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1. 发明授权

US08362070B2 Application of puerarin in the preparation of P2X3 mediated drugs for pain/nervous system diseases 失效
标题翻译：应用葛根素制备P2X3介导的药物用于疼痛/神经系统疾病
公开(公告)号：US08362070B2
公开(公告)日：2013-01-29
申请号：US12922245
申请日：2010-06-29
申请人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
发明人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
IPC分类号： A61K31/35 , A61K31/70
CPC分类号： A61K31/352
摘要： The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
摘要翻译：本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流神经性疼痛大鼠根神经节。实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用受体涉及神经系统疾病。

2. 发明申请

US20110152205A1 APPLICATION OF PUERARIN IN THE PREPARATION OF P2X3 MEDIATED DRUGS FOR PAIN/NERVOUS SYSTEM DISEASES 失效
标题翻译：在制备P2X3介导的药物用于疼痛/神经系统疾病中应用PUERARIN
公开(公告)号：US20110152205A1
公开(公告)日：2011-06-23
申请号：US12922245
申请日：2010-06-29
申请人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
发明人： Shangdong Liang , Changshui Xu , Yun Gao , Guilin Li , Jiari Lin , Shuangmei Liu , Han Liu , Jun Zhang , Xin Li
IPC分类号： A61K31/7034 , A61P25/00 , A61P29/00
CPC分类号： A61K31/352
摘要： The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
摘要翻译：本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流神经性疼痛大鼠根神经节。实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用受体涉及神经系统疾病。

3. 发明申请

US20150270751A1 ROTORS WITH SEGMENTED MAGNET CONFIGURATIONS AND RELATED DYNAMOELECTRIC MACHINES AND COMPRESSORS 有权
标题翻译：带有分段磁铁配置的转子和相关的动态电机和压缩机
公开(公告)号：US20150270751A1
公开(公告)日：2015-09-24
申请号：US14428296
申请日：2012-09-29
申请人： Pingshan CAO , Xin LI , Xin LI , EMERSON ELECTRIC CO.
发明人： Pingshan Cao , Xin Li , Xin Li
IPC分类号： H02K1/27 , F04D25/02 , F04D25/06 , H02K1/02
CPC分类号： H02K1/2773 , F04D25/026 , F04D25/06 , H02K1/02
摘要： A rotor for a dynamoelectric machine includes a rotor core having an outer periphery and at least a first set of magnets positioned within the outer periphery of the rotor core. The first set of magnets includes at least two block magnets and an arc magnet. The block magnets have a substantially parallel magnetization pattern and the arc magnet has a substantially radial magnetization pattern. The arc magnet has a concave surface facing the outer periphery of the rotor core. The first set of magnets defines a pole of the rotor. Rotors with other magnet configurations, and dynamoelectric machines and compressors incorporating such rotors, are also disclosed.
摘要翻译：一种用于电动机的转子包括具有外周边的转子芯和至少位于转子芯的外圆周内的第一组磁体。第一组磁体包括至少两个块磁体和电弧磁体。块状磁体具有基本平行的磁化模式，并且电弧磁体具有基本上径向的磁化模式。电弧磁体具有面向转子芯的外周的凹面。第一组磁体限定了转子的极点。还公开了具有其它磁体配置的转子，以及包含这种转子的电动机器和压缩机。

4. 发明申请

US20220211334A1 SCINTILLATION DETECTOR BASED SYSTEMS AND METHODS FOR USING THE SAME 有权
公开(公告)号：US20220211334A1
公开(公告)日：2022-07-07
申请号：US17700442
申请日：2022-03-21
申请人： Lars Furenlid , Xin Li
发明人： Lars Furenlid , Xin Li
IPC分类号： A61B6/03 , G01T1/202 , G01T1/20 , A61B6/00
摘要： A scintillation-crystal based gamma-ray detector with photon sensors disposed on edge surface(s) of the crystal to take advantage of total internal reflection of scintillation photons within the thin-slab detector substrate to improve spatial resolution of determination of a scintillation event (including depth-of-interaction resolution) while preserving energy resolution and detection efficiency. The proposed structure benefits from the reduced—as compared with related art—total number of readout channels elimination of need in complicated and repetitive cutting and polishing operations to form pixelated crystal arrays used in conventional PET detector modules. Detectors systems utilizing stacks of such detectors, and methods of operation of same.

5. 发明授权

US10532963B2 Methods for the oxidative dehydrogenation of butene to produce butadiene 有权
公开(公告)号：US10532963B2
公开(公告)日：2020-01-14
申请号：US16062541
申请日：2017-01-05
申请人： SABIC Global Technologies B.V. , Xin Li , Jorge Jimenez , Paulette Hazin , Reggie Tennyson , Xiankuan Zhang
发明人： Xin Li , Jorge Jimenez , Paulette Hazin , Reggie Tennyson , Xiankuan Zhang
IPC分类号： C07C5/48 , B01J23/00 , B01J27/10 , C07C11/167
摘要： Methods for producing butadiene by the oxidative dehydrogenation of butene are provided. Methods for producing butadiene from a feed stream including oxygen and butene in a molar ratio of oxygen to butene (O2/C4H8) from about 0.9 to about 1.5 can include introducing the feed stream to a catalyst in the presence of steam. The molar ratio of steam to butene (H2O/C4H8) can be from about 10 to about 20. Methods can further include reacting the butene to generate a product stream therefrom comprising butadiene and water. Methods can further include separating water from the product stream to generate a butadiene stream including greater than about 85 wt-% butadiene.

6. 发明授权

US10280649B2 Magnetic unlocking device and magnetic unlocking structure of magnetic encoding key 有权
公开(公告)号：US10280649B2
公开(公告)日：2019-05-07
申请号：US15313108
申请日：2015-04-20
申请人： Xin Li
发明人： Xin Li
IPC分类号： E05B47/00 , E05B19/00 , E05B73/00 , E05B19/26
摘要： A magnetic unlocking device and a magnetic unlocking structure of a magnetic encoding key. The magnetic unlocking structure includes a lock core device and a magnetic unlocking device. The lock core device includes a lock core casing, a lock knob which is provided in the internal cavity of the lock core casing, a lock care front end cover and a lock core rear end cover that are located at both ends of the lock core casing. The internal wall of the lock core casing is provided with a monad longitudinal moving groove and a monad horizontal rotating groove. The lock knob is provided with an unlocking hole. The external wall of the lock knob is provided with a monad longitudinal slide-way. The monad longitudinal slide-way and the monad longitudinal moving groove correspond to each other and form a monad moving cavity.

7. 发明授权

US09991494B2 Nano microporous diaphragm of post-crosslinked rubber and polyolefin composite, and manufacturing method thereof 有权
公开(公告)号：US09991494B2
公开(公告)日：2018-06-05
申请号：US14442098
申请日：2011-07-22
申请人： Xin Li , Jianhua Li , Wei Chen , Yongjun Jiao , Long Li , Xinjian Deng
发明人： Xin Li , Jianhua Li , Wei Chen , Yongjun Jiao , Long Li , Xinjian Deng
IPC分类号： H01M2/16 , H01M10/0525 , H01M2/14 , C08L21/00
CPC分类号： H01M2/1686 , B32B2457/10 , C08L21/00 , H01M2/145 , H01M2/1653 , H01M10/0525
摘要： The present invention relates to a composite nano microporous diaphragm for use in lithium ion cells using polyolefin modified with post-crosslinked rubber and manufacturing method thereof. The microporous diaphragm at least comprises a nano microporous diaphragm A layer with a chemical gel content of more than 20%, the microscopic structure thereof is designed to be the rubber material that has been evenly dispersed and has subjected to a post-crosslinking treatment in polyolefin nano microfiber matrix, forming a nano microporous diaphragm of rubber-plastic composite. The nano microporous diaphragm with high strength, thermal cutoff, high temperature resistance, as well as good liquid absorption and swelling and compression elasticity can be applied to lithium ion power cells with high safety and long cycling life.

8. 发明授权

US09670510B2 Methods of hydrolyzing and fermenting cellulosic material 有权
公开(公告)号：US09670510B2
公开(公告)日：2017-06-06
申请号：US14240663
申请日：2012-09-07
申请人： Hui Xu , Ye Chen , Xin Li , Mark Stevens , Zhengfang Kang
发明人： Hui Xu , Ye Chen , Xin Li , Mark Stevens , Zhengfang Kang
IPC分类号： C12P7/14 , C12P19/14 , C12P7/10
CPC分类号： C12P7/14 , C12P7/10 , C12P19/14 , Y02E50/16
摘要： Described herein are improved methods of degrading or converting cellulosic material into fermentable sugars using dithionite. Also described are improved methods of fermentation in the presence of dithionite.

9. 发明授权

US09489289B2 Adaptive framework automatically prioritizing software test cases 有权
标题翻译：自适应框架自动优先考虑软件测试用例
公开(公告)号：US09489289B2
公开(公告)日：2016-11-08
申请号：US14565220
申请日：2014-12-09
申请人： Ziheng Hu , Jing Li , Xin Li , Chen Zhou , Longhui Chang
发明人： Ziheng Hu , Jing Li , Xin Li , Chen Zhou , Longhui Chang
IPC分类号： G06F11/00 , G06F11/36
CPC分类号： G06F11/3684 , G06F11/3688
摘要： An automated, self-adaptive framework prioritizes software testing in a consistent and effective manner. A metric evaluates past test execution information for assigning regression testing priority. The metric may be calculated with reference to one or more of the following factors taken in combination: requirement, coverage, history, and cost. The requirement factor considers customer-assigned priority of testing the code, complexity of implementing the code, and proneness of the code to faults. The coverage factor considers code coverage, feature coverage, and common usage rate. The history factor considers previous bug found rate, case stable rate, and priority to calculate. The cost factor considers test case execution time, and step length. A value of each factor for one test case is measured according to that test case and is not related to other test cases. The calculation result representing the metric for each test case determines a priority of the test case.
摘要翻译：自动化的自适应框架以一致和有效的方式优先考虑软件测试。指标评估过去的测试执行信息，以分配回归测试优先级。可以参考以下组合中的一个或多个因素来计算度量：要求，覆盖率，历史和成本。要求因素考虑了客户分配的测试代码的优先级，实现代码的复杂性和代码的错误。覆盖率考虑代码覆盖率，功能覆盖率和常用使用率。历史因素考虑以前的错误发现率，病例稳定率和优先级来计算。成本因素考虑测试用例执行时间和步长。一个测试用例的每个因子的值根据该测试用例进行测量，与其他测试用例无关。表示每个测试用例的度量的计算结果决定了测试用例的优先级。

10. 发明申请

US20150310598A1 CONTRAST REAGENT LEAKAGE CORRECTION IN DYNAMIC SUSCEPTIBILITY CONTRAST MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：动力学不对称磁共振成像中的对比试剂泄漏校正
公开(公告)号：US20150310598A1
公开(公告)日：2015-10-29
申请号：US14694319
申请日：2015-04-23
申请人： William Rooney , Xin Li
发明人： William Rooney , Xin Li
IPC分类号： G06T7/00 , A61K49/10
CPC分类号： G06T7/00 , A61B5/055 , A61B5/4064 , A61B2576/026 , A61K49/106 , G01R33/50 , G01R33/5601 , G01R33/5608 , G06T7/0016 , G06T2200/04 , G06T2207/10088 , G06T2207/10096 , G06T2207/30016 , G06T2207/30096 , G06T2207/30104
摘要： Disclosed are methods and systems for calculating a contrast reagent (CR) extravasation rate constant and generating a contrast reagent leakage corrected relative cerebral blood volume (rCBV) image map of a brain region from dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) time-course image data based on pharmacokinetic first principles. In one example approach, a computerized method may include performing a linearization transform of a DSC MRI time-course equation which accounts for an intravascular contribution and an extravasating component, and calculating CR leakage from a slope of a linear portion of the transformed data.
摘要翻译：公开了用于计算造影剂（CR）外渗速率常数并从动态磁敏度对比（DSC）磁共振成像（MRI）时间产生脑区域的造影剂泄漏校正的相对脑血容量（rCBV）图像图的方法和系统基于药代动力学第一原则的图像数据。在一个示例性方法中，计算机化方法可以包括执行考虑血管内贡献和外渗分量的DSC MRI时程方程的线性化变换，以及从变换数据的线性部分的斜率计算CR泄漏。

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