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91. 发明申请

US20120247762A1 Anti-Channeling Pack-Off Particles Used in a Production Section of an Oil-Gas Well, and Completion Method and Production Method Using Such Particles 有权
标题翻译：油气井生产部分使用的反渠道包装颗粒，使用这种颗粒的完井方法和生产方法
公开(公告)号：US20120247762A1
公开(公告)日：2012-10-04
申请号：US13514494
申请日：2010-12-10
申请人： Bailin Pei , Feng Zhang
发明人： Bailin Pei , Feng Zhang
IPC分类号： E21B43/04 , B32B5/16
CPC分类号： E21B43/04 , C08L23/06 , C08L2207/062 , C08L2312/00 , C09K8/508 , C09K8/516 , E21B33/13 , Y10T428/2982 , C08L25/02
摘要： Anti-channeling pack-off particles used in a production section of an oil-gas well, a completion method, and a production method are provided. The anti-channeling pack-off particles are macromolecule polymer particles having an average particle diameter of 0.05-1.0 mm and a real density of 0.8-1.4 g/cm3. The particles are compactly filled into a space of the oil-gas well, which is required to be filled and packed off so that there is no channeling path after filling, thus effectively pack-off or sectioning the oil-gas well into multiple, relatively independent regions for production from the oil-gas well, and thus improving the production efficiency of the oil-gas well. Even if a channeling path occurs, a very small flow of channeling fluid of a carrier medium will move some of the anti-channeling pack-off particles in a direction towards the channeling path and accumulate those particles until the channeling path is filled, thereby achieving favorable effects of anti-channeling, packing-off, and sectional flow control.
摘要翻译：提供了在油气井的生产部分中使用的防窜流包装颗粒，完井方法和生产方法。抗通道包装颗粒是平均粒径为0.05-1.0mm，实际密度为0.8-1.4g / cm 3的高分子聚合物颗粒。颗粒被紧密地填充到油气井的空间中，这需要填充和包装，使得在填充之后不存在通道，从而有效地将油气井打包或分成多个相对独立的油气井生产区，从而提高了油气井的生产效率。即使发生通道路径，载体介质的非常小的通道流动流将沿着朝向通道的方向移动一些反向通道的包装颗粒，并且累积这些颗粒，直到引导路径被填充，从而实现反渠道，包装和截面流量控制的有利效果。

92. 发明申请

US20120219372A1 BENCH SLIDE DRILLING AND TAPPING DUAL-PURPOSE MACHINE TOOL 有权
标题翻译： BENCH滑动钻机和双刀双刀机
公开(公告)号：US20120219372A1
公开(公告)日：2012-08-30
申请号：US13510358
申请日：2011-01-11
申请人： Jing Zhan , Feng Zhang
发明人： Jing Zhan , Feng Zhang
IPC分类号： B23B47/06 , B23B47/16
CPC分类号： B23Q1/621 , B23B39/12 , B23P23/02
摘要： A bench slide drilling and tapping dual-purpose machine tool has a base, a column and a transverse arm sleeve. The transverse arm sleeve is sleeved around the column, which is vertically fixed on the base. A hydraulic cylinder body is arranged coaxially with the column is centered in the column. A bracket is connected to the upper end of the sleeve, and is connected to a telescopic rod of the hydraulic cylinder. A sliding track is connected to one side of the transverse arm sleeve. A sliding transverse arm is provided inside the sliding track. A main motor is provided on one end of the sliding transverse arm, and the other end of the sliding transverse arm is fixedly connected with a second transverse arm; a drilling driven shaft is arranged in the second transverse arm; the upper end of a main motor is connected with a main belt wheel.
摘要翻译：台架滑动钻孔和攻丝两用机床具有基座，立柱和横向臂套。横臂套筒围绕柱垂直固定在基座上。液压缸体与柱同轴布置在柱中心。支架连接到套筒的上端，并连接到液压缸的伸缩杆。滑动轨道连接到横向臂套筒的一侧。滑动横向臂设置在滑轨内。主电动机设置在滑动横臂的一端，滑动横臂的另一端与第二横臂固定连接; 钻头从动轴设置在第二横臂中; 主电机的上端与主带轮连接。

93. 发明授权

US08173152B2 Stabilized compositions containing alkaline labile drugs 有权
标题翻译：含有碱性不稳定药物的稳定组合物
公开(公告)号：US08173152B2
公开(公告)日：2012-05-08
申请号：US12294367
申请日：2007-03-22
申请人： Michael W. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael W. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61F13/02
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物共混之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

94. 发明授权

US08045586B2 Method and apparatus for transmitting overhead information 有权
标题翻译：用于发送开销信息的方法和装置
公开(公告)号：US08045586B2
公开(公告)日：2011-10-25
申请号：US11958043
申请日：2007-12-17
申请人： Jianbin Huang , Tianxiang Wang , Zhiyong Qiu , Guixue Zhao , Feng Zhang , Jun Feng , Dejun Li , Yongjun Tu , Xiaobin Song
发明人： Jianbin Huang , Tianxiang Wang , Zhiyong Qiu , Guixue Zhao , Feng Zhang , Jun Feng , Dejun Li , Yongjun Tu , Xiaobin Song
IPC分类号： H04J3/24
CPC分类号： H04J3/1611 , H04J2203/0035 , H04W52/58
摘要： A method provided by the present invention for transmitting overhead information, includes dividing and reforming overhead information into at least two overhead parts, inserting the at least two overhead parts into overhead bytes of at least two corresponding data frames, and transmitting the at least two overhead parts via the at least two data frames which are microwave frames. Overhead information transmitting apparatus and overhead information receiving apparatus are also provided by the present invention. With the method and apparatus of the present invention, the channel bandwidth resources occupied by the overhead bytes or each microwave frame are greatly reduced. If the saved channel bandwidth is used for performing the error correction code on the transmitted information, the code gain is improved and the sensitivity requirement on the receiver is reduced so that the cost of a microwave transmitting system is reduced eventually.
摘要翻译：本发明提供的用于发送开销信息的方法包括：将开销信息划分和重构为至少两个开销部分，将至少两个开销部分插入到至少两个相应数据帧的开销字节中，以及发送至少两个开销经由至少两个数据帧的部件是微波帧。本发明还提供了开销信息发送装置和开销信息接收装置。利用本发明的方法和装置，由开销字节或每个微波帧占用的信道带宽资源大大降低。如果保存的信道带宽用于对发送的信息执行纠错码，则可以提高码增益，减少对接收机的灵敏度要求，从而最终降低微波发射系统的成本。

95. 发明申请

US20110224155A1 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 有权
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：US20110224155A1
公开(公告)日：2011-09-15
申请号：US12663634
申请日：2008-06-03
申请人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Xiaodong Li , Feng Zhang , Guy Servant , Qing Chen , Vincent Darmohusodo , Richard Fine , Joseph R. Fotsing , Jeffrey Robert Hammaker , Xinshan Kang , Rachel D.A. Kimmich , Boris Klebansky , Haitian Liu , Goran Petrovic , Marketa Rinnova , Sara Adamski-Werner , Jeffrey Yamamoto , Hong Zhang , Albert Zlotnik , Mark Zoller , Karen Zoller
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Xiaodong Li , Feng Zhang , Guy Servant , Qing Chen , Vincent Darmohusodo , Richard Fine , Joseph R. Fotsing , Jeffrey Robert Hammaker , Xinshan Kang , Rachel D.A. Kimmich , Boris Klebansky , Haitian Liu , Goran Petrovic , Marketa Rinnova , Sara Adamski-Werner , Jeffrey Yamamoto , Hong Zhang , Albert Zlotnik , Mark Zoller , Karen Zoller
IPC分类号： A61K31/517 , C12N5/00 , C07D495/04 , A61K31/519 , C07D239/95 , C07D285/16 , A61K31/54 , C07D471/04 , C07D215/42 , A61K31/4706 , C07D513/04 , C07D513/20 , C07H17/02 , A61K31/706 , A61P27/00 , A23L1/226 , G06G7/58
CPC分类号： A61K31/495 , A61K31/517 , A61K31/519 , C07D239/80 , C07D239/93 , C07D239/95 , C07D239/96 , C07D285/15 , C07D405/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04 , C07D513/20 , C07H17/00 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2500/04 , G06F19/16 , G06F19/18
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
摘要翻译：本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体及其配体。本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄取组合物的甜味或治疗与化学感受受体相关的病症的方法。此外，本发明包括制备化学感受器及其配体的改性剂的方法。

96. 发明申请

US20110185581A1 COMPACT CIRCULAR SAW 审中-公开
标题翻译：紧凑圆锯
公开(公告)号：US20110185581A1
公开(公告)日：2011-08-04
申请号：US12835393
申请日：2010-07-13
申请人： Li Xing , Yibao Zhang , Feng Zhang
发明人： Li Xing , Yibao Zhang , Feng Zhang
IPC分类号： B23D45/16 , B25F5/02
CPC分类号： B23D45/16 , B25F5/02
摘要： A circular saw includes a housing, a motor having a rotating axis and a center of gravity on the rotating axis, a handle, a circular blade, a fixed guard, and a base plate having a width supporting the housing. The motor and the circular blade are parallel or coplanar with respect to each other and the circular saw does not extend beyond the width of the base plate in the width direction.
摘要翻译：圆锯包括壳体，具有旋转轴线的旋转轴线和重心在旋转轴上的电机，手柄，圆形刀片，固定护罩和具有支撑壳体的宽度的底板。马达和圆形刀片相对于彼此平行或共面，并且圆锯不延伸超过基板在宽度方向上的宽度。

97. 发明申请

US20110105998A1 SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS 有权
标题翻译：用于目标细胞光刺激的系统，方法和组合物
公开(公告)号：US20110105998A1
公开(公告)日：2011-05-05
申请号：US12988567
申请日：2009-04-08
申请人： Feng Zhang , Karl Deisseroth , Viviana Gradinaru
发明人： Feng Zhang , Karl Deisseroth , Viviana Gradinaru
IPC分类号： A61N5/06 , A61M37/00 , C12N5/02 , C12Q1/02 , C12N13/00 , C12N15/63 , C07H21/04 , C12N5/00 , A61P25/16
CPC分类号： A61N5/062 , A61K31/713 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N2005/063 , A61N2005/0651 , A61N2005/0662 , A61N2005/067 , C07K14/405 , C07K14/47 , C12N7/00 , C12N15/79 , C12N15/85 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2740/15045 , C12N2750/14143
摘要： Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
摘要翻译：结合光响应离子通道分子实现方法，系统和装置。使用响应于光刺激的光激活离子通道分子来实现一种这样的方法。该方法包括在细胞中工程化光活化离子通道分子; 以及响应于提供给所述离子通道分子的具有不激活ChR2离子通道的性质的光刺激，激活离子通道分子，以允许离子通过光活化的离子通道分子。

98. 发明授权

US07906627B2 Chimeric human sweet-umami and umami-sweet taste receptors 有权
标题翻译：嵌合人类甜味和鲜味甜味受体
公开(公告)号：US07906627B2
公开(公告)日：2011-03-15
申请号：US11583097
申请日：2006-10-19
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , C07H21/04 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

99. 发明申请

US20100304402A9 CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS 有权
标题翻译： CHIMERIC人类SWEET-UMAMI和UMAMI-SWEET TASTE RECEPTORS
公开(公告)号：US20100304402A9
公开(公告)日：2010-12-02
申请号：US11583097
申请日：2006-10-19
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

100. 发明申请

US20100145418A1 SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS 有权
标题翻译：目标细胞光刺激系统
公开(公告)号：US20100145418A1
公开(公告)日：2010-06-10
申请号：US12522520
申请日：2008-01-10
申请人： Feng Zhang , Karl Deisseroth , Edward Boyden
发明人： Feng Zhang , Karl Deisseroth , Edward Boyden
IPC分类号： A61N5/06 , C12N13/00 , C12M3/00
CPC分类号： A61N5/0622 , A61N1/36 , A61N5/06 , A61N5/0601 , A61N5/0613 , A61N2005/0626 , A61N2005/0647 , A61N2005/0652 , A61N2005/0663 , A61N2005/0665 , C12N5/0602 , C12N13/00 , G01N33/502 , G01N33/6872
摘要： Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.
摘要翻译：实现各种系统和方法来控制细胞的刺激。一种这样的方法被实施用于表达NpHR离子泵的细胞的光学刺激。该方法包括向细胞提供一系列刺激的步骤。每个刺激增加在细胞中发生去极化事件的可能性。光提供给细胞以激活表达的NpHR离子泵，从而降低在细胞中发生的去极化事件的可能性。

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