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    • 95. 发明授权
    • Cosmetic compositions containing anionic surface active agent containing
mono- or polyhydroxylated mono- or poly ether chains and a terminal
acid group
    • 包含含有单羟基或多羟基化的单醚或多醚链和末端酸基团的阴离子表面活性剂的化妆品组合物
    • US3959460A
    • 1976-05-25
    • US466060
    • 1974-05-01
    • Guy VanlergergheHenri Sebag
    • Guy VanlergergheHenri Sebag
    • C11D1/06A61K7/00
    • A61K8/46A61Q5/02A61Q5/065C07C317/00C11D1/06Y10S516/06
    • A cosmetic composition comprises an aqueous solution of an anionic surface active agent selected from the group consisting of (a) a surface active agent of the formula ##EQU1## wherein R is selected from the group consisting of alkyl and alkenyl, each having 8 to 22 carbon atoms and alkylphenyl having 12 to 22 carbon atoms;X and X' are each selected from the group consisting of oxygen, sulfur and sulfoxide;A is selected from the group consisting of ethylene, propylene and butylene;A' is selected from the group consisting of --C.sub.2 H.sub.3 (CH.sub.2 OH)-- and --CH.sub.2 CHOH--CH.sub.2 --;A" is selected from the group consisting of --CH.sub.2 CHOH--CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 -- and --CH.sub.2 CH(CH.sub.3)-- with the proviso that at least one of A' and A" is hydroxyalkylene as set forth in the respective definitions of A' and A" above;m and n represent numbers having a statistical average value between 0 and 10 inclusive with the proviso that n is other than 0 when A" is other than hydroxyalkylene and when m and n are both zero, X' is sulfoxide;R' is selected from the group consisting of hydrogen and a lower alkyl having from 1-12 carbon atoms;B. the magnesium salt of (a); andC. the alkanolamine salt of (a), said surface active agent being present in amounts ranging from 0.1-20% by weight of said composition.
    • 化妆品组合物包含阴离子表面活性剂的水溶液,其选自(a)式RX-(AO)m - (A'O)n-A“-X的表面活性剂 '-CH-COOH(I)| R'其中R选自烷基和烯基,各自具有8至22个碳原子和具有12至22个碳原子的烷基苯基; X和X'各自选自氧,硫和亚砜; A选自乙烯,丙烯和丁烯; A'选自-C 2 H 3(CH 2 OH) - 和-CH 2 CHOH-CH 2 - ; A“选自-CH 2 CHOH-CH 2 - , - CH 2 CH 2 CH 2 - 和-CH 2 CH(CH 3) - ,条件是A'和A”中的至少一个是羟基亚烷基,如各自定义 上面的“A”和“A” 具有0和10之间的统计平均值的M和N表示与N不同于0的化合物,当A“不是羟基亚烷基时,当m和n都为0时,X'是亚砜; R'选自氢和具有1-12个碳原子的低级烷基; (A)的镁盐; 和C.(A)的烷醇胺盐,表面活性剂在本发明组合物的重量百分比为0.1-20%的范围内。
    • 100. 发明授权
    • 4-hydroxyisoxazole derivatives, method of preparing same, and cosmetic
and pharmaceutical compositions containing them
    • 4-羟基异恶唑衍生物,其制备方法,以及含有它们的化妆品和药物组合物
    • US4940575A
    • 1990-07-10
    • US371058
    • 1989-06-26
    • Alexandre ZysmanHenri Sebag
    • Alexandre ZysmanHenri Sebag
    • A61K8/49A61K31/42A61Q17/04C07D261/18
    • A61Q17/04A61K8/49C07D261/18
    • 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
    • 对应于下式的4-羟基异恶唑衍生物:其中:R表示具有1至23个碳原子的直链或支链烷基或羟烷基,具有2至23个碳原子的直链或支链烯基,苯基 或苄基,R 1表示OR 2,-NHR 3或-NH-NHR 4,R 2表示氢原子或碳原子数1〜24的烷基,R 3表示氢原子,碳原子数1〜20的烷基 原子或基团,其中n为2至3,并且r'和r“相同或不同,表示氢原子或低级烷基,或当形成杂环时,如吗啉,哌啶或 哌嗪,R 4表示氢原子或苄基,和式(I)化合物的盐。 这些衍生物适用于治疗和美容领域,特别是抵消太阳的有害影响。