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91. 发明专利

JP2003532745A Energy transfer assay and reagent 有权
公开(公告)号：JP2003532745A
公开(公告)日：2003-11-05
申请号：JP2000553515
申请日：1999-06-02
申请人：アマシャムバイオサイエンスユーケイリミテッド
发明人：アラン・エル・ハミルトン , ナイジェル・ボズワース , ブライアン・スコット , マーティン・エヌ・バーチ , マルコム・ジェイ・ハッチャー
IPC分类号： G01N33/58 , C07D209/14 , C07D233/04 , C07D277/64 , C07D413/06 , C07D417/06 , C07H21/00 , C09B23/00 , C09B23/02 , G01N33/533 , G01N33/542
CPC分类号： G01N33/533 , C07H21/00 , C09B23/02 , G01N33/542 , Y10S435/968
摘要： (57)【要約】生物学的物質が関与する結合および／または開裂事象が関連する蛍光エネルギー伝達アッセイにおけるアクセプターとして使用し得る非蛍光シアニン色素、およびこのような色素を使用するアッセイ法を記載する。非蛍光シアニン色素は、式(１)：【化１】〔式中、リンカー基Ｑは少なくとも一つの２重結合を含み、ＸおよびＹを含む環と共役系を形成する；基Ｒ
3 、Ｒ
4 、Ｒ
5 およびＲ
6 はＸおよびＹを含む環に結合するか、または、所望により、Ｚ
1 およびＺ
2 環構造の原子に結合してもよい；Ｚ
1 およびＺ
2 は、各々結合を示すか、または、炭素原子、および、所望により、２個以上ではない酸素、窒素および硫黄原子から選択される５個または６個の元素を有する１個または２個の縮合芳香族環を完成させるのに必要な原子である；ＸおよびＹは、同一または異なって、ビス−Ｃ
1 −Ｃ
4 アルキル−およびＣ
4 −Ｃ
5 スピロアルキル−置換炭素、酸素、硫黄、セレン、−ＣＨ＝ＣＨ−およびＮ−Ｗから選択され、式中、Ｎは窒素およびＷは水素、基−(ＣＨ
2 )
m Ｒ
8 (式中、ｍは１から２６の整数およびＲ
8 は水素、アミノ、アルデヒド、アセタール、ケタール、ハロ、シアノ、アリール、ヘテロアリール、ヒドロキシル、スルホネート、スルフェート、カルボキシレート、置換アミノ、４級アンモニウム、ニトロ、１級アミド、置換アミド、およびアミノ、ヒドロキシル、カルボニル、カルボキシル、ホスホリルおよびスルフヒドリル基と反応性の基から選択される)から選択される；少なくとも一つの基Ｒ
1 、Ｒ
2 、Ｒ
3 、Ｒ
4 、Ｒ
5 、Ｒ
6 およびＲ
7 は標的結合基である；残りの基Ｒ
3 、Ｒ
4 、Ｒ
5 、Ｒ
6 およびＲ
7 基は、独立して水素、Ｃ
1 −Ｃ
4 アルキル、ＯＲ
9 、ＣＯＯＲ
9 、ニトロ、アミノ、アシルアミノ、４級アンモニウム、ホスフェート、スルホネートおよびスルフェートから選択され、式中、Ｒ
9 はＨおよびＣ
1 −Ｃ
4 アルキルから選択される；残りのＲ
1 およびＲ
2 は、Ｃ
1 −Ｃ
10 アルキルから選択され、これは非置換であるか、所望によりカルボキシル、スルホネートおよびニトロ基から選択される２個までの置換基で置換されていてもよいフェニルで置換されていてもよい；少なくとも一つの基Ｒ
1 、Ｒ
2 、Ｒ
3 、Ｒ
4 、Ｒ
5 、Ｒ
6 およびＲ
7 は、該色素の蛍光放射を、本質的に非蛍光であるように減少させる置換基を含むことにより特徴付けられる〕の化合物である。

92. 发明专利

JP2003280130A Methine dye and silver halide photographic sensitive material containing the same 审中-公开
标题翻译：甲基染料和银盐摄影敏感材料
公开(公告)号：JP2003280130A
公开(公告)日：2003-10-02
申请号：JP2002081018
申请日：2002-03-22
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKIZAWA HIROO
IPC分类号： G03C1/12 , C09B11/04 , C09B23/02 , G03C1/005 , G03C1/09 , G03C1/10 , G03C1/14 , G03C1/16 , G03C1/18 , G03C1/20 , G03C1/22
CPC分类号： G03C1/102 , C09B11/04 , C09B23/02 , G03C1/0051 , G03C1/09 , G03C1/127 , G03C1/14 , G03C1/16 , G03C1/18 , G03C1/20 , G03C1/22 , G03C2001/097
摘要： PROBLEM TO BE SOLVED: To provide a new methine dye compound and a high sensitivity silver halide photographic sensitive material containing the same. SOLUTION: In the silver halide photographic sensitive material having at least one photosensitive silver halide emulsion layer on a support, a compound represented by the formula Dye1-(-L 1 (-Dye2) m1 ) m2 .CIy is contained in the emulsion layer, wherein Dye1 is a first chromophore; Dye2 is a xanthene dye; L 1 is a linking group; m1 is an integer of 1-5; m2 is an integer of 1-5; CI is an ion which neutralizes an electric charge; and y s a number required to neutralize electric charges. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供新的次甲基染料化合物和含有它们的高灵敏度卤化银感光材料。解决方案：在载体上具有至少一个感光卤化银乳剂层的卤化银感光材料中，由式Dye1 - （ - L＆lt; SB＆gt;（ - Dye2）＆lt; SB m1 ） m2 。乳液层中含有，其中Dye1是第一生色团; 染料2是呫吨染料; L 1 是连接基团; m1为1-5的整数; m2为1-5的整数; CI是中和电荷的离子; 并且y是中和电荷所需的数字。版权所有（C）2004，JPO

93. 发明专利

JP2003232735A METHOD OF LABELING OR DETECTING SUBSTANCE USING LUMINESCENT ARYL SULFONATE CYANINE DYE 审中-公开
公开(公告)号：JP2003232735A
公开(公告)日：2003-08-22
申请号：JP2003002086
申请日：2003-01-08
申请人： UNIV CARNEGIE MELLON
发明人： WAGGONER ALAN S
IPC分类号： G01N21/64 , C09B23/00 , C09B23/01 , C09B23/02 , C09B23/10 , C09B23/14 , C09B62/002 , C09K11/06 , C12P21/04 , G01N21/77 , G01N21/78 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/533 , G01N33/569 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a substance contained in an aqueous liquid labeled with a dye useful for detection. SOLUTION: A method of labeling a component contained in an aqueous liquid includes a step (a) of adding a luminescent dye selected from among a group composed of cyanine, merocycanine, and styryl dues having at least one sulfonic group or sulfonate group attached to an aromatic nucleus and having reactivity to the component to the aqueous liquid containing the component and a step (b) of causing the dye and component to act upon another so that the dye may label the component. COPYRIGHT: (C)2003,JPO

94. 发明专利

JP2003501540A pH functional cyanine dye as a reactive fluorescent reagent 审中-公开
公开(公告)号：JP2003501540A
公开(公告)日：2003-01-14
申请号：JP2001502512
申请日：2000-06-08
申请人：アマーシャムバイオサイエンセスユーケーリミテッド , カーネギーメロンユニヴァーシティ
发明人：ジョン・アンソニー・スミス , ラットネイカー・ムジュムダー
IPC分类号： C07D417/06 , C07D209/14 , C07D209/60 , C09B23/00 , C09B23/02 , C09K11/07 , G01N33/52 , G01N33/84
CPC分类号： C09B23/02 , G01N33/52 , G01N33/84
摘要： (57)【要約】本発明は、ｐＨ感受性シアニン染料及びこれを蛍光指示薬として使用する方法を提供する。

95. 发明专利

JP2002541219A 失效
公开(公告)号：JP2002541219A
公开(公告)日：2002-12-03
申请号：JP2000610526
申请日：2000-03-28
IPC分类号： C07K17/02 , A61K49/00 , C07D209/14 , C07K1/107 , C07K7/08 , C07K14/47 , C07K14/575 , C07K14/655 , C09B23/00 , C09B23/02 , C09B23/08 , C09K11/06
摘要： Conjugates (I) of vasoactive intestinal peptide (VIP), somatostatin or neurotensin peptides and polymethine dyes are new. Peptide-dye conjugates of formula (I) are new. X = a sequence of 5-30 alpha -, beta - or gamma -amino acids (D or L) corresponding to the amino acid sequence of VIP, somatostatin or neurotensin or a fragment, derivative or analog thereof, optionally cyclized by a disulfide bridge between two cysteines or by an amide bridge between the N and C termini; A = H, acetyl, 1-10C alkyl (optionally substituted by 1-3 COOH groups and/or 1-6 OH groups), a polyoxyethylene group comprising 2-30 CH2CH2O units, or a polymethine dye having at least one absorption maximum in the 380-1200 nm range; and A = OH, NH2 or a polymethine dye having at least one absorption maximum in the 380-1200 nm range; provided that at least one of A and A is a polymethine dye, that when A is a polymethine dye, it is bonded to the N-terminal amino group and that when A is a polymethine dye, it is bonded to a lysine amino group or serine hydroxy group at any position within X. Independent claims are also included for the following: (1) a diagnostic method comprising administering (I) to a patient, either intravenously or to the bronchi by inhalation or to the gastrointestinal tract, esophagus or bladder by spraying and then washing out excess (I), and then performing an endoscopic investigation by local excitation of fluorescence at an excitation wavelength of 350-1200 nm and site-specific detection of the fluorescence emitted by the dye; and (2) cyanine dyes of formula (II). p = 1-3; n = 1-4 or 10; R , R = 4-sulfobutyl, 3-sulfopropyl, 2-sulfoethyl, 3-methyl-3-sulfopropyl, methyl, ethyl or propyl; R = H, COOE , CONE E , NHCOE , NHCONHE , NE E , OE , OSO3E , SO3E or SO2NHE ; and E , E = H, CH3, ethyl, or 3-6C alkyl optionally interrupted by 1-2 O atoms and/or a CO group and/or optionally substituted by 1-5 OH groups.

96. 发明专利

JP2001524969A 失效
公开(公告)号：JP2001524969A
公开(公告)日：2001-12-04
申请号：JP54699298
申请日：1998-04-02
IPC分类号： C07H17/02 , C08B37/02 , C08B37/16 , C09B23/02 , C12Q1/68 , G01N33/533 , G01N33/58

97. 发明专利

JP2001089482A AZAMETHINE COMPOUND 失效
公开(公告)号：JP2001089482A
公开(公告)日：2001-04-03
申请号：JP27095799
申请日：1999-09-24
申请人： FUJI PHOTO FILM CO LTD
发明人： NISHIGAKI JUNJI
IPC分类号： C07D498/04 , C07D513/04 , C07D519/00 , C09B23/02 , C09B23/10 , G01N33/533 , G03C1/14
摘要： PROBLEM TO BE SOLVED: To obtain an azamethine compound having excellent water solubility, useful as a fluorescent labeled reagent and a pH indicator in the field of medical diagnosis by using absorption characteristics in an aqueous medium due to no agglutination in an aqueous solution. SOLUTION: This azamethine compound is represented by the general formula (R is a substituted or nonsubstituted alkyl group; Q is a methine group substituted with an aromatic cyclic group or a polymethine group substituted with an aromatic cyclic group; A is an oxygen atom or sulfur atom; V1, V2 and V3 are each a hydrogen atom or a monofunctional substituent and adjoining two groups among them may be mutually bonded to form a ring; M1 is a counter ion; and m is a number required to neutralize the charge of molecule).

98. 发明专利

JP2000095959A CYANINE DYE 失效
公开(公告)号：JP2000095959A
公开(公告)日：2000-04-04
申请号：JP26010099
申请日：1999-09-14
申请人： AGFA GEVAERT AG
发明人： MISFELDT MICHAEL DR , HERRMANN STEFAN DR
IPC分类号： C09B23/00 , C09B23/01 , C09B23/02 , G03C1/12 , G03C1/14 , G03C1/18 , G03C1/20 , G03C1/29
摘要： PROBLEM TO BE SOLVED: To obtain a cyanine dye having an improved spectral sensitivity and excellent storage stability even under tropical conditions by selecting a cyanine dye represented by a specified formula. SOLUTION: There are provided cyanine dyes represented by formulae I and II. There is also provided a silver halide material containing a cyanine color represented by formula I and a cyanine dye represented by formula II is formula I/formula II mixing ratio of 0.1/10 to 10/0.1, particularly desirably, 1/20 to 20/1. In the formulae, R1 to R6 are each H or a substituent; R5 and R6 or R4 and R5 may be combined with each other to form a fused benzo or naphtho ring; R1 to R3 are each a benzothienyl substituent; X, X1, and X2 are each O, S, Se, CH=CH, C(CH3)2, or NR7; R7 is an alkyl; S1 and S2 are each an alkyl, a sulfoalkyl, a carboxyalkyl, a-(CH2)1-SO2-Y-SO2-alkyl, or the like; 1 is 1-6; Y is NH or methine; R14 to R19 are each H, a halogen, or the like; L and L1 to L3 are each methine; M is a counterion necessary to neutralize the charge; and n is 3, 5, or 7.

99. 发明专利

JP2000080297A NEW COMPOUND AND SILVER HALIDE PHOTOSENSITIVE MATERIAL CONTAINING THE COMPOUND 失效
公开(公告)号：JP2000080297A
公开(公告)日：2000-03-21
申请号：JP24854498
申请日：1998-09-02
申请人： FUJI PHOTO FILM CO LTD
发明人： HIOKI TAKANORI
IPC分类号： G03C1/12 , C09B23/00 , C09B23/02
摘要： PROBLEM TO BE SOLVED: To obtain a new compound capable of providing a silver halide photosensitive material having high sensitivity and small remaining color. SOLUTION: This new compound is a compound of formula I [Z1 is an atomic group required for forming a 5- or 6-membered nitrogen-containing heterocycle; R1 is an alkyl, an aryl or a heterocycle; L1 and L2 are each methine; (p1) is 0 or 1; M1 is a valence-balanced paired ion; (m1) is a number required for neutralizing the electric charge of the molecule; A is an atomic group required for forming a nitrogen-containing heterocycle, with the proviso that a thiazoline nuclear is omitted], e.g. a compound of formula II. The compound of formula I is synthesized by starting from the reaction of a compound of formula III with a compound of formula IV.

100. 发明专利

JPH11166124A PRODUCTION OF POLYMETHINE COMPOUND 失效
公开(公告)号：JPH11166124A
公开(公告)日：1999-06-22
申请号：JP33464597
申请日：1997-12-04
申请人： FUJI PHOTO FILM CO LTD
发明人： KATO TAKASHI
IPC分类号： C07D277/64 , C07D263/56 , C07D263/62 , C09B23/00 , C09B23/02
摘要： PROBLEM TO BE SOLVED: To synthesize a polymethine colorant efficiently by using a cyclic dioxyketal or a dithioketal derivative as the methine source. SOLUTION: A polymethine compound is synthesized by using a compound represented by formula I as the starting material. A compound represented by formula II is reacted with a compound represented by formula I-II and a compound represented by formula I to produce a pentamethinecyanine compound represented by formula IV. In formula I, X1 to X4 are each O or S; Q1 to Q3 are each an atomic group necessary to form a five-, six-, or seven-membered ring; R1 is H, a halogen, an aryl, or an alkyl; Z1 and Z2 are each a nitrogen- containing heterocyclic ring; L1 to L7 are each methine; L1a to L2a are each active methyl; n1 and n2 are each 0 or 1; M1 to M3 are each a charge- neutralizing ion; and m1 to m3 are each a number necessary to neutralize the charge. The compounds of formulas II and III may be the same. When they are the same, the compound of formula IV is a symmetrical coloranl, whereas, when they arc different from each other, it is asymmetrical colorant.

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