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101. 发明授权

US5731290A Method of improving the immune response 失效
标题翻译：改善免疫反应的方法
公开(公告)号：US5731290A
公开(公告)日：1998-03-24
申请号：US394872
申请日：1995-02-27
申请人： Heinz Schneider
发明人： Heinz Schneider
IPC分类号： A23L1/30 , A23L1/305 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/23 , A61K31/70 , A61P3/06 , A61P37/02 , A61P37/04 , A61P37/06 , A61K38/00 , A01N43/04
CPC分类号： A23L33/175 , A23L33/12
摘要： The invention provides diet supplements for pre-operative treatment of patients due for surgery.
摘要翻译：本发明提供了用于手术治疗患者的术前治疗的饮食补充剂。

102. 发明授权

US5726164A Nanosuspensions for intravenous administration 失效
标题翻译：用于静脉内给药的纳米悬浮液
公开(公告)号：US5726164A
公开(公告)日：1998-03-10
申请号：US619068
申请日：1996-03-20
申请人： Hans Georg Weder , Peter van Hoogevest
发明人： Hans Georg Weder , Peter van Hoogevest
IPC分类号： C07D498/22 , A61K9/08 , A61K9/10 , A61K31/55 , A61K31/553 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/32 , A61P9/00 , A61P25/00 , A61P35/00 , A61K31/35 , A61K31/40
CPC分类号： A61K31/553 , A61K47/10 , A61K47/24 , A61K9/0019 , A61K9/10
摘要： The present invention relates to a pharmaceutical composition for the intravenous administration of the sparingly soluble staurosporin derivative N-benzoyl-staurosporin. The composition comprises the following preferred components: a) the therpeutic agent N-benzoyl-staurosporin; b) a polyoxyethylene/polyoxypropylene block copolymer; c) ethanol and water as carrier liquids; and d) purified lecithin from soybeans and e) as water-soluble excipients glycerol and sorbitol.
摘要翻译：本发明涉及用于静脉内施用微溶性星形孢菌素衍生物N-苯甲酰基星形孢菌素的药物组合物。该组合物包含以下优选的组分：a）治疗剂N-苯甲酰基星形孢菌素; b）聚氧乙烯/聚氧丙烯嵌段共聚物; c）乙醇和水作为载体液体; 和d）来自大豆的纯化卵磷脂，和e）作为水溶性赋形剂甘油和山梨糖醇。

103. 发明授权

US5723721A Inbred corn line CG00685 use thereof 失效
标题翻译：近交玉米线CG00685用途
公开(公告)号：US5723721A
公开(公告)日：1998-03-03
申请号：US567869
申请日：1995-12-06
申请人： Christopher P. Clucas
发明人： Christopher P. Clucas
IPC分类号： A01H5/10 , A01H5/00 , A01H4/00 , C12N5/04
CPC分类号： A01H5/10 , Y10S47/01
摘要： According to the invention, there is provided an inbred corn line, designated CG00685. This invention thus relates to the plants and seeds of inbred corn line CG00685 and to methods for producing a corn plant produced by crossing the inbred line CG00685 with itself or with another corn line. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line CG00685 with another corn line.
摘要翻译：根据本发明，提供了称为CG00685的近交玉米线。因此，本发明涉及近交玉米品系CG00685的植物和种子以及通过将自交系CG00685与其他玉米品系交叉产生的玉米植物的生产方法。本发明还涉及通过将近交系CG00685与另一个玉米品系交叉产生的杂交玉米种子和植物。

104. 发明授权

US5723491A Fungicidal composition and method of controlling fungus infestation 失效
标题翻译：防治真菌感染的组成及方法
公开(公告)号：US5723491A
公开(公告)日：1998-03-03
申请号：US460158
申请日：1995-06-02
申请人： Cosima Nuninger , John Edward Nicholas Goggin , Dino Sozzi , Holm Ellgehausen
发明人： Cosima Nuninger , John Edward Nicholas Goggin , Dino Sozzi , Holm Ellgehausen
IPC分类号： A01N37/46 , A01N43/08 , A01P3/00 , A01N37/12 , A01N37/44
CPC分类号： A01N37/46 , A01N43/08
摘要： If the R-enantiomer of metalaxyl, furalaxyl or benalaxyl is used, this results in a markedly increased biodegradability of these plant fungicides in the soil and a higher activity on the plants, as compared with the data of the racemic active ingredients. Fungicidal compositions exhibiting said improved properties comprise either of these fungicides with a content of R-enantiomer of more than 70 percent by weight based on the total amount of active ingredient.
摘要翻译：如果使用甲霜灵，furalaxyl或benaraxyl的R-对映异构体，与外消旋活性成分的数据相比，这导致这些植物杀真菌剂在土壤中的生物降解性显着提高，对植物的活性更高。显示出所述改进性能的杀真菌组合物包含基于活性成分总量的R-对映异构体含量大于70重量％的这些杀真菌剂。

105. 发明授权

US5705502A Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof 失效
标题翻译：药理活性嘧啶胺衍生物及其制备方法
公开(公告)号：US5705502A
公开(公告)日：1998-01-06
申请号：US446742
申请日：1995-05-31
申请人： Jurg Zimmermann
发明人： Jurg Zimmermann
IPC分类号： A61K31/505 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D417/04
CPC分类号： C07D239/42 , C07D401/04
摘要： Described are N-phenyl-2-pyrimidineamine derivatives of formula I ##STR1## wherein R.sub.1 is a substituted cyclic radical, the cyclic radical being bonded at a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, --C(.dbd.O)--OR.sub.3, --C(.dbd.O)--R.sub.4, --SO.sub.2 --N(R.sub.5)--R.sub.6, --N(R.sub.7)--R.sub.8, --OR.sub.9 and fluorine-substituted lower alkyl, wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R.sub.2 is selected from halogen, cyano, carbamoyl, --C(.dbd.O)--OR.sub.10, --C(.dbd.O)--R.sub.11, --SO.sub.2 --N(R.sub.12)--R.sub.13, --N(R.sub.14)--R.sub.15, --OR.sub.16 and fluorine-substituted lower alkyl, wherein R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15 and R.sub.16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.
摘要翻译： PCT No.PCT / EP94 / 03148 Sec。 371日期：1995年5月31日 102（e）日期1995年5月31日PCT 1994年9月21日PCT PCT。 WO95 / 09851 PCT出版物日期1995年04月13日描述了式I的N-苯基-2-嘧啶胺衍生物，其中R1是取代的环状基团，环状基团在环状碳原子上键合，并且选自苯基吡啶基，噻唑基，嘧啶基，哒嗪基和咪唑基，上述环状基团的取代基选自一个或多个卤素，氰基，氨基甲酰基，-C（= O）-OR 3，-C（ = O）-R4，-SO2-N（R5）-R6，-N（R7）-R8，-OR9和氟取代的低级烷基，其中R3，R4，R5，R6，R7，R8和R9各自独立地的其它氢或未被取代或被一或二低级烷基氨基取代的低级烷基; 且R 2选自卤素，氰基，氨基甲酰基，-C（= O）-OR 10，-C（= O）-R 11，-SO 2 -N（R 12）-R 13，-N（R 14）-R 15，-OR 16和氟取代的低级烷基，其中R10，R11，R12，R13，R14，R15和R16各自独立地为氢或未被取代或被一或二低级烷基氨基取代的低级烷基。那些化合物可用于例如治疗肿瘤疾病。

106. 发明授权

US5695583A Light diffuser and process for the manufacturing of a light diffuser 失效
标题翻译：光扩散器和制造光扩散器的工艺
公开(公告)号：US5695583A
公开(公告)日：1997-12-09
申请号：US593312
申请日：1996-01-31
申请人： Hubert van den Bergh , Jerome Mizeret
发明人： Hubert van den Bergh , Jerome Mizeret
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , F21V8/00 , G02B5/02 , G02B6/24 , G02B6/245 , G02B6/36 , G02B23/26 , B32B31/00 , B05D5/06
CPC分类号： A61B18/22 , A61N5/0601 , A61N5/062 , G02B5/0221 , G02B5/0242 , G02B6/0008 , G02B6/241 , G02B6/245 , A61B2018/2261 , G02B6/3624
摘要： A light diffuser for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide, which itself comprises a core and a cladding. The core of the waveguide is exposed at an active region at the distal end. The exposed active region of the core is optically separated from a substance containing scattering particles. In a preferred embodiment, the core is roughened and is embedded in a first layer of an elastic substance, which has a refractive index similar to the refractive index of the cladding and which does not contain any scattering particles. This first layer is embedded in at least one further, second layer of an elastic substance comprising the scattering particles. This substance is surrounded by the outer tube.
摘要翻译：用于径向发射光的漫射器，其已经沿轴向馈送到扩散器中，包括光波导，其自身包括芯和包层。波导的核心在远端的有源区域露出。核心的暴露的活性区域与含有散射颗粒的物质光学分离。在优选实施例中，芯被粗糙化并且嵌入弹性物质的第一层中，其具有与包层的折射率相似的折射率，并且不包含任何散射颗粒。该第一层嵌入至少一个另外的第二层包含散射颗粒的弹性物质中。该物质被外管包围。

107. 发明授权

US5646157A Disposal of obsolete treated seed 失效
标题翻译：处理过时的处理过的种子
公开(公告)号：US5646157A
公开(公告)日：1997-07-08
申请号：US473820
申请日：1995-06-07
申请人： Kaspar J. Hohl
发明人： Kaspar J. Hohl
IPC分类号： C05F17/00 , A01N43/48 , A01N43/54 , C05F11/00
CPC分类号： C05F17/009 , Y02P20/145 , Y02W30/43 , Y10S71/901
摘要： The present invention relates to a process of disposing obsolete planting seed treated with seed-protectant coatings, especially coatings comprising captan or any of the other widely used compounds such as, for example, pirimiphos-methyl and thiram, alone or in combination with other fungicidally or even insecticidally active compounds, which process comprises subjecting the said plant seed to a compostation.
摘要翻译：本发明涉及一种处理用种子保护剂涂层处理的过时的种植种子的方法，特别是包含克隆人或任何其它广泛使用的化合物的包衣，例如单独或与其它杀真菌剂组合的广泛使用的化合物或甚至杀虫活性化合物，该方法包括使所述植物种子进行堆肥。

108. 发明授权

US5641666A Soraphen A resistant fungi and acetyl-CoA carboxylase 失效
标题翻译： Soraphen A抗真菌和乙酰辅酶A羧化酶
公开(公告)号：US5641666A
公开(公告)日：1997-06-24
申请号：US354973
申请日：1994-12-13
申请人： Hans-Friedrich Vahlensieck , Albert Hinnen
发明人： Hans-Friedrich Vahlensieck , Albert Hinnen
IPC分类号： C12N15/09 , C07K1/22 , C07K14/37 , C07K14/41 , C12N1/19 , C12N9/00 , C12Q1/25 , C12Q1/68 , C12R1/865 , C07H21/04
CPC分类号： C12N9/93 , C12Q1/25
摘要： The present invention discloses DNA molecules comprising a gene encoding yeast acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Mutations confering soraphen A resistance to acetyl-CoA carboxylase can be dominant or recessive, and they can be point mutations, deletion or insertion mutations. In addition methods of isolating a gene encoding fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition are provided as well as methods for purifying fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Purified enzyme can be used in assays to identify inhibitors of soraphen A resistant acetyl-coenzyme A carboxylase.
摘要翻译：本发明公开了包含编码对索拉帕司A抑制有抗性的酵母乙酰辅酶A羧化酶的基因的DNA分子。赋予soraphen的突变对乙酰辅酶A羧化酶的抗性可以是显性或隐性的，它们可以是点突变，缺失或插入突变。此外，还提供了分离编码对索拉帕芬A抑制有抗性的真菌乙酰辅酶A羧化酶基因的方法以及用于纯化对索拉帕A抑制有抗性的真菌乙酰辅酶A羧化酶的方法。纯化的酶可用于测定法以鉴定soraphen A抗性乙酰辅酶A羧化酶的抑制剂。

109. 发明授权

US07253257B2 Human metabotropic glutamate receptor subtype mGluR7b 失效
标题翻译：人代谢型谷氨酸受体亚型mGluR7b
公开(公告)号：US07253257B2
公开(公告)日：2007-08-07
申请号：US10331289
申请日：2002-12-30
申请人： Peter Josef Flor , Rainer Kuhn , Kristin Lindauer , Irene Püttner , Thomas Knöpfel
发明人： Peter Josef Flor , Rainer Kuhn , Kristin Lindauer , Irene Püttner , Thomas Knöpfel
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K16/286 , C07K14/70571 , C07K2319/00 , C12Q1/6876 , C12Q2600/136
摘要： The invention provides purified human metabotropic glutamate receptors, compositions comprising such receptors, and nucleic acids that encode such receptors.
摘要翻译：本发明提供纯化的人代谢型谷氨酸受体，包含此类受体的组合物和编码该受体的核酸。

110. 发明申请

US20030044978A1 EXPANDED AND GENETICALLY MODIFIED POPULATIONS OF HUMAN HEMATOPOIETIC STEM CELLS 无效
标题翻译：人类HEMATOPOIETIC干细胞的扩增和遗传修饰人群
公开(公告)号：US20030044978A1
公开(公告)日：2003-03-06
申请号：US09237291
申请日：1999-01-25
申请人： NOVARTIS CORPORATION
发明人： JUDY CAROL YOUNG , LESLEY JEAN MURRAY , ROBERT J. TUSHINSKI
IPC分类号： A61K048/00 , C12N005/08
CPC分类号： C12N5/0647 , A61K2035/124 , C12N2500/90 , C12N2501/125 , C12N2501/145 , C12N2501/23 , C12N2501/26
摘要： The present invention provides a method for promoting the survival and/or expansion of hematopoietic stem cells in culture, comprising culturing the cells in a culture including an effective amount of a mpl ligand, (particularly thrombopoietin), a flt3 ligand and interleukin 6 (IL6). Also provided is a method for modifying hematopoietic stem cells comprising contacting a gene delivery vehicle comprising a polynucleotide sequence with a population of hematopoietic stem cells cultured in the presence of an effective amount of thrombopoietin and a flt3 ligand. Additionally methods of restoring hematopoietic capability in a subject are claimed.
摘要翻译：本发明提供一种用于促进培养物中造血干细胞的存活和/或扩增的方法，包括在培养物中培养细胞，所述培养物包括有效量的mpl配体（特别是血小板生成素），flt3配体和白介素6（IL6 ）。还提供了一种修饰造血干细胞的方法，其包括将包含多核苷酸序列的基因递送载体与在有效量的血小板生成素和flt3配体存在下培养的造血干细胞群进行接触。另外要求恢复受试者造血能力的方法。

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