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91. 发明申请

US20080102104A1 Suture-specific coatings for modulated release of bioactive agents 有权
标题翻译：用于调节释放生物活性剂的缝线特异性涂层
公开(公告)号：US20080102104A1
公开(公告)日：2008-05-01
申请号：US11980163
申请日：2007-10-30
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K31/335 , A61K31/42 , A61K9/70 , A61P43/00
CPC分类号： A61L17/105 , A61K9/0024 , A61K9/7007 , A61K31/335 , A61K31/42 , A61K31/74 , A61K31/765 , A61K47/30 , A61K47/34 , A61L17/00 , A61L17/005 , A61L17/06 , A61L17/10 , A61L17/12 , A61L17/145 , A61L2300/202 , A61L2300/404 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08L67/04
摘要： Suture-specific coatings having a number average molecular weight not exceeding 20 kDa, a melting temperature above 37° C., and heat of fusion exceeding 20 J/g, are formed of copolyesters of polycaprolactone or of ε-caprolactone and at least one cyclic monomer forming a segmented polyester chain initiated by a polyaxial crystalline organic compound or an amorphous polyaxial polymeric initiator and include from about 0.01 to about 10 weight percent of at least one molecularly dispersed bioactive agent.
摘要翻译：具有数均分子量不超过20kDa，熔点高于37℃，熔化热超过20J / g的缝线特异性涂层由聚己内酯或ε-己内酯的共聚酯和至少一个环状形成由多晶结晶有机化合物或无定形多轴聚合物引发剂引发的分段聚酯链的单体，并且包括约0.01至约10重量％的至少一种分子分散的生物活性剂。

92. 发明授权

US07351426B2 Polyester/cyanoacrylate tissue adhesive compositions 有权
标题翻译：聚酯/氰基丙烯酸酯组织粘合剂组合物
公开(公告)号：US07351426B2
公开(公告)日：2008-04-01
申请号：US10792537
申请日：2004-03-03
申请人： Shalaby W. Shalaby , M. Aaron Vaughn
发明人： Shalaby W. Shalaby , M. Aaron Vaughn
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61L24/043 , A61B17/00491 , A61B17/11 , C08L35/04 , C08L67/04
摘要： This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.
摘要翻译：本发明涉及可吸收的基于氰基丙烯酸酯的组织粘合剂组合物，其主要基于与一种或多种氰基丙烯酸烷基酯结合的烷氧基氰基丙烯酸酯，抗过敏阴离子聚合的稳定剂和/或可吸收的聚合物改性剂，其具有改进的，优选的功能性质，主要用于内伤修复应用。

93. 发明授权

US07070858B2 Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom 有权
公开(公告)号：US07070858B2
公开(公告)日：2006-07-04
申请号：US10630320
申请日：2003-07-30
申请人： Shalaby W. Shalaby , Torbjorn Mathisen
发明人： Shalaby W. Shalaby , Torbjorn Mathisen
IPC分类号： C08G63/08 , C08G69/08 , A61B17/00
CPC分类号： C08G63/64 , A61L17/12 , A61L31/06 , C08G63/08 , Y10T428/13 , Y10T428/139 , Y10T428/31504 , Y10T428/31786 , C08L67/04
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

94. 发明授权

US06703035B2 Absorbable &egr;-caprolactone copolymers 失效
标题翻译：可吸收的ε-己内酯共聚物
公开(公告)号：US06703035B2
公开(公告)日：2004-03-09
申请号：US10087512
申请日：2002-03-01
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A01N2534
CPC分类号： A61L17/12 , A61L17/145 , A61L24/046 , A61L27/18 , A61L27/34 , A61L27/50 , A61L29/085 , C08G63/912 , C08L67/04
摘要： This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.
摘要翻译：本发明涉及包含缝合线的结晶，氮共聚酯润滑剂涂覆装置，其中所述润滑剂包括具有中心含氮碱的三轴共聚酯链或具有多于一个与碱性氨基酸离子连接的羧基的共聚酯。

95. 发明授权

US6117554A Modulated molecularly bonded inherently conductive polymers on substrates with conjugated multiple lamellae and shaped articles thereof 失效
标题翻译：在具有共轭多层片及其成型制品的基底上调制分子结合的固有导电聚合物
公开(公告)号：US6117554A
公开(公告)日：2000-09-12
申请号：US862945
申请日：1997-05-30
申请人： Shalaby W. Shalaby , Jacqueline M. Allan
发明人： Shalaby W. Shalaby , Jacqueline M. Allan
IPC分类号： C08G61/12 , C08J7/12 , C08J7/16 , C23C28/00 , B32B31/06 , B05D3/00 , B05D3/04 , B32B15/04
CPC分类号： C23C28/00 , C08G61/122 , C08G61/124 , C08J7/12 , C08J7/16
摘要： Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are sequentially formed in-situ onto polymeric surfaces that are chemically functionalized to molecularly bond the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, or tube, although other forms of thermoplastic and thermoset polymers can be used as the substrates for functionalization using, most preferably, phosphonylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. It has been found that the degree of electrical conductivity may be modulated by bonding further electrically conductive layers to the article. That is, each underlying conductive layer is functionalized prior to bonding of a subsequent conductive layer thereto until the degree of conductivity is achieved. In an alternative embodiment, metals such as gold or platinum may be bonded to one of the functionalized surfaces.
摘要翻译：有机固有导电聚合物，例如基于聚苯胺，聚吡咯和聚噻吩的固体导电聚合物，原位地依次形成在化学官能化以将导电聚合物分子结合到基底上的聚合物表面上。聚合物基材优选为预成型或预成型的热塑性薄膜，织物或管，尽管其它形式的热塑性和热固性聚合物可用作官能化底物，最优选使用基于膦酰基化的方法，随后暴露于氧化可聚合化合物能够形成导电聚合物。已经发现，可以通过将另外的导电层粘合到制品上来调节导电性的程度。也就是说，每个下面的导电层在其后面的导电层结合之前被功能化，直到达到导电度。在替代实施例中，诸如金或铂的金属可以结合到功能化表面之一。

96. 发明授权

US5986050A Peracylated proteins and synthetic polypeptides and process for making the same 失效
标题翻译：过酰化蛋白质和合成多肽及其制备方法
公开(公告)号：US5986050A
公开(公告)日：1999-11-16
申请号：US996366
申请日：1997-12-22
申请人： Shalaby W. Shalaby , Jacqueline M. Allan , Joel T. Corbett
发明人： Shalaby W. Shalaby , Jacqueline M. Allan , Joel T. Corbett
IPC分类号： C07K1/113 , C07K14/415 , C07K1/00 , A61K35/78
CPC分类号： C07K14/415 , C07K1/113 , Y10T428/29 , Y10T428/2913 , Y10T428/2915
摘要： A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.
摘要翻译：公开了一种修饰蛋白质或多肽的方法，其包括以下步骤：将蛋白质或多肽分散在基本上非水性的培养基中，并将所述蛋白质或多肽与具有选自以下的碳链取代基的环酸酐进行过酰化：烷基和烯基。最优选地，环状酸酐是琥珀酸酐，尽管也可以使用戊二酸酐。优选地，在酰基化蛋白质或多肽的步骤在酸催化剂，最优选Rho-甲苯磺酸的存在下进行。所得到的修饰的蛋白质或多肽可用于许多应用，包括药物递送，可吸收缝合线，以及热塑性薄膜和模塑制品。

97. 发明授权

US5898040A Microporous polymeric foams and microtextured surfaces 失效
标题翻译：微孔聚合物泡沫和微结构表面
公开(公告)号：US5898040A
公开(公告)日：1999-04-27
申请号：US19788
申请日：1998-02-06
申请人： Shalaby W. Shalaby , Susan L. Roweton
发明人： Shalaby W. Shalaby , Susan L. Roweton
IPC分类号： A61K9/12 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/56 , B01D67/00 , B01D69/14 , B29C67/20 , C08J9/26
CPC分类号： A61L27/3839 , A61K9/122 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/3847 , A61L27/3852 , A61L27/56 , B01D67/003 , B01D69/141 , B29C67/202 , C08J9/26 , B01D2323/21 , B01D2325/48 , C08J2201/042 , C08J2205/05 , Y10T428/249958 , Y10T428/31504 , Y10T428/31725 , Y10T428/31931 , Y10T428/31938
摘要： Highly uniform microporous foam suitable for medical applications and methods for preparing these foams. The highly uniform microporous foams are of controlled pore size that may be utilized in a variety of applications. In preparing the foams, an organic crystalline polymer is melted and combined with a selected solid crystalline fugitive compound to produce a substantially isotropic solution. The solution is cooled under controlled conditions, which foster solid-solid phase separation by the simultaneous crystallization of the fugitive compound and the polymer, to produce a foam precursor containing the solidified fugitive compound dispersed through a matrix of the organic polymer. Crystals of fugitive compound are then removed by solvent extraction and/or sublimation, or like process to produce microcellular foams having a continuous, open-cell structure.
摘要翻译：适用于医疗应用的高度均匀的微孔泡沫和用于制备这些泡沫的方法。高度均匀的微孔泡沫具有可控的孔径，可用于各种应用中。在制备泡沫体时，将有机结晶聚合物熔化并与选定的固体晶体化合物混合以产生基本上各向同性的溶液。将溶液在受控条件下冷却，通过使挥发性化合物和聚合物同时结晶来促进固相分离，以产生含有通过有机聚合物基质分散的固化的失散化合物的泡沫前体。然后通过溶剂萃取和/或升华或类似方法除去挥发性化合物的晶体以产生具有连续的开孔结构的微孔泡沫。

98. 发明授权

US5874509A Surface modified glasses and composites thereof 失效
标题翻译：表面改性玻璃及其复合材料
公开(公告)号：US5874509A
公开(公告)日：1999-02-23
申请号：US676004
申请日：1996-07-05
申请人： Shalaby W. Shalaby , Daniel C. Clupper , Theodore D. Taylor
发明人： Shalaby W. Shalaby , Daniel C. Clupper , Theodore D. Taylor
IPC分类号： C08G83/00 , C08K9/04 , C08K9/06 , C08L101/02
CPC分类号： C08K9/06 , C08G83/001 , C08K9/04
摘要： An inorganic glass having an aliphatic polymer covalently bonded to the surface thereof is disclosed for providing improved adhesion to a matrix polymer when the glass is employed as a composite filler, as well as for the formation of a composite absent a separate matrix polymer. The polymer is grafted onto the glass by a method which includes the steps of pretreating the surface of the glass with an activator which an activating moiety to the surface, functionalizing the pretreated surface by bonding functional moieties thereto, and polymerizing a cycloaliphatic monomer onto the functionalized surface in the presence of a ring opening polymerization catalyst. Also disclosed are novel inorganic glasses which contain both silicate and phosphate linkages.
摘要翻译：公开了一种具有与其表面共价键合的脂肪族聚合物的无机玻璃，用于当将玻璃用作复合填料时提供对基体聚合物的改善的粘附性，以及形成不含单独的基质聚合物的复合材料。聚合物通过一种方法接枝到玻璃上，所述方法包括以下步骤：用活化剂预处理玻璃的表面，活化剂是表面的活化部分，通过键合官能部分官能化预处理的表面，并将脂环族单体聚合到官能化的在开环聚合催化剂存在下进行表面处理。还公开了含有硅酸盐和磷酸酯键的新型无机玻璃。

99. 发明授权

US5847012A Microporous polymeric foams and microtextured surfaces 失效
公开(公告)号：US5847012A
公开(公告)日：1998-12-08
申请号：US562430
申请日：1995-11-24
申请人： Shalaby W. Shalaby , Susan L. Roweton
发明人： Shalaby W. Shalaby , Susan L. Roweton
IPC分类号： A61K9/12 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/56 , B01D67/00 , B01D69/14 , B29C67/20 , C08J9/26 , C08J9/28
CPC分类号： A61L27/3839 , A61K9/122 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/3847 , A61L27/3852 , A61L27/56 , B01D67/003 , B01D69/141 , B29C67/202 , C08J9/26 , B01D2323/21 , B01D2325/48 , C08J2201/042 , C08J2205/05 , Y10T428/249958 , Y10T428/31504 , Y10T428/31725 , Y10T428/31931 , Y10T428/31938
摘要： Highly uniform microporous foam suitable for medical applications and methods for preparing these foams. The highly uniform microporous foams are of controlled pore size that may be utilized in a variety of applications. In preparing the foams, an organic crystalline polymer is melted and combined with a selected solid crystalline fugitive compound to produce a substantially isotropic solution. The solution is cooled under controlled conditions, which foster solid--solid phase separation by the simultaneous crystallization of the fugitive compound and the polymer, to produce a foam precursor containing the solidified fugitive compound dispersed through a matrix of the organic polymer. Crystals of fugitive compound are then removed by solvent extraction and/or sublimation, or like process to produce microcellular foams having a continuous, open-cell structure.

100. 发明授权

US5834113A Self-reinforced ultra-high molecular weight polyethylene composite medical implants 失效
标题翻译：自增强超高分子量聚乙烯复合医用植入物
公开(公告)号：US5834113A
公开(公告)日：1998-11-10
申请号：US472404
申请日：1995-06-07
申请人： Shalaby W. Shalaby , Meng Deng
发明人： Shalaby W. Shalaby , Meng Deng
IPC分类号： A61L27/48 , A61L31/12 , B29C67/24 , B29C70/04 , B29C70/06 , B29C70/46 , B29C70/50 , C08L23/06 , D02G3/00 , A61F2/30
CPC分类号： C08L23/06 , A61L27/48 , A61L31/129 , B29C67/24 , B29C70/04 , B29C70/06 , B29C70/465 , B29C70/50 , B29K2023/0683 , B29K2105/101 , B29K2105/24 , B29L2031/7532 , C08L2203/02 , C08L2205/02 , C08L2205/16 , Y10S428/902 , Y10T428/2913 , Y10T428/2929 , Y10T428/2973 , Y10T428/31855
摘要： The invention provides composites of ultra-high molecular weight polyethylene reinforced with ultra-high molecular weight polyethylene anisotropic reinforcement of high strength and modulus. The composites have superior mechanical properties relative to non-filled ultra-high molecular weight polyethylene, including higher strength, impact strength, increased creep resistance, and improved modulus. The composites may be sterilized for biomedical use, using gamma radiation and other techniques. Further, the composites are resistant to the effect of body fluids and have lower creep rates so that they will provide implant life. The composites may be cross-linked by exposure to an acetylene environment. Also, the composites find use in other high strength, high impact applications such as sports equipment.
摘要翻译：本发明提供了具有高强度和模量的超高分子量聚乙烯各向异性增强材料的超高分子量聚乙烯复合材料。复合材料相对于未填充的超高分子量聚乙烯具有优异的机械性能，包括较高的强度，冲击强度，增加的抗蠕变性和改善的模量。可以使用γ辐射和其他技术将复合材料灭菌用于生物医学应用。此外，复合材料抵抗体液的作用，具有较低的蠕变速率，因此它们将提供植入寿命。复合材料可能通过暴露于乙炔环境而交联。此外，复合材料可用于其他高强度，高冲击应用，如运动器材。

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