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91. 发明申请

US20090299432A1 IMPEDANCE VARIABILITY ANALYSIS TO IDENTIFY LEAD-RELATED CONDITIONS 有权
标题翻译：阻碍可变性分析来识别与铅相关的条件
公开(公告)号：US20090299432A1
公开(公告)日：2009-12-03
申请号：US12180304
申请日：2008-07-25
申请人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
发明人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
IPC分类号： A61N1/37 , A61B5/053
CPC分类号： A61N1/36521 , A61N1/3706 , A61N2001/083
摘要： In general, the disclosure relates to techniques for calculating mean impedance values and impedance variability values to detect a possible condition with a lead or device-lead pathway or connection. In one example, a device may be configured to determine an impedance value for an electrical path based on a plurality of measured impedance values for the electrical path, wherein the electrical path comprises a plurality of electrodes, and to determine an impedance variability value based on at least one of the plurality of measured impedance values. The device may be further configured to determine a threshold value based on the determined impedance value and the impedance variability value, compare a newly measured impedance value for the electrical path to the threshold value, and indicate a possible condition of the electrical path based on the comparison.
摘要翻译：通常，本公开涉及用于计算平均阻抗值和阻抗变异性值以用于检测具有引线或器件引导路径或连接的可能状况的技术。在一个示例中，设备可以被配置为基于用于电路径的多个测量的阻抗值来确定电路径的阻抗值，其中电路径包括多个电极，并且基于以下方式确定阻抗变异性值：所述多个测量的阻抗值中的至少一个。该装置还可以被配置为基于所确定的阻抗值和阻抗变异性值来确定阈值，将新测量的电通路的阻抗值与阈值进行比较，并且基于该路径指示电路径的可能状态比较。

92. 发明授权

US07120484B2 Methods and apparatus for filtering EGM signals detected by an implantable medical device 有权
公开(公告)号：US07120484B2
公开(公告)日：2006-10-10
申请号：US10045722
申请日：2002-01-14
申请人： Steven N. Lu , Robert W. Stadler
发明人： Steven N. Lu , Robert W. Stadler
IPC分类号： A61B5/04
CPC分类号： A61B5/0008 , A61B5/0428 , A61B5/7232 , A61N1/3704
摘要： An analog physiologic signal, e.g., the cardiac EGM, sensed by an IMD is filtered with a high pass filter (HPF), the cut-off frequency of the HPF being within a predetermined frequency bandwidth, wherein a low-band portion of the predetermined frequency bandwidth is attenuated in the filtered physiologic signal. The filtered physiologic signal is digitized in real time order, and the digital data set is filtered in reverse time order employing a digital IIR filter having characteristics substantially matching the cut-off frequency and filter characteristics of the HPF. When the system is implemented within an IMD, the filtered digital data set is compressed by lossy compression algorithm, and the compressed data set is filtered in reverse time order. In certain embodiments, the filtered digital data set is uplink telemetry transmitted to an external medical device, and the uplink telemetered data set is filtered in reverse time order employing a digital backward IIR filter resident in the external medical device.

93. 发明授权

US06317625B1 Method and apparatus for increasing the low frequency dynamic range of a system for measuring physiological signals with an implantable medical device 失效
标题翻译：用于通过可植入医疗装置增加用于测量生理信号的系统的低频动态范围的方法和装置
公开(公告)号：US06317625B1
公开(公告)日：2001-11-13
申请号：US09713455
申请日：2000-11-15
申请人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
发明人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
IPC分类号： A61B50402
CPC分类号： A61B5/0428 , A61B5/7232 , A61N1/3925 , Y10S128/901 , Y10S128/902
摘要： A signal measuring system for use with an Implantable Medical Device (IMD) is provided for measuring physiologic signals having a relatively large effective dynamic range. In one embodiment, the system includes a High-Pass Filter (HPF), an Analog-to-Digital Converter (ADC), a Decimation Filter (DF), and a Compensation Filter (CF). The HPF receives an input signal that includes both the baseline wander imposed on a physiological signal. According to one aspect of the invention, the HPF attenuates low frequency components of the input signal, including a portion of the frequency band within the desired output signal bandwidth. The ADC then oversamples the output signal of the HPF. The DF receives the output samples from the ADC and generates output samples at rate that is at least twice the maximum frequency of the desired output signal. The CF then amplifies the low frequency end of the DF output samples. The gain and cutoff frequency of the CF are selected to offset the HPF attenuation of those low frequency components of the input signal below the cutoff frequency of the HPF and above the minimum frequency of the desired output signal. In one embodiment, the DF and CF are implemented by a processing circuit executing programmed instructions. The processing circuit may be included within the IMD, or may be partially or fully implemented within a device that is external to the IMD.
摘要翻译：提供了一种用于可植入医疗器械（IMD）的信号测量系统，用于测量具有相对较大有效动态范围的生理信号。在一个实施例中，该系统包括高通滤波器（HPF），模数转换器（ADC），抽取滤波器（DF）和补偿滤波器（CF）。 HPF接收包括施加在生理信号上的基线漂移的输入信号。根据本发明的一个方面，HPF衰减输入信号的低频分量，包括期望输出信号带宽内的一部分频带。 ADC然后对HPF的输出信号进行过采样。 DF从ADC接收输出采样，并以至少是所需输出信号的最大频率的两倍的速率生成输出采样。 CF然后放大DF输出样本的低频端。选择CF的增益和截止频率以将输入信号的那些低频分量的HPF衰减降低到低于HPF的截止频率并且高于所需输出信号的最小频率。在一个实施例中，DF和CF由执行编程指令的处理电路实现。处理电路可以包括在IMD内，或者可以部分地或完全地实现在IMD外部的设备中。

94. 发明授权

US09510763B2 Assessing intra-cardiac activation patterns and electrical dyssynchrony 有权
标题翻译：评估心脏内激活模式和电气不同步
公开(公告)号：US09510763B2
公开(公告)日：2016-12-06
申请号：US13462404
申请日：2012-05-02
申请人： Subham Ghosh , Jeffrey M. Gillberg , Robert W. Stadler
发明人： Subham Ghosh , Jeffrey M. Gillberg , Robert W. Stadler
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/05 , A61B5/02 , A61B5/0402 , A61B5/0408 , A61N1/04 , A61N1/362 , A61N1/368 , A61B5/00
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

95. 发明授权

US08954160B2 Detection of extracardiac stimulation by a cardiac rhythm management device 有权
标题翻译：心律管理装置检测心外刺激
公开(公告)号：US08954160B2
公开(公告)日：2015-02-10
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/36 , A61N1/365 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

96. 发明授权

US08644931B2 Impedance variability analysis to identify lead-related conditions 有权
标题翻译：阻抗变异性分析来识别铅相关条件
公开(公告)号：US08644931B2
公开(公告)日：2014-02-04
申请号：US12180304
申请日：2008-07-25
申请人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
发明人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/3706 , A61N2001/083
摘要： In general, the disclosure relates to techniques for calculating mean impedance values and impedance variability values to detect a possible condition with a lead or device-lead pathway or connection. In one example, a device may be configured to determine an impedance value for an electrical path based on a plurality of measured impedance values for the electrical path, wherein the electrical path comprises a plurality of electrodes, and to determine an impedance variability value based on at least one of the plurality of measured impedance values. The device may be further configured to determine a threshold value based on the determined impedance value and the impedance variability value, compare a newly measured impedance value for the electrical path to the threshold value, and indicate a possible condition of the electrical path based on the comparison.
摘要翻译：通常，本公开涉及用于计算平均阻抗值和阻抗变异性值以用于检测具有引线或器件引导路径或连接的可能状况的技术。在一个示例中，设备可以被配置为基于用于电路径的多个测量的阻抗值来确定电路径的阻抗值，其中电路径包括多个电极，并且基于以下方式确定阻抗变异性值：所述多个测量的阻抗值中的至少一个。该装置还可以被配置为基于所确定的阻抗值和阻抗变异性值来确定阈值，将新测量的电通路的阻抗值与阈值进行比较，并且基于该路径指示电路径的可能状态比较。

97. 发明申请

US20130060298A1 DETECTION OF EXTRACARDIAC STIMULATION BY A CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：通过CARDIAC RHYTHM管理设备检测提取物刺激
公开(公告)号：US20130060298A1
公开(公告)日：2013-03-07
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

98. 发明申请

US20130053916A1 LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 有权
标题翻译：电子形态分析指导的左心室选择选择
公开(公告)号：US20130053916A1
公开(公告)日：2013-02-28
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

99. 发明申请

US20120101546A1 METHOD AND APPARATUS TO DETERMINE THE RELATIVE ENERGY EXPENDITURE FOR A PLURALITY OF PACING VECTORS 有权
标题翻译：确定多边形矢量相对能源支出的方法和装置
公开(公告)号：US20120101546A1
公开(公告)日：2012-04-26
申请号：US13194100
申请日：2011-07-29
申请人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61N1/08 , A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3686 , A61N1/3708
摘要： A medical device system determines and displays relative energy expenditure information for programmable parameter values. The system establishes a programmable parameter and multiple values of the parameter to be compared. A module performs a measurements for each of the multiple values and related to energy expenditure of a battery of an implantable medical device when operating according to each of the multiple parameter values. An energy expenditure for each of the values is computed using the measurements, and a graphical user interface is generated for displaying information corresponding to the computed energy expenditure for multiple parameter values.
摘要翻译：医疗设备系统确定并显示可编程参数值的相对能量消耗信息。系统建立可编程参数和要比较的参数的多个值。当根据多个参数值中的每个参数值进行操作时，模块对可植入医疗装置的电池的能量消耗进行测量。使用测量来计算每个值的能量消耗，并且生成用于显示与多个参数值的计算能量消耗相对应的信息的图形用户界面。

100. 发明申请

US20120029373A1 PREVENTION OF FALSE ASYSTOLE OR BRADYCARDIA DETECTION 有权
标题翻译：防止异常或BRADYCARDIA检测
公开(公告)号：US20120029373A1
公开(公告)日：2012-02-02
申请号：US12846224
申请日：2010-07-29
申请人： Robert W. Stadler , Tim Dirk Jan Jongen , Richard PM Houben
发明人： Robert W. Stadler , Tim Dirk Jan Jongen , Richard PM Houben
IPC分类号： A61B5/0456
CPC分类号： A61N1/37 , A61B5/0456
摘要： In general, this disclosure is directed to signal processing based methods to reject undersensing in a signal indicative of cardiac activity, e.g., ECG. The undersensing may be due to very small signal amplitudes or due to a sudden increase in single peak amplitude resulting in an increased sensing threshold. The undersensing may result in falsely detecting a cardiac event, e.g., asystole or bradycardia. The techniques of this disclosure monitor the behavior of the signal to determine when a detected asystole is false.
摘要翻译：通常，本公开涉及基于信号处理的方法来拒绝指示心脏活动的信号（例如ECG）中的不足感。欠感应可能是由于非常小的信号幅度或由于单峰幅度的突然增加导致增加的感测阈值。不足之处可能导致错误检测心脏事件，例如心搏停止或心动过缓。本公开的技术监测信号的行为以确定检测到的心脏停搏是否为假。

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