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1. 发明申请

US20110223618A1 ASSAYS USING CHIMERIC T1R POLYPEPTIDE 有权
标题翻译：测定使用CHIMERIC T1R多肽
公开(公告)号：US20110223618A1
公开(公告)日：2011-09-15
申请号：US13020068
申请日：2011-02-03
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

2. 发明授权

US07906627B2 Chimeric human sweet-umami and umami-sweet taste receptors 有权
标题翻译：嵌合人类甜味和鲜味甜味受体
公开(公告)号：US07906627B2
公开(公告)日：2011-03-15
申请号：US11583097
申请日：2006-10-19
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , C07H21/04 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

3. 发明申请

US20100304402A9 CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS 有权
标题翻译： CHIMERIC人类SWEET-UMAMI和UMAMI-SWEET TASTE RECEPTORS
公开(公告)号：US20100304402A9
公开(公告)日：2010-12-02
申请号：US11583097
申请日：2006-10-19
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

4. 发明授权

US08247184B2 Assays using chimeric T1R polypeptides for identifying putative taste modulatory compounds 有权
标题翻译：使用嵌合T1R多肽鉴定推定的口味调节化合物的测定
公开(公告)号：US08247184B2
公开(公告)日：2012-08-21
申请号：US13020068
申请日：2011-02-03
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/53 , G01N33/567 , C12N1/00 , C12N5/07 , C12N5/10
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

5. 发明申请

US20070161053A1 Chimeric human sweet-umami and umami-sweet taste receptors 有权
标题翻译：嵌合人类甜味和鲜味甜味受体
公开(公告)号：US20070161053A1
公开(公告)日：2007-07-12
申请号：US11583097
申请日：2006-10-19
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T 1 R的细胞外部分或其变体或片段，即T 1 R 1或T 1 R 2以及另一个T 1 R或其变体或片段的跨膜部分的嵌合味觉感受器， T 1 R 1或T 1 R 2，优选与T 1 R 3多肽和合适的G蛋白相关。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

6. 发明授权

US08318447B2 Use of bitter taste receptor to screen for compounds that offset the bitter taste of chlorogenic lactone containing coffee compositions 有权
标题翻译：使用苦味受体筛选抵消含绿色内酯的咖啡组合物的苦味的化合物
公开(公告)号：US08318447B2
公开(公告)日：2012-11-27
申请号：US13094974
申请日：2011-04-27
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/00 , G01N2500/10 , Y10S514/974
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便修改（阻断）T2R相关的苦味。优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。

7. 发明授权

US07915003B2 Human T2R receptors for ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators 有权
标题翻译：用于雷尼替丁，士的宁和denatonium的人T2R受体和用于鉴定人类苦味调节剂的相关测定法
公开(公告)号：US07915003B2
公开(公告)日：2011-03-29
申请号：US12166980
申请日：2008-07-02
申请人： Xiaodong Li , Hong Xu , Huixian Tang , Qing Li
发明人： Xiaodong Li , Hong Xu , Huixian Tang , Qing Li
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。

8. 发明申请

US20080187936A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权
标题翻译：识别特异性激活人类T2R受体的双键配体和用于鉴定人类叮咬调味剂的相关测定
公开(公告)号：US20080187936A1
公开(公告)日：2008-08-07
申请号：US11555617
申请日：2006-11-01
申请人： Xiaodong LI , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
发明人： Xiaodong LI , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by these bitter ligands and related compounds and which may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。本发明还涉及这些受体在测定中用于鉴定通过这些苦味配体和相关化合物调节这些味觉受体的活化的配体的用途，并且可以用作添加剂和/或从食品，饮料，化妆品和药物中去除订单修改（阻断）T2R相关苦味。

9. 发明授权

US08148544B2 Compounds that inhibit (block) bitter taste in composition and methods of making same 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其制备方法
公开(公告)号：US08148544B2
公开(公告)日：2012-04-03
申请号：US13051052
申请日：2011-03-18
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D261/06
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

10. 发明申请

US20120015378A1 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权
标题翻译：识别特异性激活人类T2R受体的双键配体和用于鉴定人类叮咬调味剂的相关测定
公开(公告)号：US20120015378A1
公开(公告)日：2012-01-19
申请号：US13225916
申请日：2011-09-06
申请人： Xiaodong Li , Hong Xu , Qing Li , Hubdan Tang , Alexey Pronin
发明人： Xiaodong Li , Hong Xu , Qing Li , Hubdan Tang , Alexey Pronin
IPC分类号： G01N33/566 , C12Q1/02
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by these bitter ligands and related compounds and which may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。本发明还涉及这些受体在测定中用于鉴定通过这些苦味配体和相关化合物调节这些味觉受体的活化的配体的用途，并且可以用作添加剂和/或从食品，饮料，化妆品和药物中去除订单修改（阻断）T2R相关苦味。

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