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91. 发明申请

US20090270606A1 Process for the Preparation of Hydroxy Polymer Esters and Their Use 失效
标题翻译：羟基聚合物酯的制备方法及其用途
公开(公告)号：US20090270606A1
公开(公告)日：2009-10-29
申请号：US12085384
申请日：2006-12-07
申请人： Aki Laine , Hendrik Luttikhedde
发明人： Aki Laine , Hendrik Luttikhedde
IPC分类号： C08B31/04 , C07H1/00 , C08B37/00
CPC分类号： C07H1/00 , C08B3/14 , C08B31/00 , C08B31/04 , C08B37/00 , C08B37/0018 , C08B37/0033 , C08B37/0096
摘要： This invention covers a novel method for the preparation of hydroxy polymer esters of amino, alkylamino and quaternary ammonium acids and their use in several fields of industry, including the use as additives in the manufacture of paper or paperboard. The esterification of the hydroxy polymer, preferably starch, is performed under semianhydrous conditions by heating homogenized mixtures of the hydroxy polymer and reagents.
摘要翻译：本发明涉及一种制备氨基，烷基氨基和季铵酸的羟基聚合物酯的新方法及其在工业的几个领域中的应用，包括在纸或纸板的制造中用作添加剂。通过加热羟基聚合物和试剂的均化混合物，在半干水条件下进行羟基聚合物，优选淀粉的酯化。

92. 发明申请

US20090216006A1 COVALENTLY BOUND POLYSACCHARIDE-BASED CHIRAL STATIONARY PHASES AND METHOD FOR THEIR PREPARATION 审中-公开
标题翻译：基于多边形基于聚合物的手持式固定相及其制备方法
公开(公告)号：US20090216006A1
公开(公告)日：2009-08-27
申请号：US12389055
申请日：2009-02-19
申请人： Hui Xu , Yafeng Zhang , Qiwei Lu
发明人： Hui Xu , Yafeng Zhang , Qiwei Lu
IPC分类号： C08B37/00
CPC分类号： B01J20/286 , B01D15/3833 , B01J20/28004 , B01J20/28057 , B01J20/29 , B01J20/3204 , B01J20/3219 , B01J20/3274 , C08B15/06 , C08B31/00 , C08B33/00 , C08B35/00 , C08B37/0018 , C08B37/0021 , C08B37/003 , C08B37/0039 , C08B37/0051 , C08B37/0054 , C08G18/6484 , C08G18/71 , C09D105/00 , C09D105/02
摘要： The present invention relates to liquid chromatographic chiral stationary phases (CSPs) and their preparation. The CSPs are based on carbamate-derivatized polysaccharides that are covalently bound onto inorganic oxide carriers via unique linkage chemistry. The present invention also relates to methods of obtaining the said linkages, which include derivatizing and functionalizing the polysaccharides, and also chemically bonding the functionalized carbamate-derivatized polysaccharides onto inorganic oxide carriers. The polysaccharide derivatives so obtained can be used as materials for the liquid chromatographic chiral separation of enantiomers. The preferred inorganic oxides are silica, zirconium oxide, and aluminum oxide. Cellulose and amylose are the preferred chiral polysaccharides.
摘要翻译：本发明涉及液相色谱手性固定相（CSP）及其制备方法。 CSP基于氨基甲酸酯衍生的多糖，其通过独特的连接化学共价键合到无机氧化物载体上。本发明还涉及获得所述键的方法，其包括使多糖衍生化和官能化，并且还将官能化的氨基甲酸酯衍生的多糖化学键合到无机氧化物载体上。如此获得的多糖衍生物可用作对映异构体的液相色谱手性分离的材料。优选的无机氧化物是二氧化硅，氧化锆和氧化铝。纤维素和直链淀粉是优选的手性多糖。

93. 发明授权

US07348424B2 Polysaccharide containing phosphorylcholine group and process for producing the same 失效
标题翻译：含有磷酸胆碱的多糖组及其制备方法
公开(公告)号：US07348424B2
公开(公告)日：2008-03-25
申请号：US10506771
申请日：2003-04-08
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise M. Winnik
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise M. Winnik
IPC分类号： C07H5/04 , C07H5/06 , C08B37/00
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method.The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it.The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.
摘要翻译：本发明是一种含有磷酰胆碱基团的多糖的制造方法，其中将通过甘油磷酰胆碱的氧化开环反应得到的含有醛衍生物的化合物加入到含有氨基的多糖中，以及具有磷酸胆碱基团的新型多糖，这种制造方法。本发明的目的是提供一种生物相容性和保湿性优异的含磷酰胆碱基团的多糖，作为医疗用聚合物材料，以及其制造方法简单。本发明的多糖可用于例如人造器官，生物膜，医疗工具用涂剂，药物输送和化妆品中。

94. 发明授权

US07247722B2 Polysaccharide aldehydes prepared by oxidation method and used as strength additives in papermaking 失效
标题翻译：通过氧化法制备多糖醛，并在造纸中用作强度添加剂
公开(公告)号：US07247722B2
公开(公告)日：2007-07-24
申请号：US10421973
申请日：2003-04-23
申请人： A. Levent Cimedoglu , John S. Thomaides
发明人： A. Levent Cimedoglu , John S. Thomaides
IPC分类号： C08B1/00 , C08B11/00 , C08B11/08 , C08B31/04 , C08B31/18
CPC分类号： D21H17/29 , C08B11/20 , C08B31/18 , C08B37/0018 , C08B37/0096 , D21H21/18 , D21H21/20
摘要： Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.
摘要翻译：使用选择性氧化制备多糖醛，其涉及使用硝酰自由基介导的水性氧化和有限量的氧化剂和规定的反应条件。这些具有最大有效醛和最低羧酸含量的多糖醛衍生物使它们特别用作纸张的湿，临时湿和干强度添加剂。

95. 发明申请

US20050222405A1 Polysaccharide containing phosphorylcholine group and process for producing the same 失效
标题翻译：含有磷酸胆碱的多糖组及其制备方法
公开(公告)号：US20050222405A1
公开(公告)日：2005-10-06
申请号：US10506771
申请日：2003-04-08
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
IPC分类号： A61L27/00 , A61K8/73 , A61Q19/00 , C08B11/20 , C08B15/00 , C08B15/06 , C08B37/00 , C08B37/02 , C08B37/08 , C07H13/06
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method. The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it. The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.
摘要翻译：本发明是一种含有磷酰胆碱基团的多糖的制造方法，其中将通过甘油磷酰胆碱的氧化开环反应得到的含有醛衍生物的化合物加入到含有氨基的多糖中，以及具有磷酸胆碱基团的新型多糖，这种制造方法。本发明的目的是提供一种生物相容性和保湿性优异的含磷酰胆碱基团的多糖，作为医疗用聚合物材料，以及其制造方法简单。本发明的多糖可用于例如人造器官，生物膜，医疗工具用涂剂，药物输送和化妆品中。

96. 发明申请

US20040197410A1 Pullulan-containing powder, process for producing the same and use thereof 失效
标题翻译：含有支链淀粉的粉末，其制造方法及其用途
公开(公告)号：US20040197410A1
公开(公告)日：2004-10-07
申请号：US10484216
申请日：2004-01-20
发明人： Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： C12P019/04 , A61K009/14 , C08B037/00
CPC分类号： C08J3/12 , A23L29/274 , A23P20/20 , A61K8/0212 , A61K8/11 , A61K8/73 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0018 , C08J3/14 , C08J2305/00 , C08K5/15 , C08L5/00 , C08L5/16 , C08L2666/26
摘要： The object of the present invention is to overcome conventional demerits of pullulan powders prepared by conventional techniques, i.e., they could not be homogeneously mixed with non-reducing saccharides composed of glucose units when mixed together, and the resulting mixtures do not easily dissolve in water; and to provide a pullulan-containing powder with an improved rate of water dissolution, as well as to provide preparations and uses thereof. The present invention solves the above object by providing a pullulan-containing powder which uniformly comprises pullulan as a main ingredient and a non-reducing saccharide, and their process and uses; wherein the pullulan-containing powder is prepared by the steps of preparing a solution dissolving pullulan and a non-reducing saccharide homogeneously, pulverizing the solution, and collecting the resulting pullulan-containing powder. The powder has an improved rate of water dissolution, while retaining satisfactory resistance to humidity without fear of causing separation between the pullulan and the non-reducing sccharide.
摘要翻译：本发明的目的是克服通过常规技术制备的支链淀粉粉末的常规缺点，即当它们混合在一起时不能与由葡萄糖单元组成的非还原性糖类均匀混合，并且所得混合物不容易溶于水 ; 并提供具有改善的水溶解速率的含支链淀粉的粉末，以及提供其制备和用途。本发明通过提供均匀地包含支链淀粉作为主要成分和非还原性糖的支链淀粉粉末及其工艺和用途来解决上述目的。其中含有支链淀粉的粉末通过以下步骤制备：均匀地制备溶解支链淀粉和非还原性糖的溶液，粉碎溶液，并收集所得的含支链淀粉粉末。粉末具有提高的水溶解速率，同时保持令人满意的耐湿性，而不用担心在支链淀粉和非还原性螯合剂之间分离。

97. 发明授权

US06586588B1 Polysaccharide aldehydes prepared by oxidation method and used as strength additives in papermaking 失效
标题翻译：通过氧化法制备多糖醛，并在造纸中用作强度添加剂
公开(公告)号：US06586588B1
公开(公告)日：2003-07-01
申请号：US09636069
申请日：2000-08-10
申请人： A. Levent Cimecioglu , John S. Thomaides
发明人： A. Levent Cimecioglu , John S. Thomaides
IPC分类号： C08B3100
CPC分类号： C08B37/0096 , C08B11/20 , C08B31/18 , C08B37/0018 , D21H17/29 , D21H21/18 , D21H21/20
摘要： Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.
摘要翻译：使用选择性氧化制备多糖醛，其涉及使用硝酰自由基介导的水性氧化和有限量的氧化剂和规定的反应条件。这些具有最大有效醛和最低羧酸含量的多糖醛衍生物使它们特别用作纸张的湿，临时湿和干强度添加剂。

98. 发明授权

US06514407B2 Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials 失效
公开(公告)号：US06514407B2
公开(公告)日：2003-02-04
申请号：US09808190
申请日：2001-03-15
申请人： Raphael Duval
发明人： Raphael Duval
IPC分类号： C07H2300
CPC分类号： C07B57/00 , C08B15/05 , C08B37/00 , C08B37/0009 , C08B37/0012 , C08B37/0018 , C08B37/0021 , C08B37/0024 , C08B37/003 , C08B37/0054 , C08B37/0057 , Y02P20/544
摘要： There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.

99. 发明授权

US06346616B1 Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials 失效
标题翻译：可聚合和可交联的多糖或寡糖的氯代，羟基和烷氧基硅烷衍生物，它们的合成及其作为新型载体材料的来源
公开(公告)号：US06346616B1
公开(公告)日：2002-02-12
申请号：US09394868
申请日：1999-09-13
申请人： Raphaël Duval
发明人： Raphaël Duval
IPC分类号： C07H2300
CPC分类号： C07B57/00 , C08B15/05 , C08B37/00 , C08B37/0009 , C08B37/0012 , C08B37/0018 , C08B37/0021 , C08B37/0024 , C08B37/003 , C08B37/0054 , C08B37/0057 , Y02P20/544
摘要： There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.
摘要翻译：描述了多糖或寡糖的氯代，羟基和烷氧基硅烷衍生物作为可聚合和可交联的新化合物及其获得方法; 从所述衍生物获得的新颖的载体材料，并含有通过与载体共价键化学接枝并在三维网络中聚合和交联的多糖或寡糖的所述硅烷衍生物及其获得方法; 以及通过使用气相，液体或超临界色谱法，通过电泳，电色谱法或通过含有所述载体材料的膜的渗滤方法在分离或制备对映异构体中使用所述材料载体。

100. 发明授权

US5892043A Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US5892043A
公开(公告)日：1999-04-06
申请号：US773182
申请日：1996-12-27
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/48 , C08B37/00 , C08B37/02 , C07D471/00
CPC分类号： C08B37/0018 , A61K47/4823 , A61K47/48338 , C08B37/0021
摘要： A camptothecin derivative comprising a compound of the formula �I!: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is --X.sub.n --Alk.sub.m --R.sup.6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by --X.sub.n --Alk.sub.m --R.sup.6, and the remaining three groups are H, alkyl or a halogen, and one or two --CH.sub.2 -- of the alkylene in (A) or (B) may optionally be replaced by --O--, --S-- or --NH--, X is --O-- or --NH--, Alk is alkylene, R.sup.6 is --NH.sub.2, ##STR2## or --OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R 1，R 2，R 3，R 4和R 5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，并且其中之一其余三个为-Xn-Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn- Al-C-R6，其余三个基团是H，烷基或卤素，并且（A）或（B）中亚烷基的一个或两个-CH 2可以任选地被-O - ， - S-或-NH - ，X为-O-或-NH-，Alk为亚烷基，R6为-NH2，或IMA为-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物为通过氨基酸或肽或其药学上可接受的盐与具有羧基的多糖结合。所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

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