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91. 发明申请

US20050222405A1 Polysaccharide containing phosphorylcholine group and process for producing the same 失效
标题翻译：含有磷酸胆碱的多糖组及其制备方法
公开(公告)号：US20050222405A1
公开(公告)日：2005-10-06
申请号：US10506771
申请日：2003-04-08
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
IPC分类号： A61L27/00 , A61K8/73 , A61Q19/00 , C08B11/20 , C08B15/00 , C08B15/06 , C08B37/00 , C08B37/02 , C08B37/08 , C07H13/06
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method. The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it. The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.
摘要翻译：本发明是一种含有磷酰胆碱基团的多糖的制造方法，其中将通过甘油磷酰胆碱的氧化开环反应得到的含有醛衍生物的化合物加入到含有氨基的多糖中，以及具有磷酸胆碱基团的新型多糖，这种制造方法。本发明的目的是提供一种生物相容性和保湿性优异的含磷酰胆碱基团的多糖，作为医疗用聚合物材料，以及其制造方法简单。本发明的多糖可用于例如人造器官，生物膜，医疗工具用涂剂，药物输送和化妆品中。

92. 发明申请

US20040197410A1 Pullulan-containing powder, process for producing the same and use thereof 失效
标题翻译：含有支链淀粉的粉末，其制造方法及其用途
公开(公告)号：US20040197410A1
公开(公告)日：2004-10-07
申请号：US10484216
申请日：2004-01-20
发明人： Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： C12P019/04 , A61K009/14 , C08B037/00
CPC分类号： C08J3/12 , A23L29/274 , A23P20/20 , A61K8/0212 , A61K8/11 , A61K8/73 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0018 , C08J3/14 , C08J2305/00 , C08K5/15 , C08L5/00 , C08L5/16 , C08L2666/26
摘要： The object of the present invention is to overcome conventional demerits of pullulan powders prepared by conventional techniques, i.e., they could not be homogeneously mixed with non-reducing saccharides composed of glucose units when mixed together, and the resulting mixtures do not easily dissolve in water; and to provide a pullulan-containing powder with an improved rate of water dissolution, as well as to provide preparations and uses thereof. The present invention solves the above object by providing a pullulan-containing powder which uniformly comprises pullulan as a main ingredient and a non-reducing saccharide, and their process and uses; wherein the pullulan-containing powder is prepared by the steps of preparing a solution dissolving pullulan and a non-reducing saccharide homogeneously, pulverizing the solution, and collecting the resulting pullulan-containing powder. The powder has an improved rate of water dissolution, while retaining satisfactory resistance to humidity without fear of causing separation between the pullulan and the non-reducing sccharide.
摘要翻译：本发明的目的是克服通过常规技术制备的支链淀粉粉末的常规缺点，即当它们混合在一起时不能与由葡萄糖单元组成的非还原性糖类均匀混合，并且所得混合物不容易溶于水 ; 并提供具有改善的水溶解速率的含支链淀粉的粉末，以及提供其制备和用途。本发明通过提供均匀地包含支链淀粉作为主要成分和非还原性糖的支链淀粉粉末及其工艺和用途来解决上述目的。其中含有支链淀粉的粉末通过以下步骤制备：均匀地制备溶解支链淀粉和非还原性糖的溶液，粉碎溶液，并收集所得的含支链淀粉粉末。粉末具有提高的水溶解速率，同时保持令人满意的耐湿性，而不用担心在支链淀粉和非还原性螯合剂之间分离。

93. 发明授权

US06586588B1 Polysaccharide aldehydes prepared by oxidation method and used as strength additives in papermaking 失效
标题翻译：通过氧化法制备多糖醛，并在造纸中用作强度添加剂
公开(公告)号：US06586588B1
公开(公告)日：2003-07-01
申请号：US09636069
申请日：2000-08-10
申请人： A. Levent Cimecioglu , John S. Thomaides
发明人： A. Levent Cimecioglu , John S. Thomaides
IPC分类号： C08B3100
CPC分类号： C08B37/0096 , C08B11/20 , C08B31/18 , C08B37/0018 , D21H17/29 , D21H21/18 , D21H21/20
摘要： Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.
摘要翻译：使用选择性氧化制备多糖醛，其涉及使用硝酰自由基介导的水性氧化和有限量的氧化剂和规定的反应条件。这些具有最大有效醛和最低羧酸含量的多糖醛衍生物使它们特别用作纸张的湿，临时湿和干强度添加剂。

94. 发明授权

US06514407B2 Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials 失效
公开(公告)号：US06514407B2
公开(公告)日：2003-02-04
申请号：US09808190
申请日：2001-03-15
申请人： Raphael Duval
发明人： Raphael Duval
IPC分类号： C07H2300
CPC分类号： C07B57/00 , C08B15/05 , C08B37/00 , C08B37/0009 , C08B37/0012 , C08B37/0018 , C08B37/0021 , C08B37/0024 , C08B37/003 , C08B37/0054 , C08B37/0057 , Y02P20/544
摘要： There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.

95. 发明授权

US06346616B1 Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials 失效
标题翻译：可聚合和可交联的多糖或寡糖的氯代，羟基和烷氧基硅烷衍生物，它们的合成及其作为新型载体材料的来源
公开(公告)号：US06346616B1
公开(公告)日：2002-02-12
申请号：US09394868
申请日：1999-09-13
申请人： Raphaël Duval
发明人： Raphaël Duval
IPC分类号： C07H2300
CPC分类号： C07B57/00 , C08B15/05 , C08B37/00 , C08B37/0009 , C08B37/0012 , C08B37/0018 , C08B37/0021 , C08B37/0024 , C08B37/003 , C08B37/0054 , C08B37/0057 , Y02P20/544
摘要： There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.
摘要翻译：描述了多糖或寡糖的氯代，羟基和烷氧基硅烷衍生物作为可聚合和可交联的新化合物及其获得方法; 从所述衍生物获得的新颖的载体材料，并含有通过与载体共价键化学接枝并在三维网络中聚合和交联的多糖或寡糖的所述硅烷衍生物及其获得方法; 以及通过使用气相，液体或超临界色谱法，通过电泳，电色谱法或通过含有所述载体材料的膜的渗滤方法在分离或制备对映异构体中使用所述材料载体。

96. 发明授权

US5892043A Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US5892043A
公开(公告)日：1999-04-06
申请号：US773182
申请日：1996-12-27
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/48 , C08B37/00 , C08B37/02 , C07D471/00
CPC分类号： C08B37/0018 , A61K47/4823 , A61K47/48338 , C08B37/0021
摘要： A camptothecin derivative comprising a compound of the formula �I!: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is --X.sub.n --Alk.sub.m --R.sup.6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by --X.sub.n --Alk.sub.m --R.sup.6, and the remaining three groups are H, alkyl or a halogen, and one or two --CH.sub.2 -- of the alkylene in (A) or (B) may optionally be replaced by --O--, --S-- or --NH--, X is --O-- or --NH--, Alk is alkylene, R.sup.6 is --NH.sub.2, ##STR2## or --OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R 1，R 2，R 3，R 4和R 5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，并且其中之一其余三个为-Xn-Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn- Al-C-R6，其余三个基团是H，烷基或卤素，并且（A）或（B）中亚烷基的一个或两个-CH 2可以任选地被-O - ， - S-或-NH - ，X为-O-或-NH-，Alk为亚烷基，R6为-NH2，或IMA为-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物为通过氨基酸或肽或其药学上可接受的盐与具有羧基的多糖结合。所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

97. 发明授权

US4322524A Cyanoethylpullulan 失效
标题翻译：氰基乙基
公开(公告)号：US4322524A
公开(公告)日：1982-03-30
申请号：US168269
申请日：1980-07-10
申请人： Yoshiro Onda , Hiroaki Muto , Hiroshi Suzuki
发明人： Yoshiro Onda , Hiroaki Muto , Hiroshi Suzuki
IPC分类号： C08B37/00
CPC分类号： C08B37/0018
摘要： The present invention provides a novel compound cyanoethylpullulan which is a cyanoethylation product of pullulan. Pullulan is readily cyanoethylated by the reaction with acrylonitrile in the presence of an alkali catalyst such as sodium hydroxide.The cyanoethylpullulan having a degree of cyanoethylation of at least 50% has various unique properties in the heat resistance, solubility in organic solvents, film-forming property, adhesive bonding to metals and the like in comparison with related cyanoethylated products such as cyanoethylcellulose and cyanoethylated polyvinyl alcohol.
摘要翻译：本发明提供了作为支链淀粉的氰乙基化产物的新型化合物氰乙基普兰兰。在碱性催化剂如氢氧化钠的存在下，通过与丙烯腈的反应，将支链淀粉容易地氰乙基化。具有至少50％氰基乙基化度的氰乙基普兰兰与相关的氰乙基纤维素和氰乙基化聚乙烯吡咯烷酮相关的氰乙基化产物相比具有各种独特的耐热性，在有机溶剂中的溶解性，成膜性，与金属的粘合性等醇。

98. 发明授权

US4167623A Pullulan aminoalkyl ether 失效
标题翻译：支链淀粉氨基烷基醚
公开(公告)号：US4167623A
公开(公告)日：1979-09-11
申请号：US848033
申请日：1977-11-03
申请人： Fumio Fujita , Kosuke Fukami , Masanori Fujimoto
发明人： Fumio Fujita , Kosuke Fukami , Masanori Fujimoto
IPC分类号： C08B37/00 , C07H15/04
CPC分类号： C08B37/0018
摘要： Pullulan aminoalkyl ether is obtained by reacting pullulan with an aminoalkylating agent in a solvent in the presence of an alkali. This ether may be used as a cationic polymer of considerable utility in industries. For instance, when used in a paper coating material, it gives desirable effects on gloss, RI dry pick, and RI wet pick and, furthermore, as compared with pullulan, markedly improves physical properties of the coated paper such as tearing strength, tensile strength and wrinkle recovery; it improves also retention of loading materials such as clay and calcium carbonate.
摘要翻译：支链淀粉氨基烷基醚通过在碱存在下在溶剂中将支链淀粉与氨基烷基化试剂反应得到。该醚可用作工业中相当实用的阳离子聚合物。例如，当在纸张涂布材料中使用时，其对光泽度，RI干性接枝和RI湿腻子具有期望的效果，此外，与支链淀粉相比，显着改善涂布纸的物理性能如撕裂强度，拉伸强度和皱纹恢复; 它还改善了载体材料如粘土和碳酸钙的保留。

99. 发明授权

US4090016A Carboxylated pullulan and method for producing same 失效
标题翻译：羧化支链淀粉及其制备方法
公开(公告)号：US4090016A
公开(公告)日：1978-05-16
申请号：US689064
申请日：1976-05-24
申请人： Kozo Tsuji , Masanori Fujimoto , Fujio Masuko , Tsuneyuki Nagase
发明人： Kozo Tsuji , Masanori Fujimoto , Fujio Masuko , Tsuneyuki Nagase
IPC分类号： D06M15/03 , C08B37/00
CPC分类号： C08B37/0018
摘要： Carboxylated pullulan obtained by oxidizing pullulan with an oxidizing agent is readily soluble in cold water and has favorable film-forming property, yielding a film having high mechanical strengths, high modulus of elasticity and good transparency.
摘要翻译：通过用氧化剂氧化支链淀粉获得的羧基化支链淀粉很容易溶于冷水，具有良好的成膜性，产生机械强度高，弹性模量高，透明性好的膜。

100. 发明授权

US4002173A Diester crosslinked polyglucan hydrogels and reticulated sponges thereof 失效
标题翻译：二酯交联聚葡聚糖水凝胶及其网状海绵
公开(公告)号：US4002173A
公开(公告)日：1977-01-11
申请号：US568030
申请日：1975-04-14
申请人： James H. Manning , John H. Stark
发明人： James H. Manning , John H. Stark
IPC分类号： A61L15/64 , A61K31/715 , A61L15/60 , A61P7/04 , B01J20/24 , C08B33/00 , C08B33/02 , C08B37/00 , C08B37/02 , F23L3/00
CPC分类号： C08B37/0021 , A61L15/425 , A61L15/60 , C08B33/02 , C08B37/0018 , A61L2400/04
摘要： Novel hydrogel compositions of diester crosslinked polyglucans and a process for their preparation are provided. Amylose, dextran, and pullulan succinates and glutarates when crosslinked as described were found to not only have use as general fluid sorbants but also to have exceptional hemostatic activity, adherence to a wound, and bioabsorption without causing undue irritation of the tissue or toxic effects. Reticulated hydrogel sponges made of the crosslinked diesters which are particularly useful as general fluid sorbants, and those of amylose succinate and amylose glutarate are most excellent bioabsorbable hemostatic agents. The sponges are made by lyophilizing water-soluble salts of the mono- or half-esters, such as water-soluble salts of amylose succinate or amylose glutarate, under process conditions of the invention in the presence of a reticulating agent which causes a controlled melting of the salt solution as it nears the dry state during the lyophilizing step. The resulting reticulated, porous, open-celled sponge is then crosslinked by heating the sponge under dehydrating conditions to form diester-crosslinks. The sponge is highly porous, is moderately strong, and has the ability to retain up to 40 times its weight of isotonic saline. When neutralized with physiologically acceptable salts, the sponge has exceptional hemostatic activity, adherence to bleeding tissue, and bioabsorption without causing substantial irritation of the tissue or toxic effects.The invention also comprises a process of providing hemostasis at the site of a wound, employing the diester cross-linked polyglucan hydrogels or reticulated sponges thereof.
摘要翻译：提供了二酯交联聚葡聚糖的新型水凝胶组合物及其制备方法。发现当如上所述交联时，直链淀粉，葡聚糖和支链淀粉琥珀酸酯和戊二酸酯不仅可以用作普通流体吸着剂，而且具有特殊的止血活性，对伤口的粘附和生物吸收，而不会对组织造成不适当的刺激或毒性作用。特别可用作一般液体吸附剂的交联二酯制成的网状水凝胶海绵，以及直链淀粉琥珀酸酯和直链淀粉戊二酸酯的网状水凝胶海绵是最优异的生物可吸收止血剂。海绵通过在本发明的工艺条件下，在引起受控熔化的网状剂的存在下，将单酯或半酯的水溶性盐如琥珀酸直链淀粉的水溶性盐或直链淀粉戊二酸盐的水溶性盐冻干，的盐溶液，因为其在冻干步骤期间接近干燥状态。然后通过在脱水条件下加热海绵将形成的网状多孔的开孔海绵交联，形成二酯交联。海绵是高度多孔的，中等强度，并且具有保留高达40倍重量的等渗盐水的能力。当用生理上可接受的盐中和时，海绵具有特殊的止血活性，对出血组织的粘附和生物吸收，而不会对组织产生显着的刺激或毒性作用。

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