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91. 发明授权

US5916749A Human phosphatase inhibitor protein 失效
公开(公告)号：US5916749A
公开(公告)日：1999-06-29
申请号：US766738
申请日：1996-12-13
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4703
摘要： The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.

92. 发明授权

US5847094A UBCH7-like ubiquitin-conjugating enzyme 失效
公开(公告)号：US5847094A
公开(公告)日：1998-12-08
申请号：US748703
申请日：1996-11-13
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12N9/93 , A61K38/00
摘要： The present invention provides a human ubiquitin-conjugating enzyme (UBCPB) and polynucleotides which identify and encode UBCPB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding UBCPB and a method for producing UBCPB. The invention also provides for agonists, antibodies, or antagonists specifically binding UBCPB, and their use, in the prevention and treatment of diseases associated with expression of UBCPB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding UBCPB for the treatment of diseases associated with the expression of UBCPB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding UBCPB.

93. 发明授权

US5683910A Human phosphorylase kinase gamma subunit 失效
标题翻译：人类磷酸化酶激酶γ亚基
公开(公告)号：US5683910A
公开(公告)日：1997-11-04
申请号：US713828
申请日：1996-09-13
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12R1/19 , C12N9/14 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides a novel human phosphorylase kinase gamma subunit (HPHKG) and the polynucleotide which identifies and encodes HPHKG. The invention provides for expression vectors and host cells comprising the nucleic acid sequence encoding HPHKG. The invention also provides pharmaceutical compositions containing purified HPHKG or antisense molecules to HPHKG for the treatment of diseases associated with expression of HPHKG. The invention also includes diagnostic compositions containing the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HPHKG or anti-HPHKG antibodies which specifically bind to HPHKG, and the use of such compositions for diagnosis of disease.
摘要翻译：本发明提供新型人磷酸化酶激酶γ亚基（HPHKG）和识别和编码HPHKG的多核苷酸。本发明提供了包含编码HPHKG的核酸序列的表达载体和宿主细胞。本发明还提供含有纯化的HPHKG或HPHKG反义分子用于治疗与HPHKG表达相关的疾病的药物组合物。本发明还包括含有多核苷酸，片段或其互补物的诊断组合物，其与编码与HPHKG特异性结合的编码HPHKG或抗HPHKG抗体的多核苷酸的基因组序列或转录物杂交，以及这些组合物用于疾病诊断的用途。

94. 发明授权

US06436637B1 Protein phosphatase 失效
标题翻译：蛋白磷酸酶
公开(公告)号：US06436637B1
公开(公告)日：2002-08-20
申请号：US09206646
申请日：1998-12-07
申请人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
发明人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.
摘要翻译：本发明提供了人蛋白磷酸酶（PROPHO）和识别和编码PROPHO的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与PROPHO表达相关的疾病的方法。

95. 发明授权

US06432915B1 Human mitochondrial chaperone protein 失效
标题翻译：人线粒体伴侣蛋白
公开(公告)号：US06432915B1
公开(公告)日：2002-08-13
申请号：US09416488
申请日：1999-10-12
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
摘要翻译：本发明提供一种人线粒体伴侣蛋白（Hmt-GrpE）和识别和编码Hmt-GrpE的多核苷酸。本发明还提供表达载体和宿主细胞以及生产Hmt-GrpE的方法。本发明还提供特异性结合Hmt-GrpE的抗体或拮抗剂及其在预防和治疗癌症中的用途。本发明还提供诊断测定。本发明还提供了使用Hmt-GrpE鉴定抗真菌和抗原虫治疗剂。

96. 发明授权

US06428949B1 Human phosphatase inhibitor protein 失效
标题翻译：人类磷酸酶抑制蛋白
公开(公告)号：US06428949B1
公开(公告)日：2002-08-06
申请号：US09262610
申请日：1999-03-04
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C07K1447
CPC分类号： C07K14/4703
摘要： The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.
摘要翻译：本发明提供了一种鉴定和编码HPIP的新型人磷酸酶抑制蛋白（HPIP）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HPIP的核酸序列和用于产生HPIP的方法。本发明还提供了特异性结合HPIP的激动剂，抗体或拮抗剂及其在预防和治疗与HPIP表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HPIP的多核苷酸用于治疗与HPIP表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HPIP的抗体的诊断测定法。

97. 发明授权

US06395468B1 Human phosphatidylinositol synthase 失效
标题翻译：人类磷脂酰肌醇合成酶
公开(公告)号：US06395468B1
公开(公告)日：2002-05-28
申请号：US09216066
申请日：1998-12-18
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12Q100
CPC分类号： C12N9/1288 , A61K38/00 , C07K2319/00 , Y02A50/411
摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.
摘要翻译：本发明提供了人磷脂酰肌醇合成酶（PISH）和识别和编码PISH的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码PISH的核酸序列和产生PISH的方法的宿主细胞。本发明还提供了特异性结合PISH的激动剂，抗体或拮抗剂及其在预防和治疗与PISH表达相关的疾病中的用途。本发明还提供了使用PISH筛选抗原虫和抗真菌治疗剂。此外，本发明提供了反义分子用于编码PISH的多核苷酸用于治疗与PISH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合PISH的抗体的诊断测定法。

98. 发明授权

US6087108A RNA editing enzyme 失效
标题翻译： RNA编辑酶
公开(公告)号：US6087108A
公开(公告)日：2000-07-11
申请号：US128395
申请日：1998-08-03
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/00 , C12N15/55 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/00 , A61K38/00
摘要： The present invention provides a human RNA editing enzyme (REE-2) and polynucleotides which identify and encode REE-2. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for producing REE-2 and for treating diseases associated with expression of REE-2.
摘要翻译：本发明提供了人类RNA编辑酶（REE-2）和识别和编码REE-2的多核苷酸。本发明还提供表达载体和宿主细胞，激动剂，抗体或拮抗剂。本发明提供了生产REE-2和治疗与REE-2表达有关的疾病的方法。

99. 发明授权

US5977320A Antibody to novel human phosphorylase kinase gamma subunit 失效
标题翻译：新型人类磷酸化酶激酶γ亚基的抗体
公开(公告)号：US5977320A
公开(公告)日：1999-11-02
申请号：US96245
申请日：1998-06-11
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12R1/19 , C07K16/40 , C07K14/47
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides a novel human phosphorylase kinase gamma subunit (HPHKG) and the polynucleotide which identifies and encodes HPHKG. The invention provides for expression vectors and host cells comprising the nucleic acid sequence encoding HPHKG. The invention also provides pharmaceutical compositions containing purified HPHKG or antisense molecules to HPHKG for the treatment of diseases associated with expression of HPHKG. The invention also includes diagnostic compositions containing the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HPHKG or anti-HPHKG antibodies which specifically bind to HPHKG, and the use of such compositions for diagnosis of disease.
摘要翻译：本发明提供新型人磷酸化酶激酶γ亚基（HPHKG）和识别和编码HPHKG的多核苷酸。本发明提供了包含编码HPHKG的核酸序列的表达载体和宿主细胞。本发明还提供含有纯化的HPHKG或HPHKG反义分子用于治疗与HPHKG表达相关的疾病的药物组合物。本发明还包括含有多核苷酸，片段或其互补物的诊断组合物，其与编码与HPHKG特异性结合的编码HPHKG或抗HPHKG抗体的多核苷酸的基因组序列或转录物杂交，以及这些组合物用于疾病诊断的用途。

100. 发明授权

US5916764A Human phosphatidylinositol synthase 失效
公开(公告)号：US5916764A
公开(公告)日：1999-06-29
申请号：US763121
申请日：1996-12-10
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/12 , C12N15/11 , C12N15/63 , C12N1/20 , C07N21/04
CPC分类号： C12N9/1288 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.

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