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91. 发明申请

US20070079836A1 Reusable Infusion Site and Method of Using the Same 审中-公开
标题翻译：可重复使用注射部位及其使用方法
公开(公告)号：US20070079836A1
公开(公告)日：2007-04-12
申请号：US11610269
申请日：2006-12-13
申请人： Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael Miller , Nannette Van Antwerp , Bradley Enegren , William Van Antwerp , John Mastrototaro
发明人： Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael Miller , Nannette Van Antwerp , Bradley Enegren , William Van Antwerp , John Mastrototaro
IPC分类号： A61B19/00
CPC分类号： A61B5/14532 , A61B5/076 , A61B5/14503 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61M39/0208
摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.
摘要翻译：与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。

92. 发明授权

US07162289B2 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
标题翻译：用于增强可植入传感器装置完整性的方法和装置
公开(公告)号：US07162289B2
公开(公告)日：2007-01-09
申请号：US10335574
申请日：2002-12-31
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/00 , A61B5/05 , C12M1/00 , C12Q1/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

93. 发明申请

US20050233172A1 Alumina insulation for coating implantable components and other microminiature devices 有权
标题翻译：用于涂层可植入组件和其他微型设备的氧化铝绝缘
公开(公告)号：US20050233172A1
公开(公告)日：2005-10-20
申请号：US11150547
申请日：2005-06-10
申请人： Joseph Schulman , Joseph Lucisano , Rajiv Shah , Charles Byers , Shaun Pendo
发明人： Joseph Schulman , Joseph Lucisano , Rajiv Shah , Charles Byers , Shaun Pendo
IPC分类号： A61L2/00 , A61N1/02 , B05D3/00 , B32B9/00 , C23C14/00 , C23C14/04 , G03F1/00 , G03F7/20 , H01L21/308 , H01L23/29 , H05K3/28
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译：保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。氧化铝层可以在相对较低的温度下施加。一旦施加，该层提供优异的气密性，并防止漏电。即使非常薄，氧化铝层保持优异的绝缘特性。在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中一个三个月的时间。

94. 发明授权

US06923936B2 Sterile device and method for producing same 有权
公开(公告)号：US06923936B2
公开(公告)日：2005-08-02
申请号：US10034505
申请日：2001-12-28
申请人： Aaron J. Swanson , Jennifer M. Reynolds , Rajiv Shah
发明人： Aaron J. Swanson , Jennifer M. Reynolds , Rajiv Shah
IPC分类号： A61B19/02 , A61B5/00 , A61F2/24 , A61F2/44 , A61J1/14 , A61J3/00 , A61L2/08 , A61L2/10 , A61L2/18 , A61L2/20 , A61L2/26 , A61N1/362 , A61L2/00 , A61F2/48 , B05D5/12 , B65B55/02 , B65D85/84
CPC分类号： A61L2/18 , A61B5/1486 , A61B5/1495 , A61L2/08 , A61L2/206 , A61L2202/24 , Y10S422/905
摘要： A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.

95. 发明申请

US20050158205A1 Sterile device and method for producing same 有权
标题翻译：无菌装置及其制造方法
公开(公告)号：US20050158205A1
公开(公告)日：2005-07-21
申请号：US11026678
申请日：2004-12-31
申请人： Aaron Swanson , Jennifer Reynolds , Rajiv Shah
发明人： Aaron Swanson , Jennifer Reynolds , Rajiv Shah
IPC分类号： A61B19/02 , A61B5/00 , A61F2/24 , A61F2/44 , A61J1/14 , A61J3/00 , A61L2/08 , A61L2/10 , A61L2/18 , A61L2/20 , A61L2/26 , A61N1/362
CPC分类号： A61L2/18 , A61B5/1486 , A61B5/1495 , A61L2/08 , A61L2/206 , A61L2202/24 , Y10S422/905
摘要： A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.
摘要翻译：浸在无菌缓冲液中的无菌装置及其提供方法。无菌装置可以是诸如生物传感器的医疗装置，其具有生物分子作为感测元件，例如葡萄糖氧化酶。缓冲液可以是碳酸氢盐溶液。设备和缓冲液都可以长期包装和储存，同时保持灭菌。灭菌方法可以包括气体，液体和光灭菌的组合。

96. 发明申请

US20050143636A1 System and method for sensor recalibration 有权
标题翻译：传感器重新校准的系统和方法
公开(公告)号：US20050143636A1
公开(公告)日：2005-06-30
申请号：US10751327
申请日：2003-12-30
申请人： Yanan Zhang , Lu Wang , Rajiv Shah
发明人： Yanan Zhang , Lu Wang , Rajiv Shah
IPC分类号： A61B5/00 , A61B5/05 , A61M31/00 , A61K9/22
CPC分类号： A61B5/1486 , A61B5/1495 , A61B5/4839 , G06F19/00
摘要： A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.
摘要翻译：一种用于校准传感器的系统和方法。该方法可以包括但不限于编译与传感器相关的数据阵列; 基于阵列中的数据首次调整传感器参数; 基于阵列中的数据调整表示传感器输出的曲线; 并且基于阵列中的数据再次调整传感器参数。传感器可以是体内葡萄糖传感器，并且调节的传感器参数可以是电流。阵列可以包括历史以及近来的数据，例如血糖读数和传感器电极读数。

97. 发明申请

US20050056539A1 Implantable sensor electrodes and electronic circuitry 有权
标题翻译：可植入传感器电极和电子电路
公开(公告)号：US20050056539A1
公开(公告)日：2005-03-17
申请号：US10973525
申请日：2004-10-25
申请人： Wayne Morgan , David Choy , John Gord , Rajiv Shah
发明人： Wayne Morgan , David Choy , John Gord , Rajiv Shah
IPC分类号： G01N27/416 , A61B5/042 , A61B5/145 , A61B5/1486 , A61N1/05 , G01N27/327 , G01R27/14 , G01N33/50 , A61B5/05
CPC分类号： A61N1/05 , A61B5/042 , G01R27/14
摘要： An electronic circuit for sensing an output of a sensor having at least one electrode pair and circuitry for obtaining and processing the sensor output. The electrode pair may be laid out such that one electrode is wrapped around the other electrode in a U-shaped fashion. The electronic circuitry may include, among other things, a line interface for interfacing with input/output lines, a rectifier in parallel with the line interface, a counter connected to the line interface and a data converter connected to the counter and the electrode pair. The data converter may be a current-to-frequency converter. In addition, the rectifier may derive power for the electronic circuit from communication pulses received on the input/output lines.
摘要翻译：一种用于感测具有至少一个电极对的传感器的输出和用于获得和处理传感器输出的电路的电子电路。可以布置电极对，使得一个电极以U形方式缠绕在另一个电极周围。电子电路可以包括用于与输入/输出线接口的线路接口，与线路接口并联的整流器，连接到线路接口的计数器和连接到计数器和电极对的数据转换器。数据转换器可以是电流 - 频率转换器。此外，整流器可以从输入/输出线上接收的通信脉冲导出电子电路的功率。

98. 发明申请

US20050033263A1 System and method for restenosis mitigation 审中-公开
标题翻译：减轻再狭窄的系统和方法
公开(公告)号：US20050033263A1
公开(公告)日：2005-02-10
申请号：US10638215
申请日：2003-08-07
申请人： Rebecca Gottlieb , Bradley Enegren , Rajiv Shah
发明人： Rebecca Gottlieb , Bradley Enegren , Rajiv Shah
IPC分类号： A61F2/90 , A61M31/00
CPC分类号： A61F2/90 , A61F2230/0054 , A61M2025/105
摘要： A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.
摘要翻译：在脉管系统内的创伤部位减轻再狭窄的系统和方法。该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。导管可以定位在创伤部位附近，并且再狭窄缓解药物可以通过导管输送到创伤部位。再狭窄缓解药物或某些其他参数可由传感器检测。

99. 发明授权

US06512939B1 Implantable enzyme-based monitoring systems adapted for long term use 有权
标题翻译：适用于长期使用的基于植入式酶的监测系统
公开(公告)号：US06512939B1
公开(公告)日：2003-01-28
申请号：US09604179
申请日：2000-06-27
申请人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
发明人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0031
摘要： Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose, are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments, a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution comprising microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method comprises providing means, within the system, to replenish the enzyme and/or electrolyte solution.
摘要翻译：本文描述了适于长期体内使用的改进的可植入监测系统，以测量一种或多种规定物质如葡萄糖的浓度。特别地，描述了可植入酶的葡萄糖监测系统，其包括以下至少一个：用于在酶反应消耗的时候补充酶溶液的装置; 用于补充洗涤电极组件的电解液的装置; 并且微处理装置近似于电极组件。在优选实施例中，微处理器组件与固定电极组件的基板气密地相关联。此外，监测系统采用与酶和电解质室流体连通的一个或多个储存器系统，其中使用酶和电解质溶液。在另一个实施方案中，监测系统使用分别与酶和电解质储存器流体连通并且定位在皮肤表面附近的酶和电解质储存器灯泡，从而提供对酶和电解质溶液的准备进入，而不需要移除设备。本文进一步提供了包含与酶结合的微球的酶溶液; 由此通过微球固定酶，并且微球体处于流动的可流动溶液中。本文还提供了延长可植入酶的监测系统的使用寿命的方法，该方法包括在系统内提供补充酶和/或电解质溶液的装置。

100. 发明申请

US20200146596A1 Analyte Sensor 审中-公开
公开(公告)号：US20200146596A1
公开(公告)日：2020-05-14
申请号：US16625884
申请日：2018-06-22
申请人： Rajiv Shah , Bradley Liang , Katherine Wolfe , Ellen Messer , Shaun Pendo , PERCUSENNE
发明人： Rajiv Shah , Bradley Liang , Katherine Wolfe , Ellen Messer , Shaun Pendo
IPC分类号： A61B5/1486 , A61B5/00 , G01N33/50
摘要： An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

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