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101. 发明申请

US20070166327A1 Mammalian antigen-presenting T cells and bi-specific T cells 审中-公开
标题翻译：哺乳动物抗原呈递T细胞和双特异性T细胞
公开(公告)号：US20070166327A1
公开(公告)日：2007-07-19
申请号：US11700762
申请日：2007-02-01
申请人： Laurence Cooper , Michael Jensen
发明人： Laurence Cooper , Michael Jensen
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K35/12 , A61K35/17 , A61K39/0011 , A61K39/145 , A61K39/245 , A61K2039/5158 , C12N5/0636
摘要： The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to viral specific T cells that express chimeric anti-tumor receptors. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.
摘要翻译：本发明涉及哺乳动物双特异性T细胞和使用这些双特异性T细胞的方法。更具体地，本发明涉及表达嵌合抗肿瘤受体的病毒特异性T细胞。这些双特异性T细胞克隆是效应细胞的来源，其在体内依赖于用病毒抗原的刺激而持续存在，导致其转移到患有癌症和自身免疫疾病的患者之后的长期功能。

102. 发明申请

US20070094482A1 Boundary address registers for selection of ISA mode 有权
标题翻译：用于选择ISA模式的边界地址寄存器
公开(公告)号：US20070094482A1
公开(公告)日：2007-04-26
申请号：US11636462
申请日：2006-12-11
申请人： Michael Jensen , Morten Stribaek
发明人： Michael Jensen , Morten Stribaek
IPC分类号： G06F9/40
CPC分类号： G06F9/44547 , G06F9/30076 , G06F9/30189 , G06F9/30196 , G06F9/3802
摘要： An apparatus and method are provided that enable a multiple instruction set architecture (ISA) central processing unit (CPU) to distinguish between different program instructions corresponding to different ISAs during execution of a multiple-ISA application program. The apparatus allows the multiple-ISA CPU to select a particular ISA decoding mode corresponding to a program instruction. The program instruction is located at an address within an address space of the multiple-ISA CPU. The apparatus includes a plurality of boundary address registers and ISA mode selection logic. The plurality of boundary address registers can be dynamically loaded to partition the address space into a plurality of address ranges, where each of the plurality of address ranges corresponds to each of a plurality of ISA decoding modes. The ISA mode selection logic is coupled to the plurality of boundary address registers. The ISA mode selection logic receives the particular address, and compares it against the plurality of address ranges to determine the particular ISA decoding mode for the particular program instruction.
摘要翻译：提供了一种装置和方法，其使多个指令集体系结构（ISA）中央处理单元（CPU）在执行多个ISA应用程序期间区分与不同ISA相对应的不同程序指令。该装置允许多ISA CPU选择与程序指令相对应的特定ISA解码模式。程序指令位于多ISA CPU的地址空间内的地址。该装置包括多个边界地址寄存器和ISA模式选择逻辑。可以动态地加载多个边界地址寄存器以将地址空间分割成多个地址范围，其中多个地址范围中的每一个对应于多个ISA解码模式中的每一个。 ISA模式选择逻辑耦合到多个边界地址寄存器。 ISA模式选择逻辑接收特定地址，并将其与多个地址范围进行比较，以确定特定程序指令的特定ISA解码模式。

103. 发明申请

US20060246548A1 CE7-specific redirected immune cells 有权
标题翻译： CE7特异性重定向免疫细胞
公开(公告)号：US20060246548A1
公开(公告)日：2006-11-02
申请号：US11477572
申请日：2006-06-30
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： C07K14/74 , C07H21/04 , C12P21/06
CPC分类号： C07K14/7051 , A61K48/00 , C07H21/04 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30
摘要： Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain FvFc:ζ receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CE7 linked by peptide, Fc represents a hinge-CH2—CH3 region of a human IgG1, and ζ represents the intracellular signaling domain of the zeta chain of human CD3. DNA constructs encoding a chimeric T-cell receptor and a method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor are also disclosed.
摘要翻译：基因工程化的CE7特异性重定向免疫细胞，其表达具有细胞外结构域的细胞表面蛋白，所述胞外结构域包含对CE7特异的受体，细胞内信号结构域和跨膜结构域，以及用于这些细胞用于CE7 +神经母细胞瘤的细胞免疫治疗的方法被披露。在一个实施方案中，免疫细胞是T细胞，细胞表面蛋白是单链FvFc：ζ受体，其中Fv表示一个或更多个的V H链和V L链通过肽连接的CE7单链单克隆抗体代表人IgG的铰链-CH 2 H 2 C 3 H 3区域， SUB> 1，Zeta表示人CD3的zeta链的细胞内信号转导结构域。还公开了编码嵌合T细胞受体的DNA构建体和通过使用编码受体的裸DNA通过电穿孔制备表达嵌合T细胞受体的重定向T细胞的方法。

104. 发明申请

US20060206692A1 Instruction dispatch scheduler employing round-robin apparatus supporting multiple thread priorities for use in multithreading microprocessor 有权
标题翻译：指令调度调度器使用支持多线程优先级的循环设备，用于多线程微处理器
公开(公告)号：US20060206692A1
公开(公告)日：2006-09-14
申请号：US11087070
申请日：2005-03-22
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： G06F9/30
CPC分类号： G06F9/3851 , G06F9/3802 , G06F9/3861
摘要： A dispatch scheduler in a multithreading microprocessor is disclosed. Each of N concurrently executing threads has one of P priorities. P N-bit round-robin vectors are generated, each being a 1-bit left-rotated and subsequently sign-extended version of an N-bit 1-hot input vector indicating the last thread selected for dispatching at the priority. N P-input muxes each receive a corresponding one of the N bits of each of the P round-robin vectors and selects the input specified by the thread priority. Selection logic selects an instruction for dispatching from the thread having a dispatch value greater than or equal to any of the threads left thereof in the N-bit input vectors. The dispatch value of each of the threads comprises a least-significant bit equal to the corresponding P-input mux output, a most-significant bit that is true if the instruction is dispatchable, and middle bits comprising the priority of the thread.
摘要翻译：公开了一种多线程微处理器中的调度调度器。 N个并发执行线程中的每一个具有P个优先级中的一个。产生P个N位循环向量，每个向量是1位左旋转和随后的符号扩展版本的N位1-热输入向量，指示被选择用于优先调度的最后一个线程。 N个P输入多路复用器各自接收每个P循环向量的N个比特中的相应一个，并且选择由线程优先级指定的输入。选择逻辑选择用于从具有大于或等于N位输入向量中剩余的任何线程的调度值的线程调度的指令。每个线程的调度值包括等于对应的P输入多路复用器输出的最低有效位，如果指令是可调度的，则为最高有效位，以及包含线程优先级的中间位。

105. 发明申请

US20060206686A1 Three-tiered translation lookaside buffer hierarchy in a multithreading microprocessor 有权
公开(公告)号：US20060206686A1
公开(公告)日：2006-09-14
申请号：US11075041
申请日：2005-03-08
申请人： Soumya Banerjee , Michael Jensen , Ryan Kinter
发明人： Soumya Banerjee , Michael Jensen , Ryan Kinter
IPC分类号： G06F12/10
CPC分类号： G06F12/1027 , G06F2212/681
摘要： A three-tiered TLB architecture in a multithreading processor that concurrently executes multiple instruction threads is provided. A macro-TLB caches address translation information for memory pages for all the threads. A micro-TLB caches the translation information for a subset of the memory pages cached in the macro-TLB. A respective nano-TLB for each of the threads caches translation information only for the respective thread. The nano-TLBs also include replacement information to indicate which entries in the nano-TLB/micro-TLB hold recently used translation information for the respective thread. Based on the replacement information, recently used information is copied to the nano-TLB if evicted from the micro-TLB.

106. 发明申请

US20060205648A1 Liquid, aqueous pharmaceutical compositions of factor VII polypeptides 失效
标题翻译：液体，因子VII多肽的水性药物组合物
公开(公告)号：US20060205648A1
公开(公告)日：2006-09-14
申请号：US11353335
申请日：2006-02-14
申请人： Michael Jensen , Anders Petersen , Andrew Bowler
发明人： Michael Jensen , Anders Petersen , Andrew Bowler
IPC分类号： A61K38/36 , A61K31/17
CPC分类号： A61K38/4846 , A61K9/0019 , A61K31/17 , A61K38/36 , A61K47/02 , A61K47/16 , A61K47/183 , A61K47/42
摘要： The present invention is directed to liquid, aqueous pharmaceutical compositions stabilised against chemical and/or physical degradation containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising at least 0.01 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; and at least one stabilising agent (iii) comprising a —C(═N-Z1-R1)—NH-Z2-R2 motif, e.g. benzamidine compounds and guanidine compounds such as arginine.
摘要翻译：本发明涉及针对含有因子VII多肽的化学和/或物理降解稳定的液体水性药物组合物，以及用于制备和使用这些组合物的方法以及含有该组合物的小瓶，以及这些组合物在治疗中的用途的因子VII反应综合征。主要实施方案由包含至少0.01mg / mL的因子VII多肽（i）的液体含水药物组合物表示; 适于将pH保持在约4.0至约9.0范围内的缓冲剂（ii）; 和至少一种稳定剂（ⅲ），其包含-C（-NZ 1）1 -OR 1 -NH-Z 2 - SUP> 2 图案，例如苄脒化合物和胍化合物如精氨酸。

107. 发明申请

US20060150089A1 Apparatus, system, and method for editing a region of a document intersecting multiple content component types in a single operation 有权
标题翻译：用于在单个操作中编辑与多个内容组件类型相交的文档的区域的装置，系统和方法
公开(公告)号：US20060150089A1
公开(公告)日：2006-07-06
申请号：US11028118
申请日：2005-01-03
申请人： Michael Jensen , Ronald Buskirk , Ivan Woehr
发明人： Michael Jensen , Ronald Buskirk , Ivan Woehr
IPC分类号： G06F17/21 , G06F17/24
CPC分类号： G06F17/24
摘要： An apparatus, system, and method are disclosed for editing a region of a document intersecting multiple content component types in a single operation. The apparatus includes an input module, a function module, an identification module, a document editing module, and an output module. The input module receives a description of a region of a document. The region intersects a plurality of content component types. The function module obtains a function to be applied to the region. The identification module identifies a set of content components intersecting the region. The document editing module processes intersecting portions of the content components using the function. The output module updates the document with processed intersecting portions of the content components. The apparatus may additionally include a format module that determines an acceptable content component format for the function and a conversion module that converts the intersecting portions of the content components to the acceptable format.
摘要翻译：公开了用于在单个操作中编辑与多个内容组件类型相交的文档的区域的装置，系统和方法。该装置包括输入模块，功能模块，识别模块，文档编辑模块和输出模块。输入模块接收文档区域的描述。该区域与多个内容组件类型相交。功能模块获得应用于该区域的功能。识别模块识别与该区域相交的一组内容组件。文档编辑模块使用该功能处理内容组件的相交部分。输出模块用内容组件的处理相交部分更新文档。该装置可以另外包括格式模块，该格式模块确定用于该功能的可接受的内容组件格式;以及转换模块，其将内容组件的相交部分转换为可接受的格式。

108. 发明申请

US20060067920A1 Chimeric immunoreceptor useful in treating human cancers 有权
公开(公告)号：US20060067920A1
公开(公告)日：2006-03-30
申请号：US11274344
申请日：2005-11-16
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： A61K48/00 , C07K14/74
CPC分类号： C07K14/5437 , C07K14/7051 , C07K14/7155 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targetting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.

109. 发明授权

US06702138B1 Insulated beverage container and lid assembly 失效
标题翻译：绝缘饮料容器和盖组件
公开(公告)号：US06702138B1
公开(公告)日：2004-03-09
申请号：US10235992
申请日：2002-09-04
申请人： Andy Bielecki , Brian Furlong , Michael Jensen , Tim Nowack
发明人： Andy Bielecki , Brian Furlong , Michael Jensen , Tim Nowack
IPC分类号： B65D5118
CPC分类号： A47G19/2272 , A47G19/2288 , A47J41/0022
摘要： An insulated beverage container (100) has a tumbler (110), a handle assembly (120) including a collar (122) attached to the top of the tumbler, and a valved lid assembly (200). The tumbler has multiple wall construction, wherein the inner two walls (114, 116) define an insulating volume (118) therebetween that may be partially evacuated. The valved lid assembly includes an upwardly biased valve (240), near the top of the lid assembly, that may be moved from a closed position wherein the valve abuts a valve seat (214) in the lid assembly, and an open position wherein the valve is spaced apart from the valve seat. A non-skid base (102) with integral, upwardly extending grip elements provides a grip to facilitate handling of the tumbler.
摘要翻译：绝缘饮料容器（100）具有转鼓（110），手柄组件（120），其包括附接到制动栓顶部的轴环（122）和阀盖组件（200）。制动栓具有多个壁结构，其中内部两个壁（114,116）在其间限定绝缘体积（118），其可以被部分抽真空。带盖的盖组件包括靠近盖组件顶部的向上偏压的阀（240），其可以从关闭位置移动，其中阀邻接盖组件中的阀座（214），以及打开位置，其中，阀与阀座间隔开。具有整体向上延伸的抓握元件的防滑基座（102）提供抓握以便于翻转开关的操纵。

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