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    • 10. 发明授权
    • Cationic dispersions based on ceramides and/or glycoceramides
    • 基于神经酰胺和/或糖基神经酰胺的阳离子分散体
    • US5679357A
    • 1997-10-21
    • US372720
    • 1995-01-13
    • Claude DubiefDaniele Cauwet
    • Claude DubiefDaniele Cauwet
    • A61K8/41A61K8/68A61Q5/02A61Q5/12A61Q19/10A61K7/00A61K7/07
    • A61Q5/02A61K8/416A61K8/68A61Q19/10A61Q5/12Y10S514/846Y10S514/847
    • Cationic dispersion containing at least 1) one natural or synthetic ceramide or glycoceramide or a mixture of natural or synthetic ceramides and/or glycoceramides of formula (I) where R.sub.1 denotes C.sub.14 -C.sub.30 alkyl, R.sub.2 denotes hydrogen, (glycosyl).sub.n, (galactosyl).sub.m or sulfogalactosyl, n having the value 1 to 4 and m having the value 1 to 8, R.sub.3 denotes a C.sub.15 -C.sub.26 hydrocarbon radical or a C.sub.15 -C.sub.26 .alpha.-hydroxyalkyl radical in the case of the natural ceramides and/or glycoceramides; 2) a compound of formula (II) where X is an anion and a) R.sub.4, R.sub.5 and R.sub.6 denote C.sub.1 -C.sub.4 alkyl and R.sub.7 denotes C.sub.22 alkyl, or b) R.sub.4 and R.sub.5 denote C.sub.1 -C.sub.4 alkyl and: (i) R.sub.6 and R.sub.7 denote C.sub.20 -C.sub.22 alkyl; or (ii) R.sub.6 denotes C.sub.22 alkyl and R.sub.7 denotes benzyl; or c) R.sub.4 denotes C.sub.1 -C.sub.4 alkyl, R.sub.5 denotes (alkyl and/or alkenyl)amidoethyl and R.sub.6 and R.sub.7 denote 4,5-dihydroimidazole substituted in position 2 by a C.sub.13 -C.sub.21 alkyl and/or alkenyl.
    • 含有至少1)一种天然或合成的神经酰胺或甘氨酰胺或式(I)的天然或合成神经酰胺和/或糖甙酰胺的混合物,其中R 1表示C 14 -C 30烷基,R 2表示氢,(糖基)n,(半乳糖基 )m或磺基半乳糖基,n为1至4,m为1至8,R 3表示C 15 -C 26烃基或C 15 -C 26α-羟基烷基,在天然神经酰胺和/或糖苷聚酰胺的情况下; 2)式(II)化合物,其中X是阴离子,和a)R4,R5和R6表示C1-C4烷基,R7表示C22烷基,或b)R4和R5表示C1-C4烷基,和:(ⅰ)R6 并且R 7表示C 20 -C 22烷基; 或(ii)R6表示C22烷基,R7表示苄基; 或c)R 4表示C 1 -C 4烷基,R 5表示(烷基和/或烯基)酰氨基乙基,R 6和R 7表示通过C 13 -C 21烷基和/或烯基在位置2取代的4,5-二氢咪唑。