专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

WO2010151258A1 METHODS OF TREATING PSYCHOLOGICAL CONDITIONS 审中-公开
标题翻译：治疗心理条件的方法
公开(公告)号：WO2010151258A1
公开(公告)日：2010-12-29
申请号：PCT/US2009/048494
申请日：2009-06-24
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , RAY, Thomas, S.
发明人： RAY, Thomas, S.
IPC分类号： A01N33/02
CPC分类号： A61K31/137 , A61K31/343
摘要： A method and composition for inducing in a subject a tolerance to a psychoactive substance or for treating an abnormal mental condition in a subject. The composition used in the method comprises in one embodiment a 5-HT 2B receptor agonist disposed within a pharmaceutically-acceptable vehicle or carrier.
摘要翻译：在受试者中诱导对精神活性物质的耐受性或用于治疗受试者的异常精神状况的方法和组合物。该方法中使用的组合物在一个实施方案中包括设置在药学上可接受的载体或载体内的5-HT 2B受体激动剂。

92. 发明申请

WO2010002417A1 GAS CHROMATOGRAPH OVEN 审中-公开
标题翻译：气体色谱炉
公开(公告)号：WO2010002417A1
公开(公告)日：2010-01-07
申请号：PCT/US2008/082253
申请日：2008-11-03
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , WHITE, Robert, L.
发明人： WHITE, Robert, L.
IPC分类号： G01N30/02
CPC分类号： G01N30/30 , G01N2030/025 , G01N2030/3053 , G01N2030/3084
摘要： A gas chromatograph oven including a housing, a capillary tube and a thermal control assembly. The housing defining a capillary tube receiving space and having at least one outlet port to permit the passage of a fluid from the capillary tube receiving space of the housing. The capillary tube is positioned in the capillary tube receiving space of the housing and has a gas inlet end connectable to a gas injector and a gas detector end connectable to a gas detector. The thermal control assembly is in fluid communication with the capillary tube receiving space of the housing and is connectable to a source of a temperature regulating fluid.
摘要翻译：包括壳体，毛细管和热控制组件的气相色谱仪。壳体限定毛细管容纳空间并且具有至少一个出口以允许来自壳体的毛细管容纳空间的流体通过。毛细管位于壳体的毛细管容纳空间中，并且具有可连接到气体注射器的气体入口端和可连接到气体检测器的气体检测器端。热控制组件与壳体的毛细管接收空间流体连通，并且可连接到温度调节流体源。

93. 发明申请

WO2009132277A1 INHIBITION OF NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES 审中-公开
标题翻译：通过氧化亚氮纳米颗粒抑制新生血管
公开(公告)号：WO2009132277A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041675
申请日：2009-04-24
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , MCGINNIS, James, F. , ZHOU, Xiahong , WONG, Lily, L.
发明人： MCGINNIS, James, F. , ZHOU, Xiahong , WONG, Lily, L.
IPC分类号： A01N43/04
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

94. 发明申请

WO2009100121A1 GAMMA-GLUTAMYL TRANSPEPTIDASE INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： GAMMA-GLUTAMYL TRANSPEPTIDASE抑制剂及其使用方法
公开(公告)号：WO2009100121A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033063
申请日：2009-02-04
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , HANIGAN, Marie, H.
发明人： HANIGAN, Marie, H.
IPC分类号： A61K31/555 , A61K31/675
CPC分类号： A61K31/555 , A61K31/675
摘要： Enhancing the sensitivity of therapy-resistant tumor cells to antitumor agents such as chemotherapeutic agents and radiation by administering GGT inhibitor compounds that comprise a class of benzylthiadiazol benzenesulfomamides represented by the general structure Formula (1 ) The present invention also provides a method for the prophylaxis or treatment of a reversible airways obstruction in a mammal, such as a human, comprising administration of a therapeutically effective amount of a GGT inhibitor described herein for the prophylaxis or treatment of a disease associated with reverse airways obstruction such as asthma, chronic obstructive pulmonary disease (COPD), allergic reaction, respiratory tract infection or upper respiratory tract disease
摘要翻译：通过给予包含一般结构式（1）所示的一类苄基噻二唑苯磺酰胺的GGT抑制剂化合物，提高耐药性肿瘤细胞对抗肿瘤剂如化学治疗剂和辐射的敏感性本发明还提供了一种预防或治疗哺乳动物（例如人）中的可逆气道阻塞，包括施用治疗有效量的本文所述的GGT抑制剂，用于预防或治疗与反气道阻塞相关的疾病如哮喘，慢性阻塞性肺病（ COPD），过敏反应，呼吸道感染或上呼吸道疾病

95. 发明申请

WO2009026380A1 MEDICAL DEVICE WITH BIOFUNCTIONALIZED POLYMER COATING 审中-公开
标题翻译：具有生物功能聚合物涂层的医疗装置
公开(公告)号：WO2009026380A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073737
申请日：2008-08-20
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , RICE, Charles, V.
发明人： RICE, Charles, V.
IPC分类号： B05D3/00
CPC分类号： C09D133/14
摘要： The present invention is thus directed to coating compositions and methods of their use, and to the objects coated therewith, for their use as implants and medical devices In particular, the medical devices and implants of the present invention comprise biomateπals which are coated with functionalized polymers having biomolecules conjugated thereto, or with the functionalized polymers to which such biomolecules can be conjugated to form the biofunctionalized polymer The biomolecules attached to the functionalized polymers contemplated herein may be defined as natural or synthetic chemical compounds which possess an ability to covalently bond to the functional group on the functionalized polymer or a spacer thereon, preferably via a sulfhydryl group thereon The functionalized or biofunctionalized polymers of the present invention may comprise spacer molecules which are covalently linked via sulfhydryl binds to the functional groups thereof for linking to the biomolecules of the biofunctionalized polymers.
摘要翻译：因此，本发明涉及其用途的涂料组合物及其使用方法，以及涂覆于其上的物体，用作植入物和医疗装置。特别地，本发明的医疗装置和植入物包含涂覆有官能化聚合物的生物体具有与其缀合的生物分子，或与可与其结合的这些生物分子的官能化聚合物形成生物官能化聚合物。本文涉及的官能化聚合物上连接的生物分子可以定义为具有共价键合到功能性的能力的天然或合成化学化合物官能化聚合物或其上的间隔基，优选通过其上的巯基基团。本发明的官能化或生物官能化聚合物可以包含通过巯基共价连接的间隔基分子，其与其功能基团结合，用于连接生物器官的生物分子聚合物。

96. 发明申请

WO2008137066A1 USE OF COMPACTED NUCLEIC ACID NANOPARTICLES IN NON-VIRAL TREATMENTS OF OCULAR DISEASES 审中-公开
标题翻译：压迫性核酸纳米颗粒在非恶性病毒治疗中的应用
公开(公告)号：WO2008137066A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/005676
申请日：2008-05-02
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , COPERNICUS THERAPEUTICS, INC. , NAASH, Muna, I. , COOPER, Mark, J.
发明人： NAASH, Muna, I. , COOPER, Mark, J.
IPC分类号： A61K9/127 , C07K1/00
CPC分类号： A61K9/5146 , A61K9/0048 , A61K47/60
摘要： The present invention is a method of using compacted nucleic acid (such as DNA) nanoparticles for non-viral gene transfer to various tissues of the human eye or eyes of other mammals. These nanoparticles comprise, in one embodiment, a neutrally-charged complex containing a single molecule of plasmid DNA compacted with polyethylene glycol (PEG)-substituted poly lysine peptides.
摘要翻译：本发明是使用致密核酸（例如DNA）纳米颗粒将非病毒基因转移到人眼或其他哺乳动物的眼睛的各种组织的方法。在一个实施方案中，这些纳米颗粒包含含有用聚乙二醇（PEG）取代的聚赖氨酸肽压制的单分子质粒DNA的中性荷电复合物。

97. 发明申请

WO2008112631A1 TEST CELL FOR APPLYING A SHEAR STRESS TO A TEST SPECIMEN 审中-公开
标题翻译：用于将剪切应力应用于测试样本的测试单元
公开(公告)号：WO2008112631A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056408
申请日：2008-03-10
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , ABOUSLEIMAN, Younane , BRUMLEY, John , AITAHINI, Ashraf , HOANG, Son , NGYUEN, Vinh
发明人： ABOUSLEIMAN, Younane , BRUMLEY, John , AITAHINI, Ashraf , HOANG, Son , NGYUEN, Vinh
IPC分类号： G01B5/30
CPC分类号： G01N3/24 , G01N2203/0266 , G01N2203/0435
摘要： A test cell and method for stress testing a test specimen including a first platen and a second platen. Each platen having a loading surface, an inclined surface, and a longitudinal axis. The inclined surface being inclined relative to the longitudinal axis at an angle and the inclined surface having a specimen recess formed therein for receiving a portion of the test specimen such that when the inclined surface of the second platen is positioned in a face-to-face relationship with the inclined surface of the first platen, a shear stress is applied to the test specimen when an axial load is applied to the first and second platens. The platens further including fluid ports to subject the test specimen to fluid flow at various pressures and fluid chemistries and ultrasonic transducers to determine acoustic, compressional, and shear wave velocities and in multiple orientations.
摘要翻译：一种用于对包括第一压板和第二压板的试样进行应力测试的测试电池和方法。每个压板具有装载表面，倾斜表面和纵向轴线。倾斜表面相对于纵向轴线成一定角度倾斜，并且倾斜表面具有形成在其中的试样凹部，用于接收试样的一部分，使得当第二压板的倾斜表面位于面对面与第一压板的倾斜表面的关系，当向第一和第二压板施加轴向载荷时，对试样施加剪切应力。压板还包括流体端口，以使待测样品在各种压力下流体流动，并且流体化学和超声波换能器以确定声学，压缩和剪切波速以及多个取向。

98. 发明申请

WO2008094836A2 COMPUTER SYSTEM WITH DIGITAL MICROMIRROR DEVICE 审中-公开
标题翻译：带数字麦克风设备的计算机系统
公开(公告)号：WO2008094836A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052099
申请日：2008-01-25
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , REFAI, Hakki, H. , SLUSS, James, J., Jr. , DAHSHAN, Mostafa, H.
发明人： REFAI, Hakki, H. , SLUSS, James, J., Jr. , DAHSHAN, Mostafa, H.
CPC分类号： H04N9/3194 , G02B26/0833 , G06F9/451 , H04N9/3141
摘要： Algorithms stored on one or more computer readable medium for interfacing an imaging display with an electronic-ink generating system are described. The algorithms includes instructions for capturing an electronic-ink image, instructions for converting the electronic ink image into control instructions for controlling an electromechanical aspect of the imaging display, and, instructions for providing the control instructions to control circuitry of the imaging display. Interfacing projection systems and methods of interfacing electronic-ink images are also described.
摘要翻译：描述存储在一个或多个计算机可读介质上用于将成像显示器与电子墨水生成系统进行接口的算法。算法包括用于捕获电子墨水图像的指令，用于将电子墨水图像转换成用于控制成像显示器的机电方面的控制指令的指令以及用于向控制电路提供控制指令的指令。还描述了接口投影系统和接口电子墨水图像的方法。

99. 发明申请

WO2008028055A2 ISOLATION AND CHARACTERIZATION OF NOVEL CLOSTRIDIAL SPECIES 审中-公开
标题翻译：分离和特征的新型亲缘关系
公开(公告)号：WO2008028055A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077264
申请日：2007-08-30
申请人： THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY , THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , HUHNKE, Raymond, L. , LEWIS, Randy, S. , TANNER, Ralph, S.
发明人： HUHNKE, Raymond, L. , LEWIS, Randy, S. , TANNER, Ralph, S.
IPC分类号： C12P7/06 , C12N1/21
CPC分类号： C12R1/145 , C12P7/065 , C12P7/08 , Y02E50/17
摘要： A novel clostridia bacterial species (Clostridium ragsdalei, ATCC BAA-622 and/or PTA-7826, "P11") is provided. P11 is capable of synthesizing, from waste gases, products which are useful as biofuel. In particular, P11 can convert CO to ethanol. Thus, this novel bacterium transforms waste gases (e.g. syngas and refinery wastes) into useful products. P11 also catalyzes the production of acetate.
摘要翻译：提供了一种新型的梭菌菌种（Clostridium ragsdalei，ATCC BAA-622和/或PTA-7826，“P11”）。 P11能够从废气中合成可用作生物燃料的产品。特别地，P11可将CO转化为乙醇。因此，这种新型细菌将废气（例如合成气和炼厂废物）转化成有用的产物。 P11还催化乙酸盐的生产。

100. 发明申请

WO2007059362A2 ACTIVATION OF CARDIAC ALPHA RECEPTORS BY SPINAL CORD STIMULATION PRODUCES CARDIOPROTECTION AGAINST ISCHEMIA, ARRHYTHMIAS, AND HEART FAILURE 审中-公开
标题翻译：通过脊髓刺激激活CARDIAC ALPHA受体产生对ISCHEMIA，ARRHYTHMIAS和心脏衰竭的心脏保护
公开(公告)号：WO2007059362A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/045228
申请日：2006-11-21
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , FOREMAN, Robert, D. , ARDELL, Jeffrey, L. , ARMOUR, John, A. , DEJONGSTE, Michael, J. L. , LINDEROTH, Bengt, G.S.
发明人： FOREMAN, Robert, D. , ARDELL, Jeffrey, L. , ARMOUR, John, A. , DEJONGSTE, Michael, J. L. , LINDEROTH, Bengt, G.S.
IPC分类号： A61N1/36
CPC分类号： A61N1/36114

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式