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101. 发明授权

US5338829A Peptides derived from human immunodeficiency virus-1 GP160 失效
标题翻译：衍生自人类免疫缺陷病毒-1 GP160的肽
公开(公告)号：US5338829A
公开(公告)日：1994-08-16
申请号：US932078
申请日：1992-10-19
申请人： David B. Weiner , Mark I. Greene , William V. Williams
发明人： David B. Weiner , Mark I. Greene , William V. Williams
IPC分类号： A61K38/00 , A61K39/00 , C07K14/16 , C07K14/705 , C07K16/10 , A61K37/02 , C07K3/00 , C07K5/00 , C07K15/00
CPC分类号： C07K14/005 , C07K14/705 , C07K16/1063 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： This invention discloses novel polypeptides having an antigenic determinant or determinants immunologically cross-reactive with determinants of a glycoprotein having a molecular weight of approximately 41,000 daltons, and determinants of a glycoprotein having a molecular weight of approximately 160,000 daltons which are obtained from cells infected with human immunodeficiency virus-1. The invention further discloses novel polypeptides having an antigenic determinant or determinants specific for a glycoprotein having a molecular weight of approximately 41,000 daltons obtained from cells infected with human immunodeficiency virus-1, the polypeptides further having an antigenic determinant or determinants immunologically cross-reactive with at least one glycoprotein having a molecular weight of 25,000 to 35,000 daltons, 45,000 daltons to 60,000 daltons, 80,000 to 100,000 daltons or 180,000 or 220,000 daltons, which are obtained from HSB, St, HeLa and human cells. The novel polypeptides of the invention are useful in methods of interfering with the effects of HIV-1 upon host cells having cell surface polypeptides capable of binding HIV-1. Methods of assay for HIV-1 infection are also disclosed. The invention also discloses peptides having amino acid sequences of about 10 to about 50 amino acids that correspond to at least a portion of an epitope of HIV and methods for developing such biologically active peptides.
摘要翻译：本发明公开了具有与具有约41,000道尔顿分子量的糖蛋白的决定簇免疫交叉反应的抗原决定簇或决定簇的新型多肽，以及分子量约为160,000道尔顿的糖蛋白的决定簇，这些糖蛋白是从感染人的细胞获得的免疫缺陷病毒-1。本发明进一步公开了具有抗原决定簇或具有特异性的决定簇的新型多肽，该决定簇具有从感染人类免疫缺陷病毒-1的细胞获得的具有约41,000道尔顿的糖蛋白的特异性，所述多肽还具有抗原决定簇或与抗原决定簇免疫交叉反应的决定簇至少一种由HSB，St，HeLa和人细胞获得的分子量为25,000至35,000道尔顿，45,000道尔顿至60,000道尔顿，80,000至100,000道尔顿或180,000或220,000道尔顿的糖蛋白。本发明的新型多肽可用于干扰HIV-1对具有能够结合HIV-1的细胞表面多肽的宿主细胞的作用的方法。还公开了HIV-1感染的测定方法。本发明还公开了具有对应于HIV表位的至少一部分的约10至约50个氨基酸的氨基酸序列的肽和用于开发此类生物活性肽的方法。

102. 发明授权

US10799572B2 Consensus antigen constructs and vaccines made therefrom, and methods of using the same to treat malaria 有权
公开(公告)号：US10799572B2
公开(公告)日：2020-10-13
申请号：US13876148
申请日：2011-09-27
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Niranjan Y. Sardesai
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Niranjan Y. Sardesai
IPC分类号： A61K39/015 , C07K14/445 , A61K38/19 , A61K38/20 , A61K39/00
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.

103. 发明申请

US20190091322A1 DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME 审中-公开
公开(公告)号：US20190091322A1
公开(公告)日：2019-03-28
申请号：US16087146
申请日：2017-03-21
申请人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
发明人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
IPC分类号： A61K39/12 , A61K39/42 , C07K16/10
摘要： Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.

104. 发明授权

US10220082B2 WT1 vaccine 有权
公开(公告)号：US10220082B2
公开(公告)日：2019-03-05
申请号：US14651492
申请日：2013-12-13
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , INOVIO PHARMACEUTICALS, INC. , David B. Weiner , Jian Yan , Jewell Walters
发明人： David B. Weiner , Jian Yan , Jewell Walters
IPC分类号： A61K39/00 , C07K14/47
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

105. 发明授权

US10155795B2 Compositions comprising hypoxia inducible factor-1 alpha and methods of using the same 有权
公开(公告)号：US10155795B2
公开(公告)日：2018-12-18
申请号：US14776516
申请日：2014-03-14
申请人： David B. Weiner , Karuppiah Muthumani , Emile Mohler , Geoffrey Ouma
发明人： David B. Weiner , Karuppiah Muthumani , Emile Mohler , Geoffrey Ouma
IPC分类号： C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61P9/10 , C07K14/47 , A61K38/17 , A61K39/00 , A61K41/00 , A61N1/32 , A61K48/00
摘要： Disclosed herein is a therapeutic comprising hypoxia inducible factor-1 alpha (HIF-1α). Also disclosed herein is a method for treating hypoxia or ischemia in a subject in need thereof. The method may comprise administering the vaccine to the subject in need thereof.

106. 发明申请

US20170232100A1 Vaccines Having an Antigen and Interleukin-21 As An Adjuvant 审中-公开
公开(公告)号：US20170232100A1
公开(公告)日：2017-08-17
申请号：US15514948
申请日：2015-09-29
申请人： David B. Weiner , Matthew P. Morrow
发明人： David B. Weiner , Matthew P. Morrow
IPC分类号： A61K39/39 , A61N1/32 , A61K41/00 , C07K14/54 , A61K39/08 , A61K39/21
CPC分类号： A61K39/39 , A61K39/08 , A61K39/12 , A61K39/21 , A61K41/0047 , A61K48/00 , A61K2039/53 , A61K2039/55527 , A61N1/327 , C07K14/54 , C12N2740/16134 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and IL-21. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

107. 发明授权

US09732123B2 Mono or multivalent botulinum neurotoxin based vaccine using the heavy chain from serotypes of Clostridium botulinum 有权
公开(公告)号：US09732123B2
公开(公告)日：2017-08-15
申请号：US14774376
申请日：2014-03-14
申请人： David B. Weiner , Veronica Scott , Natalie Hutnick
发明人： David B. Weiner , Veronica Scott , Natalie Hutnick
IPC分类号： A61K39/02 , A61K39/08 , C07K14/33 , A61M37/00 , A61K39/00
CPC分类号： C07K14/33 , A61K39/08 , A61K2039/53 , A61K2039/55516 , A61K2039/55527 , A61K2039/55538 , A61K2039/575 , A61M37/00 , A61M2037/0007 , Y02A50/469
摘要： Disclosed herein are compositions and methods for treating Clostridium botulinum neurotoxin intoxication and in particular, vaccines against the neurotoxin that provide protection again lethal challenge with neurotoxin from one or more serotypes of Clostridium botulinum.

108. 发明授权

US09592285B2 Vaccines against multiple subtypes of influenza virus 有权
标题翻译：针对流感病毒多种亚型的疫苗
公开(公告)号：US09592285B2
公开(公告)日：2017-03-14
申请号：US12269824
申请日：2008-11-12
申请人： Ruxandra Draghia-Akli , David B. Weiner , Jian Yan , Dominick Laddy
发明人： Ruxandra Draghia-Akli , David B. Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/12 , A61K9/00 , A61K38/20 , C07K14/005 , A61K47/34 , A61K39/145 , A61K39/00
CPC分类号： A61K39/145 , A61K9/0019 , A61K38/208 , A61K38/2086 , A61K39/12 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , A61K2300/00
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
摘要翻译：本发明的一个方面涉及能够在哺乳动物中产生针对多种流感病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达共有流感抗原，其中共有流感抗原包含共有血凝素（HA），神经氨酸酶（NA），基质蛋白，核蛋白，M2胞外结构域 - 核蛋白（M2e-NP）或其组合。优选地，共有流感抗原包含HA，NA，M2e-NP或其组合。 DNA质粒包含与编码共有流感抗原的编码序列可操作地连接的启动子。此外，本发明的一个方面包括使用提供的DNA质粒疫苗在哺乳动物中引发针对多种流感病毒亚型的免疫应答的方法。

109. 发明授权

US09446112B2 Clostridium difficile DNA vaccine 有权
标题翻译：艰难梭菌DNA疫苗
公开(公告)号：US09446112B2
公开(公告)日：2016-09-20
申请号：US14232048
申请日：2012-07-12
申请人： Michele Kutzler , Scott Baliban , David B. Weiner , Niranjan Y. Sardesai , J. Joseph Kim
发明人： Michele Kutzler , Scott Baliban , David B. Weiner , Niranjan Y. Sardesai , J. Joseph Kim
IPC分类号： C07H21/04 , A61K39/00 , A61K39/08 , A61N1/32 , C07K14/33
CPC分类号： A61K39/08 , A61K2039/53 , A61N1/327 , C07K14/33
摘要： The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.
摘要翻译：本发明涉及通过向有需要的受试者施用编码毒素A和毒素B中的至少一种的至少一部分的至少一种核酸来治疗艰难梭菌相关疾病（CDAD）的组合物和方法。

110. 发明授权

US09243041B2 Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof 有权
标题翻译：编码新型疱疹抗原的核酸分子，包含其的疫苗及其使用方法
公开(公告)号：US09243041B2
公开(公告)日：2016-01-26
申请号：US13982457
申请日：2012-01-31
申请人： David B Weiner , Devon J Shedlock
发明人： David B Weiner , Devon J Shedlock
IPC分类号： A61K39/245 , A61K39/25 , A61K39/12 , C07K14/005 , C07K14/045 , C12N15/38 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K39/25 , A61K2039/53 , C12N7/00 , C12N2710/16011 , C12N2710/16111 , C12N2710/16122 , C12N2710/16134 , C12N2710/16622 , C12N2710/16634 , C12N2710/16722 , C12N2710/16734
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against herpes virus using the vaccines that are provided.
摘要翻译：本文提供了编码疱疹病毒抗原的新的共有氨基酸序列的核酸序列，以及表达序列的遗传构建体/载体和疫苗。本文还提供了使用所提供的疫苗产生针对疱疹病毒的免疫应答的方法。

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