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91. 发明申请

US20100234410A1 HYDRATE FOR MEDICAL PURPOSES 有权
标题翻译：医用水剂
公开(公告)号：US20100234410A1
公开(公告)日：2010-09-16
申请号：US12293827
申请日：2007-03-27
申请人： Makoto Ono , Shoko Yoshida
发明人： Makoto Ono , Shoko Yoshida
IPC分类号： A61K31/4709 , C07D401/10 , A61P31/04 , A61P31/06 , A61P31/08
CPC分类号： C07D401/04
摘要： The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has excellent properties for a pharmaceutical bulk powder.
摘要翻译：本发明涉及[7 - [（7S）-7-氨基-7-甲基-5-氮杂螺[2.4]庚-5-基] -6-氟-1 - [（1R，2S）-2-氟环丙基 ] -8-甲氧基-1,4-二氢-4-氧代喹啉-3-羧酸半水合物。该半水合物稳定且易于制备，并且对于药物散装粉末具有优异的性能。

92. 发明申请

US20100093785A1 DIAMINE DERIVATIVES 审中-公开
标题翻译： DIAMINE衍生物
公开(公告)号：US20100093785A1
公开(公告)日：2010-04-15
申请号：US12259496
申请日：2008-12-30
申请人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/437
CPC分类号： C07D487/04 , A61K31/428 , A61K31/429 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , C07D209/42 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14 , C07K5/06191 , C07K5/0827
摘要： A compound represented by the general formula (1): -Q1-Q2-T0-N(R1)-Q3-(R2)T1Q4 (1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
摘要翻译：由通式（1）表示的化合物：-Q1-Q2-T0-N（R1）-Q3-（R2）T1Q4（1）其中R1和R2是氢原子等; Q1是可以被取代的饱和或不饱和的5或6元环烃基，等等; Q2是单键等; Q 3为Q 5为碳原子数1〜8的亚烷基等的基团。并且T0和T1是羰基等; 其盐，其溶剂合物或其N-氧化物。该化合物可用作预防和/或治疗脑梗塞，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，瓣膜或关节置换后血栓形成，血管成形术后的血栓形成和再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。

93. 发明授权

US07691894B2 Cyclohexanecarboxylic acid compound 失效
标题翻译：环己烷羧酸化合物
公开(公告)号：US07691894B2
公开(公告)日：2010-04-06
申请号：US10562122
申请日：2004-07-23
申请人： Makoto Ono , Shigeru Noguchi
发明人： Makoto Ono , Shigeru Noguchi
IPC分类号： A61K31/40 , C07D209/02
CPC分类号： C07D403/12
摘要： The present invention provides a VLA-4 inhibitor having high water-solubility and excellent long-term stability; i.e., sodium trans-4-[1-[2,5-dichloro-4-[(1-methyl-1H-3-indolylcarbonyl)amino]phenylacetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate pentahydrate.
摘要翻译：本发明提供了具有高水溶性和优异的长期稳定性的VLA-4抑制剂; 即反式-4- [1- [2,5-二氯-4 - [（1-甲基-1H-吲哚基羰基）氨基]苯基乙酰基] - （4S） - 甲氧基 - （2S） - 吡咯烷基甲氧基]环己烷羧酸酯五水合物。

94. 发明授权

US07421357B2 Inspection data analysis program, inspection tools, review apparatus and yield analysis apparatus 有权
标题翻译：检验数据分析程序，检验工具，检查仪器和产量分析仪器
公开(公告)号：US07421357B2
公开(公告)日：2008-09-02
申请号：US10887827
申请日：2004-07-12
申请人： Makoto Ono , Yohei Asakawa
发明人： Makoto Ono , Yohei Asakawa
IPC分类号： G06F19/00 , G01R31/26
CPC分类号： H01L22/20 , G06T7/0004 , G06T2207/30148 , Y02P90/86
摘要： An operation unit executes a process for calling to a main memory first data representative of a result of equipment QC applied to a production unit. A process for reading out to the main memory an amount of change in failure in accordance with particle numbers calculated for individual defect sizes from second inspection data representative of a result of equipment QC is applied to the production unit. Electrical test data of a product processed by the production unit during a period inclusive of the time that the second inspection is carried outis also read to the main memory. A process is also executed for using the amount of change in failure in accordance with the calculated particle numbers and the particle numbers for individual sizes determined from the first inspection data to determine an impact on the product by particles generated in the production equipment when the first inspection data is detected.
摘要翻译：操作单元执行用于向主存储器调用代表应用于生产单元的设备QC的结果的第一数据的处理。对于生产单元，将向根据第二检查数据计算出的各个缺陷尺寸的粒子数量的故障量的变化量写入主存储器的处理被应用于生产单元。在包括执行第二次检查的时间段期间由生产单元处理的产品的电气测试数据也被读取到主存储器。还执行一个处理，以根据从第一检查数据确定的计算的粒子数和个体大小的粒子数量来使用故障变化量，以确定在生产设备中产生的颗粒对产品的影响时，当第一检测数据。

95. 发明授权

US07410980B2 Crystals of taxane derivative and process for their production 有权
标题翻译：紫杉烷衍生物的晶体及其生产过程
公开(公告)号：US07410980B2
公开(公告)日：2008-08-12
申请号：US10495437
申请日：2002-11-29
申请人： Seishiro Uchida , Yoshihiro Takayanagi , Makoto Ono
发明人： Seishiro Uchida , Yoshihiro Takayanagi , Makoto Ono
IPC分类号： A61K31/443 , C07D405/12
CPC分类号： A61K31/443 , C07D493/04
摘要： A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2θ) of 6.2°, 10.3°, 10.7°, 11.4°, and 12.0° in a powder X-ray diffraction pattern, and a method for preparing the aforementioned crystal, which comprises the step of performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.
摘要翻译：（1S，2S，3R，4S，5R，8R，9S，10R，13S）-4-乙酰氧基-2-苯甲酰氧基-9,10 - [（1S）-2-（二甲基氨基）亚乙二氧基] （2R，3S）-3-（叔丁氧基羰基氨基）-3-（3-氟-2-吡啶基）-2-羟基丙酸酯的20-环氧-1-羟基塔克斯-11-烯-13-基粉末X射线衍射图中衍射角（2θ）为6.2°，10.3°，10.7°，11.4°和12.0°，以及制备上述晶体的方法，包括通过使用有机物进行结晶的步骤选自酮类溶剂，腈型溶剂及其混合物的溶剂，或所述有机溶剂和水的混合物。

96. 发明申请

US20080159878A1 COMPRESSOR 审中-公开
标题翻译：压缩机
公开(公告)号：US20080159878A1
公开(公告)日：2008-07-03
申请号：US11951686
申请日：2007-12-06
申请人： Makoto Ono , Wataru Sakuma
发明人： Makoto Ono , Wataru Sakuma
IPC分类号： F04B49/00
CPC分类号： F04B27/1036 , F04B27/10 , F04B27/1054 , F04B27/1081 , F04B49/06 , F04B49/103 , F04B2201/1206
摘要： This compressor includes housing members that form a body; a drive shaft linked to a drive power source via an electromagnetic clutch; movable members moving in cooperation with the drive shaft and carrying out the compression of a fluid; a detected body moving in cooperation with the drive shaft; a drain bolt screwed into a drain bolt hole provided in a housing member in proximity to the detected body; and a detecting device detecting the rotation state of the drive shaft by the detected body. The drain bolt is provided with a permanent magnet, the detecting device is structured by a magnetic sensor that includes a magnetic impedance element, and the magnetic sensor is provided at the head portion of the drain bolt. Thereby, it is possible to provide a rotation detecting mechanism by using an existing drain bolt, without requiring the machining of a hole in the compressor body.
摘要翻译：该压缩机包括形成主体的壳体部件; 通过电磁离合器连接到驱动电源的驱动轴; 可移动构件与驱动轴协作移动并执行流体的压缩; 与驱动轴协作移动的检测体; 一个排放螺栓，螺纹连接到靠近被检测体的壳体构件中的排水螺栓孔; 以及检测装置，通过检测到的身体检测驱动轴的旋转状态。排水螺栓设置有永磁体，检测装置由包括磁阻抗元件的磁传感器构成，磁传感器设置在排水螺栓的头部。因此，可以通过使用现有的排水螺栓来提供旋转检测机构，而不需要在压缩机主体中加工孔。

97. 发明申请

US20080015215A1 DIAMINE DERIVATIVES 审中-公开
标题翻译： DIAMINE衍生物
公开(公告)号：US20080015215A1
公开(公告)日：2008-01-17
申请号：US11850788
申请日：2007-09-06
申请人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu Ohta , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Uoto , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/4365 , A61P43/00 , A61P7/00 , A61P9/00
CPC分类号： C07D487/04 , A61K31/428 , A61K31/429 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , C07D209/42 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14 , C07K5/06191 , C07K5/0827
摘要： A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
摘要翻译：由通式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Q ^{1 -N（R 1） - N（R 2） - N（R 2） - T （1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1 < / SUP>和R 2是氢原子等; Q 1是可被取代的饱和或不饱和的5或6元环烃基，等等; Q 2是单键等; Q 3是其中Q 5是具有1〜8个碳原子的亚烷基等的基团; T 0和T 1是羰基等; 其盐，其溶剂合物或其N-氧化物。该化合物可用作预防和/或治疗脑梗塞，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，瓣膜或关节置换后血栓形成，血管成形术后的血栓形成和再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。}

98. 发明申请

US20070199891A1 Separation Membrane With Selective Permeability And Process For Producing The Same 有权
标题翻译：具有选择性渗透性的分离膜及其生产方法
公开(公告)号：US20070199891A1
公开(公告)日：2007-08-30
申请号：US10599128
申请日：2005-03-18
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
IPC分类号： B01D69/00 , B01D71/28
CPC分类号： B01D69/08 , B01D67/0011 , B01D67/0013 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2325/20 , B01D2325/28 , D01D5/24 , D01F6/94
摘要： The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.
摘要翻译：本发明涉及可用于血液净化处理的选择性选择性分离膜。更具体地说，本发明涉及具有良好平衡的分离性能，高度稳定的安全性和性能的聚砜类选择性分离膜，并且也可以顺利地组装到模块中，及其制造方法。

99. 发明授权

US07231079B2 Method and system for inspecting electronic circuit pattern 有权
标题翻译：检查电路图的方法和系统
公开(公告)号：US07231079B2
公开(公告)日：2007-06-12
申请号：US10050519
申请日：2002-01-18
申请人： Hirohito Okuda , Yuji Takagi , Masahiro Watanabe , Shunji Maeda , Minori Noguchi , Yoshimasa Ooshima , Makoto Ono
发明人： Hirohito Okuda , Yuji Takagi , Masahiro Watanabe , Shunji Maeda , Minori Noguchi , Yoshimasa Ooshima , Makoto Ono
IPC分类号： G06K9/00
CPC分类号： G01N21/956 , G01N21/9501 , G01N2021/8854 , G01N2021/8861
摘要： For the purpose of reducing a false report and shortening inspection time, an area to be inspected is locally inspected under optimum inspection conditions. In order to avoid the number of detected defects from increasing explosively, and thereby to facilitate control of a critical defect, general-purpose layout data, which is used for producing a mask of a semiconductor wafer, is accumulated in a design information server 2. With reference to the layout data, an area to be inspected, which is inspected by a pattern inspecting apparatus 1, is divided into partial inspection areas including a cell portion and a non-cell portion. Inspection parameters are set for each of the partial inspection areas. In addition, the defect reviewing apparatus 8 obtains an inspection result of the pattern inspecting apparatus 1. When obtaining a defect image, the defect reviewing apparatus 8 identifies a position, where the defect occurred, from among a cell portion, a non-cell portion, a pattern dense portion, and the like according to layout data. Moreover, the defect reviewing apparatus 8 sets inspection parameters, such as pickup magnification of this defect, in response to a result of the identification to set a control criterion of criticality.
摘要翻译：为了减少虚假报告和缩短检查时间，在最佳检查条件下对被检查区域进行局部检查。为了避免检测到的缺陷数量爆炸性增加，从而有利于控制关键缺陷，用于制造半导体晶片的掩模的通用布局数据被累积在设计信息服务器2中。参照布局数据，由图案检查装置1检查的被检查区域被划分为包括单元部分和非单元部分的局部检查区域。为每个部分检查区域设置检查参数。另外，缺陷检查装置8获得图案检查装置1的检查结果。当获得缺陷图像时，缺陷检查装置8根据布局数据从单元部分，非单元部分，图案密集部分等中识别发生缺陷的位置。此外，缺陷检查装置8响应于识别的结果设置检查参数，例如该缺陷的拾取倍率，以设置关键性的控制标准。

100. 发明申请

US20070021855A1 Test data analyzing system and test data analyzing program 失效
标题翻译：测试数据分析系统和测试数据分析程序
公开(公告)号：US20070021855A1
公开(公告)日：2007-01-25
申请号：US11483740
申请日：2006-07-11
申请人： Makoto Ono , Junko Konishi
发明人： Makoto Ono , Junko Konishi
IPC分类号： G06F19/00
CPC分类号： G05B19/41875 , G05B23/024 , G05B2219/32196 , G05B2219/32206 , Y02P90/22 , Y02P90/86
摘要： Disclosed is a test data analyzing method and system for use in estimation of a defect cause of a product, such as, an integrated circuit, a liquid crystal display, an optical transceiver, a thin film magnetic head, etc., which is fabricated through plural processes. The estimation of a defect cause is achieved by selecting a wafer number to be analyzed, reading test data, reading fabrication line data, counting frequency of machine codes by wafers, grouping test data by machine codes or frequencies, comparing test data distributions between groups by machine codes, and comparing results between machine codes.
摘要翻译：公开了一种用于估计产品的缺陷原因的测试数据分析方法和系统，例如集成电路，液晶显示器，光收发器，薄膜磁头等，其通过多个过程。缺陷原因的估计是通过选择要分析的晶片数量，读取测试数据，读取制造线数据，通过晶片对机器代码的计数频率，通过机器代码或频率分组测试数据来实现的，比较组之间的测试数据分布，通过机器代码，并比较机器代码之间的结果。

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