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91. 发明申请

US20100114192A1 METHODS AND SYSTEMS FOR STIMULATING A MOTOR CORTEX OF THE BRAIN TO TREAT A MEDICAL CONDITION 有权
标题翻译：用于刺激脑的马齿苋治疗医疗条件的方法和系统
公开(公告)号：US20100114192A1
公开(公告)日：2010-05-06
申请号：US12685161
申请日：2010-01-11
申请人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
发明人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a motor cortex within a brain of a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating a medical condition include a system control unit implanted within the patient that is configured to apply at least one stimulus to a motor cortex within a brain of a patient in accordance with one or more stimulation parameters.
摘要翻译：治疗医疗状况的方法包括根据一个或多个刺激参数，用植入的系统控制单元向患者的脑内的运动皮质施加至少一种刺激。用于治疗医疗状况的系统包括植入患者体内的系统控制单元，其被配置为根据一个或多个刺激参数将至少一个刺激施加到患者脑内的运动皮质。

92. 发明授权

US07702385B2 Electrode contact configurations for an implantable stimulator 有权
标题翻译：可植入刺激器的电极接触配置
公开(公告)号：US07702385B2
公开(公告)日：2010-04-20
申请号：US11280582
申请日：2005-11-16
申请人： Michael A. Moffitt , Rafael Carbunaru , Todd K. Whitehurst , Alfred E. Mann
发明人： Michael A. Moffitt , Rafael Carbunaru , Todd K. Whitehurst , Alfred E. Mann
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An exemplary implantable stimulator includes at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. One or more of the electrode contacts disposed on the stimulator are configured to deliver monopolar stimulation and/or multipolar stimulation. Exemplary methods of stimulating a stimulation site within a patient include providing at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. The method further includes applying an electrical stimulation current to the stimulation site via one or more of the electrode contacts that are disposed on the stimulator.
摘要翻译：示例性可植入刺激器包括至少一个电极接触阵列和至少一个附加电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。设置在刺激器上的一个或多个电极接触器被配置成传递单极刺激和/或多极刺激。刺激患者内的刺激部位的示例性方法包括提供至少一个电极接触阵列和至少一个另外的电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。该方法还包括经由设置在刺激器上的一个或多个电极接触件向刺激部位施加电刺激电流。

93. 发明授权

US07627383B2 Implantable stimulator 失效
标题翻译：植入式刺激器
公开(公告)号：US07627383B2
公开(公告)日：2009-12-01
申请号：US11081417
申请日：2005-03-15
申请人： Matthew I. Haller , Jay Daulton , Todd K. Whitehurst , Rafael Carbunaru
发明人： Matthew I. Haller , Jay Daulton , Todd K. Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36007 , A61N1/37205
摘要： Exemplary implantable stimulators for stimulating a stimulation site within a patient include an electronic module configured to generate stimulation and a housing configured to house the electronic module. The housing has a shape allowing the a stimulator and a surgical device to be accommodated together within an insertion tool used to insert the stimulator into the patient. Exemplary methods of stimulating a stimulation site within a patient include generating stimulation with an electronic module and housing the electronic module in a housing. The housing has a shape allowing the housing and a surgical device to be accommodated together within an insertion tool used to insert the housing into the patient.
摘要翻译：用于刺激患者内的刺激部位的示例性可植入刺激器包括被配置为产生刺激的电子模块和被配置为容纳电子模块的壳体。壳体具有允许刺激器和外科装置在用于将刺激器插入患者体内的插入工具中一起容纳的形状。刺激患者内的刺激部位的示例性方法包括利用电子模块产生刺激并将电子模块容纳在壳体中。壳体具有允许外壳和手术装置在用于将外壳插入患者体内的插入工具中一起容纳的形状。

94. 发明授权

US07596414B2 Cuff electrode arrangement for nerve stimulation and methods of treating disorders 有权
标题翻译：用于神经刺激的袖带电极装置和治疗疾病的方法
公开(公告)号：US07596414B2
公开(公告)日：2009-09-29
申请号：US11294283
申请日：2005-12-05
申请人： Todd K. Whitehurst , Kirsten N. Jaax , Rafael Carbunaru
发明人： Todd K. Whitehurst , Kirsten N. Jaax , Rafael Carbunaru
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/37205
摘要： One embodiment is a stimulator arrangement for a nerve. The stimulator arrangement includes a cuff for placement around the nerve and a plurality of electrodes disposed on the cuff. The cuff comprises a first edge and defines a plurality of indentations along the first edge of the cuff. The stimulator arrangement may also include a stimulator unit coupled to the electrodes of the cuff. The stimulator unit may also be implantable.
摘要翻译：一个实施例是用于神经的刺激器装置。刺激器装置包括用于放置在神经周围的袖带和设置在袖带上的多个电极。袖带包括第一边缘并且限定沿着袖带的第一边缘的多个凹痕。刺激器装置还可以包括耦合到袖带的电极的刺激器单元。刺激器单元也可以是可植入的。

95. 发明申请

US20090192558A1 METHODS AND SYSTEMS OF TREATING PANCREATITIS PAIN 有权
标题翻译：治疗胰腺疼痛的方法和系统
公开(公告)号：US20090192558A1
公开(公告)日：2009-07-30
申请号：US12358073
申请日：2009-01-22
申请人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
发明人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
IPC分类号： A61N1/34
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/36071 , A61N1/37205 , A61N1/37252
摘要： Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to treat pancreatitis pain, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat pancreatitis pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
摘要翻译：治疗患有胰腺炎疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗胰腺炎疼痛，用所述一个或多个刺激参数编程所述刺激器，产生被配置为按照所述刺激器治疗胰腺炎疼痛的刺激与所述一个或多个刺激参数相关联，并且根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激位点。

96. 发明申请

US20090192555A1 FIXATION OF IMPLANTABLE PULSE GENERATORS 有权
标题翻译：可植入脉冲发生器的固定
公开(公告)号：US20090192555A1
公开(公告)日：2009-07-30
申请号：US12361432
申请日：2009-01-28
申请人： Brett Schleicher , Todd K. Whitehurst , Andrew DiGiore
发明人： Brett Schleicher , Todd K. Whitehurst , Andrew DiGiore
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61N1/37205 , A61N1/37518 , A61N1/3787
摘要： Systems and techniques for improving the fixation of implantable pulse generators. In one aspect, a device includes an implantable pulse generator that comprises electrical circuitry configured to generate an electrical pulse and a biocompatible casing that houses the electrical circuitry and on which a collection of electrodes and a collection of fixation elements are mounted. The electrodes are in electrical contact with the electrical circuitry and the fixation elements increase the surface area of the biocompatible casing to reduce the likelihood that the biocompatible casing shifts after implantation;
摘要翻译：用于改善植入式脉冲发生器固定的系统和技术。在一个方面，一种装置包括可植入式脉冲发生器，该可植入脉冲发生器包括构造成产生电脉冲的电路和容纳电路的生物相容性壳体，并且其上安装有一组电极和一组固定元件。电极与电路电接触，并且固定元件增加了生物相容性外壳的表面积，以减少植入后生物相容性外壳移位的可能性;

97. 发明申请

US20090082835A1 Apparatus and Methods For Charging An Implanted Medical Device Power Source 有权
标题翻译：一种植入式医疗器械电源充电装置及方法
公开(公告)号：US20090082835A1
公开(公告)日：2009-03-26
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

98. 发明授权

US07006875B1 Curved paddle electrode for use with a neurostimulator 有权
标题翻译：用于神经刺激器的弯曲电极
公开(公告)号：US07006875B1
公开(公告)日：2006-02-28
申请号：US10809747
申请日：2004-03-25
申请人： Janusz A. Kuzma , Todd K. Whitehurst
发明人： Janusz A. Kuzma , Todd K. Whitehurst
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0556
摘要： A curved paddle electrode allows the electrode to be placed over a relatively flat or oval shaped nerve bundle attached to fascia tissue without having to separate the nerve bundle from the fascia tissue. The electrode includes at least one suture hole that allows the electrode to be held in place over the nerve bundle through a clip-on stitch, or equivalent. In one embodiment, the curved paddle electrode provides a tripolar electrode configuration that allows three spaced-apart parallel electrode contacts to be positioned transverse to a target nerve bundle. Such electrode configuration allows bipolar or tripolar stimulation to occur. Other embodiments employ less or more than three electrode contacts. A preferred application of the curved paddle electrode is for the treatment of erectile dysfunction (ED), where the electrode is placed over the neurovascular bundle attached to the rectal fascia tissue near the rectum.
摘要翻译：弯曲的桨电极允许电极放置在附着于筋膜组织的相对平坦或椭圆形的神经束上，而不必将神经束与筋膜组织分开。电极包括至少一个缝合孔，其允许电极通过夹线或等同物保持在神经束上的适当位置。在一个实施例中，弯曲桨电极提供三极电极配置，其允许三个间隔开的平行电极触点横向于目标神经束定位。这种电极配置允许发生双极或三极刺激。其他实施例使用较少或多于三个电极触点。弯曲桨电极的优选应用是用于治疗勃起功能障碍（ED），其中电极置于附着在直肠附近的直肠筋膜组织的神经血管束上。

99. 发明授权

US07003352B1 Treatment of epilepsy by brain stimulation 失效
标题翻译：通过脑刺激治疗癫痫
公开(公告)号：US07003352B1
公开(公告)日：2006-02-21
申请号：US10428743
申请日：2003-05-02
申请人： Todd K. Whitehurst
发明人： Todd K. Whitehurst
IPC分类号： A61N1/18
CPC分类号： A61N1/36171 , A61M5/14276 , A61N1/36064
摘要： Introducing one or more stimulating drugs to the brain and/or applying electrical stimulation to the brain is used to treat epilepsy. At least one implantable system control unit (SCU) produces electrical pulses delivered via electrodes implanted in the brain and/or drug infusion pulses delivered via a catheter implanted in the brain. The stimulation is delivered to targeted brain structures to adjust the activity of those structures. The small size of the SCUs of the invention allow SCU implantation directly and entirely within the skull and/or brain. Simplicity of the preferred systems and methods and compactness of the preferred system are enabled by the modest control parameter set of these SCU, which do not require or include a sensing feature.
摘要翻译：使用一种或多种刺激性药物引入脑部和/或对脑部施加电刺激来治疗癫痫。至少一个可植入系统控制单元（SCU）产生通过植入在脑中的电极传送的电脉冲和/或通过植入在脑中的导管递送的药物输注脉冲。刺激被传递到目标脑结构以调节这些结构的活性。本发明的SCU的小尺寸允许SCU直接且完全在颅骨和/或脑内植入。优选系统和方法的简单性以及优选系统的紧凑性通过这些SCU的适度的控制参数集来实现，这些SCU不需要或包括感测特征。

100. 发明授权

US09409022B2 Methods and systems for stimulating a motor cortex of the brain to treat a medical condition 有权
公开(公告)号：US09409022B2
公开(公告)日：2016-08-09
申请号：US13050836
申请日：2011-03-17
申请人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
发明人： Kristen N. Jaax , Todd K. Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a motor cortex within a brain of a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating a medical condition include a system control unit implanted within the patient that is configured to apply at least one stimulus to a motor cortex within a brain of a patient in accordance with one or more stimulation parameters.

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