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1. 发明申请

WO2009026380A1 MEDICAL DEVICE WITH BIOFUNCTIONALIZED POLYMER COATING 审中-公开
标题翻译：具有生物功能聚合物涂层的医疗装置
公开(公告)号：WO2009026380A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073737
申请日：2008-08-20
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , RICE, Charles, V.
发明人： RICE, Charles, V.
IPC分类号： B05D3/00
CPC分类号： C09D133/14
摘要： The present invention is thus directed to coating compositions and methods of their use, and to the objects coated therewith, for their use as implants and medical devices In particular, the medical devices and implants of the present invention comprise biomateπals which are coated with functionalized polymers having biomolecules conjugated thereto, or with the functionalized polymers to which such biomolecules can be conjugated to form the biofunctionalized polymer The biomolecules attached to the functionalized polymers contemplated herein may be defined as natural or synthetic chemical compounds which possess an ability to covalently bond to the functional group on the functionalized polymer or a spacer thereon, preferably via a sulfhydryl group thereon The functionalized or biofunctionalized polymers of the present invention may comprise spacer molecules which are covalently linked via sulfhydryl binds to the functional groups thereof for linking to the biomolecules of the biofunctionalized polymers.
摘要翻译：因此，本发明涉及其用途的涂料组合物及其使用方法，以及涂覆于其上的物体，用作植入物和医疗装置。特别地，本发明的医疗装置和植入物包含涂覆有官能化聚合物的生物体具有与其缀合的生物分子，或与可与其结合的这些生物分子的官能化聚合物形成生物官能化聚合物。本文涉及的官能化聚合物上连接的生物分子可以定义为具有共价键合到功能性的能力的天然或合成化学化合物官能化聚合物或其上的间隔基，优选通过其上的巯基基团。本发明的官能化或生物官能化聚合物可以包含通过巯基共价连接的间隔基分子，其与其功能基团结合，用于连接生物器官的生物分子聚合物。

2. 发明申请

WO2021222939A1 ANTIBIOTIC AND ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2021222939A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/070485
申请日：2021-04-29
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
发明人： RICE, Charles, V.
IPC分类号： A61K38/43 , A61K31/785 , A61K31/546 , A61K31/545 , A61K31/469 , A61K31/431 , A61K31/407 , A61K45/06
摘要： Compositions, kits, and methods of use of branched poly(ethylenimine) (BPEI) compounds, including polyethylene glycol (PEG)-branched poly(ethylenimine) conjugates (PEG-BPEI) for treatment of diseases, bacterial infections, bacterial biofilms, and conditions associated with inflammation, including wounds.

3. 发明申请

WO2016205467A1 ANTIBIOTIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：抗生素组合物和使用方法
公开(公告)号：WO2016205467A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037799
申请日：2016-06-16
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
发明人： RICE, Charles, V.
IPC分类号： A61K31/397 , A61K31/33 , A61K31/395 , A61K31/15
CPC分类号： A61K31/785 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , Y02A50/469 , A61K2300/00
摘要： The present disclosure describes compositions comprising β-lactam antibiotics and branched polyethylenimines (BPEI), having efficacy against various Gram-positive bacteria, for example Gram-positive bacteria having resistance against β-lactam antibiotics, one non-limiting example of which is Methicillin-resistant Staphylococcus aureus (MRSA). The compositions result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as β-lactam antibiotics.
摘要翻译：本公开描述了包含β-内酰胺抗生素和支链聚乙烯亚胺（BPEI）的组合物，其具有针对各种革兰氏阳性细菌的功效，例如对β-内酰胺抗生素具有抗性的革兰氏阳性细菌，其一个非限制性实例是甲氧西林 - 耐药金黄色葡萄球菌（MRSA）。组合物导致这种抗性细菌菌株对传统的抗生素治疗如β-内酰胺抗生素的再敏化。

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