人： Jun Zhang , Wenjin Zhang , Robert M. Leach
发明人： Jun Zhang , Wenjin Zhang , Robert M. Leach
IPC分类号： B27K3/22 , B27K3/38 , A01N59/16 , A01N59/20 , C09K15/14 , C09K15/16
CPC分类号： B27K3/52 , B27K3/005 , B27K3/163 , B27K3/34 , B27K3/50 , C09D5/14 , C09D5/18 , C09D15/00 , Y10T428/25 , Y10T428/256 , Y10T428/31982 , Y10T428/31989 , Y10T428/662
摘要： The present invention provides wood preservative and flame retardant compositions having low leachability comprising micronized boron compounds and, optionally, one or more organic biocides which may be micronized. Also provided is a method for applying the composition to wood and wood products comprising impregnating the wood with the composition.
摘要翻译：本发明提供具有低浸出性的木材防腐剂和阻燃组合物，其包含微粉化的硼化合物和任选的一种或多种可以被微粉化的有机杀生物剂。还提供了一种将组合物施用于木材和木制品的方法，包括用该组合物浸渍木材。

104. 发明申请

US20110311522A1 MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USES THEREOF 有权
标题翻译：单克隆抗体与AVIAN流感病毒亚型H5 HAEMAGGLUTININ结合及其用途
公开(公告)号：US20110311522A1
公开(公告)日：2011-12-22
申请号：US12664696
申请日：2008-06-16
申请人： Yixin Chen , Wenxin Luo , Jun Zhang , Ningshao Xia , Yi Guan , Honglin Chen
发明人： Yixin Chen , Wenxin Luo , Jun Zhang , Ningshao Xia , Yi Guan , Honglin Chen
IPC分类号： A61K39/42 , C12N5/12 , A61P31/16 , C12Q1/70 , A61P37/04 , C07K16/10 , C07H21/00
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： The present invention provides monoclonal antibodies that bind specifically to H5 subtype avian influenza virus hemagglutinin (HA) proteins, and can block the binding activity of at least 50% of the known monoclonal antibodies to the H5 subtype avian influenza virus hemagglutinin (HA) protein. The monoclonal antibodies can be used for the detection, diagnosis, prevention, and treatment of avian influenza viruses, especially the H5 subtype of avian influenza viruses. The present invention also provides the related hybridoma cell lines, isolated nucleic acid molecules and short peptides, as well as medical composition and medical diagnostic equipment and kit containing the monoclonal antibody.
摘要翻译：本发明提供了与H5亚型禽流感病毒血凝素（HA）蛋白特异性结合的单克隆抗体，并且可以阻断至少50％的已知单克隆抗体与H5亚型禽流感病毒血凝素（HA）蛋白的结合活性。单克隆抗体可用于检测，诊断，预防和治疗禽流感病毒，特别是禽流感病毒的H5亚型。本发明还提供了相关的杂交瘤细胞系，分离的核酸分子和短肽，以及包含单克隆抗体的医药组合物和医学诊断设备和试剂盒。

105. 发明授权

US08057119B2 Cosmetic applying device 有权
标题翻译：化妆品施用装置
公开(公告)号：US08057119B2
公开(公告)日：2011-11-15
申请号：US12432041
申请日：2009-04-29
申请人： Jun Zhang
发明人： Jun Zhang
IPC分类号： A46B11/04
CPC分类号： B65D47/242 , A45D34/04 , A46B11/0013 , A46B11/0041 , A46B11/0086 , A46B2200/1046 , B65D47/248
摘要： A cosmetic applying device includes a soft tube with an end member connected to the open end of the soft tube in which fluid cosmetic material is received. The end member has two through holes in the closed end and an engaging portion extending from an inner end of the closed end. A core piece has an end inserted into the end member and an applying head extends through a passage in the core piece. A cap is threadedly connected to the soft tube to protect the applying head. When the cap is connected to the soft tube, the passage of the core piece is sealed by the engaging portion to prevent air and cosmetic material from entering the soft tube. When the cap is removed from the soft tube, the core piece is moved and the engaging portion is disengaged from the passage.
摘要翻译：化妆品涂抹装置包括软管，其端部件连接到软管的开口端，其中容纳流体化妆品材料。端部构件在封闭端部具有两个通孔和从封闭端的内端延伸的接合部分。芯片具有插入端部构件中的端部，并且施加头部延伸穿过芯部件中的通道。盖帽螺纹连接到软管上以保护施加头。当盖连接到软管时，芯片的通道被接合部分密封，以防止空气和化妆品进入软管。当帽从软管中取出时，芯片移动并且接合部分从通道脱离。

106. 发明申请

US20110246870A1 VALIDATING MARKUP LANGUAGE SCHEMAS AND SEMANTIC CONSTRAINTS 审中-公开
标题翻译：验证标记语言规划和语义约束
公开(公告)号：US20110246870A1
公开(公告)日：2011-10-06
申请号：US12753189
申请日：2010-04-02
申请人： Shiguang Dong , Haiyang Gao , Jun Zhang , Dong-Hui Zhang
发明人： Shiguang Dong , Haiyang Gao , Jun Zhang , Dong-Hui Zhang
IPC分类号： G06F17/00 , G06F11/07
CPC分类号： G06F11/3604
摘要： Semantic constraints and schemas may be validated in markup language documents. A computer may be utilized to receive a strongly-typed document object model representing a markup language document. The computer may then be utilized to load semantic constraints and validate the strongly-typed document object model representing the markup language document to determine whether the semantic constraints have been met. Then, the computer may be utilized to generate a result based on the validation. The computer may also be utilized to load schema constraints for a schema used to define a markup language document and validate a strongly-typed document object model representing the markup language document against the schema constraints. Then, the computer may be utilized to generate a result based on the validation.
摘要翻译：语义约束和模式可以在标记语言文档中进行验证。可以使用计算机来接收表示标记语言文档的强类型的文档对象模型。然后可以利用计算机来加载语义约束并验证表示标记语言文档的强类型的文档对象模型，以确定语义约束是否已被满足。然后，计算机可以用于基于验证产生结果。计算机还可以用于加载用于定义标记语言文档的模式的模式约束，并根据模式约束验证表示标记语言文档的强类型文档对象模型。然后，计算机可以用于基于验证产生结果。

107. 发明申请

US20110243904A1 RNA INTERFERENCE TARGET FOR TREATING AIDS 审中-公开
标题翻译：用于治疗艾滋病的RNA干扰目标
公开(公告)号：US20110243904A1
公开(公告)日：2011-10-06
申请号：US12602005
申请日：2008-06-02
申请人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
发明人： Tong Cheng , Tao Zhang , Yali Zhang , Ji Miao , Jun Zhang , Ningshao Xia
IPC分类号： A61K48/00 , C07H21/04 , C12N15/63 , C07H21/02 , C12N15/85 , C12N5/10 , C12N1/00 , A61K31/713 , A61K31/7088 , A61K35/12 , A61P31/18
CPC分类号： C12N15/1132 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to RNA interference target sequence targeting HIV for the treatment of AIDS. Based on the target sequence, recombinant expression vectors, packaging vectors and cells were constructed, which express a siRNA and/or a miRNA and/or a ribozyme and/or an antisense oligonucleotide targeting HIV. Also provided is the use of the recombinant expression vectors, packaging vectors and recombinant cells in the manufacture of a medicament for the treatment of AIDS.
摘要翻译：本发明涉及靶向用于治疗AIDS的HIV的RNA干扰靶序列。基于靶序列，构建重组表达载体，包装载体和细胞，其表达siRNA和/或miRNA和/或靶向HIV的核酶和/或反义寡核苷酸。还提供了重组表达载体，包装载体和重组细胞在制备用于治疗AIDS的药物中的用途。

108. 发明申请

US20110238001A1 NANOPARTICLE BASED PHOTODYNAMIC THERAPY AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：基于纳米光度的光化疗法及其制备方法
公开(公告)号：US20110238001A1
公开(公告)日：2011-09-29
申请号：US13151858
申请日：2011-06-02
申请人： Wei Chen , Jun Zhang
发明人： Wei Chen , Jun Zhang
IPC分类号： A61M37/00
CPC分类号： B82Y5/00 , A61K33/00 , A61K41/0052 , A61K41/0071 , A61K45/06 , A61K47/551 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61N5/062 , A61N2005/1098 , Y02A50/473
摘要： A novel method for cancer treatment that combines radiotherapy and photodynamic therapy (PDT). More particularly, luminescent nanoparticles with attached photosensitizers, such as porphyrins, are used as a new type of agent for photodynamic therapy. Upon exposure to ionizing radiation, light will emit from the nanoparticles to activate the photosensitizers; as a consequence, a singlet oxygen is produced to augment the killing of cancer cells by ionizing radiation. No external light is necessary to activate the photosensitizing agent within tumors. The combination of radiotherapy and PDT is more efficient than either used alone.
摘要翻译：一种结合放射治疗和光动力治疗（PDT）的新型癌症治疗方法。更具体地，使用具有附着的光敏剂如卟啉的发光纳米颗粒作为光动力学治疗的新型试剂。暴露于电离辐射后，光将从纳米颗粒中发射以激活光敏剂; 因此，产生单线态氧以增加通过电离辐射杀死癌细胞。不需要外部光来激活肿瘤内的光敏剂。放射治疗和PDT的组合比单独使用更有效。

109. 发明申请

US20110212081A1 KRÜPPEL-LIKE FACTORS AND FAT REGULATION 审中-公开
标题翻译： KRÜPPEL-LIKE因子和脂肪调节
公开(公告)号：US20110212081A1
公开(公告)日：2011-09-01
申请号：US13107202
申请日：2011-05-13
申请人： Sarwar Hashmi , Chuan Yang , Jun Zhang , Cheng-Han Huang
发明人： Sarwar Hashmi , Chuan Yang , Jun Zhang , Cheng-Han Huang
IPC分类号： A61K39/395 , C12N5/02 , C12N5/00 , A61K38/00 , A61K31/7088 , A61P3/00
CPC分类号： A61K38/1709 , C07K14/4702 , C12N15/113 , C12N2310/14
摘要： Disclosed herein are methods and cell lines used in fat regulation. The methods and cell lines incorporate Krüppel-like factors including, without limitation, klf-1 and klf-3.
摘要翻译：本文公开了用于脂肪调节的方法和细胞系。方法和细胞系包含Krüppel样因子，包括但不限于klf-1和klf-3。

110. 发明申请

US20110152205A1 APPLICATION OF PUERARIN IN THE PREPARATION OF P2X3 MEDIATED DRUGS FOR PAIN/NERVOUS SYSTEM DISEASES 失效
标题翻译：在制备P2X3介导的药物用于疼痛/神经系统疾病中应用PUERARIN
公开(公告)号：US20110152205A1
公开(公告)日：2011-06-23
申请号：US12922245
申请日：2010-06-29
申请人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
发明人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
IPC分类号： A61K31/7034 , A61P25/00 , A61P29/00
CPC分类号： A61K31/352
摘要： The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
摘要翻译：本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流神经性疼痛大鼠根神经节。实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用受体涉及神经系统疾病。

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