专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009132277A1 INHIBITION OF NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES 审中-公开
标题翻译：通过氧化亚氮纳米颗粒抑制新生血管
公开(公告)号：WO2009132277A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041675
申请日：2009-04-24
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , MCGINNIS, James, F. , ZHOU, Xiahong , WONG, Lily, L.
发明人： MCGINNIS, James, F. , ZHOU, Xiahong , WONG, Lily, L.
IPC分类号： A01N43/04
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

2. 发明公开

EP2288258A1 INHIBITION OF NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES 审中-公开
标题翻译：新生血管铈氧化物纳米颗粒抑制
公开(公告)号：EP2288258A1
公开(公告)日：2011-03-02
申请号：EP09734790.0
申请日：2009-04-24
申请人： The Board of Regents of the University of Oklahoma , University Of Central Florida Research Foundation, Inc.
发明人： MCGINNIS, James, F. , ZHOU, Xiaohong , WONG, Lily, L. , SEAL, Sudipta
IPC分类号： A01N43/04
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式