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91. 发明授权

US08007437B2 Method and apparatus for interactive 4-dimensional (4D) virtual endoscopy 有权
标题翻译：用于交互式四维（4D）虚拟内窥镜检查的方法和装置
公开(公告)号：US08007437B2
公开(公告)日：2011-08-30
申请号：US11874975
申请日：2007-10-19
申请人： Herve Jun Alfred Lombaert , Frank Sauer , Yiyong Sun , Chenyang Xu
发明人： Herve Jun Alfred Lombaert , Frank Sauer , Yiyong Sun , Chenyang Xu
IPC分类号： A61B8/00
CPC分类号： G06T7/0012 , A61B5/7289 , A61B6/503 , A61B8/0883 , A61B8/14 , G06T15/08 , G06T2207/10076 , G06T2207/10136 , G06T2207/30048
摘要： A method of performing 4-dimensional virtual endoscopy includes acquiring a sequence of cardiac images of a patient's heart from an imaging device; acquiring an electrocardiographic signal exhibiting cardiac cycles of the heart; and utilizing the electrocardiographic signal to gate the images for deriving respective 3-dimensional views in succession at corresponding cardiac cycles, from respective cardiac images at a selected phase point common to each of the corresponding cardiac cycles.
摘要翻译：执行4维虚拟内窥镜检查的方法包括从成像装置获取患者心脏的心脏图像序列; 获取显示心脏心脏周期的心电图信号; 以及利用所述心电图信号对所述图像进行门控，以在相应的心动周期连续地导出相应的三维视图，来自相应心脏周期中每个相关心的所选相位点处的各个心脏图像。

92. 发明申请

US20100311811A1 RNA-MEDIATED EPIGENETIC REGULATION OF GENE TRANSCRIPTION 审中-公开
标题翻译： RNA介导的基因转录的重组调控
公开(公告)号：US20100311811A1
公开(公告)日：2010-12-09
申请号：US12769434
申请日：2010-04-28
申请人： Frank Sauer
发明人： Frank Sauer
IPC分类号： A61K31/7115 , C12N5/071 , A61K31/7088 , C12Q1/68 , A61P43/00
CPC分类号： C12N15/63
摘要： The invention provides a method of regulating transcription of a gene that is a target for an epigenetic regulator; a method of characterizing the transcriptional activity of such a gene; a method of screening for a chromosomal element (CE) for an epigenetic regulator of a target gene; an isolated complex including an epigenetic regulator for a target gene, wherein the epigenetic regulator is specifically bound to a non-coding polynucleotide; and a method of screening for a modulator of transcription of a gene that is a target for an epigenetic regulator.
摘要翻译：本发明提供了调节作为表观遗传调节物靶标的基因的转录的方法。表征该基因的转录活性的方法; 筛选靶基因的表观遗传调节剂的染色体元件（CE）的方法; 包括靶基因的表观遗传调节剂的分离的复合物，其中所述表观遗传调节子特异性结合于非编码多核苷酸; 以及筛选作为表观遗传调节物的靶基因的转录调节物的方法。

93. 发明授权

US07822291B2 Non-rigid multi-modal registration using statistical learning methods 有权
标题翻译：使用统计学习方法的非刚性多模态注册
公开(公告)号：US07822291B2
公开(公告)日：2010-10-26
申请号：US11259560
申请日：2005-10-26
申请人： Christoph Guetter , Chenyang Xu , Joachim Hornegger , Frank Sauer
发明人： Christoph Guetter , Chenyang Xu , Joachim Hornegger , Frank Sauer
IPC分类号： G06K9/32
CPC分类号： G06K9/6206 , G06T7/33 , G06T7/35 , G06T2200/04 , G06T2207/10072 , G06T2207/20221
摘要： A computer-implemented method for non-rigid multi-modal registration, includes providing trained data corresponding to previously registered images captured by different modalities, receiving two or more images captured by the different modalities, and registering the two or more images according to context information determined based on the trained data.
摘要翻译：一种用于非刚性多模式注册的计算机实现的方法，包括提供对应于由不同模态捕获的先前注册的图像的训练数据，接收由不同模态捕获的两个或多个图像，以及根据上下文信息注册两个或多个图像根据训练数据确定。

94. 发明授权

US07740268B2 Airbag fastening system 失效
标题翻译：安全气囊紧固系统
公开(公告)号：US07740268B2
公开(公告)日：2010-06-22
申请号：US12216922
申请日：2008-07-11
申请人： Frank Sauer
发明人： Frank Sauer
IPC分类号： B60R21/20
CPC分类号： B60R21/217 , B60R21/203
摘要： An airbag fastening system in an airbag module has a clamping connection and includes a retaining ring for an injection orifice of the airbag in an airbag receptacle surrounding both the airbag module and the retaining ring. The retaining ring has a reducing width on an outer face in a main pulling direction when the airbag unfolds. At least a portion of the airbag receptacle or a component associated with the airbag receptacle has a smaller width above the retaining ring than a greatest width of the retaining ring. A lower end of the airbag forms the injection orifice, is folded over the retaining ring, and extends between the retaining ring and the airbag receptacle or the component. The retaining ring includes at least one portion having a conically tapered cross-section on the outer face in the main pulling direction when the airbag unfolds.
摘要翻译：安全气囊模块中的气囊紧固系统具有夹紧连接，并且包括用于安全气囊插入件中的用于安全气囊的注射孔的保持环，围绕安全气囊模块和保持环。当气囊展开时，保持环在主拉动方向上具有在外表面上的减小宽度。安全气囊插座的至少一部分或与安全气囊插座相关联的部件在保持环之上具有比保持环的最大宽度更小的宽度。气囊的下端形成喷射孔，折叠在保持环上，并且在保持环和气囊插座或部件之间延伸。当气囊展开时，保持环包括在主拉动方向上的外表面上具有锥形锥形横截面的至少一个部分。

95. 发明授权

US07583857B2 System and method for salient region feature based 3D multi modality registration of medical images 有权
标题翻译：用于基于区域特征的3D多模态注册医学图像的系统和方法
公开(公告)号：US07583857B2
公开(公告)日：2009-09-01
申请号：US11380673
申请日：2006-04-28
申请人： Chenyang Xu , Dieter Hahn , Yiyong Sun , Frank Sauer
发明人： Chenyang Xu , Dieter Hahn , Yiyong Sun , Frank Sauer
IPC分类号： G06K9/32
CPC分类号： G06T3/0075 , G06K9/3216 , G06K9/4671 , G06K2209/051 , G06T7/33 , G06T7/35 , G06T7/38 , G06T2207/30004
摘要： A method for aligning a pair of images includes providing a pair of images, identifying salient feature regions in both a first image and a second image, wherein each region is associated with a spatial scale, representing feature regions by a center point of each region, registering the feature points of one image with the feature points of the other image based on local intensities, ordering said feature pairs by a similarity measure, and optimizing a joint correspondence set of feature pairs by refining the center points to sub-pixel accuracy.
摘要翻译：用于对准一对图像的方法包括提供一对图像，识别第一图像和第二图像两者中的突出特征区域，其中每个区域与空间尺度相关联，其中每个区域的中心点表示特征区域，基于局部强度将一个图像的特征点与另一图像的特征点对准，通过相似性度量对所述特征对进行排序，并通过将中心点精细化为子像素精度来优化特征对的联合对应集合。

96. 发明授权

US07450743B2 Method and system of affine registration of inter-operative two dimensional images and pre-operative three dimensional images 有权
标题翻译：手术二维图像和手术前三维图像的仿射注册方法和系统
公开(公告)号：US07450743B2
公开(公告)日：2008-11-11
申请号：US11036528
申请日：2005-01-14
申请人： Hari Sundar , Chenyang Xu , Frank Sauer
发明人： Hari Sundar , Chenyang Xu , Frank Sauer
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , G06T7/33 , G06T2207/10072 , G06T2207/10121 , G06T2207/20072 , G06T2207/30101
摘要： A system and method for registering a sequence of inter-operative two dimensional (2D) medical images of a target feature with pre-operative three dimensional (3D) medical images of the target feature is disclosed. The 3D image of the target feature is converted to a first skeletal graph. The 2D image of the target feature is converted to a second skeletal graph. Graph matching of the first and second skeletal graphs is performed to obtain a rough alignment of the graphs, and the first and second skeletal graph registered.
摘要翻译：公开了一种用于将目标特征的手术间二维（2D）医学图像序列登记到目标特征的手术前三维（3D）医学图像）的系统和方法。将目标要素的3D图像转换为第一个骨架图。目标特征的2D图像被转换为第二个骨架图。执行第一和第二骨架图的图形匹配以获得图的粗略对准，并且注册第一和第二骨架图。

97. 发明申请

US20080270095A1 METHOD AND APPARATUS FOR INTERACTIVE 4-DIMENSIONAL (4D) VIRTUAL ENDOSCOPY 有权
标题翻译：交互式四维（4D）虚拟内窥镜的方法和装置
公开(公告)号：US20080270095A1
公开(公告)日：2008-10-30
申请号：US11874975
申请日：2007-10-19
申请人： Herve Jun Alfred Lombaert , Frank Sauer , Yiyong Sun , Chenyang Xu
发明人： Herve Jun Alfred Lombaert , Frank Sauer , Yiyong Sun , Chenyang Xu
IPC分类号： G06G7/60 , A61B5/02
CPC分类号： G06T7/0012 , A61B5/7289 , A61B6/503 , A61B8/0883 , A61B8/14 , G06T15/08 , G06T2207/10076 , G06T2207/10136 , G06T2207/30048
摘要： A method of performing 4-dimensional virtual endoscopy includes acquiring a sequence of cardiac images of a patient's heart from an imaging device; acquiring an electrocardiographic signal exhibiting cardiac cycles of the heart; and utilizing the electrocardiographic signal to gate the images for deriving respective 3-dimensional views in succession at corresponding cardiac cycles, from respective cardiac images at a selected phase point common to each of the corresponding cardiac cycles.
摘要翻译：执行4维虚拟内窥镜检查的方法包括从成像装置获取患者心脏的心脏图像序列; 获取显示心脏心脏周期的心电图信号; 以及利用所述心电图信号对所述图像进行门控，以在相应的心动周期连续地导出相应的三维视图，来自相应心脏周期中每个相关心的所选相位点处的各个心脏图像。

98. 发明授权

US07409108B2 Method and system for hybrid rigid registration of 2D/3D medical images 有权
标题翻译： 2D / 3D医学图像混合刚性配准的方法和系统
公开(公告)号：US07409108B2
公开(公告)日：2008-08-05
申请号：US10946204
申请日：2004-09-21
申请人： Chenyang Xu , Xiaolei Huang , Frank Sauer , Christophe Chefd'hotel , Jens Gühring , Sebastian Vogt , Yiyong Sun
发明人： Chenyang Xu , Xiaolei Huang , Frank Sauer , Christophe Chefd'hotel , Jens Gühring , Sebastian Vogt , Yiyong Sun
IPC分类号： G06K9/32 , G06K9/68
CPC分类号： G06K9/00208 , G06T7/33 , G06T7/35
摘要： A method of aligning a pair of images with a first image and a second image, wherein said images comprise a plurality of intensities corresponding to a domain of points in a D-dimensional space includes identifying feature points on both images using the same criteria, computing a feature vector for each feature point, measuring a feature dissimilarity for each pair of feature vectors, wherein a first feature vector of each pair is associated with a first feature point on the first image, and a second feature vector of each pair is associated with a second feature point on the second image. A correspondence mapping for each pair of feature points is determined using the feature dissimilarity associated with each feature point pair, and an image transformation is defined to align the second image with the first image using one or more pairs of feature points that are least dissimilar.
摘要翻译：一种将一对图像与第一图像和第二图像对准的方法，其中所述图像包括对应于D维空间中的点的区域的多个强度，包括使用相同标准在两个图像上识别特征点，计算每个特征点的特征向量，测量每对特征向量的特征不相似性，其中每对的第一特征向量与第一图像上的第一特征点相关联，并且每对的第二特征向量与第二个图像上的第二个特征点。使用与每个特征点对相关联的特征不相似度来确定每对特征点的对应关系，并且定义图像变换以使用至少不相似的一对或多对特征点将第二图像与第一图像对准。

99. 发明申请

US20070274582A1 AUTOMATIC POSITIONING OF MATCHING MULTI-PLANAR IMAGE REFORMATTING (MPR) VIEWS OF MULTIPLE 3D MEDICAL IMAGES 有权
标题翻译：匹配多平面图像重建（MPR）的多维3D医学图像的自动定位
公开(公告)号：US20070274582A1
公开(公告)日：2007-11-29
申请号：US11695096
申请日：2007-04-02
申请人： Liron Yatziv , Yiyong Sun , Chenyang Xu , Frank Sauer
发明人： Liron Yatziv , Yiyong Sun , Chenyang Xu , Frank Sauer
IPC分类号： G06K9/60
CPC分类号： G06T7/30 , G06T2207/30004
摘要： A computer-implemented method is disclosed for comparing three dimensional (3D) digital medical images. The method uses a reference MPR to position subsequent MPRs in one or more other 3D digital medical images so their content matches the reference MPR. The matched MPRs may then be used by a medical professional to diagnose a patient condition. The ability to quickly and automatically position matching MPRs for multiple 3D images eases the medical staff workload and shortens diagnostics time. Matching MPRs provides an effective way to view the 3D volumes for anatomical changes over time and to monitor medical conditions such as stenosis and tumors.
摘要翻译：公开了一种用于比较三维（3D）数字医学图像的计算机实现的方法。该方法使用参考MPR将一个或多个其他3D数字医学图像中的后续MPR定位，使得其内容与参考MPR匹配。然后，医疗专业人员可以使用匹配的MPR来诊断患者状况。快速，自动地为多个3D图像定位匹配的MPR的能力可以减轻医务人员的工作量，缩短诊断时间。匹配MPR提供了一种有效的方式来查看3D体积，以便随着时间的推移进行解剖学变化，并监测诸如狭窄和肿瘤之类的医学状况。

100. 发明申请

US20070267850A1 Airbag module assembly 有权
标题翻译：安全气囊模块总成
公开(公告)号：US20070267850A1
公开(公告)日：2007-11-22
申请号：US11798337
申请日：2007-05-11
申请人： Nick Eckert , Patrick Isermann , Milan Bachraty , Matthias Liebetrau , Frank Sauer
发明人： Nick Eckert , Patrick Isermann , Milan Bachraty , Matthias Liebetrau , Frank Sauer
IPC分类号： B60R21/217
CPC分类号： B60R21/217 , B60R21/201
摘要： A module assembly for an airbag device for protecting occupants of motor vehicles includes a carrier for the assembly, an inflatable airbag packet, a flexible protective envelope, and a fixing mechanism. The airbag packet is fixed to the carrier. The airbag packet is accommodated in the flexible protective envelope. The protective enveloped can be closed off in a gastight manner. The fixing mechanism fixes the airbag packet to the carrier. The fixing mechanism includes a holding element. The holding element, which includes a securing mechanism provided on the carrier to fix the airbag packet to the carrier, extends along an edge of the airbag packet. The securing mechanism is formed integrally on the carrier and is resiliently pivotable with respect to a lateral section of the carrier. Alternatively, the securing mechanism is fixed on the carrier as a separate assembly.
摘要翻译：用于保护机动车辆乘客的安全气囊装置的模块组件包括用于组装的载体，可充气安全气囊包，柔性保护套和固定机构。安全气囊包固定在载体上。安全气囊包被容纳在柔性保护外壳中。保护膜可以气密的方式封闭。固定机构将气囊包固定到托架上。固定机构包括保持元件。保持元件包括设置在载体上以将气囊包固定到载体上的固定机构，沿安全气囊包的边缘延伸。固定机构一体地形成在载体上并且能够相对于载体的横向部分弹性地枢转。或者，固定机构作为单独的组件固定在载体上。

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