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91. 发明申请

US20100003155A1 METHOD AND APPARATUS FOR FORMING POROUS METAL IMPLANTS 有权
标题翻译：用于形成多孔金属植入物的方法和装置
公开(公告)号：US20100003155A1
公开(公告)日：2010-01-07
申请号：US12558300
申请日：2009-09-11
申请人： Ned M. Hamman , J. Fleming , Elizabeth A. Schlueter , Isaac Janson , Jason D. Meridew , Mukesh Kumar
发明人： Ned M. Hamman , J. Fleming , Elizabeth A. Schlueter , Isaac Janson , Jason D. Meridew , Mukesh Kumar
IPC分类号： B22F3/11 , B22F1/00
CPC分类号： C09C1/00 , A61F2/30767 , A61F2/30907 , A61F2/34 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30064 , A61F2002/30166 , A61F2002/30169 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30383 , A61F2002/30451 , A61F2002/30454 , A61F2002/30604 , A61F2002/30736 , A61F2002/30827 , A61F2002/30878 , A61F2002/3092 , A61F2002/30968 , A61F2002/3411 , A61F2220/0025 , A61F2220/0058 , A61F2230/0028 , A61F2230/0047 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0023 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00131 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097 , A61F2310/00976 , A61K35/12 , A61L27/04 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/406 , A61L2300/414 , A61L2300/428 , A61L2300/606 , A61L2300/64 , B22F3/1125 , B22F2001/0066 , B22F2998/10 , C01P2004/61 , B22F1/0059 , B22F3/04 , B22F3/02 , B22F3/1021 , B22F3/1216
摘要： A method for providing a porous metal implant. A mixture of a biocompatible metal, a spacing agent, and a binder is provided. The mixture is formed into a shaped the spacing agent is removed to form a plurality of pores in the implant. A shaped porous metal implant is also provided.
摘要翻译：一种用于提供多孔金属植入物的方法。提供生物相容性金属，间隔剂和粘合剂的混合物。将混合物形成为成形物，去除间隔剂以在植入物中形成多个孔。还提供了一种成形的多孔金属植入物。

92. 发明授权

US07595303B1 Genetic adjuvants for immunotherapy 失效
标题翻译：用于免疫治疗的遗传佐剂
公开(公告)号：US07595303B1
公开(公告)日：2009-09-29
申请号：US10655873
申请日：2003-09-05
申请人： Shyam S. Mohapatra , Mukesh Kumar
发明人： Shyam S. Mohapatra , Mukesh Kumar
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： A61K38/217 , A61K38/208 , A61K39/35 , A61K39/36 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/55538
摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells generally modified with a nucleotide sequence encoding IL-12 and IFN-γ.
摘要翻译：本发明涉及用于调节免疫应答的方法和药物组合物。本发明的方法涉及向需要这种治疗的患者施用有效量的编码白细胞介素-12（IL-12），干扰素-γ（IFN-γ）或其组合的核酸分子。本发明的药物组合物含有编码IL-12和/或IFN-γ的核酸分子和可操作地连接的启动子序列。另一方面，本发明涉及含有编码IL-12和IFN-γ的核苷酸序列和可操作地连接的启动子序列的表达载体。另一方面，本发明涉及用编码IL-12和IFN-γ的核苷酸序列遗传修饰的细胞。

93. 发明申请

US20090204367A1 METHODS FOR DISTRIBUTING A RANDOM VARIABLE USING STATISTICALLY-CORRECT SPATIAL INTERPOLATION 有权
标题翻译：使用统计 - 正确空间插值分配随机变量的方法
公开(公告)号：US20090204367A1
公开(公告)日：2009-08-13
申请号：US12030462
申请日：2008-02-13
申请人： Jeffrey G. Hemmett , Mukesh Kumar , Wayne H. Woods, JR. , Cole E. Zemke
发明人： Jeffrey G. Hemmett , Mukesh Kumar , Wayne H. Woods, JR. , Cole E. Zemke
IPC分类号： G06F17/18
CPC分类号： G06F17/18
摘要： Methods for distributing a random variable by spatial interpolation with statistical corrections. The method includes assigning a numerical value of the random variable at each vertex of an array of equilateral triangles formed in a planar coordinate frame and defining a plurality of test points at respective spatial locations in the planar coordinate frame that are bounded by the array of equilateral triangles. A numerical value of the random variable is distributed at each of the test points by spatial interpolation from one or more of the numerical values of the random variable assigned at each vertex of the array of equilateral triangles. The method further includes adjusting the numerical value of the random variable distributed at each of the test points with a respective correction factor.
摘要翻译：通过统计校正的空间插值分布随机变量的方法。该方法包括在平面坐标系中形成的等边三角形阵列的每个顶点处分配随机变量的数值，并且在平面坐标系中的由等边阵列限定的相应空间位置处限定多个测试点三角形。随机变量的数值通过从等边三角形阵列的每个顶点处分配的随机变量的一个或多个数值中的空间插值分布在每个测试点。该方法还包括用相应的校正因子来调整在每个测试点分布的随机变量的数值。

94. 发明授权

US06900299B1 Interrupting the interaction of intercellular adhesion molecule-1 and respiratory syncytial virus for prevention and treatment of infection 失效
标题翻译：中断细胞间粘附分子-1和呼吸道合胞病毒的相互作用，用于预防和治疗感染
公开(公告)号：US06900299B1
公开(公告)日：2005-05-31
申请号：US10440000
申请日：2003-05-16
申请人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
发明人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
IPC分类号： A61K39/42 , A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.
摘要翻译：提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

95. 发明授权

US06896095B2 Fan shroud with built in noise reduction 有权
标题翻译：风扇罩与内置降噪
公开(公告)号：US06896095B2
公开(公告)日：2005-05-24
申请号：US10063151
申请日：2002-03-26
申请人： Hemant S. Shah , John Stuart Hollingshead , John Wang , Prakash Tuljaram Thawani , Richard Charles Kosik , Mukesh Kumar
发明人： Hemant S. Shah , John Stuart Hollingshead , John Wang , Prakash Tuljaram Thawani , Richard Charles Kosik , Mukesh Kumar
IPC分类号： F01P5/06 , F04D29/58 , F04D29/66 , F15D1/02 , A47B81/06
CPC分类号： F01P5/06 , F04D29/665 , F15D1/02
摘要： The present invention is a system and method to significantly reduce noise associated with air-moving devices such as an axial flow fan using a fan shroud and barrel combination with built in silencers such as Helmholtz resonators. The invention can be applied to a variety of applications such as a thermal management system for a fuel cell powered vehicle. The resonator can be a hollow cavity in networks attached to an outer or inner barrel or shroud and tuned to reduce noise at predetermined noise frequency ranges within the airflow. The invention can also attach stator members on the inner surface of the outer barrel to further reduce noise. Additional sound absorbing material, such as steel wool, can be disposed within the resonator cavity.
摘要翻译：本发明是一种系统和方法，该系统和方法使用具有诸如亥姆霍兹共振器的内置消音器的风扇罩和桶组合来显着降低与诸如轴流风扇等空气移动装置相关联的噪声。本发明可以应用于各种应用，例如燃料电池动力车辆的热管理系统。谐振器可以是连接到外筒或护罩上的网络中的空腔，并且被调谐以在气流中以预定的噪声频率范围减小噪声。本发明还可以将定子构件附接在外筒的内表面上以进一步降低噪音。附加的吸音材料，例如钢丝绒，可以设置在谐振腔内。

96. 发明申请

US20050103033A1 PUMP PRESSURE LIMITING METHOD 有权
标题翻译：泵压力限制方法
公开(公告)号：US20050103033A1
公开(公告)日：2005-05-19
申请号：US10685197
申请日：2003-10-14
申请人： William Schwartz , Mukesh Kumar , Gene Cox
发明人： William Schwartz , Mukesh Kumar , Gene Cox
IPC分类号： F04B49/20 , F04D15/00 , F25B49/00 , F25D17/02 , F25B1/00 , G05D15/00 , G05D16/00 , G05D23/00
CPC分类号： F04D15/0066 , F04B49/20 , F04B2205/05 , F04B2205/06 , F25B49/00 , F25D17/02
摘要： A novel pump pressure limiting method for preventing coolant in a cooling system from reaching pressures that exceed predetermined system coolant pressure limits. The method includes reducing the system coolant pressure, as needed to prevent system over-pressurization, by reducing the operational speed of a coolant pump used to pump the coolant through the system. In one embodiment, the system coolant pressure is determined directly, by measurement of the pressure of the coolant in the system typically using pressure sensors. The operational speed of the coolant pump is then reduced until the system coolant pressure decreases to within the predetermined pressure limits. In another embodiment, the system pressure is determined indirectly, by obtaining pressure-indicating data such as coolant temperature. The coolant system pressure is then correlated with the coolant temperature or other data and then the operational speed of the coolant pump is reduced accordingly.
摘要翻译：一种用于防止冷却系统中的冷却剂达到超过预定系统冷却剂压力极限的压力的新型泵压力限制方法。该方法包括通过降低用于泵送冷却剂通过系统的冷却剂泵的操作速度，根据需要降低系统冷却剂压力以防止系统过压。在一个实施例中，通过使用压力传感器测量系统中的冷却剂的压力来直接确定系统冷却剂压力。然后冷却剂泵的操作速度降低，直到系统冷却剂压力降低到预定压力极限内。在另一个实施例中，通过获得诸如冷却剂温度的压力指示数据来间接确定系统压力。然后将冷却剂系统压力与冷却剂温度或其他数据相关联，然后相应地减小冷却剂泵的操作速度。

97. 发明授权

US06606729B2 Corner simulation methodology 失效
公开(公告)号：US06606729B2
公开(公告)日：2003-08-12
申请号：US09682613
申请日：2001-09-27
申请人： Blaine J. Gross , Mukesh Kumar
发明人： Blaine J. Gross , Mukesh Kumar
IPC分类号： G06F1750
CPC分类号： G06F17/5036
摘要： A method and system for creating a worst case scenario model for a given integrated circuit. The method comprises the steps of sorting skew parameters of each device into groups; and assigning a positive or negative value for each one of the groups to represent the effect of the corresponding skew parameters on the functionality of the integrated circuit. The preferred embodiment of the invention provides some of the benefits of both conventional corner simulation and Monte Carlo simulation. This approach can be implemented with only a few additional simulation iterations, which mitigates the disadvantage of Monte Carlo simulations requiring many simulation iterations. Also, this approach allows a greater degree of flexibility with respect to determining a specific corner file definition, allowing the designer to explore a greater area of model parameter space to insure that the circuit will meet performance requirements over extremes of process technology variation.

98. 发明授权

US06226655B1 Method and apparatus for retrieving data from a network using linked location identifiers 有权
标题翻译：用于使用链接的位置标识符从网络检索数据的方法和装置
公开(公告)号：US06226655B1
公开(公告)日：2001-05-01
申请号：US09204214
申请日：1998-12-02
申请人： Gilbert Borman , Rajat Bhatnagar , Arul Sebastian , Anup Mathur , Vinay Wadhwa , Mukesh Kumar , C. Vinay Kumar Singh
发明人： Gilbert Borman , Rajat Bhatnagar , Arul Sebastian , Anup Mathur , Vinay Wadhwa , Mukesh Kumar , C. Vinay Kumar Singh
IPC分类号： G06F1516
CPC分类号： H04L67/2819 , G06F17/30873 , H04L29/06 , H04L67/2823 , H04L67/42 , H04L69/329
摘要： A computer implemented method and system for retrieving information through a browser connected to a network. A first file of information is received which includes a first mark-up language to identify contents of the information, which contents include site identifiers. The site identifiers corresponding for example to file locations on the Internet. The first file is displayed in a browser window. Responsive to receiving the first file of information by the browser, the first file of information is parsed by a jumper to generate a list of site identifiers. This list of site identifiers is then stored by the jumper and displayed in a jumper window. Responsive to an activation by the user, a computer is directed to perform the following steps. The jumper determines which of the stored site identifiers is currently selected and automatically selects the next. Next the jumper directs the browser to access the file at the site corresponding to automatically selected site identifier. Finally, the browser is directed to display the file the browser has retrieved in the browser window.
摘要翻译：一种用于通过连接到网络的浏览器检索信息的计算机实现的方法和系统。接收到第一个信息文件，其包括用于识别信息内容的第一标记语言，哪个内容包括站点标识符。站点标识符对应于例如Internet上的文件位置。第一个文件显示在浏览器窗口中。响应于浏览器接收第一个信息文件，第一个信息文件由跳线解析，以生成站点标识符列表。然后，该位置标识符列表由跳线存储并显示在跳线窗口中。响应于用户的激活，计算机被指示执行以下步骤。跳线确定当前选择了哪个存储的站点标识符，并自动选择下一个。接下来，跳线指示浏览器访问与自动选择的站点标识符相对应的站点处的文件。最后，浏览器被指示显示浏览器在浏览器窗口中检索的文件。

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